PL3371185T3 - Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych - Google Patents

Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych

Info

Publication number
PL3371185T3
PL3371185T3 PL16793974T PL16793974T PL3371185T3 PL 3371185 T3 PL3371185 T3 PL 3371185T3 PL 16793974 T PL16793974 T PL 16793974T PL 16793974 T PL16793974 T PL 16793974T PL 3371185 T3 PL3371185 T3 PL 3371185T3
Authority
PL
Poland
Prior art keywords
hexahydroimidazo
imidazo
tetrahydro
pyridine
kinase inhibitors
Prior art date
Application number
PL16793974T
Other languages
English (en)
Inventor
Matthew Colin Thor Fyfe
Original Assignee
Topivert Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1519382.4A external-priority patent/GB201519382D0/en
Application filed by Topivert Pharma Limited filed Critical Topivert Pharma Limited
Publication of PL3371185T3 publication Critical patent/PL3371185T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
PL16793974T 2015-11-03 2016-11-02 Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych PL3371185T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1519382.4A GB201519382D0 (en) 2015-11-03 2015-11-03 Kinase inhibitors
GB201606971 2016-04-21
EP16793974.3A EP3371185B1 (en) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
PCT/GB2016/053392 WO2017077288A1 (en) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
PL3371185T3 true PL3371185T3 (pl) 2021-04-06

Family

ID=57256357

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16793974T PL3371185T3 (pl) 2015-11-03 2016-11-02 Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych

Country Status (8)

Country Link
US (2) US10556901B2 (pl)
EP (2) EP3371185B1 (pl)
CA (1) CA3037248A1 (pl)
DK (1) DK3371185T3 (pl)
ES (1) ES2840650T3 (pl)
PL (1) PL3371185T3 (pl)
PT (1) PT3371185T (pl)
WO (1) WO2017077288A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3371185T3 (da) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
PL3712152T3 (pl) 2015-11-03 2021-08-02 Topivert Pharma Limited Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
EP3592743A1 (en) 2017-03-09 2020-01-15 Theravance Biopharma R&D IP, LLC Fused imidazo-piperidine jak inhibitors
JP7153031B2 (ja) 2017-05-01 2022-10-13 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤化合物を使用する処置方法
SG11201909376TA (en) 2017-05-01 2019-11-28 Theravance Biopharma R&D Ip Llc Crystalline forms of a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
AR116114A1 (es) * 2018-09-04 2021-03-31 Theravance Biopharma R&D Ip Llc Amidas heterocíclicas de entre 5 y 7 miembros como inhibidores de jak
EA202190681A1 (ru) 2018-09-04 2021-05-28 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Амиды диметиламиноазетидина в качестве jak ингибиторов
CA3108848A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
MX2021004582A (es) 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
JP2022518741A (ja) 2019-01-23 2022-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
MX2021010242A (es) * 2019-02-25 2021-09-21 Henan Medinno Pharmaceutical Tech Co Ltd Compuesto inhibidor de jak y uso del mismo.
CN114075199A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2024008088A1 (zh) * 2022-07-04 2024-01-11 河南迈英诺医药科技有限公司 作为trk抑制剂和/或ret抑制剂的化合物及其用途

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US5783701A (en) 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
EP2175858B1 (en) 2007-07-11 2014-09-10 Pfizer Inc. Pharmaceutical compositions and methods of treating dry eye disorders
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
FR2981917B1 (fr) 2011-10-26 2013-11-15 Cadorit Ag Recipient pour emballer un premier fluide et un deuxieme fluide
KR102061382B1 (ko) 2012-06-22 2019-12-31 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 환상 화합물의 합성
AU2015260905A1 (en) 2014-05-14 2016-12-01 Pfizer Inc. Pyrazolopyridines and pyrazolopyrimidines
EP3303348B1 (en) 2015-05-28 2019-08-07 Theravance Biopharma R&D IP, LLC Naphthyridine compounds as jak kinase inhibitors
PL3712152T3 (pl) 2015-11-03 2021-08-02 Topivert Pharma Limited Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych
DK3371185T3 (da) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
SG11201803686UA (en) 2015-11-24 2018-06-28 Theravance Biopharma R&D Ip Llc Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
SG11201809342YA (en) 2016-04-28 2018-11-29 Theravance Biopharma R&D Ip Llc Pyrimidine compounds as jak kinase inhibitors
EP3592743A1 (en) * 2017-03-09 2020-01-15 Theravance Biopharma R&D IP, LLC Fused imidazo-piperidine jak inhibitors

Also Published As

Publication number Publication date
ES2840650T3 (es) 2021-07-07
EP3831830A1 (en) 2021-06-09
EP3371185B1 (en) 2020-09-30
US10556901B2 (en) 2020-02-11
PT3371185T (pt) 2020-12-28
CA3037248A1 (en) 2017-05-11
EP3371185A1 (en) 2018-09-12
US20180370963A1 (en) 2018-12-27
US20200223843A1 (en) 2020-07-16
DK3371185T3 (da) 2020-11-30
US10882859B2 (en) 2021-01-05
WO2017077288A1 (en) 2017-05-11

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