PE20181093A1 - Compuestos heterociclicos y usos de los mismos - Google Patents
Compuestos heterociclicos y usos de los mismosInfo
- Publication number
- PE20181093A1 PE20181093A1 PE2018000414A PE2018000414A PE20181093A1 PE 20181093 A1 PE20181093 A1 PE 20181093A1 PE 2018000414 A PE2018000414 A PE 2018000414A PE 2018000414 A PE2018000414 A PE 2018000414A PE 20181093 A1 PE20181093 A1 PE 20181093A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- refers
- formula
- heterocyclic compounds
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
Referido a un compuesto de formula (I), una sal, solvato, tautomero, isomero o analogo deutorado farmaceuticamente aceptable, en donde: R1 es ciano, halo o alquilo(C1-C3) opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente del grupo que consiste en halo, metilo, etilo, metoxi y etoxi; X cuando esta presente, es halo. Tambien se refiere a una composicion farmaceutica que comprende un compuesto heterociclico de formula (I) y otro agente terapeutico; metodos para su preparacion, compuestos intermedios y sus usos en el tratamiento de la enfermedad como el cancer, afeccion autoinmune, afeccion inflamatoria o combinacion de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562221508P | 2015-09-21 | 2015-09-21 |
Publications (1)
Publication Number | Publication Date |
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PE20181093A1 true PE20181093A1 (es) | 2018-07-09 |
Family
ID=57113709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2018000414A PE20181093A1 (es) | 2015-09-21 | 2016-09-19 | Compuestos heterociclicos y usos de los mismos |
Country Status (22)
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US (6) | US9771363B2 (es) |
EP (2) | EP4071149A3 (es) |
JP (2) | JP6863970B2 (es) |
KR (1) | KR20180052757A (es) |
CN (2) | CN113754656A (es) |
AU (1) | AU2016328619B2 (es) |
BR (1) | BR112018005497A2 (es) |
CA (2) | CA3129180A1 (es) |
CL (1) | CL2018000730A1 (es) |
CO (1) | CO2018004124A2 (es) |
ES (1) | ES2913048T3 (es) |
HK (1) | HK1255102A1 (es) |
IL (1) | IL258180B (es) |
MX (1) | MX2018003432A (es) |
MY (1) | MY195977A (es) |
NZ (1) | NZ741112A (es) |
PE (1) | PE20181093A1 (es) |
PH (1) | PH12018500591A1 (es) |
RU (1) | RU2744897C2 (es) |
SG (1) | SG10201912386RA (es) |
TW (1) | TWI732785B (es) |
WO (1) | WO2017053243A1 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ582772A (en) | 2007-07-17 | 2012-06-29 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
PT2672967T (pt) | 2011-02-07 | 2018-12-07 | Plexxikon Inc | Compostos e métodos de modulação da quinase e suas indicações |
US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
AU2013312477B2 (en) | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
CA2895239C (en) | 2012-12-21 | 2020-10-27 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
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