PL2616486T3 - Warianty czynnika viii mające zmniejszony wychwyt komórkowy - Google Patents

Warianty czynnika viii mające zmniejszony wychwyt komórkowy

Info

Publication number
PL2616486T3
PL2616486T3 PL11769805T PL11769805T PL2616486T3 PL 2616486 T3 PL2616486 T3 PL 2616486T3 PL 11769805 T PL11769805 T PL 11769805T PL 11769805 T PL11769805 T PL 11769805T PL 2616486 T3 PL2616486 T3 PL 2616486T3
Authority
PL
Poland
Prior art keywords
factor viii
cellular uptake
decreased cellular
viii variants
variants
Prior art date
Application number
PL11769805T
Other languages
English (en)
Inventor
Henriët MEEMS
Alexander Benjamin Meijer
Koenraad Mertens
Ole Hvilsted Olsen
Kasper Lamberth
Peder Lisby Noerby
Laust Bruun Johnsen
Marianne Kjalke
Henning Ralf Stennicke
Johannes Jacobus Voorberg
Maartje Van Den Biggelaar
Original Assignee
Stichting Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Sanquin Bloedvoorziening filed Critical Stichting Sanquin Bloedvoorziening
Publication of PL2616486T3 publication Critical patent/PL2616486T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL11769805T 2010-09-15 2011-09-14 Warianty czynnika viii mające zmniejszony wychwyt komórkowy PL2616486T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP10176731 2010-09-15
US38473110P 2010-09-21 2010-09-21
EP11173768 2011-07-13
US201161507666P 2011-07-14 2011-07-14
PCT/EP2011/065913 WO2012035050A2 (en) 2010-09-15 2011-09-14 Factor viii variants having a decreased cellular uptake
EP11769805.0A EP2616486B1 (en) 2010-09-15 2011-09-14 Factor viii variants having a decreased cellular uptake

Publications (1)

Publication Number Publication Date
PL2616486T3 true PL2616486T3 (pl) 2019-05-31

Family

ID=45832010

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11769805T PL2616486T3 (pl) 2010-09-15 2011-09-14 Warianty czynnika viii mające zmniejszony wychwyt komórkowy

Country Status (7)

Country Link
US (4) US9321827B2 (pl)
EP (2) EP3466968A1 (pl)
JP (2) JP6042335B2 (pl)
CN (2) CN103209992A (pl)
AU (1) AU2011303916A1 (pl)
PL (1) PL2616486T3 (pl)
WO (1) WO2012035050A2 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104411716B (zh) 2012-04-24 2018-09-07 诺和诺德股份有限公司 适用于治疗血友病的化合物
CN104411323A (zh) 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的药物组合物
JP2015533152A (ja) 2012-10-15 2015-11-19 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 第ｖｉｉ因子コンジュゲート
EP2934147B1 (en) 2012-12-20 2019-11-27 BASF Agro B.V. Compositions comprising a triazole compound
DK3219707T3 (da) 2013-01-09 2019-09-23 Basf Agro Bv Fremgangsmåde til fremstilling af substituerede oxiraner og triazoler
CN106028817A (zh) 2013-07-08 2016-10-12 巴斯夫农业公司 包含***化合物和生物农药的组合物
AU2014336252A1 (en) 2013-10-15 2016-04-07 Novo Nordisk Health Care Ag Coagulation factor VII polypeptides
EP3114138B1 (en) 2014-03-05 2021-11-17 Pfizer Inc. Improved muteins of clotting factor viii
UA119672C2 (uk) 2014-06-25 2019-07-25 Басф Агро Б.В. Пестицидні композиції
WO2018199214A1 (ja) * 2017-04-27 2018-11-01 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
CN113301911A (zh) * 2018-10-23 2021-08-24 费城儿童医院 用于调节因子viii功能的组合物和方法
WO2020212415A1 (en) 2019-04-17 2020-10-22 Novo Nordisk A/S Bispecific antibodies
US20230176071A1 (en) * 2020-05-08 2023-06-08 UCB Biopharma SRL Arrays and methods for identifying binding sites on a protein

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2645588A (en) 1987-12-04 1989-06-15 Scripps Clinic And Research Foundation The von willebrand factor binding domain of factor viii
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
WO1994015625A1 (en) * 1993-01-15 1994-07-21 Enzon, Inc. Factor viii - polymeric conjugates
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
CZ298579B6 (cs) 1998-04-28 2007-11-14 Applied Research Systems Ars Holding N. V. Konjugát polyolu a interferonu-beta
US6759216B1 (en) 1998-11-06 2004-07-06 Emory University Glycosylated, low antigenicity low immunogenicity factor VIII
DE59914490D1 (de) 1998-11-10 2007-10-18 Sanquin Bloedvoorziening Ein faktor viii-polypeptid mit faktor viii:c-aktivität
SG159381A1 (en) * 2001-10-10 2010-03-30 Novo Nordisk As Remodeling and glycoconjugation of peptides
WO2003040211A2 (en) * 2001-11-07 2003-05-15 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
WO2003047507A2 (en) 2001-11-30 2003-06-12 Emory University Factor viii c2 domain variants
CA2484155C (en) 2002-04-29 2015-10-13 Baxter International Inc. Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
JP5570809B2 (ja) 2006-09-01 2014-08-13 ノボ ノルディスク ヘルス ケア アーゲー 修飾タンパク質
WO2008151258A2 (en) * 2007-06-04 2008-12-11 Neose Technologies, Inc. O-linked glycosylation using n-acetylglucosaminyl transferases
CN101965200B (zh) 2008-02-27 2013-06-19 诺沃-诺迪斯克有限公司 缀合的因子ⅷ分子
WO2011060371A2 (en) 2009-11-13 2011-05-19 Puget Sound Blood Center Factor viii t cell epitope variants having reduced immunogenicity

Also Published As

Publication number Publication date
EP2616486B1 (en) 2019-01-02
AU2011303916A1 (en) 2013-03-21
US20180327479A1 (en) 2018-11-15
CN104788557A (zh) 2015-07-22
US9321827B2 (en) 2016-04-26
EP3466968A1 (en) 2019-04-10
JP2016180002A (ja) 2016-10-13
WO2012035050A3 (en) 2012-06-14
EP2616486A2 (en) 2013-07-24
US20170066813A1 (en) 2017-03-09
JP6042335B2 (ja) 2016-12-14
US10047142B2 (en) 2018-08-14
JP6336522B2 (ja) 2018-06-06
CN103209992A (zh) 2013-07-17
WO2012035050A2 (en) 2012-03-22
US10906960B2 (en) 2021-02-02
US20140057848A1 (en) 2014-02-27
JP2013541521A (ja) 2013-11-14
US20160002314A1 (en) 2016-01-07

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