PL1893603T3 - Pochodne piperydyn-4-yloamidowe i ich zastosowanie jako antagonistów podtypu 5 receptora SST - Google Patents
Pochodne piperydyn-4-yloamidowe i ich zastosowanie jako antagonistów podtypu 5 receptora SSTInfo
- Publication number
- PL1893603T3 PL1893603T3 PL06755285T PL06755285T PL1893603T3 PL 1893603 T3 PL1893603 T3 PL 1893603T3 PL 06755285 T PL06755285 T PL 06755285T PL 06755285 T PL06755285 T PL 06755285T PL 1893603 T3 PL1893603 T3 PL 1893603T3
- Authority
- PL
- Poland
- Prior art keywords
- piperidin
- antagonists
- receptor subtype
- amide derivatives
- sst receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104774 | 2005-06-02 | ||
| EP06755285A EP1893603B1 (en) | 2005-06-02 | 2006-05-23 | Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists |
| PCT/EP2006/062515 WO2006128803A1 (en) | 2005-06-02 | 2006-05-23 | Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1893603T3 true PL1893603T3 (pl) | 2010-03-31 |
Family
ID=36763959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06755285T PL1893603T3 (pl) | 2005-06-02 | 2006-05-23 | Pochodne piperydyn-4-yloamidowe i ich zastosowanie jako antagonistów podtypu 5 receptora SST |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7772253B2 (pl) |
| EP (1) | EP1893603B1 (pl) |
| JP (1) | JP4949387B2 (pl) |
| KR (1) | KR100962732B1 (pl) |
| CN (1) | CN101189226A (pl) |
| AR (1) | AR054277A1 (pl) |
| AT (1) | ATE445612T1 (pl) |
| AU (1) | AU2006254256B2 (pl) |
| BR (1) | BRPI0611138A2 (pl) |
| CA (1) | CA2608819A1 (pl) |
| DE (1) | DE602006009804D1 (pl) |
| DK (1) | DK1893603T3 (pl) |
| ES (1) | ES2330788T3 (pl) |
| IL (1) | IL187426A (pl) |
| MX (1) | MX2007014928A (pl) |
| NO (1) | NO20076060L (pl) |
| PL (1) | PL1893603T3 (pl) |
| PT (1) | PT1893603E (pl) |
| RU (1) | RU2403250C2 (pl) |
| TW (1) | TWI315305B (pl) |
| WO (1) | WO2006128803A1 (pl) |
| ZA (1) | ZA200710169B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
| US8026365B2 (en) * | 2007-05-25 | 2011-09-27 | Hoffman-La Roche Inc. | 4,4-disubstituted piperidine derivatives |
| JP2013508350A (ja) * | 2009-10-20 | 2013-03-07 | ファイザー・インク | ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール |
| JP2013518084A (ja) | 2010-02-01 | 2013-05-20 | ビーエーエスエフ ソシエタス・ヨーロピア | 有害動物を駆除するための置換されたケトン性イソオキサゾリン化合物および誘導体 |
| WO2012024183A1 (en) | 2010-08-18 | 2012-02-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| US20130184320A1 (en) | 2010-10-01 | 2013-07-18 | Basf Se | Imine Compounds |
| EP2621900A1 (en) | 2010-10-01 | 2013-08-07 | Basf Se | Imine substituted 2, 4 - diaryl - pyrroline derivatives as pesticides |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| CN115215787A (zh) * | 2021-04-19 | 2022-10-21 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH598231A5 (pl) | 1973-07-27 | 1978-04-28 | Hoffmann La Roche | |
| AR216043A1 (es) * | 1974-03-21 | 1979-11-30 | Anphar Sa | Procedimiento para la preparacion de 1-derivados de benzoilamino-4-piperidina y sus sales fisiologicamente aceptables |
| GB1574418A (en) * | 1976-11-16 | 1980-09-03 | Anphar Sa | Piperidine derivatives |
| CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
| JPS5592384A (en) * | 1978-12-30 | 1980-07-12 | Beecham Group Ltd | Compound having pharmacological activity |
| US5098915A (en) * | 1989-09-05 | 1992-03-24 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides |
| SE9702794D0 (sv) | 1997-07-24 | 1997-07-24 | Astra Pharma Prod | New compounds |
| PL203116B1 (pl) | 1999-05-04 | 2009-08-31 | Schering Corp | Piperazynopiperydynowa pochodna użyteczna jako antagonista CCR5, zawierająca ją kompozycja farmaceutyczna i jej zastosowanie |
| US6344358B1 (en) * | 1999-05-28 | 2002-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property |
| FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| JP4137159B2 (ja) * | 2003-06-17 | 2008-08-20 | ファイザー・インク | セロトニン及びノルアドレナリン再取り込み阻害薬としてのｎ−ピロリジン−３−イル−アミド誘導体 |
| CN1875002B (zh) | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
-
2006
- 2006-05-23 EP EP06755285A patent/EP1893603B1/en not_active Not-in-force
- 2006-05-23 ES ES06755285T patent/ES2330788T3/es active Active
- 2006-05-23 DE DE602006009804T patent/DE602006009804D1/de active Active
- 2006-05-23 MX MX2007014928A patent/MX2007014928A/es active IP Right Grant
- 2006-05-23 CA CA002608819A patent/CA2608819A1/en not_active Abandoned
- 2006-05-23 PT PT06755285T patent/PT1893603E/pt unknown
- 2006-05-23 JP JP2008514062A patent/JP4949387B2/ja not_active Expired - Fee Related
- 2006-05-23 DK DK06755285T patent/DK1893603T3/da active
- 2006-05-23 WO PCT/EP2006/062515 patent/WO2006128803A1/en active Application Filing
- 2006-05-23 AU AU2006254256A patent/AU2006254256B2/en not_active Ceased
- 2006-05-23 KR KR1020077028019A patent/KR100962732B1/ko not_active IP Right Cessation
- 2006-05-23 PL PL06755285T patent/PL1893603T3/pl unknown
- 2006-05-23 AT AT06755285T patent/ATE445612T1/de active
- 2006-05-23 CN CNA2006800194138A patent/CN101189226A/zh active Pending
- 2006-05-23 BR BRPI0611138-6A patent/BRPI0611138A2/pt not_active IP Right Cessation
- 2006-05-23 RU RU2007148224/04A patent/RU2403250C2/ru not_active IP Right Cessation
- 2006-05-26 US US11/442,619 patent/US7772253B2/en not_active Expired - Fee Related
- 2006-05-30 TW TW095119084A patent/TWI315305B/zh not_active IP Right Cessation
- 2006-05-31 AR AR20060102259A patent/AR054277A1/es not_active Application Discontinuation
-
2007
- 2007-11-15 IL IL187426A patent/IL187426A/en not_active IP Right Cessation
- 2007-11-26 ZA ZA200710169A patent/ZA200710169B/xx unknown
- 2007-11-26 NO NO20076060A patent/NO20076060L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100962732B1 (ko) | 2010-06-09 |
| JP2008545730A (ja) | 2008-12-18 |
| US20060276508A1 (en) | 2006-12-07 |
| CA2608819A1 (en) | 2006-12-07 |
| EP1893603A1 (en) | 2008-03-05 |
| IL187426A0 (en) | 2008-02-09 |
| AU2006254256B2 (en) | 2012-04-12 |
| ATE445612T1 (de) | 2009-10-15 |
| EP1893603B1 (en) | 2009-10-14 |
| TW200716547A (en) | 2007-05-01 |
| PT1893603E (pt) | 2009-11-24 |
| ZA200710169B (en) | 2008-12-31 |
| ES2330788T3 (es) | 2009-12-15 |
| BRPI0611138A2 (pt) | 2010-08-17 |
| NO20076060L (no) | 2007-12-28 |
| JP4949387B2 (ja) | 2012-06-06 |
| TWI315305B (en) | 2009-10-01 |
| RU2403250C2 (ru) | 2010-11-10 |
| IL187426A (en) | 2011-10-31 |
| CN101189226A (zh) | 2008-05-28 |
| DK1893603T3 (da) | 2009-11-30 |
| AU2006254256A1 (en) | 2006-12-07 |
| KR20080008391A (ko) | 2008-01-23 |
| MX2007014928A (es) | 2008-02-15 |
| AR054277A1 (es) | 2007-06-13 |
| US7772253B2 (en) | 2010-08-10 |
| DE602006009804D1 (de) | 2009-11-26 |
| WO2006128803A1 (en) | 2006-12-07 |
| RU2007148224A (ru) | 2009-07-20 |
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