PE20190574A1 - Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno - Google Patents
Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgenoInfo
- Publication number
- PE20190574A1 PE20190574A1 PE2019000439A PE2019000439A PE20190574A1 PE 20190574 A1 PE20190574 A1 PE 20190574A1 PE 2019000439 A PE2019000439 A PE 2019000439A PE 2019000439 A PE2019000439 A PE 2019000439A PE 20190574 A1 PE20190574 A1 PE 20190574A1
- Authority
- PE
- Peru
- Prior art keywords
- modified
- amino acid
- methods
- polypeptide
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003098 androgen Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102000001307 androgen receptors Human genes 0.000 abstract 5
- 108010080146 androgen receptors Proteins 0.000 abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001756 ligand binding domains Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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Abstract
Referida a una proteina de fusion que comprende un polipeptido del receptor de androgeno (AR) que comprende al menos 95% de identidad de secuencia con un dominio de union a ligando que tiene la secuencia de aminoacidos de las posiciones de aminoacidos 554 a 919 en SEQ ID NO: 1 y que comprende una sustitucion de aminoacido F876L en SEQ ID NO: 1, en la que dicho polipeptido AR se fusiona con un polipeptido heterologo, una secuencia de senal de secrecion, una etiqueta de epitopo o una etiqueta de afinidad. Asimismo, se refiere a moleculas de ADNc que codifican el AR modificado, un vector, celula huesped, un microchip, un sistema para detectar un AR modificado, asi como tambien metodos de uso del AR modificado para el tratamiento de enfermedades o condiciones, lo que incluye a los canceres, tales como los canceres de prostata resistentes a la castracion, que son mediados o dependientes de los receptores de androgeno
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261676842P | 2012-07-27 | 2012-07-27 | |
US201361783763P | 2013-03-14 | 2013-03-14 | |
US201361829123P | 2013-05-30 | 2013-05-30 |
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PE20190574A1 true PE20190574A1 (es) | 2019-04-22 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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PE2015000095A PE20150644A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
PE2019001034A PE20190845A1 (es) | 2012-07-27 | 2013-07-26 | Metodos para determinar resistencia a terapia de receptor de androgeno |
PE2019000439A PE20190574A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
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PE2015000095A PE20150644A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
PE2019001034A PE20190845A1 (es) | 2012-07-27 | 2013-07-26 | Metodos para determinar resistencia a terapia de receptor de androgeno |
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US (2) | US9617602B2 (es) |
EP (2) | EP2877599B1 (es) |
JP (3) | JP6297556B2 (es) |
KR (2) | KR102210183B1 (es) |
CN (3) | CN108048567A (es) |
AU (3) | AU2013295543B2 (es) |
BR (2) | BR112015001801A2 (es) |
CA (1) | CA2879926A1 (es) |
CL (1) | CL2015000194A1 (es) |
CO (1) | CO7280477A2 (es) |
CR (1) | CR20150022A (es) |
CY (1) | CY1122651T1 (es) |
DK (1) | DK2877599T3 (es) |
EA (2) | EA035535B1 (es) |
EC (1) | ECSP15007420A (es) |
ES (1) | ES2764381T3 (es) |
GT (1) | GT201500019A (es) |
HK (1) | HK1211060A1 (es) |
HR (1) | HRP20192342T1 (es) |
HU (1) | HUE047781T2 (es) |
IL (2) | IL236844B (es) |
LT (1) | LT2877599T (es) |
MX (2) | MX370507B (es) |
NI (1) | NI201500004A (es) |
NZ (4) | NZ740700A (es) |
PE (3) | PE20150644A1 (es) |
PH (2) | PH12015500175B1 (es) |
PL (1) | PL2877599T3 (es) |
PT (1) | PT2877599T (es) |
RS (1) | RS59812B1 (es) |
SG (2) | SG11201500184TA (es) |
SI (1) | SI2877599T1 (es) |
UA (1) | UA118178C2 (es) |
WO (1) | WO2014018926A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3062106B1 (en) | 2008-04-16 | 2020-11-11 | The Johns Hopkins University | Method for determining androgen receptor variants in prostate cancer |
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