PL3061760T3 - Deuterowane pochodne benzochinoliny jako inhibitory pęcherzykowego transportera monoamin 2 - Google Patents

Deuterowane pochodne benzochinoliny jako inhibitory pęcherzykowego transportera monoamin 2

Info

Publication number
PL3061760T3
PL3061760T3 PL15185548T PL15185548T PL3061760T3 PL 3061760 T3 PL3061760 T3 PL 3061760T3 PL 15185548 T PL15185548 T PL 15185548T PL 15185548 T PL15185548 T PL 15185548T PL 3061760 T3 PL3061760 T3 PL 3061760T3
Authority
PL
Poland
Prior art keywords
deuterated
inhibitors
monoamine transporter
vesicular monoamine
benzoquinolizine
Prior art date
Application number
PL15185548T
Other languages
English (en)
Inventor
Thomas G. Gant
Manoucherhr Shahbaz
Original Assignee
Auspex Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42107127&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3061760(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Auspex Pharmaceuticals, Inc. filed Critical Auspex Pharmaceuticals, Inc.
Publication of PL3061760T3 publication Critical patent/PL3061760T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
PL15185548T 2008-09-18 2009-09-18 Deuterowane pochodne benzochinoliny jako inhibitory pęcherzykowego transportera monoamin 2 PL3061760T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9789608P 2008-09-18 2008-09-18
EP15185548.3A EP3061760B1 (en) 2008-09-18 2009-09-18 Deuterated benzoquinolizine derivatives as inhibitors of vesicular monoamine transporter 2
EP09820972.9A EP2326643B1 (en) 2008-09-18 2009-09-18 Benzoquinoline inhibitors of vesicular monoamine transporter 2
EP13160950.5A EP2610254B1 (en) 2008-09-18 2009-09-18 Deuterated benzoquinoline derivatives as inhibitors of vesicular monoamine transporter 2

Publications (1)

Publication Number Publication Date
PL3061760T3 true PL3061760T3 (pl) 2018-07-31

Family

ID=42107127

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15185548T PL3061760T3 (pl) 2008-09-18 2009-09-18 Deuterowane pochodne benzochinoliny jako inhibitory pęcherzykowego transportera monoamin 2

Country Status (20)

