PL431215A1 - Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production - Google Patents

Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production

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Publication number
PL431215A1
PL431215A1 PL431215A PL43121519A PL431215A1 PL 431215 A1 PL431215 A1 PL 431215A1 PL 431215 A PL431215 A PL 431215A PL 43121519 A PL43121519 A PL 43121519A PL 431215 A1 PL431215 A1 PL 431215A1
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PL
Poland
Prior art keywords
arginine
bis
copper
hydrate
crystalline form
Prior art date
Application number
PL431215A
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Polish (pl)
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PL237064B1 (en
Inventor
Agnieszka Wojciechowska
Jan Janczak
Adrianna Matusiak
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Politechnika Wrocławska
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Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL431215A priority Critical patent/PL237064B1/en
Publication of PL431215A1 publication Critical patent/PL431215A1/en
Publication of PL237064B1 publication Critical patent/PL237064B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Zgłoszenie dotyczy krystalicznej formy kompleksu azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1, znajdującej zastosowanie jako składnik leku o działaniu przeciwgrzybicznym i antybakteryjnym. Przedmiotem zgłoszenia jest również sposób wytwarzania krystalicznej formy kompleksu azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1, który charakteryzuje się tym, że jedną część molową uwodnionej soli chlorku miedzi (II), rozpuszcza się w wodzie i poddaje się reakcji z dwoma częściami molowymi wodnego roztworu L-argininy, następnie powstałą mieszaninę poddaje się reakcji z trzema częściami molowymi wodnego roztworu KN3, po czym klarowną mieszaninę pozostawia się do powolnego odparowywania w temperaturze pokojowej, po minimum 40 dniach otrzymuje się krystaliczną formę azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1.The application relates to a crystalline form of the bis (L-arginine) chloroclopzide (II) bis (L-arginine) diazide-copper (II) hydrate 1/7 complex of the formula I, which is used as an antifungal and antibacterial drug component. The subject of the application is also a process for the preparation of the crystalline form of the complex bis (L-arginine) chloroclopzide (II) bis (L-arginine) diazide copper (II) hydrate 1/7 of the formula I, which is characterized in that one molar part of the hydrated chloride salt is copper (II), is dissolved in water and reacted with two parts by mole of L-arginine aqueous solution, then the resulting mixture is reacted with three parts by mole of aqueous KN3 solution, after which the clear mixture is allowed to evaporate slowly at room temperature. after a minimum of 40 days, the crystalline form of bis (L-arginine) chloroclop (II) azide bis (L-arginine) diazide copper (II) hydrate 1/7 of formula 1 is obtained.

PL431215A 2019-09-19 2019-09-19 Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production PL237064B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL431215A PL237064B1 (en) 2019-09-19 2019-09-19 Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431215A PL237064B1 (en) 2019-09-19 2019-09-19 Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production

Publications (2)

Publication Number Publication Date
PL431215A1 true PL431215A1 (en) 2020-05-18
PL237064B1 PL237064B1 (en) 2021-03-08

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PL431215A PL237064B1 (en) 2019-09-19 2019-09-19 Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production

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PL (1) PL237064B1 (en)

Also Published As

Publication number Publication date
PL237064B1 (en) 2021-03-08

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