DK1200412T3 - Antiproliferative imidazolforbindelser - Google Patents

Antiproliferative imidazolforbindelser

Info

Publication number
DK1200412T3
DK1200412T3 DK00950584T DK00950584T DK1200412T3 DK 1200412 T3 DK1200412 T3 DK 1200412T3 DK 00950584 T DK00950584 T DK 00950584T DK 00950584 T DK00950584 T DK 00950584T DK 1200412 T3 DK1200412 T3 DK 1200412T3
Authority
DK
Denmark
Prior art keywords
antiproliferative
compounds
imidazole compounds
iinhibit
processes
Prior art date
Application number
DK00950584T
Other languages
English (en)
Inventor
Le Wang
Qun Li
Keith W Woods
Hing L Sham
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1200412T3 publication Critical patent/DK1200412T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK00950584T 1999-08-02 2000-07-21 Antiproliferative imidazolforbindelser DK1200412T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/365,936 US6201001B1 (en) 1999-08-02 1999-08-02 Imidazole antiproliferative agents
PCT/US2000/020053 WO2001009103A2 (en) 1999-08-02 2000-07-21 Imidazole antiproliferative agents

Publications (1)

Publication Number Publication Date
DK1200412T3 true DK1200412T3 (da) 2004-03-22

Family

ID=23441008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00950584T DK1200412T3 (da) 1999-08-02 2000-07-21 Antiproliferative imidazolforbindelser

Country Status (11)

Country Link
US (1) US6201001B1 (da)
EP (1) EP1200412B1 (da)
JP (1) JP2003527318A (da)
AT (1) ATE254110T1 (da)
CA (1) CA2378942A1 (da)
DE (1) DE60006536T2 (da)
DK (1) DK1200412T3 (da)
ES (1) ES2212778T3 (da)
MX (1) MXPA02001213A (da)
PT (1) PT1200412E (da)
WO (1) WO2001009103A2 (da)

Families Citing this family (39)

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US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
WO2002080811A2 (en) 2001-04-07 2002-10-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7678065B2 (en) * 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
AU2002305400A1 (en) * 2001-05-03 2002-11-18 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US20040229960A1 (en) * 2001-07-13 2004-11-18 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
US7331984B2 (en) * 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7163543B2 (en) * 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US6933316B2 (en) 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US20060148674A1 (en) * 2004-12-31 2006-07-06 Luduena Richard F Therapeutic composition
WO2007139808A2 (en) * 2006-05-25 2007-12-06 Ayyala Ramesh S Device for delivery of antifibrotic agents & method
AU2007319383A1 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20090264382A1 (en) 2007-11-21 2009-10-22 David Chaplin Methods for Treating Hematopoietic Neoplasms
EP4088772A1 (en) * 2008-01-28 2022-11-16 Implantica Patent Ltd. A drainage device
CN101602730B (zh) * 2008-06-12 2013-06-19 北大方正集团有限公司 取代的咪唑衍生物
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CN102190625B (zh) * 2010-03-18 2013-08-28 南京圣和药业有限公司 二苯乙烯类肿瘤靶向药物Combretastatin A4类似物
CN102985410B (zh) * 2010-05-05 2015-05-27 拜罗伊特大学 在癌症的治疗中使用的考布他汀类似物
CN102863388B (zh) * 2011-07-05 2015-04-29 南京圣和药业股份有限公司 肿瘤靶向药物Combretastatin A4衍生物
CN105753787B (zh) * 2011-07-05 2018-05-15 南京圣和药业股份有限公司 肿瘤靶向药物Combretastatin A4衍生物
EP2755549A1 (en) 2011-09-13 2014-07-23 Dose Medical Corporation Intraocular physiological sensor
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
AU2014228822A1 (en) 2013-03-15 2015-10-01 Memorial Sloan-Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
CN104771396B (zh) * 2014-01-14 2019-04-26 南京圣和药业股份有限公司 4-(3,5-二甲氧苯基)-5-(3-羟基-4-甲氧基苯基)咪唑的应用
WO2017031157A1 (en) 2015-08-18 2017-02-23 Mateon Therapeutics, Inc. Use of vdas to enhance immunomodulating therapies against tumors
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

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FR2122395A1 (en) * 1971-01-19 1972-09-01 Berlin Chemie Veb Pharmacologically active imidazoles - by condensing alpha-aminoketones with formamide
JPS6481673A (en) * 1987-09-22 1989-03-27 Takashi Yamada Automatic generator
US5296609A (en) * 1993-04-09 1994-03-22 Syntex Pharmaceuticals, Ltd. Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives
JPH1081673A (ja) 1996-09-06 1998-03-31 Ajinomoto Co Inc 複素環誘導体、及びそれを含有する制癌剤
US5886025A (en) * 1997-03-06 1999-03-23 Baylor University Anti-mitotic agents which inhibit tubulin polymerization

Also Published As

Publication number Publication date
PT1200412E (pt) 2004-04-30
JP2003527318A (ja) 2003-09-16
EP1200412B1 (en) 2003-11-12
US6201001B1 (en) 2001-03-13
ATE254110T1 (de) 2003-11-15
DE60006536T2 (de) 2004-09-23
DE60006536D1 (de) 2003-12-18
EP1200412A2 (en) 2002-05-02
WO2001009103A3 (en) 2001-05-31
ES2212778T3 (es) 2004-08-01
WO2001009103A2 (en) 2001-02-08
CA2378942A1 (en) 2001-02-08
MXPA02001213A (es) 2002-07-30

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