PL3611174T3 - Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a - Google Patents
Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2aInfo
- Publication number
- PL3611174T3 PL3611174T3 PL18781739.0T PL18781739T PL3611174T3 PL 3611174 T3 PL3611174 T3 PL 3611174T3 PL 18781739 T PL18781739 T PL 18781739T PL 3611174 T3 PL3611174 T3 PL 3611174T3
- Authority
- PL
- Poland
- Prior art keywords
- triazolo
- receptor inhibitor
- pyrimidine derivative
- pyrimidine
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710224553 | 2017-04-07 | ||
CN201710737871 | 2017-08-24 | ||
CN201810129208 | 2018-02-08 | ||
PCT/CN2018/082119 WO2018184590A1 (zh) | 2017-04-07 | 2018-04-08 | 作为A 2A受体抑制剂的[1,2,4]***并[1,5-c]嘧啶衍生物 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3611174T3 true PL3611174T3 (pl) | 2022-08-08 |
Family
ID=63712048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL18781739.0T PL3611174T3 (pl) | 2017-04-07 | 2018-04-08 | Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a |
Country Status (9)
Country | Link |
---|---|
US (1) | US11117899B2 (pl) |
EP (1) | EP3611174B1 (pl) |
JP (1) | JP7065113B2 (pl) |
CN (1) | CN110446712B (pl) |
DK (1) | DK3611174T3 (pl) |
ES (1) | ES2919474T3 (pl) |
PL (1) | PL3611174T3 (pl) |
PT (1) | PT3611174T (pl) |
WO (1) | WO2018184590A1 (pl) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109535161B (zh) * | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | ***并嘧啶类衍生物、其制备方法及其在医药上的应用 |
CN117903140A (zh) * | 2018-02-27 | 2024-04-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶 |
US11649239B2 (en) | 2018-04-28 | 2023-05-16 | Medshine Discovery Inc. | Crystal form a of (5-amino-8-(2-methyl-6-(trifluoromethyl)pyridin-4-yl)-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methanol (compound 1) |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
TWI829716B (zh) * | 2018-07-05 | 2024-01-21 | 美商英塞特公司 | 作為a2a/a2b 抑制劑之稠合吡嗪衍生物 |
TWI820209B (zh) | 2018-09-12 | 2023-11-01 | 大陸商迪哲(江蘇)醫藥股份有限公司 | ***并-嘧啶化合物及其用途 |
MA55142A (fr) * | 2018-11-20 | 2022-02-23 | Merck Sharp & Dohme | Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation |
WO2020106560A1 (en) | 2018-11-20 | 2020-05-28 | Merck Sharp & Dohme Corp. | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
MX2021006026A (es) * | 2018-11-30 | 2021-07-06 | Tuojie Biotech Shanghai Co Ltd | Pirimidina y derivado heterociclico de nitrogeno de cinco miembros, metodo de preparacion y usos medicos de los mismos. |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
CN111848625B (zh) * | 2019-04-24 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | 一种杂芳基并[4,3-c]嘧啶-5-胺类化合物的制备方法及中间体 |
EP4021907A1 (en) * | 2019-08-26 | 2022-07-06 | Incyte Corporation | Triazolopyrimidines as a2a / a2b inhibitors |
WO2021156439A1 (en) | 2020-02-06 | 2021-08-12 | Astrazeneca Ab | Triazole compounds as adenosine receptor antagonists |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE257156T1 (de) * | 1997-03-24 | 2004-01-15 | Kyowa Hakko Kogyo Kk | (1,2,4)triazolo(1,5-c)pyrimidin-derivate |
TWI330183B (pl) | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
AR038366A1 (es) | 2001-11-30 | 2005-01-12 | Schering Corp | Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion |
AU2003272886A1 (en) * | 2002-09-24 | 2004-04-19 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE |
DE602004018637D1 (de) * | 2003-04-09 | 2009-02-05 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
CN109535161B (zh) * | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | ***并嘧啶类衍生物、其制备方法及其在医药上的应用 |
CN117903140A (zh) * | 2018-02-27 | 2024-04-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶 |
CN109535162B (zh) | 2018-12-13 | 2020-03-24 | 浙江圣达生物药业股份有限公司 | 一种n-对氨基苯甲酰谷氨酰叶酸的制备方法 |
-
2018
- 2018-04-08 DK DK18781739.0T patent/DK3611174T3/da active
- 2018-04-08 PL PL18781739.0T patent/PL3611174T3/pl unknown
- 2018-04-08 PT PT187817390T patent/PT3611174T/pt unknown
- 2018-04-08 EP EP18781739.0A patent/EP3611174B1/en active Active
- 2018-04-08 JP JP2019554827A patent/JP7065113B2/ja active Active
- 2018-04-08 ES ES18781739T patent/ES2919474T3/es active Active
- 2018-04-08 CN CN201880020259.9A patent/CN110446712B/zh active Active
- 2018-04-08 US US16/500,901 patent/US11117899B2/en active Active
- 2018-04-08 WO PCT/CN2018/082119 patent/WO2018184590A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3611174A4 (en) | 2020-09-09 |
PT3611174T (pt) | 2022-07-07 |
JP2020516606A (ja) | 2020-06-11 |
CN110446712B (zh) | 2021-09-14 |
WO2018184590A1 (zh) | 2018-10-11 |
ES2919474T3 (es) | 2022-07-26 |
JP7065113B2 (ja) | 2022-05-11 |
CN110446712A (zh) | 2019-11-12 |
EP3611174B1 (en) | 2022-06-08 |
US11117899B2 (en) | 2021-09-14 |
US20200131184A1 (en) | 2020-04-30 |
DK3611174T3 (da) | 2022-07-04 |
EP3611174A1 (en) | 2020-02-19 |
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