PE74899A1 - Derivados de ergolina - Google Patents
Derivados de ergolinaInfo
- Publication number
- PE74899A1 PE74899A1 PE1998000425A PE00042598A PE74899A1 PE 74899 A1 PE74899 A1 PE 74899A1 PE 1998000425 A PE1998000425 A PE 1998000425A PE 00042598 A PE00042598 A PE 00042598A PE 74899 A1 PE74899 A1 PE 74899A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- nitro
- phenyl
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), SU BASE LIBRE, SU ENANTIOMERO, O SU SAL; DONDE R1 ES H, ALQUILO C1-C4, -(CH2)n-FENILO(R7), n ES 1-4; R7 ES F, Cl, OH, ALQUILO C1-C4 O ALCOXI C1-C4; R2 ES H, Cl, Br, I, ALQUILO C1-C4, TIOALQUILO C1-C4; R3 ES H, ALQUILO C1-C4; R4 ES -FENILO(R8,R9,R10) O UN GRUPO DE FORMULA (c, d); R8 ES F, Cl, NITRO, CN; R9 Y R10 SON H, F, Cl, NITRO, CN; R11 ES ALQUILO C1-C4, ALQUENILO C2-C5 O UN GRUPO DE FORMULA e o f; X ES O o S; R5 Y R6 SON H o FORMAN JUNTOS UN ENLACE. R8 NO ES 4-NO2 SI R1, R2, R9 Y R10 SON H; R3 ES METILO Y R5 Y R6 SON UN ENLACE. SE PREFIERE LA CONFIGURACION [5R, 10R]. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO (I) PUEDE SER UTIL PARA EL TRATAMIENTO DE LA DEPRESION, ANSIEDAD Y DESORDENES BIPOLARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711043.1A GB9711043D0 (en) | 1997-05-29 | 1997-05-29 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE74899A1 true PE74899A1 (es) | 1999-09-14 |
Family
ID=10813201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000425A PE74899A1 (es) | 1997-05-29 | 1998-05-27 | Derivados de ergolina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6221870B1 (es) |
| EP (1) | EP0986558A2 (es) |
| JP (1) | JP2001527580A (es) |
| KR (1) | KR20010013103A (es) |
| CN (1) | CN1259946A (es) |
| AR (1) | AR012870A1 (es) |
| AU (1) | AU727841B2 (es) |
| BR (1) | BR9809491A (es) |
| CA (1) | CA2288810A1 (es) |
| CO (1) | CO4950561A1 (es) |
| CZ (1) | CZ289466B6 (es) |
| GB (1) | GB9711043D0 (es) |
| HU (1) | HUP0002311A3 (es) |
| ID (1) | ID22916A (es) |
| IL (1) | IL132571A0 (es) |
| NO (1) | NO995482L (es) |
| NZ (1) | NZ500386A (es) |
| PE (1) | PE74899A1 (es) |
| PL (1) | PL336502A1 (es) |
| RU (1) | RU2191776C2 (es) |
| SK (1) | SK160899A3 (es) |
| TR (1) | TR199902848T2 (es) |
| WO (1) | WO1998054183A2 (es) |
| ZA (1) | ZA984560B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10341317B4 (de) * | 2003-09-03 | 2008-10-23 | Axxonis Pharma Ag | Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid |
| DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
| DE10053397A1 (de) | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
| NZ530007A (en) * | 2001-06-08 | 2006-02-24 | Sod Conseils Rech Applic | Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity |
| FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
| KR101000923B1 (ko) * | 2004-01-08 | 2010-12-13 | 삼성전자주식회사 | 원격 제어기의 매크로 설정 장치 및 방법 |
| US20100048549A1 (en) * | 2005-05-18 | 2010-02-25 | Siegfried Wurster | Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4 |
| JP2007067096A (ja) * | 2005-08-30 | 2007-03-15 | Fujitsu Ltd | 半導体装置 |
| IN2012DN04858A (es) * | 2009-12-23 | 2015-09-25 | Map Pharmaceuticals Inc | |
| MX2013015373A (es) | 2011-06-23 | 2014-02-11 | Map Pharmaceuticals Inc | Nuevos analogos de fluoroergolina. |
| CA2859173A1 (en) | 2011-12-19 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel iso-ergoline derivatives |
| US8946420B2 (en) | 2011-12-21 | 2015-02-03 | Map Pharmaceuticals, Inc. | Neuromodulatory compounds |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| CN104768565B (zh) | 2012-11-01 | 2017-04-26 | 益普生制药股份有限公司 | 促生长素抑制素类似物及其二聚体 |
| TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素－多巴胺嵌合體類似物 |
| EP3253753A4 (en) | 2015-01-20 | 2018-06-27 | Xoc Pharmaceuticals, Inc | Ergoline compounds and uses thereof |
| AU2016209490B2 (en) | 2015-01-20 | 2020-09-03 | Xoc Pharmaceuticals, Inc. | Isoergoline compounds and uses thereof |
| JP2020522504A (ja) | 2017-06-01 | 2020-07-30 | エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ | 多環式化合物およびそれらの用途 |
| JP7099717B2 (ja) | 2019-09-30 | 2022-07-12 | 株式会社理研バイオ | ソマトスタチン受容体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3592816A (en) | 1966-02-08 | 1971-07-13 | Sandoz Ltd | N-substituted piperazides of lysergic acid |
| CH475252A (de) * | 1966-02-08 | 1969-07-15 | Sandoz Ag | Verfahren zur Herstellung neuer Lysergsäure-Derivate |
| GB1188197A (en) | 1967-10-11 | 1970-04-15 | Sandoz Ltd | Lysergic Acid Derivatives |
| NL6818658A (es) * | 1968-01-18 | 1969-07-22 | ||
| GB1580448A (en) * | 1976-12-06 | 1980-12-03 | Farmaceutici Italia | 8 -acetyl-6-methyl-ergoline i derivatives |
| GB8501078D0 (en) * | 1985-01-16 | 1985-02-20 | Erba Farmitalia | Piperazin-1-yl-ergo-line derivatives |
| TW357143B (en) | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
-
1997
- 1997-05-29 GB GBGB9711043.1A patent/GB9711043D0/en active Pending
-
1998
- 1998-05-27 SK SK1608-99A patent/SK160899A3/sk unknown
- 1998-05-27 PE PE1998000425A patent/PE74899A1/es not_active Application Discontinuation
- 1998-05-27 AR ARP980102461A patent/AR012870A1/es unknown
- 1998-05-27 US US09/424,377 patent/US6221870B1/en not_active Expired - Fee Related
- 1998-05-27 JP JP50023799A patent/JP2001527580A/ja active Pending
- 1998-05-27 KR KR19997011082A patent/KR20010013103A/ko active IP Right Grant
- 1998-05-27 AU AU82108/98A patent/AU727841B2/en not_active Ceased
- 1998-05-27 WO PCT/EP1998/003125 patent/WO1998054183A2/en not_active Application Discontinuation
- 1998-05-27 EP EP98932090A patent/EP0986558A2/en not_active Withdrawn
- 1998-05-27 BR BR9809491-2A patent/BR9809491A/pt not_active IP Right Cessation
- 1998-05-27 CN CN98805488A patent/CN1259946A/zh active Pending
- 1998-05-27 NZ NZ500386A patent/NZ500386A/en unknown
- 1998-05-27 IL IL13257198A patent/IL132571A0/xx unknown
- 1998-05-27 CA CA002288810A patent/CA2288810A1/en not_active Abandoned
- 1998-05-27 HU HU0002311A patent/HUP0002311A3/hu unknown
- 1998-05-27 CZ CZ19994245A patent/CZ289466B6/cs not_active IP Right Cessation
- 1998-05-27 RU RU99127433/04A patent/RU2191776C2/ru active
- 1998-05-27 PL PL98336502A patent/PL336502A1/xx unknown
- 1998-05-27 ID IDW991445A patent/ID22916A/id unknown
- 1998-05-27 TR TR1999/02848T patent/TR199902848T2/xx unknown
- 1998-05-28 ZA ZA984560A patent/ZA984560B/xx unknown
- 1998-05-28 CO CO98030085A patent/CO4950561A1/es unknown
-
1999
- 1999-11-09 NO NO995482A patent/NO995482L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995482D0 (no) | 1999-11-09 |
| RU2191776C2 (ru) | 2002-10-27 |
| AR012870A1 (es) | 2000-11-22 |
| ID22916A (id) | 1999-12-16 |
| CN1259946A (zh) | 2000-07-12 |
| NZ500386A (en) | 2002-05-31 |
| AU8210898A (en) | 1998-12-30 |
| HUP0002311A2 (hu) | 2000-12-28 |
| CZ289466B6 (cs) | 2002-01-16 |
| AU727841B2 (en) | 2001-01-04 |
| IL132571A0 (en) | 2001-03-19 |
| HUP0002311A3 (en) | 2002-08-28 |
| ZA984560B (en) | 1998-11-30 |
| JP2001527580A (ja) | 2001-12-25 |
| TR199902848T2 (xx) | 2000-02-21 |
| CA2288810A1 (en) | 1998-12-03 |
| NO995482L (no) | 1999-11-09 |
| SK160899A3 (en) | 2000-07-11 |
| WO1998054183A2 (en) | 1998-12-03 |
| US6221870B1 (en) | 2001-04-24 |
| KR20010013103A (ko) | 2001-02-26 |
| CO4950561A1 (es) | 2000-09-01 |
| EP0986558A2 (en) | 2000-03-22 |
| BR9809491A (pt) | 2000-10-17 |
| GB9711043D0 (en) | 1997-07-23 |
| PL336502A1 (en) | 2000-07-03 |
| CZ424599A3 (cs) | 2000-03-15 |
| WO1998054183A3 (en) | 1999-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |