PE20121471A1 - Derivados de sulfonamida heterociclicos utiles como inhibidores de mek - Google Patents
Derivados de sulfonamida heterociclicos utiles como inhibidores de mekInfo
- Publication number
- PE20121471A1 PE20121471A1 PE2012000608A PE2012000608A PE20121471A1 PE 20121471 A1 PE20121471 A1 PE 20121471A1 PE 2012000608 A PE2012000608 A PE 2012000608A PE 2012000608 A PE2012000608 A PE 2012000608A PE 20121471 A1 PE20121471 A1 PE 20121471A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- helpful
- heterocyclic sulfonamide
- mek inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE SULFONAMIDA HETEROCICLICO DE FORMULA (I) DONDE: R1a Y R1b SON HIDROXILO, CIANO, NITRO, ALQUILO C1-6, ALQUENILO C2-6, ENTRE OTROS; R2a ES H O ALQUILO C1-6; R2b ES ALQUILO C1-6, ALQUENILO C2-6, CICLOALQUILO, ARILO, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-6, ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO POR HALOGENO, HIDROXIALQUILO C1-6 O ALCOXILO C1-6, R5 ES H, HALOGENO, ALQUILO C1-3 O ALQUILO C1-3 SUSTITUIDO POR HALOGENO; X ES -N(R6)-; R6 ES H O ALQUILO C1-6; W ES NR22, O O S. R22 ES H, ALQUILO C1-6, ALQUENILO C2-6, CICLOALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [7-(4-BROMO-2-FLUORO-FENIL-AMINO)-6-METIL-5-OXO-1,2,3,5-TETRAHIDRO-IMIDAZO-[1,2-a]-PIRIDIN-8-IL]-AMIDA DEL ACIDO CICLOPROPAN-SULFONICO; [7-(2-FLUORO-4-YODO-FENIL-AMINO)-6-METIL-5-OXO-1,2,3,5-TETRAHIDRO-IMIDAZO-[1,2-a]-PIRIDIN-8-IL]-AMIDA DEL ACIDO 1-(2,3-DIHIDROXI-PROPIL)-CICLOPROPAN-SULFONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES INHIBIDOR DE LA PROTEINA CINASA DE MEK SIENDO UTIL EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS COMO CANCER E INFLAMACION
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2678CH2009 | 2009-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20121471A1 true PE20121471A1 (es) | 2012-11-01 |
Family
ID=43416908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000608A PE20121471A1 (es) | 2009-11-04 | 2010-11-02 | Derivados de sulfonamida heterociclicos utiles como inhibidores de mek |
Country Status (29)
Country | Link |
---|---|
US (1) | US8466289B2 (es) |
EP (1) | EP2496575B1 (es) |
JP (1) | JP5466767B2 (es) |
KR (1) | KR101398772B1 (es) |
CN (1) | CN102596951B (es) |
AR (1) | AR078900A1 (es) |
AU (1) | AU2010317167B2 (es) |
BR (1) | BR112012010519A2 (es) |
CA (1) | CA2779935A1 (es) |
CL (1) | CL2012001027A1 (es) |
CO (1) | CO6541547A2 (es) |
CR (1) | CR20120234A (es) |
DO (1) | DOP2012000127A (es) |
EA (1) | EA201200651A1 (es) |
EC (1) | ECSP12011878A (es) |
ES (1) | ES2487628T3 (es) |
GT (1) | GT201200138A (es) |
IL (1) | IL219113A0 (es) |
MA (1) | MA33721B1 (es) |
MX (1) | MX2012005293A (es) |
MY (1) | MY156209A (es) |
NI (1) | NI201200084A (es) |
NZ (1) | NZ599565A (es) |
PE (1) | PE20121471A1 (es) |
TN (1) | TN2012000153A1 (es) |
TW (1) | TW201139449A (es) |
UY (1) | UY33000A (es) |
WO (1) | WO2011054828A1 (es) |
ZA (1) | ZA201202530B (es) |
Families Citing this family (15)
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EA201391820A1 (ru) * | 2011-06-09 | 2014-12-30 | Новартис Аг | Гетероциклические сульфонамидные производные |
