MX340541B - Secuencias de aminoacidos mejoradas dirigidas contra virus sincitial respiratorio humano y polipeptidos que comprenden las mismas para la prevencion y/o tratamiento de infecciones del tracto respiratorio. - Google Patents
Secuencias de aminoacidos mejoradas dirigidas contra virus sincitial respiratorio humano y polipeptidos que comprenden las mismas para la prevencion y/o tratamiento de infecciones del tracto respiratorio.Info
- Publication number
- MX340541B MX340541B MX2011013013A MX2011013013A MX340541B MX 340541 B MX340541 B MX 340541B MX 2011013013 A MX2011013013 A MX 2011013013A MX 2011013013 A MX2011013013 A MX 2011013013A MX 340541 B MX340541 B MX 340541B
- Authority
- MX
- Mexico
- Prior art keywords
- hrsv
- bivalent
- monovalent
- prevention
- treatment
- Prior art date
Links
- 241000711920 Human orthopneumovirus Species 0.000 title 1
- 206010057190 Respiratory tract infections Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a secuencias de aminoácidos que están dirigidas contra y/o que pueden enlazar específicamente proteína F de hRSV, así como a compuestos o constructos, y en particular proteínas y polipéptidos, que comprenden o consisten esencialmente de una o más de tales secuencias de aminoácidos. Las secuencias de aminoácidos, polipéptidos y compuestos y composiciones terapéuticas proporcionadas por la invención muestran una estabilidad mejorada, menor inmunogenicidad y/o afinidad mejorada y/o avidez para la proteína F de hRSV. La invención también se refiere a los usos de tales secuencias de aminoácidos, polipéptidos, compuestos o constructos para propósitos terapéuticos y/o profilácticos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18439609P | 2009-06-05 | 2009-06-05 | |
US26501409P | 2009-11-30 | 2009-11-30 | |
PCT/EP2010/057921 WO2010139808A2 (en) | 2009-06-05 | 2010-06-07 | IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (hRSV) AND POLYPEPTIDES COMPRISING THE SAME FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2011013013A MX2011013013A (es) | 2012-01-30 |
MX340541B true MX340541B (es) | 2016-07-13 |
Family
ID=42333502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011013013A MX340541B (es) | 2009-06-05 | 2010-06-07 | Secuencias de aminoacidos mejoradas dirigidas contra virus sincitial respiratorio humano y polipeptidos que comprenden las mismas para la prevencion y/o tratamiento de infecciones del tracto respiratorio. |
Country Status (25)
Country | Link |
---|---|
US (3) | US8945567B2 (es) |
EP (2) | EP2438087B1 (es) |
JP (2) | JP6081196B2 (es) |
KR (1) | KR101852204B1 (es) |
CN (2) | CN102459332B (es) |
AU (1) | AU2010255638B2 (es) |
BR (1) | BRPI1010830A2 (es) |
CA (1) | CA2764398A1 (es) |
CY (1) | CY1119265T1 (es) |
DK (1) | DK2438087T3 (es) |
ES (1) | ES2643034T3 (es) |
HR (1) | HRP20171194T1 (es) |
HU (1) | HUE035773T2 (es) |
IL (1) | IL216341A0 (es) |
LT (1) | LT2438087T (es) |
MX (1) | MX340541B (es) |
NZ (1) | NZ597314A (es) |
PH (1) | PH12019500644A1 (es) |
PL (1) | PL2438087T3 (es) |
PT (1) | PT2438087T (es) |
RU (2) | RU2016103067A (es) |
SG (1) | SG176095A1 (es) |
SI (1) | SI2438087T1 (es) |
WO (1) | WO2010139808A2 (es) |
ZA (1) | ZA201108892B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9193780B2 (en) | 2008-06-05 | 2015-11-24 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
ES2643034T3 (es) | 2009-06-05 | 2017-11-21 | Ablynx N.V. | Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias |
US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
EP2513145B1 (en) | 2009-12-14 | 2018-01-24 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
AU2011214299B2 (en) | 2010-02-11 | 2014-07-31 | Ablynx Nv | Methods and compositions for the preparation of aerosols |
US20130261288A1 (en) | 2010-10-29 | 2013-10-03 | Ablynx N.V. | Method for the production of immunoglobulin single variable domains |
US9534039B2 (en) | 2011-05-09 | 2017-01-03 | Ablynx N.V. | Method for the production of immunoglobulin single variable domains |
US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
RU2721707C2 (ru) | 2013-03-14 | 2020-05-21 | Макродженикс, Инк. | Биспецифичные молекулы, иммунореактивные с иммунными эффекторными клетками, экспрессирующими активирующий рецептор |
US20150065504A1 (en) | 2013-08-21 | 2015-03-05 | Alios Biopharma, Inc. | Antiviral compounds |
WO2016022464A1 (en) * | 2014-08-05 | 2016-02-11 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
MX2017004076A (es) | 2014-09-29 | 2017-07-04 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
EP3204041A1 (en) * | 2014-10-10 | 2017-08-16 | Ablynx N.V. | Methods of treating rsv infections |
CA2963030C (en) | 2014-10-10 | 2021-07-13 | Vectura Gmbh | Inhalation device for use in aerosol therapy of respiratory diseases |
MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
JP6836760B2 (ja) | 2015-06-18 | 2021-03-03 | フエー・イー・ベー・フエー・ゼツト・ウエー | Rsv融合前fタンパク質に対する免疫グロブリン単一可変ドメイン抗体 |
EP3124042A1 (en) * | 2015-07-28 | 2017-02-01 | VIB, vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
EP3452505A1 (en) | 2016-05-02 | 2019-03-13 | Ablynx NV | Treatment of rsv infection |
WO2017220645A1 (en) | 2016-06-23 | 2017-12-28 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
CN106279410B (zh) * | 2016-09-29 | 2019-08-20 | 华南理工大学 | 一种二型登革热病毒ns1蛋白多价纳米抗体及制备方法 |
IL303833A (en) | 2016-10-21 | 2023-08-01 | Adimab Llc | Respiratory syncytial virus antibodies and methods for their production and use |
WO2018075954A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
WO2018075974A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
EP3695003A4 (en) | 2017-10-13 | 2021-12-22 | Adimab, LLC | ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS AND METHOD OF GENERATING AND USING THEREOF |
JP7123607B2 (ja) * | 2018-04-09 | 2022-08-23 | シャープ株式会社 | ユーザ装置、制御装置、及び通信制御方法 |
EP3953390A1 (en) | 2019-04-10 | 2022-02-16 | Regeneron Pharmaceuticals, Inc. | Human antibodies that bind ret and methods of use thereof |
CN111748571B (zh) * | 2019-10-11 | 2022-05-03 | 浙江禾霖生物科技有限公司 | 一种将枯草芽孢杆菌工程化为生产纳米抗体的多功能稳定平台的方法 |
PE20221865A1 (es) | 2019-11-25 | 2022-12-02 | Mabloc Llc | Anticuerpos contra el virus de la fiebre amarilla y metodos de su generacion y uso |
US20210230248A1 (en) * | 2020-01-25 | 2021-07-29 | Jun Chen | Multivalent pharmacophores for high avidity and overexpressed-target specific binding and uses thereof |
WO2024133935A1 (en) | 2022-12-23 | 2024-06-27 | Ablynx Nv | Protein-based conjugation carriers |
CN116693673B (zh) * | 2023-07-26 | 2023-10-20 | 中国人民解放军军事科学院军事医学研究院 | 广谱抗SARS和SARS-CoV-2的纳米抗体、多价纳米抗体及其应用 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1120945A (en) | 1964-08-11 | 1968-07-24 | Fisons Pharmaceuticals Ltd | Applicator in combination with a pressurised aerosol dispensing container |
CA2001774C (en) | 1988-10-28 | 2001-10-16 | James A. Wells | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
DE69112207T2 (de) | 1990-04-05 | 1996-03-28 | Roberto Chestnut Hill Mass. Crea | "walk-through"-mutagenese. |
EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
CA2137558A1 (en) | 1992-07-17 | 1994-02-03 | Wayne A. Marasco | Method of intracellular binding of target molecules |
EP0656946B2 (en) | 1992-08-21 | 2010-03-31 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
US5910488A (en) | 1993-06-07 | 1999-06-08 | Vical Incorporated | Plasmids suitable for gene therapy |
JPH08511160A (ja) | 1993-06-09 | 1996-11-26 | ユニリーバー・ナームローゼ・ベンノートシャープ | 形質転換真カビによってScFvフラグメントを含んでなる融合タンパク質を生産する方法 |
US6091639A (en) | 1993-08-27 | 2000-07-18 | Kabushiki Kaisha Toshiba | Non-volatile semiconductor memory device and data programming method |
EP0759170B1 (en) | 1993-09-10 | 2008-07-09 | The Trustees Of Columbia University In The City Of New York | Uses of green fluorescent protein |
WO1995021191A1 (en) | 1994-02-04 | 1995-08-10 | William Ward | Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein |
WO1995022618A1 (en) | 1994-02-22 | 1995-08-24 | Dana-Farber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
US5693492A (en) | 1995-05-05 | 1997-12-02 | Merck & Co., Inc. | DNA encoding glutamate gated chloride channels |
US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
EP0833907A1 (en) | 1995-06-23 | 1998-04-08 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
