PE20231102A1 - Procesos para preparar un inhibidor de jak1 - Google Patents

Procesos para preparar un inhibidor de jak1

Info

Publication number
PE20231102A1
PE20231102A1 PE2022002824A PE2022002824A PE20231102A1 PE 20231102 A1 PE20231102 A1 PE 20231102A1 PE 2022002824 A PE2022002824 A PE 2022002824A PE 2022002824 A PE2022002824 A PE 2022002824A PE 20231102 A1 PE20231102 A1 PE 20231102A1
Authority
PE
Peru
Prior art keywords
compound
preparing
processes
azetidin
benzamide
Prior art date
Application number
PE2022002824A
Other languages
English (en)
Inventor
Yingrui Dai
Zhongjiang Jia
Yongchun Pan
James M Parks
Anthony J Tomaine
Jianji Wang
Aibin Zhang
Jiacheng Zhou
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20231102A1 publication Critical patent/PE20231102A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
    • B01J31/28—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of the platinum group metals, iron group metals or copper

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN PROCESO PARA PREPARAR 4-[3-(CIANOMETIL)-3-(3',5'-DIMETIL-1H,1'H-4,4'-BIPIRAZOL-1-IL)AZETIDIN-1-IL]-2,5-DIFLUORO-N-[(1S)-2,2,2-TRIFLUORO-1-METILETIL]BENZAMIDA (COMPUESTO 1), Y SAL DE ACIDO FOSFORICO DE ESTE, QUE COMPRENDE HACER REACCIONAR EL COMPUESTO 1X (S)-4-(3-(CIANOMETILENO)AZETIDIN-1-IL)-2,5-DIFLUORO-N-(1,1,1-TRIFLUOROPROPAN-2-IL)BENZAMIDA CON EL COMPUESTO 2X 3,5-DIMETIL-1H,1'H-[4,4']BIPIRAZOLILO EN PRESENCIA DE 1,8-DIAZABICICLO[5.4.0]UNDEC-7-ENO (DBU) Y UN COMPONENTE DISOLVENTE ORGANICO TAL COMO DIMETILFORMAMIDA A UNA TEMPERATURA DE ENTRE 50 °C Y 60 °C. DICHO COMPUESTO 1 ES UTIL COMO INHIBIDOR SELECTIVO DE JAK1 (CINASA JANO 1).
PE2022002824A 2020-06-02 2021-06-02 Procesos para preparar un inhibidor de jak1 PE20231102A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063033618P 2020-06-02 2020-06-02
PCT/US2021/035400 WO2021247668A1 (en) 2020-06-02 2021-06-02 Processes of preparing a jak1 inhibitor

Publications (1)

Publication Number Publication Date
PE20231102A1 true PE20231102A1 (es) 2023-07-19

Family

ID=76601838

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022002824A PE20231102A1 (es) 2020-06-02 2021-06-02 Procesos para preparar un inhibidor de jak1

Country Status (18)

Country Link
US (1) US11685731B2 (es)
EP (1) EP4157831A1 (es)
JP (1) JP2023528868A (es)
KR (1) KR20230027086A (es)
CN (1) CN115836065A (es)
AR (1) AR122505A1 (es)
AU (1) AU2021283271A1 (es)
BR (1) BR112022024632A2 (es)
CA (1) CA3184275A1 (es)
CL (1) CL2022003363A1 (es)
CO (1) CO2022017344A2 (es)
CR (1) CR20220612A (es)
EC (1) ECSP22091930A (es)
IL (1) IL298118A (es)
MX (1) MX2022015221A (es)
PE (1) PE20231102A1 (es)
TW (1) TW202210471A (es)
WO (1) WO2021247668A1 (es)

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MX2023006542A (es) 2020-12-08 2023-08-25 Incyte Corp Inhibidores de la vía cinasa jano 1 (jak1) para el tratamiento del vitiligo.

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Also Published As

Publication number Publication date
CO2022017344A2 (es) 2023-03-07
AU2021283271A1 (en) 2022-12-15
MX2022015221A (es) 2023-03-08
CN115836065A (zh) 2023-03-21
CR20220612A (es) 2023-04-11
EP4157831A1 (en) 2023-04-05
JP2023528868A (ja) 2023-07-06
BR112022024632A2 (pt) 2023-02-28
AR122505A1 (es) 2022-09-14
KR20230027086A (ko) 2023-02-27
CA3184275A1 (en) 2021-12-09
US11685731B2 (en) 2023-06-27
US20210380563A1 (en) 2021-12-09
ECSP22091930A (es) 2023-02-28
WO2021247668A1 (en) 2021-12-09
IL298118A (en) 2023-01-01
CL2022003363A1 (es) 2023-05-19
TW202210471A (zh) 2022-03-16

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