Country Link
US (15) US8524733B2 (pl)
EP (4) EP3061760B1 (pl)
JP (3) JP5616345B2 (pl)
CN (2) CN104311552A (pl)
AU (1) AU2009303758B8 (pl)
BR (1) BRPI0913457B8 (pl)
CA (2) CA2972242A1 (pl)
CY (1) CY1120060T1 (pl)
DK (2) DK2326643T3 (pl)
ES (4) ES2563820T3 (pl)
HK (3) HK1186728A1 (pl)
HR (1) HRP20180239T1 (pl)
HU (1) HUE038158T2 (pl)
LT (1) LT3061760T (pl)
NO (1) NO3061760T3 (pl)
NZ (1) NZ591615A (pl)
PL (1) PL3061760T3 (pl)
PT (1) PT3061760T (pl)
SI (1) SI3061760T1 (pl)
WO (1) WO2010044981A2 (pl)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0913457B8 (pt) 2008-09-18 2021-08-31 Auspex Pharmaceutical Inc Composto e composição farmacêutica
PE20121469A1 (es) * 2009-11-10 2012-11-01 Pfizer Inhibidores de n1- pirazoloespirocetona acetil-coa carboxilasa
US20120003330A1 (en) * 2010-06-01 2012-01-05 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
EP3673893A1 (en) 2010-08-27 2020-07-01 Sienna Biopharmaceuticals, Inc. Compositions and methods for targeted thermomodulation
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
WO2012081031A1 (en) * 2010-12-15 2012-06-21 Enaltec Labs Pvt. Ltd. Process for preparing tetrabenazine
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
NZ705372A (en) * 2012-09-18 2018-07-27 Auspex Pharmaceuticals Inc Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2014058904A1 (en) 2012-10-11 2014-04-17 Nanocomposix, Inc. Silver nanoplate compositions and methods
JP2016506957A (ja) 2013-01-31 2016-03-07 オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｖｍａｔ２のベンゾキノロン阻害剤
US20160207917A1 (en) * 2013-09-27 2016-07-21 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
MX2016006622A (es) * 2013-11-22 2016-12-09 Auspex Pharmaceuticals Inc Metodos para tratar actividad muscular anormal.
WO2015077521A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
EA201791466A1 (ru) * 2013-12-03 2017-11-30 Оспекс Фармасьютикалз, Инк. Способы получения соединений бензохинолина
AU2015209330A1 (en) * 2014-01-27 2016-07-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2015120317A1 (en) * 2014-02-07 2015-08-13 Neurocrine Biosciences, Inc. Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof
WO2015120110A2 (en) 2014-02-07 2015-08-13 Auspex Pharmaceuticals, Inc. Novel pharmaceutical formulations
KR20240011255A (ko) 2014-05-06 2024-01-25 뉴로크린 바이오사이언시즈 인코퍼레이티드 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
MA41557A (fr) * 2015-02-18 2017-12-26 Auspex Pharmaceuticals Inc Inhibiteurs diméthoxyphényles du transporteur vésiculaire des monoamines 2
EA201791977A1 (ru) * 2015-03-06 2018-01-31 Оспекс Фармасьютикалз, Инк. Способы лечения патологических непроизвольных движений
US20180071024A1 (en) * 2015-03-20 2018-03-15 Sienna Biopharmaceuticals, Inc. Enhanced efficacy and targeted topical delivery of drugs to skin with nanoparticles
CN115322188A (zh) 2015-10-30 2022-11-11 纽罗克里生物科学有限公司 Valbenazine盐及其多晶形物
HUE059065T2 (hu) 2015-12-23 2022-10-28 Neurocrine Biosciences Inc Szintetikus eljárás (S)-(2R,3R,11BR)-3-izobutil-9,10-dimetoxi-2,3,4,6,7,11B-hexahidro-1H-pirido [2,1-A]izokinolin-2-il-2-amino-3-metilbutanoát-di(4-metilbenzolszulfonát) elõállítására
US10479787B2 (en) 2016-04-22 2019-11-19 Lupin Limited Process for preparation of tetrabenazine and deutetrabenazine
WO2017221169A1 (en) 2016-06-24 2017-12-28 Lupin Limited Premixes of deutetrabenazine
CN107936008B (zh) * 2016-10-13 2022-06-14 泰州华元医药科技有限公司 氘代化合物及其医药用途
TW202345829A (zh) 2016-12-02 2023-12-01 美商紐羅克里生物科學有限公司 戊苯那嗪（valbenazine）於治療精神***症或情感性精神***症之用途
WO2018130345A1 (en) 2017-01-10 2018-07-19 Sandoz Ag Crystalline valbenazine free base
JP7199361B2 (ja) 2017-01-27 2023-01-05 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
JP2020508337A (ja) 2017-02-27 2020-03-19 サンド・アクチエンゲゼルシヤフト バルベナジン塩の結晶形態
WO2018164996A1 (en) 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
CA3056612A1 (en) 2017-03-15 2018-09-20 Auspex Pharmaceuticals, Inc. Analogs of deutetrabenazine, their preparation and use
JOP20190239A1 (ar) 2017-04-19 2019-10-09 Neurocrine Biosciences Inc مركبات مثبطة لـ vmat2 وتركيبات منها
US20200179352A1 (en) 2017-04-26 2020-06-11 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
CN111372567B (zh) 2017-09-21 2024-03-15 纽罗克里生物科学有限公司 高剂量的缬苯那嗪制剂和与其相关的组合物、方法和试剂盒
US10786495B2 (en) * 2017-10-10 2020-09-29 The Regents Of The University Of California Vesicular monoamine transporter 2 inhibitors for treating stuttering
SG11202003194YA (en) 2017-10-10 2020-05-28 Neurocrine Biosciences Inc Methods for the administration of certain vmat2 inhibitors
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
WO2019130252A2 (en) * 2017-12-29 2019-07-04 Mylan Laboratories Ltd Methods and intermediates for preparing deutetrabenazine
US11806326B2 (en) 2018-01-29 2023-11-07 Jonathan Sackner-Bernstein Methods for dopamine modulation in human neurologic diseases
US11505549B2 (en) * 2018-02-01 2022-11-22 Lakshmi Prasad ALAPARTHI Process for preparation of Deutetrabenazine
