PL3060041T3 - Związki prostacykliny - Google Patents

Związki prostacykliny

Info

Publication number
PL3060041T3
PL3060041T3 PL14855785T PL14855785T PL3060041T3 PL 3060041 T3 PL3060041 T3 PL 3060041T3 PL 14855785 T PL14855785 T PL 14855785T PL 14855785 T PL14855785 T PL 14855785T PL 3060041 T3 PL3060041 T3 PL 3060041T3
Authority
PL
Poland
Prior art keywords
prostacyclin compounds
prostacyclin
compounds
Prior art date
Application number
PL14855785T
Other languages
English (en)
Inventor
Vladimir Malinin
Walter Perkins
Franziska LEIFER
Donna KONICEK
Zhili Li
Adam PLAUNT
Original Assignee
Insmed Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insmed Incorporated filed Critical Insmed Incorporated
Publication of PL3060041T3 publication Critical patent/PL3060041T3/pl

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
MX2016005293A (es) 2013-10-25 2016-08-12 Insmed Inc Compuestos de prostaciclina, composiciones y metodos de uso de los mismos.
JP6866043B2 (ja) * 2014-11-18 2021-04-28 インスメッド インコーポレイテッド トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
AU2017261317A1 (en) 2016-05-05 2018-12-13 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
WO2017223400A1 (en) * 2016-06-24 2017-12-28 Insmed Incorporated Prostacyclin compounds and compositions for treating sarcoidosis
CA3038276A1 (en) 2016-09-26 2018-03-29 United Therapeutics Corporation Treprostinil prodrugs
CA3138530A1 (en) * 2019-04-29 2020-11-05 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
AU2020337342A1 (en) 2019-08-23 2022-02-24 United Therapeutics Corporation Treprostinil prodrugs
US10781160B1 (en) * 2019-10-04 2020-09-22 Chirogate International Inc. Hexadecyl Treprostinil crystals and methods for preparation thereof
US11339110B2 (en) 2019-12-19 2022-05-24 Chirogate International Inc. Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom
EP4126856A4 (en) * 2020-03-25 2024-05-01 Insmed Incorporated PHARMACEUTICAL FORMULATIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF
IL296567A (en) 2020-04-17 2022-11-01 United Therapeutics Corp Terfostinil for use in the treatment of interstitial lung disease
JP2023529828A (ja) 2020-06-09 2023-07-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニルのフマリルジケトピペリジンプロドラッグ
MX2023004812A (es) * 2020-10-28 2023-07-06 Insmed Inc Composiciones de polvo seco de profarmacos de treprostinil y metodos de uso de estos.
US11447440B2 (en) 2020-10-29 2022-09-20 Chirogate International Inc. Treprostinil monohydrate crystals and methods for preparation thereof
WO2022132655A1 (en) 2020-12-14 2022-06-23 United Therapeutics Corporation Methods of treating disease with treprostinil prodrugs
KR20240012354A (ko) 2021-03-03 2024-01-29 유나이티드 쎄러퓨틱스 코포레이션 (e)-3,6-비스[4-(n-카보닐-2-프로페닐)아미도부틸]-2,5-디케토피페라진(fdkp)을 추가로 포함하는, 트레프로스티닐 및 이의 프로드러그의 건조 분말 조성물
CN117015524A (zh) * 2021-03-16 2023-11-07 江苏恒瑞医药股份有限公司 一种曲前列环素衍生物及其用途
CN115850686A (zh) * 2021-09-27 2023-03-28 广州谷森制药有限公司 新型氘代peg脂质化合物、其制备方法、组合物和应用
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
US20230263807A1 (en) 2022-02-08 2023-08-24 United Therapeutics Corporation Treprostinil iloprost combination therapy
CN115894240A (zh) * 2022-10-14 2023-04-04 广州楷石医药有限公司 曲前列尼尔的前体药物及其应用
CN115448839A (zh) * 2022-10-14 2022-12-09 广州楷石医药有限公司 一种曲前列尼尔的前体药物