ATE184613T1 (de) | 1995-09-22 | 1999-10-15 | Novo Nordisk As | Varianten des grünen fluoreszenzproteins, gfp |
US6027881A (en) | 1996-05-08 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence |
US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
CA2270288A1 (en) * | 1996-11-01 | 1998-05-14 | Smithkline Beecham Corporation | Human monoclonal antibodies |
WO1998021355A1 (en) | 1996-11-15 | 1998-05-22 | Life Technologies, Inc. | Mutants of green fluorescent protein |
EP1027073A2 (en) | 1996-11-19 | 2000-08-16 | Sangstat Medical Corporation | Enhanced effects for hapten conjugated therapeutics |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
FR2766826B1 (fr) | 1997-08-04 | 2001-05-18 | Pasteur Institut | Vecteurs derives d'anticorps pour le transfert de substances dans les cellules |
EP1469883A2 (en) | 1998-02-19 | 2004-10-27 | Xcyte Therapies, Inc. | Compositions and methods for regulating lymphocyte activation |
GB9824632D0 (en) | 1998-11-10 | 1999-01-06 | Celltech Therapeutics Ltd | Biological compounds |
JP2002535993A (ja) | 1999-02-05 | 2002-10-29 | リイクスニフェルシタイト ライデン | 組換え体細胞における代謝物の生合成を変調する方法 |
AP1447A (en) | 1999-04-22 | 2005-08-12 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins. |
AR030019A1 (es) * | 1999-05-18 | 2003-08-13 | Smithkline Beecham Corp | Anticuerpos monoclonales humanos y fragmentos funcionales del mismo, un procedimiento para su produccion, composiciones farmaceuticas que los comprenden, una molecula aislada de acido nucleico, un plasmido recombinante, una celula hospedante y el uso de dichos anticuerpos para la manufactura de un m |
EP1198572A2 (en) | 1999-08-02 | 2002-04-24 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
GB9922124D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
DE19955408A1 (de) | 1999-11-18 | 2001-05-23 | Bayer Ag | GABA-B-Rezeptoren |
CA2390691C (en) | 1999-12-24 | 2016-05-10 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
US6741957B1 (en) | 2000-07-21 | 2004-05-25 | Daimlerchrysler Corporation | Analytical tire model for vehicle durability and ride comfort analysis |
US6818216B2 (en) | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
US7054297B1 (en) | 2000-12-28 | 2006-05-30 | Cisco Technology, Inc. | Distribution of packets to high data rate communications devices using multicast protocols |
EP1361892A4 (en) | 2001-01-17 | 2004-10-13 | Trubion Pharmaceuticals Inc | BINDING DOMAIN FUSION PROTEIN Immunoglobulin |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
JP4336771B2 (ja) | 2001-03-09 | 2009-09-30 | モルフォシス アーゲー | 血清アルブミン結合部分 |
JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
CA2456121A1 (en) | 2001-08-03 | 2003-02-20 | Medical Research Council | Intracellular antibodies |
FR2829940A1 (fr) | 2001-09-27 | 2003-03-28 | Synt Em | Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central |
KR100599789B1 (ko) | 2001-12-03 | 2006-07-12 | 삼성에스디아이 주식회사 | 방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법 |
WO2003050531A2 (en) | 2001-12-11 | 2003-06-19 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
CA2468690A1 (en) | 2001-12-18 | 2003-06-26 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
AU2003210060B2 (en) | 2002-03-22 | 2010-02-25 | Aprogen, Inc. | Humanized antibody and process for preparing same |
US7132100B2 (en) * | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
EP1600459A3 (en) | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
US7004940B2 (en) | 2002-10-10 | 2006-02-28 | Ethicon, Inc. | Devices for performing thermal ablation having movable ultrasound transducers |
JP2006512910A (ja) | 2002-10-23 | 2006-04-20 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | A34およびa33様3dna、タンパク質、それらに対する抗体、ならびに同一物を使用した治療方法 |
EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
JP4490290B2 (ja) | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ,コーポレイション | 加水分解安定性マレイミド末端ポリマー |
CN100439400C (zh) | 2003-01-10 | 2008-12-03 | 埃博灵克斯股份有限公司 | 治疗性多肽,其同源物、其片段及其在调节血小板介导的聚集方面的应用 |
EP1639009B1 (en) | 2003-05-30 | 2013-02-27 | Merus B.V. | Fab library for the preparation of a mixture of antibodies |
US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
RU2005140664A (ru) | 2003-06-27 | 2007-08-27 | Байорен, Инк. (Us) | Просматривающий мутагенез |
PT1639011E (pt) | 2003-06-30 | 2009-01-20 | Domantis Ltd | Anticorpos (dab) de domínio único peguilados |
DE502004012374D1 (de) | 2003-06-30 | 2011-05-19 | Siemens Ag | Verfahren zur überwachung des programmlaufs in einem mikro-computer |
AU2003264053A1 (en) | 2003-08-12 | 2005-03-10 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
EP1512696A1 (en) | 2003-08-14 | 2005-03-09 | Diatos | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
CA2554054C (en) | 2004-01-20 | 2013-06-04 | Merus B.V. | Mixtures of binding proteins |
AU2005214988A1 (en) | 2004-02-17 | 2005-09-01 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
US7207410B2 (en) | 2004-04-29 | 2007-04-24 | Daimlerchrysler Corporation | Apparatus and method for enhanced impact sensing |
BRPI0512235A (pt) | 2004-06-18 | 2008-02-19 | Ambrx Inc | polipeptìdeos ligadores de antìgenos e seus usos |
WO2006023144A2 (en) | 2004-07-06 | 2006-03-02 | Bioren Inc. | Look-through mutagenesis for developing altered polypeptides with enhanced properties |
US7180370B2 (en) | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
AU2005286770A1 (en) | 2004-09-21 | 2006-03-30 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
RU2007117752A (ru) | 2004-10-13 | 2008-11-20 | Аблинкс Н.В. (Be) | Нанотела (nanobodies тм) против бета-амилоида и полипептидов, содержащих бета-амилоид, для лечения нейродегенеративных заболеваний, таких как болезнь альцгеймера |
TW200636064A (en) * | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
CA2585891A1 (en) | 2004-10-29 | 2006-05-11 | Medimmune, Inc. | Methods of preventing and treating rsv infections and related conditions |
MX2007006593A (es) * | 2004-12-02 | 2008-03-04 | Domantis Ltd | Anticuerpos de dominio simple anti-il 1r1 y sus usos terapeuticos. |
CA2604032C (en) * | 2005-04-06 | 2017-08-22 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
JP4976376B2 (ja) | 2005-04-08 | 2012-07-18 | メディミューン,エルエルシー | 哺乳動物メタニューモウイルスに対する抗体 |
BR122013001996B1 (pt) | 2005-05-18 | 2022-02-01 | Ablynx N.V. | Nanocorpos melhorados contra fator alfa de necrose tumoral |
AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
CA2663042A1 (en) | 2006-09-08 | 2008-03-13 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
CA2666511A1 (en) | 2006-10-11 | 2008-04-17 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and uses thereof |
US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
JP2010507624A (ja) | 2006-10-27 | 2010-03-11 | アブリンクス エン.ヴェー. | ポリペプチド及びタンパク質の鼻内送達 |
CN101611056A (zh) | 2006-12-05 | 2009-12-23 | 埃博灵克斯股份有限公司 | 能够结合于血清蛋白的肽 |
CA2672944A1 (en) | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Amino acid sequences directed against chemokines and polypeptides comprising the same for the treatment of chemokine-related diseases and disorders |
CA2691940C (en) | 2007-07-03 | 2018-03-06 | Joost Alexander Kolkman | Methods for providing improved immunoglobulin sequences |
AU2008328784B2 (en) | 2007-11-27 | 2014-03-27 | Ablynx N.V. | Immunoglobulin constructs |
EP2096121A1 (en) | 2008-02-29 | 2009-09-02 | Institut Pasteur Of Shanghai | Antiviral peptides comprising lipid attachment signals and methods of use |
US9193780B2 (en) * | 2008-06-05 | 2015-11-24 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
PT2387583T (pt) | 2009-01-14 | 2018-12-24 | Ablynx Nv | Administração pulmonar de domínios de variável única de imunoglobulina e construtos dos mesmos |
AU2010243551B2 (en) | 2009-04-30 | 2015-03-26 | Ablynx Nv | Method for the production of domain antibodies |
ES2643034T3 (es) | 2009-06-05 | 2017-11-21 | Ablynx N.V. | Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias |
US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
-
2010
- 2010-06-07 ES ES10724497.2T patent/ES2643034T3/es active Active
- 2010-06-07 SI SI201031523T patent/SI2438087T1/sl unknown
- 2010-06-07 WO PCT/EP2010/057921 patent/WO2010139808A2/en active Application Filing
