PL98706B1 - Sposob wytwarzania nowych pochodnych kwasu tiazolidynooctowego - Google Patents

Sposob wytwarzania nowych pochodnych kwasu tiazolidynooctowego Download PDF

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Publication number
PL98706B1
PL98706B1 PL1975178903A PL17890375A PL98706B1 PL 98706 B1 PL98706 B1 PL 98706B1 PL 1975178903 A PL1975178903 A PL 1975178903A PL 17890375 A PL17890375 A PL 17890375A PL 98706 B1 PL98706 B1 PL 98706B1
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PL
Poland
Prior art keywords
acid
carbon atoms
general formula
alkyl radical
solution
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Application number
PL1975178903A
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English (en)
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Publication of PL98706B1 publication Critical patent/PL98706B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Claims (5)

  1. Zastrzezenia patentowe 1. Sposób wytwarzania nowych pochodnych kwa* su tiazolidynonooctowego o ogólnym wzorze 1, W którym Rj oznacza rodnik alkilowy o l—l ato¬ mach wegla, albo ich soli, znamienny tym, ze zwiazek o ogólnym wzorze 2, w którym Ri ma wy¬ zej podane znaczenie, a R2 oznacza rodnik alkilowy o 2—6 atomach wegla, traktuje sie w niskiej tem¬ peraturze okclo 40% roztworem bromowodoru w kwasie octowym, zageszcza mieszanine reakcyjna, wyosabnia otrzymany produkt i ewentualnie pod¬ daje go reakcji z fizjologicznie dopuszczalna za¬ sada, otrzymujac odpowiednia sól tego kwasu.
  2. 2. Sposób wedlug zastrz. 1, znamienny tym, ze reakcje prowadzi sie w temperaturze od -^5°C do 25°C.
  3. 3. Sposób wedlug zastrz. 1, znamienny tym, ze zageszczona mieszanine poreakcyjna traktuje sie wcda i doprowadza wartosc pH roztworu do 6, wy- co tracajac kwas o wzorze 1, w którym Rx ma zna¬ czenie podane w zastrz. 1,
  4. 4. Sposób wytwarzania nowych pochodnych kwa¬ su tiazoilidynooctwego o ogólnym wzorze 1, w któ¬ rym Rj oznacza rodnik alkilowy o 1—\ atomach w wegla, albo ich soli znamienny tym, ze zwiazali 95 40 45 5« 55$8704 6 ogólnym wzorze 2. w którym Rj ma wyzej po¬ dane zmaczenie, a R2 oznacza rodnik alkilowy o 2—ti atomach atomach wegla traktuje sie w ni¬ skiej temperaturze okolo 40% roztworu bromowo- doru w organicznym kwasie zawierajacym 1 lub 3—5, atomów wegla, po czym mieszanine reakcyj¬ na zageszcza sie i wyosabnia otrzymany produkt,
  5. 5. Sposób wedlug zastrz. 4, znamienny tym, ze stosuje sie okolo 4ii,/t roztwór bromowc-doru w kwasie propiomnvym lub maslowym. 5—CH-lO HOOC-CH-d^-0 1 Hxóri H R20OC-CH«C^C=O ' R< Uibt Prac. Poligraf. UP PRL naklad 120+18 PL
PL1975178903A 1974-03-25 1975-03-19 Sposob wytwarzania nowych pochodnych kwasu tiazolidynooctowego PL98706B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2414345A DE2414345C3 (de) 1974-03-25 1974-03-25 (Z)-(3-Methyl-4-oxo-5-piperidinothiazolidin-2-yIiden)-esssigsäure und Verfahren zur Herstellung von Thiazolidinessigsäure-Derivaten

Publications (1)

Publication Number Publication Date
PL98706B1 true PL98706B1 (pl) 1978-05-31

Family

ID=5911109

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1975178903A PL98706B1 (pl) 1974-03-25 1975-03-19 Sposob wytwarzania nowych pochodnych kwasu tiazolidynooctowego

Country Status (15)

Country Link
US (1) US3971794A (pl)
JP (1) JPS5310068B2 (pl)
AR (1) AR204131A1 (pl)
BE (1) BE826697A (pl)
BG (1) BG25086A3 (pl)
CA (1) CA1025868A (pl)
CS (1) CS188942B2 (pl)
DD (1) DD119050A5 (pl)
DE (1) DE2414345C3 (pl)
HU (1) HU169421B (pl)
PH (2) PH12256A (pl)
PL (1) PL98706B1 (pl)
RO (1) RO64271A (pl)
SU (1) SU543348A3 (pl)
ZA (1) ZA751279B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802387C2 (de) * 1978-01-20 1980-04-03 Goedecke Ag, 1000 Berlin Verfahren zur Herstellung von Thiazo-üdin-4-on-essigsäure-Derivaten
AU531659B2 (en) * 1979-03-22 1983-09-01 Goedecke Aktiengesellschaft (+)-(3-methyl-4-oxo - 5n-piperidinothiazolidin-2-ylidene) acetic acid esters

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064003A (en) * 1962-11-13 Carboxylic acid derivatives of sub-
US3072653A (en) * 1961-03-06 1963-01-08 Warner Lamber Pharmaceutical C 5-amino derivatives of 4-thiazolidinones and process therefor

Also Published As

Publication number Publication date
PH12425A (en) 1979-02-15
DE2414345B2 (de) 1979-04-05
DE2414345C3 (de) 1980-02-21
BG25086A3 (en) 1978-07-12
AR204131A1 (es) 1975-11-20
CA1025868A (en) 1978-02-07
SU543348A3 (ru) 1977-01-15
DD119050A5 (pl) 1976-04-05
AU7894375A (en) 1976-09-16
PH12256A (en) 1978-12-12
BE826697A (fr) 1975-09-15
ZA751279B (en) 1976-01-28
CS188942B2 (en) 1979-03-30
RO64271A (fr) 1979-05-15
US3971794A (en) 1976-07-27
JPS5310068B2 (pl) 1978-04-11
DE2414345A1 (de) 1975-10-02
HU169421B (pl) 1976-11-28
JPS50130771A (pl) 1975-10-16

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