PT1232160E - Derivados de espiro[2h-1-benzopiran-2,4¿-piperidina] como inibidores do transporte de glicina - Google Patents

Derivados de espiro[2h-1-benzopiran-2,4¿-piperidina] como inibidores do transporte de glicina Download PDF

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Publication number
PT1232160E
PT1232160E PT00977546T PT00977546T PT1232160E PT 1232160 E PT1232160 E PT 1232160E PT 00977546 T PT00977546 T PT 00977546T PT 00977546 T PT00977546 T PT 00977546T PT 1232160 E PT1232160 E PT 1232160E
Authority
PT
Portugal
Prior art keywords
benzopyran
derivates
spiro
piperidine
transport inhibitors
Prior art date
Application number
PT00977546T
Other languages
English (en)
Inventor
Samuel George Gibson
David John Miller
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of PT1232160E publication Critical patent/PT1232160E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT00977546T 1999-11-17 2000-11-13 Derivados de espiro[2h-1-benzopiran-2,4¿-piperidina] como inibidores do transporte de glicina PT1232160E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99309137 1999-11-17

Publications (1)

Publication Number Publication Date
PT1232160E true PT1232160E (pt) 2008-09-30

Family

ID=8241739

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00977546T PT1232160E (pt) 1999-11-17 2000-11-13 Derivados de espiro[2h-1-benzopiran-2,4¿-piperidina] como inibidores do transporte de glicina

Country Status (29)

Country Link
US (2) US6645973B1 (pt)
EP (1) EP1232160B1 (pt)
JP (1) JP4825386B2 (pt)
KR (1) KR100776226B1 (pt)
CN (1) CN1199974C (pt)
AR (1) AR026487A1 (pt)
AT (1) ATE398622T1 (pt)
AU (1) AU779518B2 (pt)
BR (1) BR0015586A (pt)
CA (1) CA2389491C (pt)
CO (1) CO5261618A1 (pt)
CY (1) CY1108339T1 (pt)
CZ (1) CZ293920B6 (pt)
DE (1) DE60039247D1 (pt)
DK (1) DK1232160T3 (pt)
ES (1) ES2307536T3 (pt)
HK (1) HK1047282B (pt)
HU (1) HUP0204162A3 (pt)
IL (2) IL149286A0 (pt)
NO (1) NO327743B1 (pt)
NZ (1) NZ518671A (pt)
PE (1) PE20010750A1 (pt)
PL (1) PL206071B1 (pt)
PT (1) PT1232160E (pt)
RU (1) RU2250211C2 (pt)
SK (1) SK287040B6 (pt)
TW (1) TWI243173B (pt)
WO (1) WO2001036423A1 (pt)
ZA (1) ZA200203320B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
CN100549004C (zh) * 2003-10-01 2009-10-14 阿得罗公司 螺环杂环衍生物及其应用方法
RU2355690C2 (ru) * 2004-01-08 2009-05-20 Ф.Хоффманн-Ля Рош Аг Производные диазаспиропиперидина
ES2295963T3 (es) * 2004-01-08 2008-04-16 F. Hoffmann-La Roche Ag Derivados diaza-espiropiperidina como inhibidores del transportador 1 de glicina y transportador 2 de glicina.
EP1735057B1 (en) * 2004-03-22 2015-02-25 Apkarian Technologies LLC Method and compositions for treatment of chronic neuropathic pain
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101184749B (zh) * 2005-03-31 2012-12-05 阿得罗公司 螺环杂环衍生物及其使用方法
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2009536175A (ja) * 2006-05-05 2009-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 特定の細胞サイクル酵素の阻害剤としてのスピロ−（ｔｈｏ）ベンゾピラン−２，４’−ピペリジン−及びシクロヘキサン誘導体
AU2007294968A1 (en) * 2006-09-12 2008-03-20 Adolor Corporation Use of N-containing spirocompounds for the enhancement of cognitive function
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
KR100888468B1 (ko) * 2007-08-31 2009-03-11 한국화학연구원 항암활성을 갖는1'-알킬피페리딘-4'-스피로-2-6-(아미도)-2ｈ-벤조피란유도체
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
TWI543984B (zh) * 2010-07-09 2016-08-01 艾伯維公司 作為s1p調節劑的螺-哌啶衍生物
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
CN116621187B (zh) * 2023-07-24 2023-09-22 江苏泓顺硅基半导体科技有限公司 一种用于高温氯化提纯石英砂的设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IL107881A0 (en) 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
CA2155108A1 (en) * 1993-02-12 1994-08-18 John J. Baldwin Nitrogen-containing spirocycles
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
EP0871440B1 (en) 1995-12-07 2006-03-22 Daniel C. Javitt Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists
HUP9600928A3 (en) 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
AU737095B2 (en) 1996-05-31 2001-08-09 Nps Pharmaceuticals, Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
DK1014966T3 (da) 1996-05-31 2006-12-04 Allelix Neuroscience Inc Farmaceutisk præparat til behandling af neurologiske og neuropsykiatriske lidelser
US5919653A (en) 1996-08-20 1999-07-06 Allelix Neuroscience Inc. Nucleic acids encoding a human glycine transporter
AU2030999A (en) 1998-01-09 1999-07-26 Allelix Neuroscience, Inc. Glycine transport inhibitors
TW555757B (en) 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
CN1249057C (zh) * 2000-04-27 2006-04-05 巴斯利尔药物股份公司 用作抗菌剂的色烯基甲基嘧啶二胺

Also Published As

Publication number Publication date
EP1232160A1 (en) 2002-08-21
JP2003527340A (ja) 2003-09-16
PL355975A1 (en) 2004-05-31
WO2001036423A1 (en) 2001-05-25
US20040029904A1 (en) 2004-02-12
ZA200203320B (en) 2003-08-27
HK1047282B (zh) 2008-08-29
CO5261618A1 (es) 2003-03-31
KR20020050287A (ko) 2002-06-26
HUP0204162A2 (hu) 2003-04-28
AU1521901A (en) 2001-05-30
AR026487A1 (es) 2003-02-12
DK1232160T3 (da) 2008-10-06
SK287040B6 (sk) 2009-10-07
IL149286A0 (en) 2002-11-10
CN1390221A (zh) 2003-01-08
RU2250211C2 (ru) 2005-04-20
CA2389491C (en) 2010-11-02
PE20010750A1 (es) 2001-07-19
ATE398622T1 (de) 2008-07-15
CZ20021724A3 (cs) 2002-08-14
PL206071B1 (pl) 2010-06-30
CN1199974C (zh) 2005-05-04
CY1108339T1 (el) 2014-02-12
BR0015586A (pt) 2002-07-09
CZ293920B6 (cs) 2004-08-18
NO20022320L (no) 2002-05-15
NO327743B1 (no) 2009-09-14
NZ518671A (en) 2003-10-31
ES2307536T3 (es) 2008-12-01
HUP0204162A3 (en) 2006-01-30
KR100776226B1 (ko) 2007-11-16
US6645973B1 (en) 2003-11-11
TWI243173B (en) 2005-11-11
JP4825386B2 (ja) 2011-11-30
CA2389491A1 (en) 2001-05-25
SK8432002A3 (en) 2002-10-08
DE60039247D1 (de) 2008-07-31
AU779518B2 (en) 2005-01-27
EP1232160B1 (en) 2008-06-18
HK1047282A1 (en) 2003-02-14
NO20022320D0 (no) 2002-05-15
US7507824B2 (en) 2009-03-24
IL149286A (en) 2008-08-07

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