EP3549584A1 (en) | 2013-03-12 | 2019-10-09 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Combinations of inhibitors of mek, egfr and erbb2 in the treatment of kras-mutant lung cancer, and kras-mutant colon cancer |
US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
EP3046557A1 (en) | 2013-09-20 | 2016-07-27 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
EP3018131A1 (en) | 2014-11-07 | 2016-05-11 | Bayer Pharma Aktiengesellschaft | Synthesis of copanlisib and its dihydrochloride salt |
US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
CN106518885B (zh) * | 2016-10-26 | 2018-10-16 | 云南大学 | 1,3-二氮杂环并吡啶季铵盐类化合物及其中间体化合物、制备方法和应用 |
EP3752154A4 (en) * | 2018-02-12 | 2021-12-29 | Array Biopharma, Inc. | Methods and combination therapy to treat biliary tract cancer |
WO2019197605A2 (en) | 2018-04-12 | 2019-10-17 | Umc Utrecht Holding B.V. | Drug combinations for use in the treatment of ras-mutant cancer |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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-
2010
- 2010-11-02 AU AU2010317167A patent/AU2010317167B2/en not_active Ceased
- 2010-11-02 KR KR1020127011513A patent/KR101398772B1/ko not_active IP Right Cessation
- 2010-11-02 MX MX2012005293A patent/MX2012005293A/es not_active Application Discontinuation
- 2010-11-02 MY MYPI2012001828A patent/MY156209A/en unknown
- 2010-11-02 CN CN201080050118.5A patent/CN102596951B/zh not_active Expired - Fee Related
- 2010-11-02 CA CA2779935A patent/CA2779935A1/en not_active Abandoned
- 2010-11-02 PE PE2012000608A patent/PE20121471A1/es not_active Application Discontinuation
- 2010-11-02 NZ NZ599565A patent/NZ599565A/xx not_active IP Right Cessation
- 2010-11-02 EA EA201200651A patent/EA201200651A1/ru unknown
- 2010-11-02 JP JP2012537373A patent/JP5466767B2/ja not_active Expired - Fee Related
- 2010-11-02 ES ES10771491.7T patent/ES2487628T3/es active Active
- 2010-11-02 EP EP10771491.7A patent/EP2496575B1/en not_active Not-in-force
- 2010-11-02 BR BR112012010519A patent/BR112012010519A2/pt not_active IP Right Cessation
- 2010-11-02 WO PCT/EP2010/066659 patent/WO2011054828A1/en active Application Filing
- 2010-11-03 US US12/938,583 patent/US8466289B2/en not_active Expired - Fee Related
- 2010-11-03 TW TW099137826A patent/TW201139449A/zh unknown
- 2010-11-03 AR ARP100104067A patent/AR078900A1/es unknown
- 2010-11-04 UY UY0001033000A patent/UY33000A/es not_active Application Discontinuation
-
2012
- 2012-04-03 TN TNP2012000153A patent/TN2012000153A1/en unknown
- 2012-04-05 ZA ZA2012/02530A patent/ZA201202530B/en unknown
- 2012-04-05 IL IL219113A patent/IL219113A0/en unknown
- 2012-04-23 CL CL2012001027A patent/CL2012001027A1/es unknown
- 2012-05-02 MA MA34828A patent/MA33721B1/fr unknown
- 2012-05-03 GT GT201200138A patent/GT201200138A/es unknown
- 2012-05-03 NI NI201200084A patent/NI201200084A/es unknown
- 2012-05-04 CR CR20120234A patent/CR20120234A/es unknown
- 2012-05-04 DO DO2012000127A patent/DOP2012000127A/es unknown
- 2012-05-04 CO CO12073066A patent/CO6541547A2/es not_active Application Discontinuation
- 2012-05-10 EC ECSP12011878 patent/ECSP12011878A/es unknown
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