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2947526A1 (de) * 1978-11-29 1980-06-12 Ono Pharmaceutical Co Prostacyclin-analoge
US4668814A (en) 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
JPS61289034A (ja) 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
US4837342A (en) * 1986-02-28 1989-06-06 Sagami Chemical Research Center Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient
GB8814438D0 (en) 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
GB9011588D0 (en) 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
US6165500A (en) 1990-08-24 2000-12-26 Idea Ag Preparation for the application of agents in mini-droplets
CA2056039A1 (en) 1991-01-22 1992-07-23 Philip L. Fuchs Carbacyclin analogs
US5190972A (en) 1992-01-27 1993-03-02 The University Of Melbourne Method of combatting cyclosporine organ toxicity with prostaglandin analogs
CA2091152C (en) 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
CN1055835C (zh) * 1993-09-29 2000-08-30 姜春 一种连黄松丸、胶囊及其制备方法
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
CN1142781C (zh) 1997-11-14 2004-03-24 联合治疗公司 9－脱氧－2′,9－α－亚甲基－3－氧杂－4,5,6－三去甲－3,7－(1′,3′－间亚苯基)－13,14－二氢－***素F1在治疗外周血管疾病中的用途
CA2316539C (en) 1997-12-26 2008-11-18 Yamanouchi Pharmaceutical Co., Ltd. Sustained-release pharmaceutical composition
WO2000006120A1 (en) 1998-07-31 2000-02-10 Korea Institute Of Science And Technology Lipid emulsion and solid lipid nanoparticle as a gene or drug carrier
US6265495B1 (en) 1998-09-22 2001-07-24 Nippon Shokubai Co., Ltd. Method for production of esterified product
US6521212B1 (en) 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
CA2359652A1 (en) 1999-03-31 2000-10-05 United Therapeutics Corporation Novel prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of peripheral vascular disease and pulmonaryhypertension
US6242482B1 (en) * 2000-06-05 2001-06-05 United Therapeutics Corporation Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
US6306435B1 (en) * 2000-06-26 2001-10-23 Yung Shin Pharmaceutical Industrial Co. Ltd. Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
WO2003000236A1 (en) 2001-06-23 2003-01-03 Lyotropic Therapeutics, Inc Particles with improved solubilization capacity
US20030108512A1 (en) * 2001-12-10 2003-06-12 Robert Shorr Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
AU2003258075A1 (en) 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
MXPA05012467A (es) 2003-05-19 2006-02-22 Baxter Int Particulas solidas que comprenden un anticonvulsivo o un inmunosupresor revestido con uno o mas modificadores de superficie.
DE60308828T2 (de) 2003-05-20 2007-05-24 Ethypharm Orale pharmazeutische Zusammensetzung mit verzögerter Freisetzung
ES2670872T3 (es) 2003-05-22 2018-06-01 United Therapeutics Corporation Polimorfo de una sal de dietanolamina de treprostinil
JP5190200B2 (ja) 2003-12-16 2013-04-24 ユナイテッド セラピューティクス コーポレイション 虚血性病変の治療および予防のためのトレプロスチニルの用途
CA2549801C (en) 2003-12-16 2012-10-16 United Therapeutics Corporation Use of treprostinil to improve kidney functions
CA2562614C (en) 2004-04-12 2013-09-17 United Therapeutics, Inc. Use of treprostinil to treat neuropathic diabetic foot ulcers
GB0416328D0 (en) 2004-07-21 2004-08-25 Univ Cardiff Use of dry powder compositions for pulmonary delivery
RU2007106714A (ru) 2004-07-26 2008-09-10 Байер Шеринг Фарма Аг (De) Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц
US7858650B2 (en) * 2004-10-22 2010-12-28 Ono Pharmaceutical Co., Ltd. Medicinal composition for inhalation
CA2631493A1 (en) 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
CN101495122B (zh) 2006-05-15 2011-10-05 联合治疗公司 使用定量吸入器给予曲前列尼
US20090036465A1 (en) 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
EP2491932A3 (en) 2007-02-09 2012-12-12 United Therapeutics Corporation Use of biomarkers for monitoring the course of treatment of a pulmonary disease upon treatment with treprostinil
WO2008124632A1 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
ES2728785T3 (es) 2007-09-07 2019-10-28 United Therapeutics Corp Soluciones tampón con actividad bactericida selectiva contra las bacterias gramnegativas y métodos para usarlas
JP5851691B2 (ja) 2007-12-17 2016-02-03 ユナイテッド セラピューティクス コーポレーション リモジュリンの活性成分であるトレプロスチニルを製造する改良方法
CN102015613B (zh) 2008-05-08 2013-07-31 联合治疗公司 曲前列素一水合物
WO2009152160A1 (en) 2008-06-10 2009-12-17 Gilead Sciences, Inc. Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
WO2009158010A1 (en) 2008-06-27 2009-12-30 Concert Pharmaceuticals, Inc. Prostacyclin analogs
WO2010039531A1 (en) 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Therapeutic compounds
CA2737350A1 (en) 2008-09-25 2010-04-01 Aradigm Corporation Deep lung pulmonary delivery of treprostinil
WO2010100656A2 (en) 2009-02-20 2010-09-10 Micro Labs Limited Storage stable prostaglandin product
WO2010129757A1 (en) 2009-05-07 2010-11-11 United Therapeutics Corporation Solid formulations of prostacyclin analogs
WO2011005505A2 (en) 2009-06-22 2011-01-13 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
US20120270934A1 (en) 2009-07-03 2012-10-25 Concert Pharmaceuticals, Inc. Prostacyclin derivatives
RS53234B (en) 2009-08-07 2014-08-29 Scipharm Sàrl Composition for the treatment of cystic fibrosis
JP2013502436A (ja) 2009-08-21 2013-01-24 ターゲッティド デリバリー テクノロジーズ リミテッド 小胞状の製剤
CN101669904B (zh) 2009-09-29 2011-06-22 北京中海康医药科技发展有限公司 一种依前列醇脂质纳米粒及制备方法
US20130030359A1 (en) 2010-01-22 2013-01-31 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aromatic amine-containing drugs
DK2525830T3 (en) 2010-01-22 2016-08-15 Ascendis Pharma As DIPEPTID-BASED PRODRUG LINKERS TO ALIFATIC AMINE-CONTAINING MEDICINES
JP5681276B2 (ja) 2010-03-15 2015-03-04 ユナイテッド セラピューティクス コーポレイション 肺高血圧症のための治療
JP6046034B2 (ja) 2010-06-03 2016-12-14 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの製造
EP2582235A4 (en) 2010-06-15 2014-04-30 United Therapeutics Corp ORAL TREATMENT OF DIGITAL ISCHEMIC LESIONS
US20120010159A1 (en) 2010-07-09 2012-01-12 United Therapeutics Corporation Combination therapies with cox-2 inhibitors and treprostinil
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
WO2012107364A1 (en) 2011-02-07 2012-08-16 Scipharm Sàrl Novel composition for the treatment of cystic fibrosis
JP5780775B2 (ja) 2011-02-18 2015-09-16 株式会社Ｌｔｔバイオファーマ プロスタグランジンｉ２誘導体を含有するナノ粒子
CN103476762B (zh) 2011-03-02 2015-04-22 联合治疗公司 用于生产曲前列环素的中间体的合成
US9532950B2 (en) 2011-03-14 2017-01-03 National University Corporation Hokkaido University Vector for pulmonary delivery, inducing agent, and uses
EP2741778A1 (en) 2011-08-12 2014-06-18 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
CA2843506C (en) 2011-08-12 2020-05-12 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
WO2013024052A1 (en) 2011-08-12 2013-02-21 Ascendis Pharma A/S Carrier-linked treprostinil prodrugs
EP2741779A1 (en) 2011-08-12 2014-06-18 Ascendis Pharma A/S High-loading water-soluble carrier-linked prodrugs
CN103874480A (zh) 2011-08-12 2014-06-18 阿森迪斯药物股份有限公司 前列环素的缓释组合物
CA2843504C (en) 2011-08-12 2020-08-25 Ascendis Pharma A/S Protein carrier-linked prodrugs
US8524939B2 (en) 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
HUE034485T2 (en) 2012-06-15 2018-02-28 Scipharm Sarl Process for the preparation of treprostinil and its derivatives
AU2013296611B2 (en) 2012-08-01 2017-11-23 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
JP6357481B2 (ja) 2012-11-30 2018-07-11 インスメッド， インコーポレイテッド プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法
ES2963968T3 (es) 2013-01-09 2024-04-03 United Therapeutics Corp Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas
US9505737B2 (en) * 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
CN105164098A (zh) 2013-03-14 2015-12-16 联合治疗公司 曲前列环素的固体形式
CN109608326A (zh) 2013-03-15 2019-04-12 联合治疗公司 曲前列环素的盐
US9102660B2 (en) 2013-03-25 2015-08-11 United Therapeutics Corporaiton Process of making prostacyclin compounds with linker thiol and pegylated forms
WO2014179295A1 (en) 2013-04-30 2014-11-06 United Therapeutics Corporation Controlled release pharmaceutical formulations
WO2014203278A2 (en) 2013-06-19 2014-12-24 Msn Laboratories Private Limited NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
AU2014331796B2 (en) 2013-10-11 2020-05-07 Gilead Sciences, Inc. Spray dry formulations
MX2016005293A (es) 2013-10-25 2016-08-12 Insmed Inc Compuestos de prostaciclina, composiciones y metodos de uso de los mismos.
WO2015138423A1 (en) 2014-03-11 2015-09-17 Insmed Incorporated Prostacylin compositions and methods for using the same
ES2908142T3 (es) 2014-06-13 2022-04-27 United Therapeutics Corp Formulaciones de treprostinil
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
JP6866043B2 (ja) 2014-11-18 2021-04-28 インスメッド インコーポレイテッド トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法
WO2016176555A1 (en) * 2015-04-29 2016-11-03 Insmed Incorporated Prostacyclin compounds, compositions and methods of use thereof
WO2017008076A1 (en) 2015-07-09 2017-01-12 Insmed Incorporated Compositions and methods for treating lung diseases and lung injury
AU2017261317A1 (en) 2016-05-05 2018-12-13 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
WO2017223400A1 (en) 2016-06-24 2017-12-28 Insmed Incorporated Prostacyclin compounds and compositions for treating sarcoidosis
CA3038276A1 (en) 2016-09-26 2018-03-29 United Therapeutics Corporation Treprostinil prodrugs
AU2019282808A1 (en) 2018-06-07 2021-01-07 Mannkind Corporation Composition and method for inhalation
EP3673895A1 (en) 2018-12-28 2020-07-01 Université Libre de Bruxelles Dry powder inhalation formulation and its use for the therapeutic treatment of lungs
CA3138530A1 (en) 2019-04-29 2020-11-05 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
EP4126856A4 (en) 2020-03-25 2024-05-01 Insmed Incorporated PHARMACEUTICAL FORMULATIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF
MX2023004812A (es) 2020-10-28 2023-07-06 Insmed Inc Composiciones de polvo seco de profarmacos de treprostinil y metodos de uso de estos.

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IL245184A0 (en) 2016-06-30
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