PE20231102A1 - Procesos para preparar un inhibidor de jak1 - Google Patents
Procesos para preparar un inhibidor de jak1Info
- Publication number
- PE20231102A1 PE20231102A1 PE2022002824A PE2022002824A PE20231102A1 PE 20231102 A1 PE20231102 A1 PE 20231102A1 PE 2022002824 A PE2022002824 A PE 2022002824A PE 2022002824 A PE2022002824 A PE 2022002824A PE 20231102 A1 PE20231102 A1 PE 20231102A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- preparing
- processes
- azetidin
- benzamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
- B01J31/28—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of the platinum group metals, iron group metals or copper
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCESO PARA PREPARAR 4-[3-(CIANOMETIL)-3-(3',5'-DIMETIL-1H,1'H-4,4'-BIPIRAZOL-1-IL)AZETIDIN-1-IL]-2,5-DIFLUORO-N-[(1S)-2,2,2-TRIFLUORO-1-METILETIL]BENZAMIDA (COMPUESTO 1), Y SAL DE ACIDO FOSFORICO DE ESTE, QUE COMPRENDE HACER REACCIONAR EL COMPUESTO 1X (S)-4-(3-(CIANOMETILENO)AZETIDIN-1-IL)-2,5-DIFLUORO-N-(1,1,1-TRIFLUOROPROPAN-2-IL)BENZAMIDA CON EL COMPUESTO 2X 3,5-DIMETIL-1H,1'H-[4,4']BIPIRAZOLILO EN PRESENCIA DE 1,8-DIAZABICICLO[5.4.0]UNDEC-7-ENO (DBU) Y UN COMPONENTE DISOLVENTE ORGANICO TAL COMO DIMETILFORMAMIDA A UNA TEMPERATURA DE ENTRE 50 °C Y 60 °C. DICHO COMPUESTO 1 ES UTIL COMO INHIBIDOR SELECTIVO DE JAK1 (CINASA JANO 1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063033618P | 2020-06-02 | 2020-06-02 | |
PCT/US2021/035400 WO2021247668A1 (en) | 2020-06-02 | 2021-06-02 | Processes of preparing a jak1 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20231102A1 true PE20231102A1 (es) | 2023-07-19 |
Family
ID=76601838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022002824A PE20231102A1 (es) | 2020-06-02 | 2021-06-02 | Procesos para preparar un inhibidor de jak1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US11685731B2 (es) |
EP (1) | EP4157831A1 (es) |
JP (1) | JP2023528868A (es) |
KR (1) | KR20230027086A (es) |
CN (1) | CN115836065A (es) |
AR (1) | AR122505A1 (es) |
AU (1) | AU2021283271A1 (es) |
BR (1) | BR112022024632A2 (es) |
CA (1) | CA3184275A1 (es) |
CL (1) | CL2022003363A1 (es) |
CO (1) | CO2022017344A2 (es) |
CR (1) | CR20220612A (es) |
EC (1) | ECSP22091930A (es) |
IL (1) | IL298118A (es) |
MX (1) | MX2022015221A (es) |
PE (1) | PE20231102A1 (es) |
TW (1) | TW202210471A (es) |
WO (1) | WO2021247668A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE033587T2 (hu) | 2013-05-17 | 2017-12-28 | Incyte Corp | Bipirazol-származékok mint JAK inhibitorok |
PE20212186A1 (es) | 2018-02-16 | 2021-11-11 | Incyte Corp | Inhibidores de la via de jak1 para el tratamiento de trastornos relacionados con citoquinas |
US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
MX2023006542A (es) | 2020-12-08 | 2023-08-25 | Incyte Corp | Inhibidores de la vía cinasa jano 1 (jak1) para el tratamiento del vitiligo. |
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UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
PE20050952A1 (es) | 2003-09-24 | 2005-12-19 | Novartis Ag | Derivados de isoquinolina como inhibidores de b-raf |
RU2007123675A (ru) | 2004-11-24 | 2008-12-27 | Новартис АГ (CH) | Комбинации ингибиторов jak |
LT2474545T (lt) | 2005-12-13 | 2017-02-27 | Incyte Holdings Corporation | Heteroarilu pakeisti pirolo[2,3-b]piridinai ir pirolo[2,3-b]pirimidinai kaip janus kinazės inhibitoriai |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
CA2689663C (en) | 2007-06-13 | 2016-08-09 | Incyte Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
BRPI0820544A2 (pt) | 2007-11-16 | 2015-06-16 | Incyte Corp | 4-pirazolil-n-arilpirimidin-2-aminas e pirazolil-n-heteroarilpirimidin-2-aminas como inibidores de janus cinase |
RS55263B1 (sr) | 2008-03-11 | 2017-02-28 | Incyte Holdings Corp | Derivati azetidina i ciklobutana kao jak inhibitori |
CL2009001884A1 (es) | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
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-
2021
- 2021-06-02 AU AU2021283271A patent/AU2021283271A1/en active Pending
- 2021-06-02 PE PE2022002824A patent/PE20231102A1/es unknown
- 2021-06-02 JP JP2022574313A patent/JP2023528868A/ja active Pending
- 2021-06-02 TW TW110119976A patent/TW202210471A/zh unknown
- 2021-06-02 AR ARP210101500A patent/AR122505A1/es unknown
- 2021-06-02 IL IL298118A patent/IL298118A/en unknown
- 2021-06-02 KR KR1020227045757A patent/KR20230027086A/ko active Search and Examination
- 2021-06-02 MX MX2022015221A patent/MX2022015221A/es unknown
- 2021-06-02 CN CN202180048817.4A patent/CN115836065A/zh active Pending
- 2021-06-02 WO PCT/US2021/035400 patent/WO2021247668A1/en active Application Filing
- 2021-06-02 EP EP21734728.5A patent/EP4157831A1/en active Pending
- 2021-06-02 BR BR112022024632A patent/BR112022024632A2/pt unknown
- 2021-06-02 CR CR20220612A patent/CR20220612A/es unknown
- 2021-06-02 US US17/337,065 patent/US11685731B2/en active Active
- 2021-06-02 CA CA3184275A patent/CA3184275A1/en active Pending
-
2022
- 2022-11-29 CL CL2022003363A patent/CL2022003363A1/es unknown
- 2022-12-01 CO CONC2022/0017344A patent/CO2022017344A2/es unknown
- 2022-12-01 EC ECSENADI202291930A patent/ECSP22091930A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2022017344A2 (es) | 2023-03-07 |
AU2021283271A1 (en) | 2022-12-15 |
MX2022015221A (es) | 2023-03-08 |
CN115836065A (zh) | 2023-03-21 |
CR20220612A (es) | 2023-04-11 |
EP4157831A1 (en) | 2023-04-05 |
JP2023528868A (ja) | 2023-07-06 |
BR112022024632A2 (pt) | 2023-02-28 |
AR122505A1 (es) | 2022-09-14 |
KR20230027086A (ko) | 2023-02-27 |
CA3184275A1 (en) | 2021-12-09 |
US11685731B2 (en) | 2023-06-27 |
US20210380563A1 (en) | 2021-12-09 |
ECSP22091930A (es) | 2023-02-28 |
WO2021247668A1 (en) | 2021-12-09 |
IL298118A (en) | 2023-01-01 |
CL2022003363A1 (es) | 2023-05-19 |
TW202210471A (zh) | 2022-03-16 |
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