PE20200341A1 - Composiciones y compuestos terapeuticos y metodos para utilizarlos - Google Patents
Composiciones y compuestos terapeuticos y metodos para utilizarlosInfo
- Publication number
- PE20200341A1 PE20200341A1 PE2019001932A PE2019001932A PE20200341A1 PE 20200341 A1 PE20200341 A1 PE 20200341A1 PE 2019001932 A PE2019001932 A PE 2019001932A PE 2019001932 A PE2019001932 A PE 2019001932A PE 20200341 A1 PE20200341 A1 PE 20200341A1
- Authority
- PE
- Peru
- Prior art keywords
- compositions
- methods
- therapeutic compounds
- compound
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Referido a un compuesto de formula I, o una sal o estereoisomero farmaceuticamente aceptable de ese, en donde R1 es H o CH3; R2 es halogeno, alquilo C1-C6, alquenilo C2-C6, entre otros; R3 es H o NH2; R4 es H o CH3 y R5 es H o NH2. Este compuesto es inhibidor de JAK cinasa. Tambien se refiere a composiciones farmaceuticas que incluyen tal inhibidor JAK y un portador, adyuvante o vehiculo farmaceuticamente aceptable, y su uso en el tratamiento de enfermedad inflamatoria, como el asma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017085276 | 2017-05-22 | ||
US201862640865P | 2018-03-09 | 2018-03-09 | |
PCT/EP2018/063262 WO2018215389A1 (en) | 2017-05-22 | 2018-05-21 | Therapeutic compounds and compositions, and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20200341A1 true PE20200341A1 (es) | 2020-02-14 |
Family
ID=62386421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019001932A PE20200341A1 (es) | 2017-05-22 | 2018-05-21 | Composiciones y compuestos terapeuticos y metodos para utilizarlos |
Country Status (19)
Country | Link |
---|---|
US (3) | US10307426B2 (es) |
EP (1) | EP3630766A1 (es) |
JP (2) | JP7256757B2 (es) |
KR (1) | KR20200010390A (es) |
CN (1) | CN110650959B (es) |
AU (1) | AU2018274577A1 (es) |
BR (1) | BR112019024322A2 (es) |
CA (1) | CA3061236A1 (es) |
CL (1) | CL2019003258A1 (es) |
CO (1) | CO2019010559A2 (es) |
CR (1) | CR20190520A (es) |
MA (1) | MA48942A (es) |
MX (1) | MX2019013308A (es) |
PE (1) | PE20200341A1 (es) |
PH (1) | PH12019502601A1 (es) |
RU (1) | RU2769696C2 (es) |
SG (1) | SG11201909735YA (es) |
TW (1) | TW201902896A (es) |
WO (1) | WO2018215389A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2769696C2 (ru) * | 2017-05-22 | 2022-04-05 | Ф. Хоффманн-Ля Рош Аг | Терапевтические соединения и композиции и способы их применения |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
MA56518A (fr) | 2019-06-18 | 2022-04-27 | Hoffmann La Roche | Inhibiteurs de sulfone pyrazolopyrimidine de jak kinases et leurs utilisations |
EP3986899A1 (en) * | 2019-06-18 | 2022-04-27 | F. Hoffmann-La Roche AG | Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES517193A0 (es) | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
US4847256A (en) | 1986-10-16 | 1989-07-11 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines |
AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
US5728536A (en) | 1993-07-29 | 1998-03-17 | St. Jude Children's Research Hospital | Jak kinases and regulation of Cytokine signal transduction |
US6136595A (en) | 1993-07-29 | 2000-10-24 | St. Jude Children's Research Hospital | Jak kinases and regulations of cytokine signal transduction |
US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
US5705625A (en) | 1994-12-15 | 1998-01-06 | The Johns Hopkins University School Of Medicine | Nucleic Acid Encoding novel protein tyrosine kinase |
US7070972B1 (en) | 1995-01-13 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Janus family kinases and identification of immune modulators |
WO1997002289A1 (en) | 1995-07-06 | 1997-01-23 | Zeneca Limited | Peptide inhibitors of fibronectine |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
US7091020B1 (en) | 1995-12-05 | 2006-08-15 | Incyte Corporation | Human Jak2 kinase |
ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
FR2791562B1 (fr) | 1999-03-29 | 2004-03-05 | Oreal | Composition tinctoriale contenant une pyrazolo-[1,5-a]- pyrimidine et une polyaminopyrimidine monocyclique a titre de bases d'oxydation et un coupleur, et procedes de teinture |
YU25500A (sh) | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
ATE303387T1 (de) | 1999-07-02 | 2005-09-15 | Eisai Co Ltd | Kondensierte imidazolderivate und arzneimittel gegen diabetes mellitus |
EE05351B1 (et) | 1999-12-10 | 2010-10-15 | Pfizer Products Inc. | Prrolo[2,3-d]primidiinhendid |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
EP1241176A1 (en) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Purine derivatives for the treatment of ischemia |
DE60214428T2 (de) | 2001-12-20 | 2007-09-20 | Bayer Healthcare Ag | 1, 4-dihydro-1, 4-diphenylpyridin-derivate |
CA2483306A1 (en) | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
US7161003B1 (en) | 2002-09-04 | 2007-01-09 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
US7550470B2 (en) | 2002-12-11 | 2009-06-23 | Merck & Co. Inc. | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors |
US20070270408A1 (en) | 2003-04-11 | 2007-11-22 | Novo Nordisk A/S | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines |
JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤および抗高血圧剤を使用する併用療法 |
JP2006522744A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 |
WO2004089471A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF |
WO2005004810A2 (en) | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Arylsulfonamide derivatives |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
US20060030536A1 (en) | 2004-04-09 | 2006-02-09 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
US7517888B2 (en) | 2004-04-28 | 2009-04-14 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
MXPA06014637A (es) | 2004-06-25 | 2007-02-12 | Amgen Inc | Triazoles e indazoles condensados utiles en el tratamiento de enfermedades mediadas por citocinas y otras enfermedades. |
AU2005304784B2 (en) | 2004-11-04 | 2011-03-24 | Vertex Pharmaceuticals Incorporated | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases |
GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
JP2009502734A (ja) | 2005-07-29 | 2009-01-29 | アステラス製薬株式会社 | Lck阻害剤としての縮合複素環 |
WO2007039797A1 (en) | 2005-10-03 | 2007-04-12 | Pfizer Products Inc. | Use of cannabinoid receptor-1 antagonist for treating inflammation and arthritis |
AR056206A1 (es) * | 2005-10-06 | 2007-09-26 | Schering Corp | Pirazolpirimidinas como inhibidores de protein quinasas |
CN101316847A (zh) | 2005-10-06 | 2008-12-03 | 先灵公司 | 用作蛋白激酶抑制剂的吡唑并(1,5a)嘧啶化合物 |
WO2007048065A2 (en) | 2005-10-21 | 2007-04-26 | Exelixis, Inc. | Pyrimidinones as casein kinase ii (ck2) modulators |
US7795273B2 (en) | 2005-12-08 | 2010-09-14 | Novartis Ag | Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors |
US8541406B2 (en) | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
RU2009120389A (ru) | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
CA2670083A1 (en) | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
WO2009017954A1 (en) | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
EP2212297B1 (en) | 2007-10-12 | 2011-05-25 | Ingenium Pharmaceuticals GmbH | Inhibitors of protein kinases |
CN104311563B (zh) | 2007-11-28 | 2016-12-07 | 达那-法伯癌症研究所 | Bcr-abl的小分子豆蔻酸酯抑制剂及其使用方法 |
CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
CA2727036C (en) | 2008-06-20 | 2017-03-21 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
WO2010019762A1 (en) | 2008-08-13 | 2010-02-18 | Jenrin Discovery | Purine compounds as cannabinoid receptor blockers |
EP2962566A1 (en) | 2008-10-31 | 2016-01-06 | Genentech, Inc. | Pyrazolopyrimidine jak inhibitor compounds and methods |
WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
UA110324C2 (en) | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
