PL3200791T3 - Sposoby i produkty pośrednie w otrzymywaniu antagonistów C5AR - Google Patents
Sposoby i produkty pośrednie w otrzymywaniu antagonistów C5ARInfo
- Publication number
- PL3200791T3 PL3200791T3 PL15845610T PL15845610T PL3200791T3 PL 3200791 T3 PL3200791 T3 PL 3200791T3 PL 15845610 T PL15845610 T PL 15845610T PL 15845610 T PL15845610 T PL 15845610T PL 3200791 T3 PL3200791 T3 PL 3200791T3
- Authority
- PL
- Poland
- Prior art keywords
- intermediates
- processes
- preparation
- c5ar antagonists
- c5ar
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462057107P | 2014-09-29 | 2014-09-29 | |
EP15845610.3A EP3200791B1 (en) | 2014-09-29 | 2015-09-28 | Processes and intermediates in the preparation of c5ar antagonists |
PCT/US2015/052697 WO2016053890A1 (en) | 2014-09-29 | 2015-09-28 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3200791T3 true PL3200791T3 (pl) | 2020-08-10 |
Family
ID=55583729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL15845610T PL3200791T3 (pl) | 2014-09-29 | 2015-09-28 | Sposoby i produkty pośrednie w otrzymywaniu antagonistów C5AR |
Country Status (19)
Country | Link |
---|---|
US (5) | US9745268B2 (pl) |
EP (2) | EP3200791B1 (pl) |
JP (1) | JP6898229B6 (pl) |
KR (2) | KR102593431B1 (pl) |
CN (2) | CN106999481B (pl) |
AU (2) | AU2015324111B2 (pl) |
BR (1) | BR112017006232B1 (pl) |
CA (2) | CA3220371A1 (pl) |
DK (1) | DK3200791T3 (pl) |
ES (2) | ES2802428T3 (pl) |
IL (1) | IL251061B (pl) |
MA (1) | MA52308A (pl) |
MX (2) | MX368492B (pl) |
NZ (2) | NZ767823A (pl) |
PL (1) | PL3200791T3 (pl) |
PT (1) | PT3200791T (pl) |
RU (1) | RU2712233C2 (pl) |
SG (1) | SG11201702185UA (pl) |
WO (1) | WO2016053890A1 (pl) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011006550A (es) | 2008-12-22 | 2011-07-20 | Chemocentryx Inc | C5ar antagonistas. |
SI2585064T1 (sl) * | 2010-06-24 | 2017-08-31 | Chemocentryx, Inc. | Antagonisti C5AR |
CA3220371A1 (en) * | 2014-09-29 | 2016-04-07 | Chemocentryx, Inc. | Processes and intermediates in the preparation of c5ar antagonists |
JP7339733B2 (ja) | 2016-01-14 | 2023-09-06 | ケモセントリックス,インコーポレイティド | C3腎症を処置する方法 |
JP2021501175A (ja) | 2017-10-30 | 2021-01-14 | ケモセントリックス,インコーポレイティド | 免疫調節剤としての重水素化化合物 |
EP3801519A4 (en) | 2018-06-07 | 2022-03-30 | ChemoCentryx, Inc. | DOSAGE AND EFFECT OF A C5A ANTAGONIST IN ANCA-ASSOCIATED VASCULITIS |
AU2019389031B2 (en) | 2018-11-30 | 2023-06-15 | Chemocentryx, Inc. | Capsule formulations |
KR102207333B1 (ko) * | 2019-09-09 | 2021-01-27 | 성균관대학교산학협력단 | 4중 연속 고리 화합물의 신규한 제조방법 |
CA3236258A1 (en) | 2019-11-08 | 2021-05-14 | Chemocentryx, Inc. | Salt forms of a complement component c5a receptor |
JP2022554019A (ja) | 2019-11-08 | 2022-12-27 | ケモセントリックス,インコーポレイティド | 補体成分C5a受容体の遊離塩基結晶形態 |
BR112022007489A2 (pt) | 2019-11-08 | 2022-07-12 | Chemocentryx Inc | Forma amorfa de um receptor c5a de componente do complemento |
WO2022078269A1 (zh) * | 2020-10-16 | 2022-04-21 | 苏州科睿思制药有限公司 | Avacopan的晶型及其制备方法和用途 |
