PL2424889T3 - Sposób wytwarzania przeciwciał domenowych - Google Patents

Sposób wytwarzania przeciwciał domenowych

Info

Publication number
PL2424889T3
PL2424889T3 PL10719752T PL10719752T PL2424889T3 PL 2424889 T3 PL2424889 T3 PL 2424889T3 PL 10719752 T PL10719752 T PL 10719752T PL 10719752 T PL10719752 T PL 10719752T PL 2424889 T3 PL2424889 T3 PL 2424889T3
Authority
PL
Poland
Prior art keywords
production
domain antibodies
antibodies
domain
Prior art date
Application number
PL10719752T
Other languages
English (en)
Inventor
Peter Schotte
Patrick Stanssens
Christine Labeur
Jean-Luc Jonniaux
Marc Jozef Lauwereys
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42332495&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2424889(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of PL2424889T3 publication Critical patent/PL2424889T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624Disulfide-stabilized antibody (dsFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PL10719752T 2009-04-30 2010-04-30 Sposób wytwarzania przeciwciał domenowych PL2424889T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17418409P 2009-04-30 2009-04-30
US30483410P 2010-02-16 2010-02-16
PCT/EP2010/055916 WO2010125187A2 (en) 2009-04-30 2010-04-30 Method for the production of domain antibodies
EP10719752.7A EP2424889B1 (en) 2009-04-30 2010-04-30 Method for the production of domain antibodies

Publications (1)

Publication Number Publication Date
PL2424889T3 true PL2424889T3 (pl) 2016-01-29

Family

ID=42332495

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10719752T PL2424889T3 (pl) 2009-04-30 2010-04-30 Sposób wytwarzania przeciwciał domenowych

Country Status (12)

Country Link
US (2) US9464138B2 (pl)
EP (3) EP2424889B1 (pl)
AU (1) AU2010243551B2 (pl)
CA (1) CA2759370C (pl)
CY (1) CY1124137T1 (pl)
DK (2) DK2424889T3 (pl)
ES (2) ES2864956T3 (pl)
HK (1) HK1219741A1 (pl)
HU (1) HUE053480T2 (pl)
PL (1) PL2424889T3 (pl)
PT (1) PT2424889E (pl)
WO (1) WO2010125187A2 (pl)

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AU2015200057B9 (en) * 2009-06-05 2017-03-09 Ablynx Nv Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hRSV) Nanobody constructs for the prevention and/or treatment of respiratory tract infections
MX340541B (es) 2009-06-05 2016-07-13 Alblynx Nv Secuencias de aminoacidos mejoradas dirigidas contra virus sincitial respiratorio humano y polipeptidos que comprenden las mismas para la prevencion y/o tratamiento de infecciones del tracto respiratorio.
EP2507262A1 (en) 2009-11-30 2012-10-10 Ablynx N.V. Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
WO2011161266A1 (en) 2010-06-25 2011-12-29 Ablynx Nv Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4
ES2660895T3 (es) 2010-10-29 2018-03-26 Ablynx N.V. Método para la producción de dominios variables individuales de inmunoglobulina
PL2702164T3 (pl) 2011-04-29 2016-06-30 Biocon Res Limited Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania
US9670519B2 (en) * 2011-04-29 2017-06-06 Biocon Limited Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
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WO2012152823A1 (en) 2011-05-09 2012-11-15 Ablynx Nv Method for the production of immunoglobulin single variable domains
RU2661677C2 (ru) * 2011-05-27 2018-07-18 Аблинкс Нв Ингибирование резорбции кости с помощью связывающих rank-l пептидов
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
HUE050007T2 (hu) 2014-05-16 2020-11-30 Ablynx Nv Immunglobulin variábilis domének
CN107406497A (zh) * 2014-12-19 2017-11-28 埃博灵克斯股份有限公司 半胱氨酸连接的纳米抗体二聚体
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US11046767B2 (en) 2015-05-13 2021-06-29 Ablynx N.V. T cell recruiting polypeptides based on CD3 reactivity
RS59376B1 (sr) 2015-05-13 2019-11-29 Ablynx Nv Polipeptidi koji regrutuju t-ćelije na bazi tcr-alfa/beta reaktivnosti
PT3334747T (pt) * 2015-08-13 2023-12-12 Amgen Inc Formulação de gonadotrofina líquida estável
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KR102665596B1 (ko) 2016-11-16 2024-05-14 아블린쓰 엔.브이. Cd123 및 tcr 알파/베타에 결합할 수 있는 t 세포 동원 폴리펩티드
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WO2019116310A1 (en) * 2017-12-13 2019-06-20 King Abdullah University Of Science And Technology Functionalized polymeric membranes for the separation, recovery, and/or purification of antibodies
AR117650A1 (es) * 2018-10-11 2021-08-18 Amgen Inc Procesamiento posterior de constructos de anticuerpos biespecíficos
WO2021198260A1 (en) 2020-03-30 2021-10-07 Ablynx Nv Method for the production and purification of multivalent immunoglobulin single variable domains
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US20240117038A1 (en) 2022-07-18 2024-04-11 Ablynx N.V. Cx3cr1-binding compounds, methods and uses thereof
US20240132624A1 (en) 2022-07-27 2024-04-25 Ablynx N.V. Polypeptides binding to a specific epitope of the neonatal fc receptor

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Also Published As

Publication number Publication date
CY1124137T1 (el) 2022-05-27
AU2010243551A1 (en) 2011-11-10
HK1219741A1 (zh) 2017-04-13
EP3828201A1 (en) 2021-06-02
DK2424889T3 (en) 2015-11-02
US20120157664A1 (en) 2012-06-21
EP2424889A2 (en) 2012-03-07
EP2424889B1 (en) 2015-08-12
EP2982690A1 (en) 2016-02-10
WO2010125187A2 (en) 2010-11-04
CA2759370A1 (en) 2010-11-04
CA2759370C (en) 2020-02-11
ES2551854T3 (es) 2015-11-24
US9464138B2 (en) 2016-10-11
PT2424889E (pt) 2015-11-12
ES2864956T3 (es) 2021-10-14
EP2982690B1 (en) 2021-01-27
HUE053480T2 (hu) 2021-06-28
AU2010243551B2 (en) 2015-03-26
US20170081692A1 (en) 2017-03-23
DK2982690T3 (da) 2021-04-12
WO2010125187A3 (en) 2011-01-20

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