WO2019166962A1 (en) 2018-03-01 2019-09-06 Mylan Laboratories Ltd Deutetrabenazine polymorphs and methods for their preparation
MX2020011269A (es) * 2018-04-25 2020-12-11 Shinkei Therapeutics Llc Dispositivo de administración transdérmica de tetrabenazina.
US10632107B2 (en) 2018-05-14 2020-04-28 Apotex Inc. Crystalline forms of benzoquinoline inhibitors of vesicular monoamine transporter 2
CN112638387A (zh) 2018-06-14 2021-04-09 纽罗克里生物科学有限公司 Vmat2抑制剂化合物、组合物和与其相关的方法
CN108794337A (zh) * 2018-07-10 2018-11-13 上海华堇生物技术有限责任公司 一种3,4-二羟基-β-硝基苯乙烯的新制备方法
EP3836926A4 (en) 2018-08-15 2022-05-04 Neurocrine Biosciences, Inc. METHODS OF ADMINISTRATION OF CERTAIN VMAT2 INHIBITORS
MA53904A (fr) 2018-10-18 2021-08-25 Oncopeptides Ab Composés contenant du deutérium
TWI784220B (zh) * 2018-12-13 2022-11-21 美商奧斯拜客斯製藥有限公司 腦性麻痺運動障礙之治療方法
EP3928886B1 (en) 2019-02-22 2023-11-22 IHI Corporation Thrust foil bearing, and method for manufacturing base plate of thrust foil bearing
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
EP4153136B1 (en) 2020-06-10 2024-01-10 Auspex Pharmaceuticals, Inc. Osmotic dosage forms comprising deutetrabenazine and methods of use thereof
WO2022061058A1 (en) 2020-09-17 2022-03-24 Auspex Pharmaceuticals, Inc. Multiparticulate dosage forms comprising deutetrabenazine
CN116456970A (zh) 2020-10-12 2023-07-18 奥斯佩克斯医药公司 包括氘代丁苯那嗪的胃滞留剂型
WO2022203984A1 (en) 2021-03-22 2022-09-29 Neurocrine Biosciences, Inc. Vmat2 inhibitors and methods of use
AU2022301324A1 (en) 2021-06-30 2024-02-08 Neurocrine Biosciences, Inc. Valbenazine for use in the add-on treatment of schizophrenia
WO2023044418A1 (en) 2021-09-17 2023-03-23 Auspex Pharmaceuticals, Inc. Multiparticulate dosage forms comprising deutetrabenazine
WO2023172849A1 (en) 2022-03-07 2023-09-14 Neurocrine Biosciences, Inc. Valbenazine, a vmat2 inhibitor, as a free base a tosylate or ditosylate salt, for use in the treatment of chorea associated with huntington's disease
WO2023240186A1 (en) 2022-06-08 2023-12-14 Auspex Pharmaceuticals, Inc. Osmotic dosage forms comprising deutetrabenazine and methods of use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830993A (en) 1958-04-15 Quinolizine derivatives
US3045021A (en) 1959-09-24 1962-07-17 Hoffmann La Roche Preparation of substituted 2-oxobenzoquinolizines
US4316897A (en) 1980-09-10 1982-02-23 Hoffmann-La Roche Inc. Method of lowering serum prolactin
KR20040068613A (ko) * 1994-03-25 2004-07-31 이소테크니카 인코포레이티드 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
PT1104760E (pt) 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
EP1134290A3 (en) 2000-03-14 2004-01-02 Pfizer Products Inc. Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
EP1684806B1 (en) * 2003-11-21 2008-06-25 Memory Pharmaceuticals Corporation Compositions comprising l-type calcium channel blockers and cholinesterase inhibitors
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
WO2006053067A2 (en) 2004-11-09 2006-05-18 Prestwick Pharmaceuticals, Inc. Combination of amantadine and a tetrabenazine compound for treating hyperkinetic disorders
DE602006010979D1 (de) 2005-01-19 2010-01-21 Rigel Pharmaceuticals Inc Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
US20080033011A1 (en) 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
US7750168B2 (en) 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
KR101429302B1 (ko) 2006-05-02 2014-08-11 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 방사성 표지된 디히드로테트라베나진 유도체 및 조영제로서의 이의 용도
CA2668689C (en) 2006-11-08 2015-12-29 Neurocrine Biosciences Inc. Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto
EP2420505A1 (en) 2006-11-21 2012-02-22 Rigel Pharmaceuticals, Inc. Prodrug salts of 2, 4- pyrimidinediamine compounds and their uses
WO2008112278A2 (en) 2007-03-12 2008-09-18 The Trustees Of Columbia University In The City Of New York Methods and compositions for modulating insulin secretion and glucose metabolism
US7897768B2 (en) * 2007-06-08 2011-03-01 General Electric Company Method for making tetrabenazine compounds
EP2173344B1 (en) 2007-06-29 2016-04-06 Clarencew Pty Ltd. Treatment or prophylaxis or neurological or neuropsychiatric disorders via ocular administration
WO2009124357A1 (en) 2008-04-10 2009-10-15 Malvin Leonard Eutick Fast dissolving oral formulations for critical drugs
GB2462611A (en) 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
WO2011019956A2 (en) 2009-08-12 2011-02-17 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
BRPI0913457B8 (pt) 2008-09-18 2021-08-31 Auspex Pharmaceutical Inc Composto e composição farmacêutica
US20100113496A1 (en) 2008-09-25 2010-05-06 Auspex Pharmaceuticals, Inc. Piperidine modulators of vmat2
BR112012020585A2 (pt) 2010-02-24 2018-04-17 Auspex Pharmaceuticals Inc composto, composição farmacêutica e método de tratamento de um distúrbio mediado por tirosina quinase
US20120003330A1 (en) 2010-06-01 2012-01-05 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2

