CO5590915A2 - Derivados de piperidina como antagonistas nk1 ( receptor del neuropeptido neuroquinina-1) con actividad antagonista superior en tratamientos de trastornos fisiologicos y disminucion de efectos colaterales - Google Patents

Derivados de piperidina como antagonistas nk1 ( receptor del neuropeptido neuroquinina-1) con actividad antagonista superior en tratamientos de trastornos fisiologicos y disminucion de efectos colaterales

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Publication number
CO5590915A2
CO5590915A2 CO04054290A CO04054290A CO5590915A2 CO 5590915 A2 CO5590915 A2 CO 5590915A2 CO 04054290 A CO04054290 A CO 04054290A CO 04054290 A CO04054290 A CO 04054290A CO 5590915 A2 CO5590915 A2 CO 5590915A2
Authority
CO
Colombia
Prior art keywords
alkyl
group
independently selected
neuropachine
neuropeptide
Prior art date
Application number
CO04054290A
Other languages
English (en)
Inventor
Sunil Paliwal
Gregory A Reichard
Cheng Wang
Dong Xiao
Hon-Chung Tsui
Neng-Yang Shih
Juan D Arredondo
Michelle Laci Wrobleski
Anandan Palani
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23337634&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5590915(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO5590915A2 publication Critical patent/CO5590915A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

1.- Un compuesto de la fórmula (I) o una sal para uso farmacéutico del mismo, en donde Ar1 y Ar2 se seleccionan cada una independientemente del grupo que consiste en R17-heteroarilo y X1 es -O-, -S-, -SO-, -SO2-, -NH34-, -N(COR12)- o -N(SO2R15)-; cuando X1 es -SO-, -SO2-, -N(COR12)- o -N(SO2R15)-, entonces: R1 y R2 se seleccionan cada uno independientemente del grupo que consiste en H, alquilo de C1-C6, hidroxi(alquilo de C1-C3), cicloalquilo de C1-C8, -CH2F, y -CHF2 y -CF3; o R1 y R2, junto con el átomo de carbono al que ambos están unidos, forman un anillo de alquileno de C3 a C6; o cuando X1 es -O-, -S- o -NR34 entonces: R1 y R2 se seleccionan cada uno independientemente del grupo que consiste en H, alquilo de C1-C6, hidroxi(alquilo de C1-C3), cicloalquilo de C3-C8, -CH2F, -CHF2 y -CF3; o R1 y R2, junto con el átomo de carbono al que ambos están unidos, forman un anillo de alquileno de C3 a C6 químicamente viable; o R1 y R2, entre sí y junto con el átomo de carbono al que ambos están unidos, forman un grupo C=O; R3 se selecciona del grupo que consiste en H, alquilo de C1-C6, hidroxi(alquilo de C1-C3) cicloalquilo de C3-C8, -CH2F, -CHF2 y -CF3; cada R6 se selecciona independientemente del grupo que consiste en H, alquilo de C1-C6 y -OH; cada R7 se selecciona independientemente del grupo que consiste en H y alquilo de C1-C6; n2 es 1 a 4; R4 y R5 se seleccionan independientemente del grupo que consiste en -(CR28R29)n1-G, donde, n1 es 0 a 5, y G es -H, CF3, -CHF2, -CH2F, -OH, -O-(alquilo de C1-C6), -OCH2F, OCHF2, -OCF3, OCH2CF3, -O-(cicloalquilo de C3-C6), -O-(C1-C6)alquil(cicloalquilo de C3-C8), -NR13R14, -SO2NR13R14, -NR12SO2R13, -NR12C(O)R14, -NR12C(O)OR13, -NR12(C(O)NR13R14), ...
CO04054290A 2001-12-18 2004-06-09 Derivados de piperidina como antagonistas nk1 ( receptor del neuropeptido neuroquinina-1) con actividad antagonista superior en tratamientos de trastornos fisiologicos y disminucion de efectos colaterales CO5590915A2 (es)

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