PE20160529A1 - Uso de una combinacion de un inhibidor de mek y un inhibidor de erk para el tratamiento de enfermedades hiperproliferativas - Google Patents

Uso de una combinacion de un inhibidor de mek y un inhibidor de erk para el tratamiento de enfermedades hiperproliferativas

Info

Publication number
PE20160529A1
PE20160529A1 PE2016000076A PE2016000076A PE20160529A1 PE 20160529 A1 PE20160529 A1 PE 20160529A1 PE 2016000076 A PE2016000076 A PE 2016000076A PE 2016000076 A PE2016000076 A PE 2016000076A PE 20160529 A1 PE20160529 A1 PE 20160529A1
Authority
PE
Peru
Prior art keywords
inhibitor
treatment
combination
hyperproliferative diseases
gdc
Prior art date
Application number
PE2016000076A
Other languages
English (en)
Inventor
Mark Merchant
Marcia Belvin
John Moffat
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20160529A1 publication Critical patent/PE20160529A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La invencion proporciona combinaciones que comprenden un inhibidor de MEK tal como GDC-0973, GDC-0623, GSK-112 0212 (trametinib), AZD-6244 (selumetinib), etc; o una de sus sales farmaceuticamente aceptables y un inhibidor de ERK (tal como GDC-0994, [(S)-1-(1-(4-cloro-3-fluorofenil)-2-hidroxietil)-4-(2-((1-metil-1H-pirazol-5-il)amino)pirimidin-4-il)piridin-2(1H)-ona]. Las combinaciones son particularmente utiles para tratar trastornos hiperproliferativos, tal como el cancer
PE2016000076A 2013-09-05 2014-09-04 Uso de una combinacion de un inhibidor de mek y un inhibidor de erk para el tratamiento de enfermedades hiperproliferativas PE20160529A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361874206P 2013-09-05 2013-09-05

Publications (1)

Publication Number Publication Date
PE20160529A1 true PE20160529A1 (es) 2016-05-21

Family

ID=51492945

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000076A PE20160529A1 (es) 2013-09-05 2014-09-04 Uso de una combinacion de un inhibidor de mek y un inhibidor de erk para el tratamiento de enfermedades hiperproliferativas

Country Status (21)

Country Link
US (1) US9532987B2 (es)
EP (1) EP3041471A1 (es)
JP (2) JP2016531139A (es)
KR (1) KR20160048807A (es)
CN (1) CN105517548B (es)
AR (1) AR097556A1 (es)
AU (1) AU2014317119B2 (es)
CA (1) CA2916619A1 (es)
CL (1) CL2016000042A1 (es)
EA (1) EA034872B1 (es)
HK (1) HK1218072A1 (es)
IL (1) IL243251B (es)
MA (1) MA38827A1 (es)
MX (1) MX370417B (es)
PE (1) PE20160529A1 (es)
PH (1) PH12016500270A1 (es)
SG (1) SG11201600989VA (es)
TW (1) TW201605477A (es)
UA (1) UA120423C2 (es)
WO (1) WO2015032840A1 (es)
ZA (1) ZA201600091B (es)

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KR102396710B1 (ko) * 2013-12-30 2022-05-10 어레이 바이오파마 인크. 세린/트레오닌 키나제 저해제
WO2016162325A1 (en) 2015-04-07 2016-10-13 Astrazeneca Ab Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1 (2h)-one derivatives as kinase inhibitors
SI3374359T1 (sl) 2015-11-09 2020-04-30 Astrazeneca Ab Derivati dihidroimidazopirazinona uporabni pri zdravljenju raka
WO2017080980A1 (en) 2015-11-09 2017-05-18 Astrazeneca Ab Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer
CN105330643B (zh) * 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 卡比替尼的制备方法
KR20180134347A (ko) * 2016-04-15 2018-12-18 제넨테크, 인크. 암의 진단 및 치료 방법
WO2018039211A1 (en) * 2016-08-23 2018-03-01 Genentech, Inc. Combination therapy for the treatment of pancreatic cancer
MY194462A (en) * 2016-11-25 2022-11-30 Genuv Inc Composition for Promoting Differentiation of and Protecting Neural Stem Cells and Method for Inducing Neural Regeneration using same
JP2019019094A (ja) * 2017-07-19 2019-02-07 学校法人福岡大学 変異ｋｒａｓ関連シグナル阻害用組成物
JP2020532982A (ja) 2017-09-08 2020-11-19 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんの診断及び治療方法
WO2019139970A1 (en) * 2018-01-09 2019-07-18 Duke University Topical administration of mek inhibiting agents for the treatment of skin disorders
EP3752200A1 (en) 2018-02-13 2020-12-23 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
WO2021007499A1 (en) * 2019-07-11 2021-01-14 Emory University Combination therapies for managing cancer

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Also Published As

Publication number Publication date
SG11201600989VA (en) 2016-03-30
JP2016531139A (ja) 2016-10-06
JP2019031517A (ja) 2019-02-28
US9532987B2 (en) 2017-01-03
HK1218072A1 (zh) 2017-02-03
AR097556A1 (es) 2016-03-23
MA38827A1 (fr) 2017-10-31
EA201690513A1 (ru) 2016-07-29
WO2015032840A1 (en) 2015-03-12
ZA201600091B (en) 2017-04-26
MX370417B (es) 2019-12-10
AU2014317119B2 (en) 2019-12-05
CL2016000042A1 (es) 2016-08-05
CA2916619A1 (en) 2015-03-12
TW201605477A (zh) 2016-02-16
CN105517548B (zh) 2020-01-21
KR20160048807A (ko) 2016-05-04
MX2016002857A (es) 2016-06-22
US20150111869A1 (en) 2015-04-23
EA034872B1 (ru) 2020-03-31
CN105517548A (zh) 2016-04-20
EP3041471A1 (en) 2016-07-13
AU2014317119A1 (en) 2016-03-03
UA120423C2 (uk) 2019-12-10
PH12016500270A1 (en) 2016-05-16
IL243251B (en) 2019-02-28

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