Also Published As

Publication number Publication date
JP2015007124A (ja) 2015-01-15
US20190375746A1 (en) 2019-12-12
EP2610254A1 (en) 2013-07-03
EP2610254B1 (en) 2015-11-25
US20160375005A1 (en) 2016-12-29
EP3345905A1 (en) 2018-07-11
US20160220558A1 (en) 2016-08-04
US20130296360A1 (en) 2013-11-07
DK2326643T3 (da) 2013-08-05
US20200347048A1 (en) 2020-11-05
CA2972242A1 (en) 2010-04-22
AU2009303758B8 (en) 2015-02-19
EP3061760A1 (en) 2016-08-31
ES2896678T3 (es) 2022-02-25
JP5970037B2 (ja) 2016-08-17
JP2016172782A (ja) 2016-09-29
US20100130480A1 (en) 2010-05-27
CA2736409A1 (en) 2010-04-22
CA2736409C (en) 2017-07-11
BRPI0913457A2 (pt) 2020-06-09
EP3345905B1 (en) 2021-09-01
BRPI0913457B8 (pt) 2021-08-31
JP2012503010A (ja) 2012-02-02
NZ591615A (en) 2012-07-27
US20140206712A1 (en) 2014-07-24
US20150328207A1 (en) 2015-11-19
AU2009303758A8 (en) 2015-02-19
HRP20180239T1 (hr) 2018-05-18
CN102186848B (zh) 2014-11-12
US20160158220A1 (en) 2016-06-09
HK1222853A1 (zh) 2017-07-14
EP3061760B1 (en) 2017-11-08
LT3061760T (lt) 2018-02-26
US20140350044A1 (en) 2014-11-27
US20150080427A1 (en) 2015-03-19
SI3061760T1 (en) 2018-04-30
HK1186728A1 (zh) 2014-03-21
US20220267317A1 (en) 2022-08-25
EP2326643A2 (en) 2011-06-01
CN102186848A (zh) 2011-09-14
CY1120060T1 (el) 2018-12-12
US8524733B2 (en) 2013-09-03
ES2425623T3 (es) 2013-10-16
AU2009303758B2 (en) 2014-10-23
JP6138322B2 (ja) 2017-05-31
EP2326643B1 (en) 2013-05-29
WO2010044981A2 (en) 2010-04-22
NO3061760T3 (pl) 2018-04-07
DK3061760T3 (en) 2018-02-05
ES2652289T3 (es) 2018-02-01
HK1257880A1 (zh) 2019-11-01
US20170166562A1 (en) 2017-06-15
HUE038158T2 (hu) 2018-09-28
BRPI0913457B1 (pt) 2021-07-20
WO2010044981A3 (en) 2010-06-17
CN104311552A (zh) 2015-01-28
EP2326643A4 (en) 2012-03-21
ES2563820T3 (es) 2016-03-16
AU2009303758A1 (en) 2010-04-22
US20140206713A1 (en) 2014-07-24
US20160367548A1 (en) 2016-12-22
JP5616345B2 (ja) 2014-10-29
PT3061760T (pt) 2018-01-04

Similar Documents

Publication Publication Date Title
HK1257880A1 (zh) 氘化的苯並喹啉衍生物作為纈氨酸單胺轉運蛋白2的抑制劑
HRP20180662T1 (hr) 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze
TWI347321B (en) Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PL2178840T3 (pl) Pochodne kwasu azabifenyloaminobenzoesowego jako inhibitory dhodh
HK1139936A1 (en) Substituted pyrimidodiazepines useful as plk1 inhibitors
HK1143367A1 (en) Quinazolin-oxime derivatives as hsp90 inhibitors hsp90 -
ZA200807263B (en) Novel heteroaryl-substituted arylaminopyrldine derivatives as MEK inhibitors
HK1125924A1 (en) Thieno-pyridine derivatives as mek inhibitors mek -
DK2010496T3 (da) 4-anilinoquinolin-3-carbonsyreamider som CSF-1R-kinaseinhibitorer
SI2225238T1 (sl) Derivati amidov 6,7-dihidro-5H-imidazo(1,2-a)imidazol-3-karboksilne kisline
ZA200807074B (en) 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors
ZA200908612B (en) 1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase
IL196000A0 (en) 2-arylindole derivatives as npges-i inhibitors
ZA200808598B (en) Pyrrolopyrimidine derivatives used as HSP90 inhibitors
ZA201000383B (en) Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors