PL433216A1 - Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation - Google Patents

Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation

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Publication number
PL433216A1
PL433216A1 PL433216A PL43321620A PL433216A1 PL 433216 A1 PL433216 A1 PL 433216A1 PL 433216 A PL433216 A PL 433216A PL 43321620 A PL43321620 A PL 43321620A PL 433216 A1 PL433216 A1 PL 433216A1
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Poland
Prior art keywords
arginine
bis
copper
hydrate
diazide
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PL433216A
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Polish (pl)
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PL240033B1 (en
Inventor
Agnieszka Wojciechowska
Jan Janczak
Adrianna Matusiak
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Politechnika Wrocławska
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Priority to PL433216A priority Critical patent/PL240033B1/en
Publication of PL433216A1 publication Critical patent/PL433216A1/en
Publication of PL240033B1 publication Critical patent/PL240033B1/en

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Abstract

Wynalazek dotyczy krystalicznej formy kompleksu bis(L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6 znajdującej zastosowanie jako składnik leku o działaniu przeciwgrzybicznym i antybakteryjnym. Wynalazek zapewnia również sposób wytwarzania krystalicznej formy kompleksu bis(L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6 który charakteryzuje się tym, że jedną część molową uwodnionej soli mrówczanu miedzi (II), rozpuszcza się w wodzie i poddaje się reakcji z dwoma lub trzema częściami molowymi wodnego roztworu L-argininy, następnie powstałą mieszaninę poddaje się reakcji z jedną częścią molową wodnego roztworu KN3, po czym klarowną mieszaninę pozostawia się do powolnego odparowywania w temperaturze pokojowej, a po minimum 21 dniach otrzymuje się krystaliczną formę hexsa hydrat bis (L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6.The invention relates to a crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azoformate copper (II) hydrate 1/6, which is used as an antifungal and antibacterial drug component. The invention also provides a method for the preparation of the crystalline form of the bis (L-arginine) diazide complex (II) bis (L-arginine) azoformate copper (II) hydrate 1/6 which is characterized in that one molar part of the hydrated copper (II) formate salt dissolves in water and reacted with two or three parts by mole of L-arginine aqueous solution, then the resulting mixture is reacted with one part by mole of aqueous KN3 solution, after which the clear mixture is allowed to evaporate slowly at room temperature and after a minimum of 21 hours. days, the crystalline form of bis (L-arginine) diazide hydrate hexa hydrate (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 is obtained.

PL433216A 2020-03-12 2020-03-12 Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation PL240033B1 (en)

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PL433216A PL240033B1 (en) 2020-03-12 2020-03-12 Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation

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Application Number Priority Date Filing Date Title
PL433216A PL240033B1 (en) 2020-03-12 2020-03-12 Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation

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PL433216A1 true PL433216A1 (en) 2021-09-13
PL240033B1 PL240033B1 (en) 2022-02-07

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PL433216A PL240033B1 (en) 2020-03-12 2020-03-12 Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation

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