EP4137133A1 (en) | 2021-08-19 | 2023-02-22 | Sandoz AG | Crystalline form of avacopan |
WO2022263263A1 (en) | 2021-06-16 | 2022-12-22 | Sandoz Ag | Crystalline form of avacopan |
CN113957106B (zh) * | 2021-11-03 | 2024-04-19 | 暨明医药科技(苏州)有限公司 | 一种Avacopan及其中间体的制备方法 |
CN114262291B (zh) * | 2022-01-04 | 2023-05-19 | 重庆医科大学 | 一种阿伐可泮的合成方法 |
WO2023158722A2 (en) | 2022-02-16 | 2023-08-24 | Teva Pharmaceuticals International Gmbh | Processes for preparation of avacopan and intermediates thereof |
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US4686100A (en) | 1985-04-02 | 1987-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for the treatment of adult respiratory distress syndrome |
IL141724A0 (en) | 1998-08-28 | 2002-03-10 | Scios Inc | INHIBITORS OF P38-α KINASE |
RU2197288C2 (ru) | 1999-08-03 | 2003-01-27 | Тверская медицинская академия | Способ лечения больных хроническим гломерулонефритом |
JP2003532726A (ja) | 2000-05-05 | 2003-11-05 | スミスクライン・ビーチャム・コーポレイション | 新規抗感染症薬 |
NZ523444A (en) * | 2000-06-29 | 2004-12-24 | Abbott Lab | Aryl phenylcyclopropyl sulphide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
KR100802332B1 (ko) | 2000-08-10 | 2008-02-13 | 미쯔비시 웰 파마 가부시키가이샤 | 신규한 3-치환된 요소 유도체 및 그의 의학적 용도 |
KR100842791B1 (ko) | 2000-09-14 | 2008-07-01 | 미쓰비시 타나베 파마 코퍼레이션 | 신규한 아미드 유도체 및 그의 의약적 용도 |
CN1454086A (zh) | 2000-09-29 | 2003-11-05 | 神经能质公司 | 高亲和性小分子C5a受体调节物 |
SE524438C2 (sv) | 2000-10-05 | 2004-08-10 | Magnus Georg Goertz | Fjärrstyrt dörrelaterat låsarrangemang, första och andra datorpogramprodukt, bärande medium och ett datorlösbart medium |
DE10293174D2 (de) | 2001-07-19 | 2004-07-01 | Luk Lamellen & Kupplungsbau | Übertragungsstrecke zum Ansteuern einer Kupplung |
MXPA04001301A (es) | 2001-08-17 | 2004-07-08 | Tanox Inc | Inhibidores de la ruta del complemento que se unen a c5 y c5a son evitar la formacion de c5b. |
BR0212892A (pt) | 2001-09-21 | 2004-08-03 | Mitsubishi Pharma Corp | Derivados de 4-pirimidona-3-substituìdo |
ITMI20012025A1 (it) | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
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EP1487796A4 (en) | 2002-03-28 | 2005-11-16 | Neurogen Corp | SUBSTITUTED BIARYLAMIDES AS MODULATORS OF THE C5A RECEPTOR |
JP2006508894A (ja) | 2002-03-28 | 2006-03-16 | ニューロジェン・コーポレーション | C5a受容体調節因子としての置換テトラヒドロイソキノリン |
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US7455837B2 (en) | 2002-11-05 | 2008-11-25 | The Regents Of The University Of Michigan | Compositions and methods for the diagnosis and treatment of sepsis |
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HUE061548T2 (hu) | 2008-11-10 | 2023-07-28 | Alexion Pharma Inc | Komplementtel összefüggõ rendellenességek kezelésére szolgáló eljárások és készítmények |
US20110275639A1 (en) * | 2008-12-22 | 2011-11-10 | Chemocentryx, Inc. | C5aR ANTAGONISTS |
MX2011006550A (es) * | 2008-12-22 | 2011-07-20 | Chemocentryx Inc | C5ar antagonistas. |
