PE20221045A1 - Anticuerpos biespecificos contra ceacam5 y cd3 - Google Patents
Anticuerpos biespecificos contra ceacam5 y cd3Info
- Publication number
- PE20221045A1 PE20221045A1 PE2022000432A PE2022000432A PE20221045A1 PE 20221045 A1 PE20221045 A1 PE 20221045A1 PE 2022000432 A PE2022000432 A PE 2022000432A PE 2022000432 A PE2022000432 A PE 2022000432A PE 20221045 A1 PE20221045 A1 PE 20221045A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- cancer
- binding portion
- portion comprises
- human
- Prior art date
Links
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 title abstract 5
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 title abstract 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 206010062878 Gastrooesophageal cancer Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 201000006974 gastroesophageal cancer Diseases 0.000 abstract 1
- 102000047627 human CEACAM5 Human genes 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Developmental Biology & Embryology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se encuentra relacionada a anticuerpos biespecificos, los cuales se unen al antigeno carcinoembrionario humano CEACAM5 (CEA) y a CD3e humano. Este anticuerpo biespecifico comprende una primera porcion de union, que especificamente se une a CEACAM5 humano, y una segunda porcion de union, que especificamente se une a CD3e humano, en donde: a) la primera porcion de union comprende una region de cadena pesada variable (VH), la cual comprende una CDRH1 de SEQ ID NO: 2, una CDRH2 de SEQ ID NO: 3 y una CDRH3 de SEQ ID NO: 4; b) la primera porcion de union comprende una region variable de cadena ligera (VL) que comprende un conjunto de CDRLs; c) la segunda porcion de union comprende una VH que comprende una CDRH1 de SEQ ID NO: 2, CDRH2 de SEQ ID NO: 3 y CDRH3 de SEQ ID NO: 4; y, d) la segunda porcion de union comprende una VL que comprende una CDRL1 de SEQ ID NO: 18, CDRL2 de SEQ ID NO: 19, y CDRL3 de SEQ ID NO: 20. Estos anticuerpos se emplean en el tratamiento de un sujeto que tiene un cancer que expresa CEA, en donde el cancer es seleccionado a partir del grupo que consiste de cancer colorrectal, cancer de pulmon de celulas no pequenas (NSCLC), cancer de esofago, cancer gastroesofagico, cancer de pancreas y cancer de mama.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962902150P | 2019-09-18 | 2019-09-18 | |
EP19198124 | 2019-09-18 | ||
PCT/IB2020/058690 WO2021053587A1 (en) | 2019-09-18 | 2020-09-17 | Bispecific antibodies against ceacam5 and cd3 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221045A1 true PE20221045A1 (es) | 2022-06-22 |
Family
ID=72615918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022000432A PE20221045A1 (es) | 2019-09-18 | 2020-09-17 | Anticuerpos biespecificos contra ceacam5 y cd3 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20230136228A1 (es) |
EP (1) | EP4013512B1 (es) |
JP (1) | JP2022548947A (es) |
KR (1) | KR20220113353A (es) |
CN (1) | CN114786776A (es) |
AU (1) | AU2020350205A1 (es) |
BR (1) | BR112022004995A2 (es) |
CA (1) | CA3150265A1 (es) |
CL (1) | CL2022000663A1 (es) |
CO (1) | CO2022004685A2 (es) |
IL (1) | IL291482A (es) |
MX (1) | MX2022003110A (es) |
PE (1) | PE20221045A1 (es) |
WO (1) | WO2021053587A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021329375A1 (en) | 2020-08-20 | 2023-04-20 | A2 Biotherapeutics, Inc. | Compositions and methods for treating ceacam positive cancers |
AU2021329371A1 (en) | 2020-08-20 | 2023-04-20 | A2 Biotherapeutics, Inc. | Compositions and methods for treating mesothelin positive cancers |
US20240002544A1 (en) | 2022-03-07 | 2024-01-04 | Novimmune Sa | Cd28 bispecific antibodies for targeted t cell activation |
WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
CN116925232A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 靶向ceacam和cd3的多特异性抗体及其用途 |
WO2023242351A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ag | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
WO2024084052A1 (en) | 2022-10-21 | 2024-04-25 | Novimmune Sa | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US20020165360A1 (en) | 2000-11-30 | 2002-11-07 | Junghans Richard P. | Chimeric effector cell receptors against carcinoembryonic antigen |
IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
US7232888B2 (en) | 2002-07-01 | 2007-06-19 | Massachusetts Institute Of Technology | Antibodies against tumor surface antigens |
AU2003288675B2 (en) | 2002-12-23 | 2010-07-22 | Medimmune Limited | Antibodies against PD-1 and uses therefor |
US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
MX2007015942A (es) | 2005-07-01 | 2008-03-07 | Medarex Inc | Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada. |
JP5686953B2 (ja) | 2005-10-11 | 2015-03-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 交差種特異的(cross−species−specific)抗体を含む組成物および該組成物の使用 |
NZ569204A (en) | 2005-12-21 | 2012-03-30 | Micromet Ag | Pharmaceutical compositions with resistance to soluble CEA - comprising antibodies that bind to CD3 and CEA |
IL177158A0 (en) | 2006-07-30 | 2008-01-20 | Assaf Klar | Method for designing and implementing improved longitudinal flexibility multilayered pipeline |
NZ580755A (en) | 2007-04-03 | 2012-05-25 | Micromet Ag | Cross-species-specific cd3-epsilon binding domain |
WO2008119566A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
BRPI0809594A2 (pt) | 2007-04-03 | 2019-08-27 | Micromet Ag | polipeptídeo, seqüência de ácido nucléico, vetor, hospedeiro, processo para a produção de um polipeptídeo, composição farmacêutica, uso de um polipeptídeo, método para prevenção, tratamento ou melhora de uma doença, em um indivíduo com necessidade do mesmo, kit, método para a identificação de um polipeptídeo(s) |
DK2170959T3 (da) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | Antistoffer mod human programmeret dødsreceptor pd-1 |
KR20090010580A (ko) | 2007-07-24 | 2009-01-30 | 조용식 | 페트용 토이렛 |
DK3056514T3 (da) | 2008-01-15 | 2019-07-01 | Univ Leland Stanford Junior | Fremgangsmåder til at manipulere fagocytose medieret af cd47 |
EP3722317A1 (en) | 2008-01-15 | 2020-10-14 | The Board of Trustees of the Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
ES2639857T3 (es) | 2008-02-11 | 2017-10-30 | Cure Tech Ltd. | Anticuerpos monoclonales para el tratamiento del tumor |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
AU2009288289B2 (en) | 2008-08-25 | 2012-11-08 | Amplimmune, Inc. | PD-1 antagonists and methods of use thereof |
CA2734908A1 (en) | 2008-08-25 | 2010-03-11 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
SI2352763T2 (sl) | 2008-10-01 | 2022-11-30 | Amgen Research (Munich) Gmbh | Bispecifična enoverižna protitelesa s specifičnostjo za tarčne antigene z visoko molekulsko maso |
SI2356153T1 (sl) | 2008-10-01 | 2016-07-29 | Amgen Research (Munich) Gmbh | Bispecifično enoverižno protitelo, specifično za križane vrste |
EP2352765B1 (en) | 2008-10-01 | 2018-01-03 | Amgen Research (Munich) GmbH | Cross-species-specific single domain bispecific single chain antibody |
TWI686405B (zh) | 2008-12-09 | 2020-03-01 | 建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
CA2774260C (en) | 2009-09-16 | 2018-10-09 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
DK2569013T3 (da) | 2010-05-14 | 2017-02-13 | Univ Leland Stanford Junior | Humaniserede og kimære monoklonale antistoffer til cd47 |
JP5997154B2 (ja) | 2010-08-16 | 2016-09-28 | ノビミューン エスアー | 多重特異性多価抗体の生成方法 |
UA115030C2 (uk) | 2011-03-02 | 2017-09-11 | Рош Глікарт Аг | Антитіло, яке зв'язується зі зв'язаним з мембраною карциноембріональним антигеном (сеа) |
US8846042B2 (en) | 2011-05-16 | 2014-09-30 | Fabion Pharmaceuticals, Inc. | Multi-specific FAB fusion proteins and methods of use |
US20140242081A1 (en) | 2011-07-18 | 2014-08-28 | Micromet Ag | Dosing regimens for treatment of cea-expressing cancers |
KR102049817B1 (ko) | 2011-08-01 | 2019-12-02 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법 |
KR102492792B1 (ko) | 2011-10-11 | 2023-01-30 | 제넨테크, 인크. | 이중특이적 항체의 개선된 어셈블리 |
PT2768857T (pt) | 2011-10-19 | 2020-01-27 | Novimmune Sa | Métodos para purificar anticorpos |
US20140140989A1 (en) | 2012-02-06 | 2014-05-22 | Inhibrx Llc | Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof |
HUE13746964T2 (hu) | 2012-02-06 | 2020-01-28 | Inhibrx Inc | CD47 antitestek és alkalmazási eljárásaik |
US9212224B2 (en) | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
ES2625742T3 (es) | 2012-11-20 | 2017-07-20 | Sanofi | Anticuerpos anti-CEACAM5 y usos de los mismos |
ES2784631T3 (es) | 2012-12-03 | 2020-09-29 | Novimmune Sa | Anticuerpos anti-CD47 y métodos de uso de los mismos |
MA38308B1 (fr) | 2013-02-26 | 2022-09-30 | Hoffmann La Roche | Molécules de liaison à l'antigène bispécifiques activant des lymphocytes t |
KR20150122203A (ko) | 2013-02-26 | 2015-10-30 | 로슈 글리카트 아게 | T 세포 활성화 이중특이적 항원 결합 분자 |
RU2705795C2 (ru) | 2013-08-20 | 2019-11-12 | Мерк Шарп И Доум Корп. | Лечение рака комбинацией антагониста pd-1 и динациклиба |
ES2728668T3 (es) | 2014-01-08 | 2019-10-28 | Univ Leland Stanford Junior | Terapia dirigida para el cáncer de pulmón de células pequeñas |
CA2936244A1 (en) | 2014-01-21 | 2015-07-30 | Medimmune, Llc | Compositions and methods for modulating and redirecting immune responses |
EP3166974A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Anti-pd-l1 antibodies and diagnostic uses thereof |
WO2016036678A1 (en) | 2014-09-02 | 2016-03-10 | Medimmune, Llc | Formulations of bispecific antibodies |
KR102318994B1 (ko) | 2015-01-23 | 2021-10-29 | 헬릭스 바이오파마 코포레이션 | 치료학적 목적을 위한 항체-우레아제 접합체 |
CA2981204C (en) | 2015-03-31 | 2023-09-19 | Novimmune Sa | Method for optimizing the assembly and production of hetero-multimeric protein complexes |
CN107849137B (zh) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | 双特异性抗ceaxcd3 t细胞活化性抗原结合分子 |
GB2546072B (en) | 2016-01-05 | 2019-07-10 | Bja Trading Ltd | Attachment assembly and method of using same |
IL259588B2 (en) | 2016-01-08 | 2023-09-01 | Hoffmann La Roche | Methods for the treatment of cea-positive cancer using pd-1 spindle-binding antagonists and bispecific antibodies against anti-cea and anti-cd3 |
AU2017250809B2 (en) | 2016-04-15 | 2024-02-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for determining and achieving therapeutically effective doses of anti-CD47 agents in treatment of cancer |
US20200255515A1 (en) | 2016-05-09 | 2020-08-13 | Celgene Corporation | Cd47 antibodies and methods of use thereof |
EP3493845A4 (en) | 2016-08-03 | 2020-04-15 | The Board of Trustees of the Leland Stanford Junior University | INTERRUPTION OF FC RECEPTOR USE ON MACROPHAGES TO IMPROVE THE EFFECTIVENESS OF ANTI-SIRPALPHA ANTIBODY THERAPY |
WO2018053328A1 (en) | 2016-09-16 | 2018-03-22 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
WO2018199593A1 (ko) | 2017-04-24 | 2018-11-01 | 재단법인 목암생명과학연구소 | Her3 및 cd3에 결합하는 이중특이적 항체 |
US11200906B2 (en) | 2017-09-15 | 2021-12-14 | Lg Electronics, Inc. | Audio encoding method, to which BRIR/RIR parameterization is applied, and method and device for reproducing audio by using parameterized BRIR/RIR information |
WO2019157432A1 (en) | 2018-02-12 | 2019-08-15 | Forty Seven, Inc. | Anti-cancer regimen using anti-cd47 and anti-cd20 antibodies |
EP3765520A1 (en) | 2018-03-14 | 2021-01-20 | NovImmune SA | Anti-cd3 epsilon antibodies and methods of use thereof |
-
2020
- 2020-09-17 PE PE2022000432A patent/PE20221045A1/es unknown
- 2020-09-17 AU AU2020350205A patent/AU2020350205A1/en active Pending
- 2020-09-17 CA CA3150265A patent/CA3150265A1/en active Pending
- 2020-09-17 MX MX2022003110A patent/MX2022003110A/es unknown
- 2020-09-17 EP EP20776239.4A patent/EP4013512B1/en active Active
- 2020-09-17 JP JP2022517810A patent/JP2022548947A/ja active Pending
- 2020-09-17 CN CN202080073507.3A patent/CN114786776A/zh active Pending
- 2020-09-17 US US17/761,531 patent/US20230136228A1/en active Pending
- 2020-09-17 KR KR1020227012787A patent/KR20220113353A/ko unknown
- 2020-09-17 WO PCT/IB2020/058690 patent/WO2021053587A1/en unknown
- 2020-09-17 BR BR112022004995A patent/BR112022004995A2/pt unknown
-
2022
- 2022-03-17 IL IL291482A patent/IL291482A/en unknown
- 2022-03-18 CL CL2022000663A patent/CL2022000663A1/es unknown
- 2022-04-12 CO CONC2022/0004685A patent/CO2022004685A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL291482A (en) | 2022-05-01 |
BR112022004995A2 (pt) | 2022-06-21 |
CA3150265A1 (en) | 2021-03-25 |
EP4013512A1 (en) | 2022-06-22 |
MX2022003110A (es) | 2022-06-27 |
KR20220113353A (ko) | 2022-08-12 |
JP2022548947A (ja) | 2022-11-22 |
WO2021053587A1 (en) | 2021-03-25 |
CL2022000663A1 (es) | 2023-01-06 |
AU2020350205A1 (en) | 2022-05-12 |
CO2022004685A2 (es) | 2022-07-08 |
CN114786776A (zh) | 2022-07-22 |
US20230136228A1 (en) | 2023-05-04 |
EP4013512B1 (en) | 2024-02-14 |
EP4013512C0 (en) | 2024-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20221045A1 (es) | Anticuerpos biespecificos contra ceacam5 y cd3 | |
CL2020003046A1 (es) | Construcciones de anticuerpo biespecificos que se unen a dll3 y cd3 ( divisional de la solicitud 267-2018) | |
PE20231386A1 (es) | Anticuerpos biespecificos contra ceacam5 y cd47 | |
PE20221262A1 (es) | Anticuerpos terapeuticos y sus usos | |
JP2013529183A5 (es) | ||
RU2019118257A (ru) | Анти-cd47 антитела и способы их применения | |
PE20181082A1 (es) | Constructos de anticuerpos para flt3 y cd3 | |
RU2504553C2 (ru) | Антитела к her | |
JP2018035138A5 (es) | ||
IL302078A (en) | Anti-CCR8 monoclonal antibodies and their uses | |
PE20191546A1 (es) | Moleculas de union antigeno biespecificas que comprenden el clon 20h4.9 anti-41bb | |
JP2020500538A5 (es) | ||
IL299221A (en) | CD3 binding antibodies | |
RU2008101772A (ru) | Антагонисты рецепторов для лечения метастатического рака | |
CL2013003140A1 (es) | Un anticuerpo monoclonal humano aislado o fragmento de union a antigeno del mismo que se une a masp-2 humana; molecula de acido nucleico, casette de expresion, celula que la expresa, metodo de produccion, composicion que la contiene, articulo que lo contiene. | |
RU2016122041A (ru) | Новые анти-клаудин антитела и способы их применения | |
NZ623347A (en) | Novel anti-dr5 antibody | |
RU2018124319A (ru) | Новые антитела к клаудину и способы их применения | |
CL2010001544A1 (es) | Anticuerpo monoclonal humanizado o fragmento de union al mismo que se une y neutraliza al factor de crecimiento endotelial vascular humano (hvegf); composicion que lo comprende; acido nucleico codificante; vector; celula huesped; su uso para tratar o prevenir una enfermedad mediada por vegf; e hibridoma. | |
JP2015517300A5 (es) | ||
RU2011116112A (ru) | Биспецифические анти-egfr/анти-igf-1r антитела | |
RU2013136172A (ru) | Белки, связывающие антиген фактор роста, подобный гепаринсвязывающему эпидермальному фактору роста | |
JP2017528476A5 (es) | ||
ES2571129T3 (es) | Anticuerpos anti-CTLA4 humanizados | |
AR082194A1 (es) | Anticuerpos anti-ron |