PL433216A1 - Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation - Google Patents
Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparationInfo
- Publication number
- PL433216A1 PL433216A1 PL433216A PL43321620A PL433216A1 PL 433216 A1 PL433216 A1 PL 433216A1 PL 433216 A PL433216 A PL 433216A PL 43321620 A PL43321620 A PL 43321620A PL 433216 A1 PL433216 A1 PL 433216A1
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- PL
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- Prior art keywords
- arginine
- bis
- copper
- hydrate
- diazide
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy krystalicznej formy kompleksu bis(L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6 znajdującej zastosowanie jako składnik leku o działaniu przeciwgrzybicznym i antybakteryjnym. Wynalazek zapewnia również sposób wytwarzania krystalicznej formy kompleksu bis(L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6 który charakteryzuje się tym, że jedną część molową uwodnionej soli mrówczanu miedzi (II), rozpuszcza się w wodzie i poddaje się reakcji z dwoma lub trzema częściami molowymi wodnego roztworu L-argininy, następnie powstałą mieszaninę poddaje się reakcji z jedną częścią molową wodnego roztworu KN3, po czym klarowną mieszaninę pozostawia się do powolnego odparowywania w temperaturze pokojowej, a po minimum 21 dniach otrzymuje się krystaliczną formę hexsa hydrat bis (L-arginina)diazydomiedź(II)bis(L-arginina)azydomrówczanomiedź(II) hydrat 1/6.The invention relates to a crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azoformate copper (II) hydrate 1/6, which is used as an antifungal and antibacterial drug component. The invention also provides a method for the preparation of the crystalline form of the bis (L-arginine) diazide complex (II) bis (L-arginine) azoformate copper (II) hydrate 1/6 which is characterized in that one molar part of the hydrated copper (II) formate salt dissolves in water and reacted with two or three parts by mole of L-arginine aqueous solution, then the resulting mixture is reacted with one part by mole of aqueous KN3 solution, after which the clear mixture is allowed to evaporate slowly at room temperature and after a minimum of 21 hours. days, the crystalline form of bis (L-arginine) diazide hydrate hexa hydrate (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 is obtained.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PL433216A PL240033B1 (en) | 2020-03-12 | 2020-03-12 | Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL433216A PL240033B1 (en) | 2020-03-12 | 2020-03-12 | Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
PL433216A1 true PL433216A1 (en) | 2021-09-13 |
PL240033B1 PL240033B1 (en) | 2022-02-07 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PL433216A PL240033B1 (en) | 2020-03-12 | 2020-03-12 | Crystalline form of the complex bis (L-arginine) diazide copper (II) bis (L-arginine) azidoformate copper (II) hydrate 1/6 and method of its preparation |
Country Status (1)
Country | Link |
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PL (1) | PL240033B1 (en) |
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2020
- 2020-03-12 PL PL433216A patent/PL240033B1/en unknown
Also Published As
Publication number | Publication date |
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PL240033B1 (en) | 2022-02-07 |
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