PL2531027T3 - Kombinacja terapeutyczna zawierająca dolutegrawir, abakawir i lamiwudynę - Google Patents

Kombinacja terapeutyczna zawierająca dolutegrawir, abakawir i lamiwudynę

Info

Publication number
PL2531027T3
PL2531027T3 PL11737484T PL11737484T PL2531027T3 PL 2531027 T3 PL2531027 T3 PL 2531027T3 PL 11737484 T PL11737484 T PL 11737484T PL 11737484 T PL11737484 T PL 11737484T PL 2531027 T3 PL2531027 T3 PL 2531027T3
Authority
PL
Poland
Prior art keywords
dolutegravir
abacavir
lamivudine
therapeutic combination
therapeutic
Prior art date
Application number
PL11737484T
Other languages
English (en)
Inventor
Mark Richard Underwood
Original Assignee
Viiv Healthcare Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44319704&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2531027(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viiv Healthcare Co filed Critical Viiv Healthcare Co
Publication of PL2531027T3 publication Critical patent/PL2531027T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL11737484T 2010-01-27 2011-01-24 Kombinacja terapeutyczna zawierająca dolutegrawir, abakawir i lamiwudynę PL2531027T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29858910P 2010-01-27 2010-01-27
EP11737484.3A EP2531027B1 (en) 2010-01-27 2011-01-24 Therapeutic combination comprising dolutegravir, abacavir and lamivudine
PCT/US2011/022219 WO2011094150A1 (en) 2010-01-27 2011-01-24 Antiviral therapy

Publications (1)

Publication Number Publication Date
PL2531027T3 true PL2531027T3 (pl) 2016-01-29

Family

ID=44319704

Family Applications (3)

Application Number Title Priority Date Filing Date
PL16187411T PL3127542T3 (pl) 2010-01-27 2011-01-24 Terapia przeciwwirusowa
PL11737484T PL2531027T3 (pl) 2010-01-27 2011-01-24 Kombinacja terapeutyczna zawierająca dolutegrawir, abakawir i lamiwudynę
PL15164931T PL2932970T3 (pl) 2010-01-27 2011-01-24 Terapia antywirusowa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL16187411T PL3127542T3 (pl) 2010-01-27 2011-01-24 Terapia przeciwwirusowa

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL15164931T PL2932970T3 (pl) 2010-01-27 2011-01-24 Terapia antywirusowa

Country Status (45)

Country Link
US (12) US20120295898A1 (pl)
EP (6) EP2531027B1 (pl)
JP (8) JP2013518107A (pl)
KR (4) KR101830715B1 (pl)
CN (2) CN102791129B (pl)
AP (1) AP3551A (pl)
AU (1) AU2011209788C1 (pl)
BR (1) BR112012018670A2 (pl)
CA (4) CA3003988C (pl)
CL (1) CL2012002080A1 (pl)
CO (1) CO6602152A2 (pl)
CR (1) CR20120423A (pl)
CY (4) CY1116509T1 (pl)
DK (4) DK3127542T3 (pl)
DO (2) DOP2012000205A (pl)
EA (4) EA032868B1 (pl)
EC (1) ECSP12012106A (pl)
ES (4) ES2969969T3 (pl)
FI (1) FI3494972T3 (pl)
FR (1) FR18C1043I2 (pl)
HK (3) HK1179522A1 (pl)
HR (4) HRP20240168T1 (pl)
HU (4) HUE037812T2 (pl)
IL (5) IL221007A (pl)
LT (4) LT2932970T (pl)
LU (1) LUC00090I2 (pl)
MA (1) MA34002B1 (pl)
ME (2) ME03058B (pl)
MX (4) MX356891B (pl)
MY (1) MY188334A (pl)
NO (2) NO2932970T3 (pl)
NZ (4) NZ627824A (pl)
PE (2) PE20160180A1 (pl)
PH (2) PH12016500195A1 (pl)
PL (3) PL3127542T3 (pl)
PT (4) PT2531027E (pl)
RS (4) RS65183B1 (pl)
SG (3) SG182614A1 (pl)
SI (4) SI3494972T1 (pl)
SM (1) SMT201500177B (pl)
TN (1) TN2012000376A1 (pl)
TR (1) TR201807704T4 (pl)
UA (1) UA105556C2 (pl)
WO (1) WO2011094150A1 (pl)
ZA (1) ZA201205586B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2531027E (pt) 2010-01-27 2015-09-16 Viiv Healthcare Co Combinação terapêutica compreendendo dolutegravir, abacavir e lamivudina
CA2885763C (en) 2012-10-23 2021-04-06 Cipla Limited Pharmaceutical antiretroviral composition
CA3012242C (en) 2012-12-21 2021-11-02 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP2767272A1 (en) * 2013-02-18 2014-08-20 Ratiopharm GmbH Solid pharmaceutical dosage form of dolutegravir
EP2956123A1 (en) * 2013-02-18 2015-12-23 ratiopharm GmbH Solid pharmaceutical dosage form of dolutegravir
AU2014286993B2 (en) 2013-07-12 2018-10-25 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
NO2865735T3 (pl) 2013-07-12 2018-07-21
WO2015048363A1 (en) 2013-09-27 2015-04-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
IN2014MU00916A (pl) 2014-03-20 2015-09-25 Cipla Ltd
JP6768522B2 (ja) 2014-06-04 2020-10-14 サンフォード−バーンハム メディカル リサーチ インスティテュート Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (pl) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
EP3177629B1 (en) 2014-07-29 2020-01-29 LEK Pharmaceuticals d.d. Novel hydrates of dolutegravir sodium
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
EP3277691B1 (en) 2015-04-02 2019-01-30 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP3334419A1 (en) * 2015-08-14 2018-06-20 Sandoz AG Solid pharmaceutical composition of abacavir, lamivudine, and efavirenz
WO2017205585A1 (en) * 2016-05-27 2017-11-30 Viiv Healthcare Company Combinations and uses treatments thereof
WO2018028841A1 (en) * 2016-08-12 2018-02-15 Sandoz Ag Solid pharmaceutical composition of abacavir, lamivudine, and efavirenz
WO2018042332A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
JP2020527570A (ja) * 2017-07-18 2020-09-10 ヴィーブ ヘルスケア カンパニー 組み合わせ薬物療法
JP2020528413A (ja) * 2017-07-21 2020-09-24 ヴィーブ ヘルスケア カンパニー Hiv感染症及びaidsを治療するためのレジメン
MX2020000790A (es) 2017-07-21 2020-11-11 Viiv Healthcare Co Pautas para el tratamiento de infecciones por el vih y sida.
WO2019074826A2 (en) * 2017-10-13 2019-04-18 Viiv Healthcare Company FORMULATION OF BICOLET PHARMACEUTICAL TABLET
BR112021018827A2 (pt) 2019-03-22 2021-11-23 Gilead Sciences Inc Compostos de carbamoilpiridona tricíclica em ponte e seu uso farmacêutico
BR112022013452A2 (pt) * 2020-01-09 2022-09-13 Univ Washington Combinações de agentes terapêuticos de ação prolongada e métodos das mesmas
EP4110783A1 (en) 2020-02-24 2023-01-04 Gilead Sciences, Inc. Tetracyclic compounds for treating hiv infection
HUE064467T2 (hu) 2021-01-19 2024-03-28 Gilead Sciences Inc Szubsztituált piridotriazin-származékok és alkalmazásuk
WO2023164293A1 (en) * 2022-02-28 2023-08-31 Jericho Sciences, Llc Methods for viral infections

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9111902D0 (en) 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
US5519021A (en) 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
GB9402161D0 (en) 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
IL113432A (en) 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
UA49803C2 (uk) 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
MY115461A (en) 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5849911A (en) 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
US6544961B1 (en) * 1996-06-25 2003-04-08 Smithkline Beecham Corporation Combinations comprising VX478, zidovudine, FTC and/or 3TC for use in the treatments of HIV
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
GB9709945D0 (en) 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
GB9721780D0 (en) 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6087383A (en) 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
GB9805898D0 (en) 1998-03-20 1998-05-13 Glaxo Group Ltd Process for the sythesis of hiv protease inhibitors
WO1999048371A1 (en) 1998-03-27 1999-09-30 The Regents Of The University Of California Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
GB9809213D0 (en) * 1998-04-29 1998-07-01 Glaxo Group Ltd Pharmaceutical compositions
GB9815567D0 (en) 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
MXPA02007426A (es) 2000-01-31 2003-10-14 Cook Biotech Inc Valvulas restringidas y uso de las mismas.
HU229025B1 (en) 2001-04-10 2013-07-29 Pfizer Pyrazole derivatives for treating hiv, pharmaceutical compositions containing them and process for their preparation
US7638522B2 (en) * 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
TW200403061A (en) * 2002-06-04 2004-03-01 Glaxo Group Ltd Pharmaceutical compositions
CN1302779C (zh) 2002-06-27 2007-03-07 美迪维尔公司 含有阿巴卡韦和阿洛夫定的药物制剂及其用途
US20040224916A1 (en) * 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
KR20070002006A (ko) * 2004-02-11 2007-01-04 스미스클라인 비참 코포레이션 Hiv 인테그라제 억제제
US20080076738A1 (en) * 2004-04-14 2008-03-27 Cai Zhenhong R Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
WO2005112930A1 (en) * 2004-05-21 2005-12-01 Japan Tobacco Inc. Combinations comprising a 4-isoquinolone derivative and anti-hiv agents
US7176196B2 (en) 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
ATE495747T1 (de) 2004-08-23 2011-02-15 Teva Pharma Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
KR101284361B1 (ko) 2004-09-02 2013-07-15 얀센 파마슈티카 엔.브이. 4-((4-((4-(2-시아노에텐일)-2,6-디메틸페닐)아미노-2-피리미딘일)아미노)벤조니트릴의 하이드로클로라이드
EP2256124A1 (en) 2004-09-17 2010-12-01 IDENIX Pharmaceuticals, Inc. Phospho-indoles as HIV inhibitors
JP2008531716A (ja) 2005-03-04 2008-08-14 スミスクライン ビーチャム コーポレーション 化合物
CN101212903B (zh) * 2005-04-28 2013-07-24 史密丝克莱恩比彻姆公司 具有hiv整合酶抑制活性的多环氨基甲酰基吡啶酮衍生物
PL3284520T3 (pl) * 2005-04-28 2020-01-31 Viiv Healthcare Company Policykliczna pochodna karbamoilopirydonu mająca aktywność hamowania integrazy HIV
CN101336107A (zh) * 2005-12-30 2008-12-31 吉里德科学公司 改善hiv整合酶抑制剂的药物动力学的方法
WO2007079260A1 (en) 2005-12-30 2007-07-12 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
KR101501475B1 (ko) * 2006-01-20 2015-03-19 얀센 알 앤드 디 아일랜드 Tmc278을 이용한 hiv 감염의 장기간 요법
US20080039428A1 (en) 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
NZ573887A (en) 2006-07-21 2012-02-24 Gilead Sciences Inc Antiviral protease inhibitors
EP2078029B1 (en) 2006-09-29 2014-05-14 IDENIX Pharmaceuticals, Inc. Enantiomerically pure phosphoindole as hiv inhibitor
WO2008103899A1 (en) 2007-02-23 2008-08-28 Auspex Pharmaceuticals, Inc. Preparation and utility of non-nucleoside reverse transcriptase inhibitors
PT2487166T (pt) 2007-02-23 2016-10-17 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
US8354421B2 (en) 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
MX2009013804A (es) 2007-06-29 2010-02-03 Korea Res Inst Chem Tech Inhibidores novedosos de transcriptasa inversa de vih.
CN101796040A (zh) 2007-07-06 2010-08-04 吉里德科学公司 治疗剂的药代动力学特性调节剂
EP2175857B1 (en) * 2007-07-12 2013-09-11 Janssen R&D Ireland Crystalline form of (e) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
WO2009058923A1 (en) 2007-10-31 2009-05-07 Smithkline Beecham Corporation Ccr5 antagonists as therapeutic agents
US8466177B2 (en) 2007-11-01 2013-06-18 The Uab Research Foundation Treating and preventing viral infections
US8108055B2 (en) 2007-12-28 2012-01-31 Larry Wong Method, system and apparatus for controlling an electrical device
WO2009082818A1 (en) 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel c-21-keto lupane derivatives preparation and use thereof
CA2711424A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
US8759379B2 (en) 2008-01-04 2014-06-24 Gilead Sciences, Inc. Inhibitors of cytochrome P450
AU2009214779A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17beta lupane derivatives
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
PL2320908T3 (pl) * 2008-07-25 2014-06-30 Viiv Healthcare Co Proleki dolutegrawiru
RU2527451C2 (ru) * 2008-12-11 2014-08-27 Вайв Хелткер Компани Синтез карбамоилпиридоновых ингибиторов интегразы вич и промежуточных соединений
CN104788367A (zh) 2008-12-11 2015-07-22 盐野义制药株式会社 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体
PT2531027E (pt) 2010-01-27 2015-09-16 Viiv Healthcare Co Combinação terapêutica compreendendo dolutegravir, abacavir e lamivudina
GB201006038D0 (en) 2010-04-12 2010-05-26 Unilever Plc Improvements relating to antiviral compositions
EP2590971A4 (en) 2010-06-17 2014-12-10 Fuzians Biomedicals Inc COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE

Also Published As

Publication number Publication date
US10426780B2 (en) 2019-10-01
MX2012008774A (es) 2012-08-17
HUE037812T2 (hu) 2018-09-28
CN105311033B (zh) 2019-05-07
KR101964923B1 (ko) 2019-04-02
EA202190473A3 (ru) 2021-12-31
ES2543066T3 (es) 2015-08-14
HRP20181531T1 (hr) 2018-11-16
BR112012018670A2 (pt) 2018-02-06
CY1120457T1 (el) 2019-07-10
NZ627826A (en) 2016-01-29
SI2932970T1 (en) 2018-07-31
RS54123B1 (en) 2015-12-31
EA201690872A2 (ru) 2016-08-31
IL257267B (en) 2019-08-29
CY2018029I1 (el) 2019-07-10
PT2531027E (pt) 2015-09-16
CA3060290A1 (en) 2011-08-04
JP2013518107A (ja) 2013-05-20
IL245182B (en) 2018-04-30
US20170216284A1 (en) 2017-08-03
SI3494972T1 (sl) 2024-03-29
EP2932970B1 (en) 2018-03-21
MA34002B1 (fr) 2013-02-01
US20150238496A1 (en) 2015-08-27
EA201892277A1 (ru) 2019-03-29
PE20160180A1 (es) 2016-05-04
ZA201205586B (en) 2014-01-29
PT2932970T (pt) 2018-06-08
RS57323B1 (sr) 2018-08-31
SG182614A1 (en) 2012-08-30
HUE040554T2 (hu) 2019-03-28
IL281959A (en) 2021-05-31
SMT201500177B (it) 2015-09-07
WO2011094150A1 (en) 2011-08-04
SG10201707183TA (en) 2017-10-30
IL257267A (en) 2018-03-29
HK1179522A1 (en) 2013-10-04
TR201807704T4 (tr) 2018-06-21
JP2022071126A (ja) 2022-05-13
JP2019167371A (ja) 2019-10-03
LT2932970T (lt) 2018-06-25
NZ601319A (en) 2014-08-29
CA2967453A1 (en) 2011-08-04
CA2787691C (en) 2018-07-17
EP2932970A1 (en) 2015-10-21
ECSP12012106A (es) 2013-05-31
DK3127542T3 (en) 2018-11-12
PH12016500195B1 (en) 2016-12-05
MY188334A (en) 2021-11-30
HRP20150770T1 (hr) 2015-08-28
JP2017008087A (ja) 2017-01-12
EP2531027A1 (en) 2012-12-12
HRP20240168T1 (hr) 2024-04-26
IL221007A (en) 2016-06-30
AP3551A (en) 2016-01-18
US20160199379A1 (en) 2016-07-14
EP3127542B1 (en) 2018-08-22
IL267658B (en) 2021-04-29
NO2932970T3 (pl) 2018-08-18
US20170079982A1 (en) 2017-03-23
RS65183B1 (sr) 2024-03-29
EA201690872A3 (ru) 2016-12-30
CY2018029I2 (el) 2019-07-10
NZ627824A (en) 2016-02-26
SI3127542T1 (sl) 2018-11-30
KR20170078868A (ko) 2017-07-07
FR18C1043I2 (fr) 2019-10-11
KR20180078358A (ko) 2018-07-09
CA3003988C (en) 2020-01-07
PH12016500195A1 (en) 2016-12-05
TN2012000376A1 (en) 2014-01-30
JP2021091705A (ja) 2021-06-17
DOP2012000205A (es) 2012-10-15
ES2688925T3 (es) 2018-11-07
LUC00090I2 (pl) 2019-01-08
JP6268386B2 (ja) 2018-01-31
JP2016145204A (ja) 2016-08-12
PL3127542T3 (pl) 2019-03-29
FR18C1043I1 (pl) 2018-11-30
IL281959B (en) 2021-12-01
KR101830715B1 (ko) 2018-04-04
DK2932970T3 (en) 2018-05-28
US20200230147A1 (en) 2020-07-23
CA2787691A1 (en) 2011-08-04
SI2531027T1 (sl) 2015-08-31
NZ627827A (en) 2016-02-26
US11234985B2 (en) 2022-02-01
EP3494972B1 (en) 2023-12-13
IL221007A0 (en) 2012-09-24
KR20160111536A (ko) 2016-09-26
ES2969969T3 (es) 2024-05-23
CL2012002080A1 (es) 2012-11-30
CN102791129A (zh) 2012-11-21
ME02182B (me) 2015-10-20
ES2670811T3 (es) 2018-06-01
EP3494972A1 (en) 2019-06-12
RS57728B1 (sr) 2018-12-31
HUE026849T2 (en) 2016-08-29
HK1209629A1 (en) 2016-04-08
CA3003988A1 (en) 2011-08-04
LTPA2018013I1 (lt) 2018-11-12
EP3351249A1 (en) 2018-07-25
LTC2932970I2 (lt) 2022-04-25
CN102791129B (zh) 2015-09-30
FI3494972T3 (fi) 2024-03-01
NO2018036I1 (no) 2018-10-15
EP4316599A2 (en) 2024-02-07
LT3494972T (lt) 2024-03-12
EA037601B1 (ru) 2021-04-20
CA2967453C (en) 2018-07-17
EA032868B1 (ru) 2019-07-31
HK1250335A1 (zh) 2018-12-14
CA3060290C (en) 2022-07-12
HUS1800042I1 (hu) 2018-11-28
US20180200254A1 (en) 2018-07-19
MX356891B (es) 2018-06-19
US20160339033A1 (en) 2016-11-24
EA025176B1 (ru) 2016-11-30
PH12018502489A1 (en) 2020-06-15
CR20120423A (es) 2012-11-22
EA201290583A1 (ru) 2013-04-30
CN105311033A (zh) 2016-02-10
KR20120128640A (ko) 2012-11-27
CO6602152A2 (es) 2013-01-18
UA105556C2 (uk) 2014-05-26
US20170281636A1 (en) 2017-10-05
JP2023085431A (ja) 2023-06-20
IL267658A (en) 2019-08-29
PE20121524A1 (es) 2012-12-03
EP2531027A4 (en) 2013-07-03
US20170119777A1 (en) 2017-05-04
EA202190473A2 (ru) 2021-06-30
CY1116509T1 (el) 2017-03-15
PT3494972T (pt) 2024-02-12
AU2011209788C1 (en) 2014-08-28
IL245182A0 (en) 2016-06-30
AP2012006445A0 (en) 2012-08-31
DK3494972T3 (da) 2024-01-29
DK2531027T3 (en) 2015-07-20
US20180098992A1 (en) 2018-04-12
JP2018127473A (ja) 2018-08-16
AU2011209788A1 (en) 2012-08-16
PL2932970T3 (pl) 2018-08-31
KR101883750B1 (ko) 2018-07-31
EP2531027B1 (en) 2015-05-06
HRP20180855T1 (hr) 2018-06-29
ME03058B (me) 2019-01-20
PT3127542T (pt) 2018-11-26
EP4316599A3 (en) 2024-04-10
MX367937B (es) 2019-09-12
SG10201509476RA (en) 2015-12-30
LT3127542T (lt) 2018-11-26
US20120295898A1 (en) 2012-11-22
MX367938B (es) 2019-09-12
CY1121040T1 (el) 2019-12-11
DOP2021000147A (es) 2022-01-16
EP3127542A1 (en) 2017-02-08
AU2011209788B2 (en) 2014-02-06
US20210401850A1 (en) 2021-12-30

Similar Documents

Publication Publication Date Title
HK1179522A1 (en) Therapeutic combination comprising dolutegravir, abacavir and lamivudine dolutegravirabacvir lamivudine
IL222481A0 (en) Combination therapy
GB201012175D0 (en) Procedure and mechanisms
EP2552323A4 (en) COMBINATION THERAPY
GB201005394D0 (en) Therapy
GB0905485D0 (en) Antiviral therapy
GB0916997D0 (en) Combination therapy
GB201011138D0 (en) Vaporiser
GB0907973D0 (en) Combination therapy
GB0922098D0 (en) Therapeutic use
GB0921244D0 (en) Therapy
GB0914820D0 (en) WATerian therapy
GB0903321D0 (en) Therapy
GB0903319D0 (en) Therapy
GB0903145D0 (en) Medicaments uses and methods
GB0908952D0 (en) Antiviral therapy
GB0904261D0 (en) New therapeutic use
GB0901902D0 (en) Medicament
GB0903318D0 (en) Medicament