PL431215A1 - Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production - Google Patents
Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its productionInfo
- Publication number
- PL431215A1 PL431215A1 PL431215A PL43121519A PL431215A1 PL 431215 A1 PL431215 A1 PL 431215A1 PL 431215 A PL431215 A PL 431215A PL 43121519 A PL43121519 A PL 43121519A PL 431215 A1 PL431215 A1 PL 431215A1
- Authority
- PL
- Poland
- Prior art keywords
- arginine
- bis
- copper
- hydrate
- crystalline form
- Prior art date
Links
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 title abstract 8
- 229930064664 L-arginine Natural products 0.000 title abstract 8
- 235000014852 L-arginine Nutrition 0.000 title abstract 8
- 150000001540 azides Chemical class 0.000 title 1
- 229910052802 copper Inorganic materials 0.000 title 1
- 239000010949 copper Substances 0.000 title 1
- -1 diazide-copper (II) hydrate Chemical compound 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical group [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940124350 antibacterial drug Drugs 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000003841 chloride salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Zgłoszenie dotyczy krystalicznej formy kompleksu azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1, znajdującej zastosowanie jako składnik leku o działaniu przeciwgrzybicznym i antybakteryjnym. Przedmiotem zgłoszenia jest również sposób wytwarzania krystalicznej formy kompleksu azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1, który charakteryzuje się tym, że jedną część molową uwodnionej soli chlorku miedzi (II), rozpuszcza się w wodzie i poddaje się reakcji z dwoma częściami molowymi wodnego roztworu L-argininy, następnie powstałą mieszaninę poddaje się reakcji z trzema częściami molowymi wodnego roztworu KN3, po czym klarowną mieszaninę pozostawia się do powolnego odparowywania w temperaturze pokojowej, po minimum 40 dniach otrzymuje się krystaliczną formę azydek bis(L-arginina)chloromiedzi(II)bis(L-arginina)diazydomiedź(II) hydrat 1/7 o wzorze 1.The application relates to a crystalline form of the bis (L-arginine) chloroclopzide (II) bis (L-arginine) diazide-copper (II) hydrate 1/7 complex of the formula I, which is used as an antifungal and antibacterial drug component. The subject of the application is also a process for the preparation of the crystalline form of the complex bis (L-arginine) chloroclopzide (II) bis (L-arginine) diazide copper (II) hydrate 1/7 of the formula I, which is characterized in that one molar part of the hydrated chloride salt is copper (II), is dissolved in water and reacted with two parts by mole of L-arginine aqueous solution, then the resulting mixture is reacted with three parts by mole of aqueous KN3 solution, after which the clear mixture is allowed to evaporate slowly at room temperature. after a minimum of 40 days, the crystalline form of bis (L-arginine) chloroclop (II) azide bis (L-arginine) diazide copper (II) hydrate 1/7 of formula 1 is obtained.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL431215A PL237064B1 (en) | 2019-09-19 | 2019-09-19 | Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL431215A PL237064B1 (en) | 2019-09-19 | 2019-09-19 | Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production |
Publications (2)
Publication Number | Publication Date |
---|---|
PL431215A1 true PL431215A1 (en) | 2020-05-18 |
PL237064B1 PL237064B1 (en) | 2021-03-08 |
Family
ID=70725740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL431215A PL237064B1 (en) | 2019-09-19 | 2019-09-19 | Crystalline form of azide bis(L-arginine)chlorine-copper(Il)bis(L-arginine)diazido-copper(II) hydrate 1/7 complex and method of its production |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL237064B1 (en) |
-
2019
- 2019-09-19 PL PL431215A patent/PL237064B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL237064B1 (en) | 2021-03-08 |
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