- 2010-06-07 BR BRPI1010830A patent/BRPI1010830A2/pt not_active IP Right Cessation
- 2010-06-07 CA CA2764398A patent/CA2764398A1/en not_active Abandoned
- 2010-06-07 KR KR1020127000199A patent/KR101852204B1/ko active IP Right Grant
- 2010-06-07 CN CN201080024764.4A patent/CN102459332B/zh not_active Expired - Fee Related
- 2010-06-07 NZ NZ597314A patent/NZ597314A/xx not_active IP Right Cessation
- 2010-06-07 PL PL10724497T patent/PL2438087T3/pl unknown
- 2010-06-07 RU RU2016103067A patent/RU2016103067A/ru unknown
- 2010-06-07 JP JP2012513641A patent/JP6081196B2/ja not_active Expired - Fee Related
- 2010-06-07 MX MX2011013013A patent/MX340541B/es active IP Right Grant
- 2010-06-07 RU RU2011153239/10A patent/RU2577134C2/ru active
- 2010-06-07 DK DK10724497.2T patent/DK2438087T3/en active
- 2010-06-07 AU AU2010255638A patent/AU2010255638B2/en not_active Ceased
- 2010-06-07 US US13/375,357 patent/US8945567B2/en active Active
- 2010-06-07 EP EP10724497.2A patent/EP2438087B1/en active Active
- 2010-06-07 EP EP17162779.7A patent/EP3205670A1/en not_active Withdrawn
- 2010-06-07 LT LTEP10724497.2T patent/LT2438087T/lt unknown
- 2010-06-07 HU HUE10724497A patent/HUE035773T2/en unknown
- 2010-06-07 SG SG2011084274A patent/SG176095A1/en unknown
- 2010-06-07 CN CN201510509040.3A patent/CN105061592A/zh active Pending
- 2010-06-07 PT PT107244972T patent/PT2438087T/pt unknown
-
2011
- 2011-11-02 ZA ZA2011/08892A patent/ZA201108892B/en unknown
- 2011-11-14 IL IL216341A patent/IL216341A0/en unknown
-
2014
- 2014-09-29 US US14/499,772 patent/US9803001B2/en active Active
-
2017
- 2017-01-18 JP JP2017006690A patent/JP6677659B2/ja not_active Expired - Fee Related
- 2017-08-02 HR HRP20171194TT patent/HRP20171194T1/hr unknown
- 2017-08-08 CY CY20171100847T patent/CY1119265T1/el unknown
- 2017-09-22 US US15/712,247 patent/US11028151B2/en active Active
-
2019
- 2019-03-25 PH PH12019500644A patent/PH12019500644A1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019500644A1 (en) | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections | |
TW201129377A (en) | Binding proteins that bind to human FGFR1c, human β-Klotho and both human FGFR1c and human β-Klotho | |
WO2010130830A3 (en) | Anti-sclerostin vhh and their use for treating bone diseases | |
MX358836B (es) | Proteinas f del vrs modificadas y metodos de uso de las mismas. | |
WO2010130832A3 (en) | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions | |
WO2010115998A3 (en) | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders | |
WO2009147248A3 (en) | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases | |
WO2013173129A3 (en) | Treatment of amd using aav sflt-1 | |
WO2010136311A3 (en) | Compositions and methods for antibodies targeting complement protein c3b | |
MX2009012650A (es) | Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos. | |
WO2009126688A3 (en) | Novel compositions and methods for the treatment of immune related diseases | |
WO2011110655A3 (en) | Immunogenic composition or vaccine against gram - negative bacterial, for example neiserial, infection or disease | |
WO2008101985A3 (en) | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization | |
MX2010004482A (es) | Anticuerpos anti-proteina g vsr. | |
WO2012058393A3 (en) | Dkk1 antibodies and methods of use | |
MX2012005037A (es) | Inmunoglobulinas de dominio variable doble y usos de las mismas. | |
MX2012004415A (es) | Inmunoglobulinas de dominio variable doble y usos de las mismas. | |
SG178602A1 (en) | Dual variable domain immunoglobulins and uses thereof | |
MX340014B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX2012001262A (es) | Inmunoglobulinas de dominio variable doble y usos de las misma. | |
MX340015B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX2011011669A (es) | Inmunoglobulinas de dominio variable dual y usos de las misma. | |
MX342291B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX340016B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
NZ594480A (en) | Methods and compositions for diagnosis and treatment of cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |