PE20211290A1 - Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson - Google Patents

Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson

Info

Publication number
PE20211290A1
PE20211290A1 PE2020000566A PE2020000566A PE20211290A1 PE 20211290 A1 PE20211290 A1 PE 20211290A1 PE 2020000566 A PE2020000566 A PE 2020000566A PE 2020000566 A PE2020000566 A PE 2020000566A PE 20211290 A1 PE20211290 A1 PE 20211290A1
Authority
PE
Peru
Prior art keywords
disease
parkinson
treatment
propyl
propharmacs
Prior art date
Application number
PE2020000566A
Other languages
English (en)
Inventor
Klaus Gjervig Jensen
Lisbet Kværnø
Martin Juhl
Morten Jørgensen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of PE20211290A1 publication Critical patent/PE20211290A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (Id) QUE SON PROFARMACOS DEL AGONISTA DE DOPAMINA (4AR,10AR)-1-N-PROPIL-1,2,3,4,4A,5,10,10A-OCTAHIDRO-BENZO[G]QUINOLINA-6,7-DIOL DONDE R1 Y R2 SON COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: ACIDO (2S,3S,4S,5R,6S)-3,4,5-TRIHIDROXI-6-(((4AR,10AR)-7-HIDROXI-1-PROPIL-1,2,3,4,4A,5,10,10A-OCTAHIDROBENZO[G]QUINOLIN-6-IL)OXI)TETRAHIDRO-2H-PIRAN-2-CARBOXILICO; ACIDO (2S,2'S,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-(((4AR,10AR)-1-PROPIL-1,2,3,4,4A,5,10,10A-OCTAHIDROBENZO[G]QUINOLINO-6,7-DIIL)BIS(OXI))BIS(3,4,5-TRIHIDROXITETRAHIDRO-2H-PIRAN-2-CARBOXILICO); ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, SINDROME DE LAS PIERNAS INQUIETAS, ENFERMEDAD DE ALZHEIMER.
PE2020000566A 2017-11-24 2018-11-23 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson PE20211290A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700674 2017-11-24
PCT/EP2018/082361 WO2019101917A1 (en) 2017-11-24 2018-11-23 New catecholamine prodrugs for use in the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
PE20211290A1 true PE20211290A1 (es) 2021-07-20

Family

ID=64661284

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000566A PE20211290A1 (es) 2017-11-24 2018-11-23 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson

Country Status (25)

Country Link
US (4) US10729710B2 (es)
EP (1) EP3713933A1 (es)
JP (4) JP7320507B2 (es)
KR (1) KR20200092955A (es)
CN (3) CN117653649A (es)
AR (1) AR113908A1 (es)
AU (2) AU2018371193B2 (es)
BR (1) BR112019014981A2 (es)
CA (1) CA3082757A1 (es)
CL (1) CL2020001343A1 (es)
CO (1) CO2020006224A2 (es)
CR (1) CR20200225A (es)
EA (1) EA202090987A8 (es)
EC (1) ECSP20030074A (es)
GE (1) GEP20227446B (es)
IL (1) IL274648B1 (es)
JO (1) JOP20200114A1 (es)
MA (1) MA50800A (es)
MX (2) MX2020005366A (es)
PE (1) PE20211290A1 (es)
PH (1) PH12020550631A1 (es)
SG (1) SG11202004461YA (es)
TW (1) TWI816716B (es)
UA (1) UA127575C2 (es)
WO (1) WO2019101917A1 (es)

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JP7320507B2 (ja) 2017-11-24 2023-08-03 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
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JP2023145579A (ja) 2023-10-11
RU2020116419A (ru) 2021-12-27
GEP20227446B (en) 2022-12-12
IL274648B1 (en) 2024-06-01
MA50800A (fr) 2020-09-30
US20220257623A1 (en) 2022-08-18
UA127575C2 (uk) 2023-10-18
TW201924693A (zh) 2019-07-01
US20190160083A1 (en) 2019-05-30
MX2022016276A (es) 2023-02-09
US20240156851A1 (en) 2024-05-16
EP3713933A1 (en) 2020-09-30
CO2020006224A2 (es) 2020-05-29
AU2018371193B2 (en) 2022-12-22
SG11202004461YA (en) 2020-06-29
AU2023201741A1 (en) 2023-04-20
JP2023145580A (ja) 2023-10-11
JP7320684B2 (ja) 2023-08-03
US11707476B2 (en) 2023-07-25
JP7320507B2 (ja) 2023-08-03
EA202090987A1 (ru) 2020-08-07
AR113908A1 (es) 2020-06-24
JOP20200114A1 (ar) 2020-05-17
WO2019101917A1 (en) 2019-05-31
BR112019014981A2 (pt) 2020-04-07
JP2021504345A (ja) 2021-02-15
KR20200092955A (ko) 2020-08-04
US10729710B2 (en) 2020-08-04
CA3082757A1 (en) 2019-05-31
ECSP20030074A (es) 2020-07-31
US20200338102A1 (en) 2020-10-29
US11110110B2 (en) 2021-09-07
CN117599073A (zh) 2024-02-27
JP2023055830A (ja) 2023-04-18
CL2020001343A1 (es) 2020-09-25
CR20200225A (es) 2020-07-25
MX2020005366A (es) 2020-08-13
CN117653649A (zh) 2024-03-08
CN111386267A (zh) 2020-07-07
JP7443606B2 (ja) 2024-03-05
CN111386267B (zh) 2023-12-12
IL274648A (en) 2020-06-30
EA202090987A8 (ru) 2020-09-29
AU2018371193A1 (en) 2020-06-11
TWI816716B (zh) 2023-10-01
PH12020550631A1 (en) 2021-02-22

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