WO2011035143A2 (en) | 2009-09-17 | 2011-03-24 | The Regents Of The University Of Michigan | Methods and compositions for inhibiting rho-mediated diseases and conditions |
SI2585064T1 (sl) * | 2010-06-24 | 2017-08-31 | Chemocentryx, Inc. | Antagonisti C5AR |
WO2013192345A1 (en) | 2012-06-20 | 2013-12-27 | Novartis Ag | Complement pathway modulators and uses thereof |
US20160060351A1 (en) | 2013-05-08 | 2016-03-03 | Novo Nordisk A/S | Use of C5AR Antagonists |
CA3220371A1 (en) * | 2014-09-29 | 2016-04-07 | Chemocentryx, Inc. | Processes and intermediates in the preparation of c5ar antagonists |
JP7339733B2 (ja) | 2016-01-14 | 2023-09-06 | ケモセントリックス,インコーポレイティド | C3腎症を処置する方法 |
JP7121722B2 (ja) | 2016-04-04 | 2022-08-18 | ケモセントリックス,インコーポレイティド | 可溶性C5aRアンタゴニスト |
AU2021410668A1 (en) | 2020-12-21 | 2023-07-06 | Chemocentryx, Inc. | Treatment of c3 glomerulopathy using a c5a inhibitor |
-
2015
- 2015-09-28 CA CA3220371A patent/CA3220371A1/en active Pending
- 2015-09-28 CN CN201580052937.6A patent/CN106999481B/zh active Active
- 2015-09-28 ES ES15845610T patent/ES2802428T3/es active Active
- 2015-09-28 KR KR1020177011789A patent/KR102593431B1/ko active IP Right Grant
- 2015-09-28 EP EP15845610.3A patent/EP3200791B1/en active Active
- 2015-09-28 PT PT158456103T patent/PT3200791T/pt unknown
- 2015-09-28 SG SG11201702185UA patent/SG11201702185UA/en unknown
- 2015-09-28 MA MA052308A patent/MA52308A/fr unknown
- 2015-09-28 DK DK15845610.3T patent/DK3200791T3/da active
- 2015-09-28 AU AU2015324111A patent/AU2015324111B2/en active Active
- 2015-09-28 MX MX2017003789A patent/MX368492B/es active IP Right Grant
- 2015-09-28 US US14/867,669 patent/US9745268B2/en active Active
- 2015-09-28 KR KR1020237035689A patent/KR20230149873A/ko active Application Filing
- 2015-09-28 BR BR112017006232-1A patent/BR112017006232B1/pt active IP Right Grant
- 2015-09-28 CA CA2960733A patent/CA2960733C/en active Active
- 2015-09-28 RU RU2017114960A patent/RU2712233C2/ru active
- 2015-09-28 EP EP20160995.5A patent/EP3682879B1/en active Active
- 2015-09-28 ES ES20160995T patent/ES2926828T3/es active Active
- 2015-09-28 WO PCT/US2015/052697 patent/WO2016053890A1/en active Application Filing
- 2015-09-28 PL PL15845610T patent/PL3200791T3/pl unknown
- 2015-09-28 NZ NZ767823A patent/NZ767823A/en unknown
- 2015-09-28 NZ NZ730123A patent/NZ730123A/en unknown
- 2015-09-28 JP JP2017516679A patent/JP6898229B6/ja active Active
- 2015-09-28 CN CN202110432100.1A patent/CN113121415A/zh active Pending
-
2017
- 2017-03-09 IL IL251061A patent/IL251061B/en active IP Right Grant
- 2017-03-23 MX MX2019011911A patent/MX2019011911A/es unknown
- 2017-07-25 US US15/659,468 patent/US10266492B2/en active Active
-
2019
- 2019-03-21 US US16/360,195 patent/US10532982B2/en active Active
- 2019-12-06 US US16/706,296 patent/US20200354320A1/en not_active Abandoned
-
2021
- 2021-06-22 AU AU2021204209A patent/AU2021204209B2/en active Active
-
2022
- 2022-02-08 US US17/667,289 patent/US11845729B2/en active Active
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