BR112022002580A2 - Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos - Google Patents

Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos

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Publication number
BR112022002580A2
BR112022002580A2 BR112022002580A BR112022002580A BR112022002580A2 BR 112022002580 A2 BR112022002580 A2 BR 112022002580A2 BR 112022002580 A BR112022002580 A BR 112022002580A BR 112022002580 A BR112022002580 A BR 112022002580A BR 112022002580 A2 BR112022002580 A2 BR 112022002580A2
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Prior art keywords
rip1
inhibitory compounds
preparation
methods
compounds
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BR112022002580A
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English (en)
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Taylor Vanessa
Bhamidipati Somasekhar
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Rigel Pharmaceuticals Inc
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Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of BR112022002580A2 publication Critical patent/BR112022002580A2/pt

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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract

COMPOSTOS INIBITÓRIOS DE RIP1 E MÉTODOS PARA PREPARAÇÃO E USO DOS MESMOS. São descritos aqui compostos inibitórios de quinase, tal como compostos inibidores de proteína-1 quinase de interação com receptor (RIP1), bem como composições farmacêuticas e combinações compreendendo tais compostos inibitórios. Os compostos descritos, composições farmacêuticas, e/ou combinações podem ser usados para tratar ou prevenir uma doença ou condição associada à quinase, particularmente uma doença ou condição associada com RIP1.
BR112022002580A 2019-09-06 2020-09-04 Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos BR112022002580A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962897223P 2019-09-06 2019-09-06
US201962932404P 2019-11-07 2019-11-07
US202063001016P 2020-03-27 2020-03-27
US202063004319P 2020-04-02 2020-04-02
US202063004290P 2020-04-02 2020-04-02
US202063004301P 2020-04-02 2020-04-02
PCT/US2020/049451 WO2021046382A1 (en) 2019-09-06 2020-09-04 Rip1 inhibitory compounds and methods for making and using the same

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BR112022002580A2 true BR112022002580A2 (pt) 2022-07-19

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BR112022002581A BR112022002581A2 (pt) 2019-09-06 2020-09-04 Inibidores heterocíclicos de rip1 quinase
BR112022002580A BR112022002580A2 (pt) 2019-09-06 2020-09-04 Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos
BR112022002991A BR112022002991A2 (pt) 2019-09-06 2020-09-04 Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos

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US (6) US11407736B2 (pt)
EP (3) EP4025572A1 (pt)
JP (4) JP7376218B2 (pt)
KR (3) KR20220042431A (pt)
CN (3) CN114728918A (pt)
AU (3) AU2020341681B2 (pt)
BR (3) BR112022002581A2 (pt)
CA (3) CA3149900A1 (pt)
CO (1) CO2022002630A2 (pt)
DO (1) DOP2022000051A (pt)
EC (1) ECSP22016571A (pt)
IL (3) IL290779A (pt)
JO (1) JOP20220062A1 (pt)
MX (3) MX2022002718A (pt)
PE (1) PE20221628A1 (pt)
TW (3) TW202122388A (pt)
WO (3) WO2021046447A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2988601C (en) * 2015-07-02 2021-12-07 F. Hoffmann-La Roche Ag Bicyclic lactams and methods of use thereof
PE20210414A1 (es) 2018-05-03 2021-03-04 Rigel Pharmaceuticals Inc Compuestos inhibidores de rip1 y metodos para preparar y usar los mismos
MA52488B1 (fr) 2018-05-03 2023-11-30 Rigel Pharmaceuticals Inc Composés inhibiteurs de rip1 et leurs procédés de fabrication et d'utilisation
WO2021046447A1 (en) * 2019-09-06 2021-03-11 Rigel Pharmaceuticals, Inc. Heterocyclic rip1 kinase inhibitors
AU2020341708B2 (en) 2019-09-06 2024-01-04 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
WO2021092336A1 (en) 2019-11-07 2021-05-14 Rigel Pharmaceuticals, Inc. Heterocyclic rip1 inhibitory compounds
IL295975A (en) * 2020-02-28 2022-10-01 Univ Texas Inhibitors of receptor interaction with protein kinase i for the treatment of disease
AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k
TWI824259B (zh) 2020-07-01 2023-12-01 美商雷傑製藥公司 Rip1k抑制劑
WO2022171111A1 (en) * 2021-02-10 2022-08-18 Zai Lab (Us) Llc Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof
AR125587A1 (es) * 2021-03-11 2023-08-02 Rigel Pharmaceuticals Inc Inhibidores heterocíclicos de la quinasa de rip1
CN113045560B (zh) * 2021-03-30 2022-09-06 港科鹏禾生物(苏州)有限公司 一种酰胺类衍生物及其制备方法和应用
EP4329766A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Ripk1 inhibitors and methods of use
EP4329765A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Phenyl azepines as ripk1 inhibitors and methods of use thereof
CN114989156A (zh) * 2021-05-19 2022-09-02 成都贝诺科成生物科技有限公司 一种受体相互作用蛋白抑制剂及其制备方法和用途
WO2023020486A1 (zh) * 2021-08-17 2023-02-23 广州市恒诺康医药科技有限公司 Rip1激酶抑制剂类化合物及其组合物和用途
CN115737650A (zh) * 2021-09-03 2023-03-07 复旦大学 一种嘧啶类衍生物或其药学上可接受的盐在制备治疗结核病药物中的应用
CN116478150A (zh) * 2022-01-21 2023-07-25 中国科学院上海药物研究所 具有ripk1抑制活性的化合物、其制备方法及其用途
CN114736197B (zh) * 2022-06-13 2022-09-13 南京医工医药技术有限公司 咪唑啉酮衍生物及其用途
CN115353513A (zh) * 2022-07-29 2022-11-18 中国人民解放军海军军医大学 一种抑制程序性细胞坏死的硫代七元环衍生物及其应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
EP0431519B1 (en) 1989-12-04 1994-06-15 G.D. Searle & Co. System for transdermal albuterol administration
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
JPH07502219A (ja) 1991-12-18 1995-03-09 ミネソタ　マイニング　アンド　マニュファクチャリング　カンパニー 多重層型バリアー構造体
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
EP3034494A1 (en) 2007-08-15 2016-06-22 President and Fellows of Harvard College Heterocyclic inhibitors of necroptosis
TWI648273B (zh) 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（三）
US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
CA2958645A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
AU2016217496B2 (en) 2015-02-13 2019-03-07 Glaxosmithkline Intellectual Property Development Limited Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
CA2988601C (en) 2015-07-02 2021-12-07 F. Hoffmann-La Roche Ag Bicyclic lactams and methods of use thereof
WO2017064217A1 (en) 2015-10-13 2017-04-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis
CN108431004B (zh) 2015-10-23 2021-02-12 武田药品工业株式会社 杂环化合物
US10961258B2 (en) 2015-12-21 2021-03-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
US9815850B2 (en) * 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
EP3526219B1 (en) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclic pyridone lactams and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
CA3052767A1 (en) 2017-02-27 2018-08-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
PE20210414A1 (es) * 2018-05-03 2021-03-04 Rigel Pharmaceuticals Inc Compuestos inhibidores de rip1 y metodos para preparar y usar los mismos
MA52488B1 (fr) * 2018-05-03 2023-11-30 Rigel Pharmaceuticals Inc Composés inhibiteurs de rip1 et leurs procédés de fabrication et d'utilisation
AU2019296091A1 (en) 2018-06-26 2021-01-21 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Cell necrosis inhibitor, preparation method therefor and use thereof
CN111138448B (zh) 2018-11-02 2022-08-02 中国科学院上海药物研究所 抑制rip1激酶的杂环酰胺及其用途
WO2020088194A1 (zh) 2018-11-02 2020-05-07 中国科学院上海药物研究所 抑制rip1激酶的杂环酰胺及其用途
WO2021046447A1 (en) 2019-09-06 2021-03-11 Rigel Pharmaceuticals, Inc. Heterocyclic rip1 kinase inhibitors
AU2020341708B2 (en) 2019-09-06 2024-01-04 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k

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