AR078675A1 (es) | 2009-10-20 | 2011-11-23 | Cellzome Ltd | Derivados de pirazolo[3,4-d]pirimidina inhibidores de jak quinasas, composiciones farmaceuticas que los comprenden, metodo para prepararlos y uso de los mismos para el tratamiento o profilaxis de trastornos inmunologicos, inflamatorios y autoinmunes. |
CN102869359A (zh) | 2010-03-17 | 2013-01-09 | 弗·哈夫曼-拉罗切有限公司 | 咪唑并吡啶和嘌呤化合物、组合物和使用方法 |
KR20130094693A (ko) | 2010-04-30 | 2013-08-26 | 셀좀 리미티드 | Jak 저해제로서의 피라졸 화합물 |
CN110003219A (zh) | 2010-07-13 | 2019-07-12 | 弗·哈夫曼-拉罗切有限公司 | 作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物 |
WO2012075393A2 (en) | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
EP2688872A4 (en) | 2011-03-22 | 2014-08-27 | Merck Sharp & Dohme | AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES |
US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
ES2666353T3 (es) | 2012-09-06 | 2018-05-04 | Bristol-Myers Squibb Company | Inhibidores de JAK3 de imidazopiridazina y su uso para el tratamiento de enfermedades inflamatorias y autoinmunitarias |
DK2917181T3 (da) | 2012-11-09 | 2020-01-13 | Medicines For Malaria Venture Mmv | Heteroarylderivater og anvendelser deraf |
WO2015006181A1 (en) | 2013-07-11 | 2015-01-15 | Merck Sharp & Dohme Corp. | Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4) |
UY35821A (es) | 2013-11-08 | 2015-06-30 | Takeda Pharmaceutical | Compuesto heterocíclico |
WO2015073267A1 (en) | 2013-11-15 | 2015-05-21 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
RU2707076C2 (ru) | 2014-05-23 | 2019-11-22 | Файбро Энимал Хэлс Корпорейшн | Комбинация, композиция и способ введения комбинации или композиции животным |
SI3145929T1 (sl) | 2014-05-23 | 2021-10-29 | Hoffmann La Roche | 5-kloro-2-difluorometoksifenil pirazolopirimidinove spojine, ki so zaviralci janusove kinaze |
JO3701B1 (ar) | 2014-05-23 | 2021-01-31 | Regeneron Pharma | مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي |
AU2015342887B2 (en) | 2014-11-06 | 2020-09-10 | Bial - R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
US10329295B2 (en) | 2015-03-12 | 2019-06-25 | Merck Sharp & Dohme Corp. | Pyrrolotriazine inhibitors of IRAK4 activity |
EP3268004B1 (en) | 2015-03-12 | 2019-12-18 | Merck Sharp & Dohme Corp. | Pyrrolopyridazine inhibitors of irak4 activity |
US10329294B2 (en) | 2015-03-12 | 2019-06-25 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of IRAK4 activity |
WO2016144844A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Carboxamide inhibitors of irak4 activity |
TW201720828A (zh) | 2015-11-23 | 2017-06-16 | 赫孚孟拉羅股份公司 | 治療性化合物及組合物以及其使用方法 |
EP3416967B1 (en) | 2016-02-18 | 2022-02-09 | F. Hoffmann-La Roche AG | Therapeutic compounds, compositions and methods of use thereof |
CA3046435A1 (en) | 2016-12-29 | 2018-07-05 | F. Hoffmann-La Roche Ag | Pyrazolopyrimidine compounds and methods of use thereof |
CN110494434B (zh) | 2017-03-14 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 吡唑并氯苯基化合物、其组合物及其使用方法 |
TW201900648A (zh) | 2017-05-22 | 2019-01-01 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及組成物以及其使用方法 |
RU2769696C2 (ru) * | 2017-05-22 | 2022-04-05 | Ф. Хоффманн-Ля Рош Аг | Терапевтические соединения и композиции и способы их применения |
-
2018
- 2018-05-21 RU RU2019141734A patent/RU2769696C2/ru active
- 2018-05-21 TW TW107117163A patent/TW201902896A/zh unknown
- 2018-05-21 US US15/984,747 patent/US10307426B2/en active Active
- 2018-05-21 SG SG11201909735Y patent/SG11201909735YA/en unknown
- 2018-05-21 CA CA3061236A patent/CA3061236A1/en active Pending
- 2018-05-21 PE PE2019001932A patent/PE20200341A1/es unknown
- 2018-05-21 CR CR20190520A patent/CR20190520A/es unknown
- 2018-05-21 CN CN201880033741.6A patent/CN110650959B/zh active Active
- 2018-05-21 BR BR112019024322-4A patent/BR112019024322A2/pt not_active Application Discontinuation
- 2018-05-21 AU AU2018274577A patent/AU2018274577A1/en not_active Abandoned
- 2018-05-21 JP JP2019564544A patent/JP7256757B2/ja active Active
- 2018-05-21 WO PCT/EP2018/063262 patent/WO2018215389A1/en active Application Filing
- 2018-05-21 EP EP18727747.0A patent/EP3630766A1/en active Pending
- 2018-05-21 KR KR1020197037532A patent/KR20200010390A/ko unknown
- 2018-05-21 MA MA048942A patent/MA48942A/fr unknown
- 2018-05-21 MX MX2019013308A patent/MX2019013308A/es unknown
-
2019
- 2019-04-17 US US16/387,187 patent/US20190240227A1/en not_active Abandoned
- 2019-09-27 CO CONC2019/0010559A patent/CO2019010559A2/es unknown
- 2019-11-14 CL CL2019003258A patent/CL2019003258A1/es unknown
- 2019-11-20 PH PH12019502601A patent/PH12019502601A1/en unknown
-
2020
- 2020-07-28 US US16/940,542 patent/US20200352951A1/en not_active Abandoned
-
2023
- 2023-02-14 JP JP2023020805A patent/JP2023058657A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110650959B (zh) | 2023-04-18 |
JP2023058657A (ja) | 2023-04-25 |
MX2019013308A (es) | 2020-02-12 |
JP2020520959A (ja) | 2020-07-16 |
EP3630766A1 (en) | 2020-04-08 |
TW201902896A (zh) | 2019-01-16 |
MA48942A (fr) | 2020-04-08 |
PH12019502601A1 (en) | 2020-06-08 |
RU2019141734A3 (es) | 2021-08-10 |
CR20190520A (es) | 2020-01-21 |
BR112019024322A2 (pt) | 2020-06-16 |
US20190240227A1 (en) | 2019-08-08 |
US20180333416A1 (en) | 2018-11-22 |
US10307426B2 (en) | 2019-06-04 |
RU2769696C2 (ru) | 2022-04-05 |
RU2019141734A (ru) | 2021-06-23 |
CN110650959A (zh) | 2020-01-03 |
JP7256757B2 (ja) | 2023-04-12 |
AU2018274577A1 (en) | 2019-10-10 |
CA3061236A1 (en) | 2018-11-29 |
CO2019010559A2 (es) | 2019-10-09 |
CL2019003258A1 (es) | 2020-04-17 |
WO2018215389A1 (en) | 2018-11-29 |
KR20200010390A (ko) | 2020-01-30 |
US20200352951A1 (en) | 2020-11-12 |
SG11201909735YA (en) | 2019-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20200341A1 (es) | Composiciones y compuestos terapeuticos y metodos para utilizarlos | |
PE20211782A1 (es) | Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos | |
CO2017011172A2 (es) | Compuestos de 1-ciano-pirrolidina como inhibidores de usp30 | |
PE20191541A1 (es) | Composiciones y metodos para inhibir la accion de la arginasa | |
CO2019011809A2 (es) | Compuestos de imidazo-piperidina fusionada como inhibidores de jak | |
ECSP22050936A (es) | Compuestos tric?clicos sustituidos | |
PE20181298A1 (es) | Inhibidores de bromodominio bivalentes y usos de los mismos | |
SV2016005328A (es) | Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1 | |
PE20181045A1 (es) | Compuestos utiles como inmunomoduladores | |
PE20190656A1 (es) | Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 | |
SV2018005663A (es) | Compuestos de imidazo [4,5-c] quinolin-2-ona y su uso en el tratamiento del cancer | |
PE20180232A1 (es) | Derivados de indol mono o disustituidos como inhibidores de la replicacion viral del dengue | |
PE20190395A1 (es) | Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos | |
PE20151981A1 (es) | Pontenciador de inhibidores del homologo de zeste | |
MX2016017030A (es) | Inhibidores de cinasa de interaccion con proteina cinasa activada por mitogeno (mnk) y metodos relacionados con los mismos. | |
PE20160686A1 (es) | Nuevas dihidroquinolizinonas para el tratamiento y profilaxis de la infeccion por virus de la hepatitis b | |
CL2013002690A1 (es) | Compuestos derivados de bis(fluoroalquil)-1,4-benzodiazepinona, inhibidores de notch; compuesto cristalino; composicion farmaceutica que los comprende; combinacion farmaceutica; y su uso para el tratamiento del cancer. | |
PE20180024A1 (es) | Triazolopirazinonas como inhibidores de pde1 | |
UY32462A (es) | Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644 | |
AR113803A1 (es) | Compuesto de pirimidina como inhibidor de jak quinasas | |
AR108046A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue | |
PE20212303A1 (es) | Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer | |
MX2016016530A (es) | Inhibidores de fosfatidilinositol 3-quinasa. | |
ECSP17069696A (es) | Compuestos novedosos | |
CO2019004978A2 (es) | Compuestos terapéuticos y métodos para utilizarlos |