PL3986561T3 - Pochodne pirydo[2,3-d]pirymidyny jako inhibitory replikacji ludzkiego wirusa niedoboru odporności - Google Patents

Pochodne pirydo[2,3-d]pirymidyny jako inhibitory replikacji ludzkiego wirusa niedoboru odporności

Info

Publication number
PL3986561T3
PL3986561T3 PL20743783.1T PL20743783T PL3986561T3 PL 3986561 T3 PL3986561 T3 PL 3986561T3 PL 20743783 T PL20743783 T PL 20743783T PL 3986561 T3 PL3986561 T3 PL 3986561T3
Authority
PL
Poland
Prior art keywords
pyrido
inhibitors
immunodeficiency virus
human immunodeficiency
virus replication
Prior art date
Application number
PL20743783.1T
Other languages
English (en)
Inventor
Eric P Gillis
Christiana Iwuagwu
Original Assignee
VIIV Healthcare UK (No.5) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VIIV Healthcare UK (No.5) Limited filed Critical VIIV Healthcare UK (No.5) Limited
Publication of PL3986561T3 publication Critical patent/PL3986561T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL20743783.1T 2019-06-19 2020-06-17 Pochodne pirydo[2,3-d]pirymidyny jako inhibitory replikacji ludzkiego wirusa niedoboru odporności PL3986561T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962863406P 2019-06-19 2019-06-19
PCT/IB2020/055653 WO2020254985A1 (en) 2019-06-19 2020-06-17 Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication

Publications (1)

Publication Number Publication Date
PL3986561T3 true PL3986561T3 (pl) 2024-06-10

Family

ID=71738195

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20743783.1T PL3986561T3 (pl) 2019-06-19 2020-06-17 Pochodne pirydo[2,3-d]pirymidyny jako inhibitory replikacji ludzkiego wirusa niedoboru odporności

Country Status (26)

Country Link
US (1) US20210323967A1 (pl)
EP (1) EP3986561B1 (pl)
JP (1) JP2022537047A (pl)
KR (1) KR20220024608A (pl)
CN (1) CN114245795A (pl)
AR (1) AR119174A1 (pl)
AU (1) AU2020295793B2 (pl)
BR (1) BR112021025655A2 (pl)
CA (1) CA3143136A1 (pl)
CL (1) CL2021003388A1 (pl)
CO (1) CO2021017479A2 (pl)
CR (1) CR20210664A (pl)
DK (1) DK3986561T3 (pl)
FI (1) FI3986561T3 (pl)
IL (1) IL288750A (pl)
LT (1) LT3986561T (pl)
MA (1) MA56526B1 (pl)
MX (1) MX2021016149A (pl)
PE (1) PE20220510A1 (pl)
PL (1) PL3986561T3 (pl)
PT (1) PT3986561T (pl)
RS (1) RS65304B1 (pl)
SI (1) SI3986561T1 (pl)
TW (1) TW202115055A (pl)
UY (1) UY38755A (pl)
WO (1) WO2020254985A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020084492A1 (en) 2018-10-24 2020-04-30 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
UY38982A (es) * 2019-12-09 2021-06-30 Viiv Healthcare Co Composiciones farmacéuticas
US20230355626A1 (en) * 2020-03-06 2023-11-09 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2023062559A1 (en) 2021-10-13 2023-04-20 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000032A1 (en) * 2008-07-02 2010-01-07 Avexa Limited Compounds having antiviral properties
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
EP2729448B1 (en) 2011-07-06 2015-09-09 Gilead Sciences, Inc. Compounds for the treatment of hiv
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
EP2943487B1 (en) 2013-01-09 2016-11-16 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
ES2642265T3 (es) 2013-01-09 2017-11-16 Gilead Sciences, Inc. Compuestos terapéuticos para el tratamiento de infecciones virales
TWI706945B (zh) 2013-03-01 2020-10-11 美商基利科學股份有限公司 供治療反轉錄病毒科病毒感染之治療性化合物
WO2015130966A1 (en) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Antiviral agents
WO2015130964A1 (en) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Therapeutic compounds
PT3186239T (pt) 2014-08-29 2019-01-10 Gilead Sciences Inc Agentes antirretrovirais
FI3597646T3 (fi) * 2016-08-19 2023-09-07 Gilead Sciences Inc Hi-virusinfektion profylaktiseen tai terapeuttiseen hoitoon käyttökelpoisia terapeuttisia yhdisteitä
WO2018045150A1 (en) * 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
UY37710A (es) * 2017-05-02 2018-11-30 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
UY38559A (es) * 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana

Also Published As

Publication number Publication date
TW202115055A (zh) 2021-04-16
AR119174A1 (es) 2021-12-01
CA3143136A1 (en) 2020-12-24
SI3986561T1 (sl) 2024-04-30
MA56526A (fr) 2022-04-27
AU2020295793A1 (en) 2022-01-20
PE20220510A1 (es) 2022-04-07
US20210323967A1 (en) 2021-10-21
CN114245795A (zh) 2022-03-25
IL288750A (en) 2022-02-01
UY38755A (es) 2020-11-30
CO2021017479A2 (es) 2022-04-19
RS65304B1 (sr) 2024-04-30
WO2020254985A1 (en) 2020-12-24
FI3986561T3 (fi) 2024-05-02
CL2021003388A1 (es) 2022-09-30
DK3986561T3 (da) 2024-03-04
EP3986561A1 (en) 2022-04-27
BR112021025655A2 (pt) 2022-02-01
EP3986561B1 (en) 2024-02-14
AU2020295793B2 (en) 2023-07-06
PT3986561T (pt) 2024-03-15
LT3986561T (lt) 2024-04-25
MA56526B1 (fr) 2024-05-31
MX2021016149A (es) 2022-05-18
KR20220024608A (ko) 2022-03-03
CR20210664A (es) 2022-01-21
JP2022537047A (ja) 2022-08-23

Similar Documents

Publication Publication Date Title
IL288750A (en) Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication
EP3774775B8 (en) 4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication
ZA201707499B (en) Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof
RS64261B1 (sr) Supstituisani derivati tieno[2,3-d]pirimidina kao inhibitori menin-mll i načini upotrebe
SG11201907095UA (en) DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS
WO2017108723A3 (en) PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
HK1222659A1 (zh) 吡咯並 嘧啶衍生物，它們的製備方法和它們作爲激酶抑制劑的用途
PH12015501779B1 (en) Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)
MX2017007429A (es) Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).
MX2023000782A (es) 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia.
IL250561A0 (en) History of imidazo[2,1-a]pyridine for use as inhibitors of human immunodeficiency virus replication
WO2015120237A3 (en) 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication
EP3173412A4 (en) 2,4-disubstituted 7h-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof
MX2017013874A (es) Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
WO2015110491A3 (en) Pyrazolo[1,5-a]pyrimidines as antiviral compounds
MX2017016149A (es) Compuestos triciclicos y su uso como inhibidores de la fosfodiesterasa.
EP3560931A4 (en) METHOD FOR PRODUCING A 7H-PYRROLO [2,3-D] PYRIMIDINE DERIVATIVE, AND CO-CRYSTAL OF SAID DERIVATIVE
HK1257799A1 (zh) 6-取代的吡啶並[2，3-d]嘧啶類化合物作為蛋白激酶抑制劑
EP3546458A4 (en) PYRIDO [3,4-D] PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL ACCEPTABLE SALT THEREOF
SG10201810361TA (en) 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication
MX368323B (es) Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr).
EP4038064C0 (en) N-SUBSTITUTED-6-OXO-1,6-DIHYDROPYRIMIDINE-2-YL DERIVATIVES AS HUMAN IMMUNODEFICIENCY VIRUS REPLICATION INHIBITORS
AU2017903305A0 (en) DERIVATIVES OF 4-(IMIDAZO[1,2-a]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE AND THEIR USE AS INHIBITORS OF PROTEIN KINASES
EP3727379A4 (en) PYRAZOLO [1,5-A] PYRIDINE DERIVATIVE SALTS AND THEIR USE