PE20120666A1 - Inhibidores de los virus flaviviridae - Google Patents
Inhibidores de los virus flaviviridaeInfo
- Publication number
- PE20120666A1 PE20120666A1 PE2012000069A PE2012000069A PE20120666A1 PE 20120666 A1 PE20120666 A1 PE 20120666A1 PE 2012000069 A PE2012000069 A PE 2012000069A PE 2012000069 A PE2012000069 A PE 2012000069A PE 20120666 A1 PE20120666 A1 PE 20120666A1
- Authority
- PE
- Peru
- Prior art keywords
- trans
- carboxyl
- methyl
- thiophene
- cyclohexanocarbonyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE TIOFENO-2-CARBOXILICO DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C12), ALQUENILO(C2-C12), CICLOALQUILO(C3-C12), ENTRE OTROS; R2 ES ALQUINILO(C2-C12), CICLOALQUILO(C3-C12), ARILO(C6-C14), ENTRE OTROS; R3 ES ALQUILENO(C1-C12), ALQUENILENO(C2-C12), ARILENO(C6-C14), ENTRE OTROS; L ES -O-, -S-, -S(O)- O -S(O)2-; HET ES HETEROCICLILO DE 3 A 12 MIEMBROS O HETEROARILO DE 3 A 14 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON Q4, EN DONDE Q4 ES HALOGENO, OXO, NO2, N(=O), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 5-(3,3-DIMETIL-BUT-1-INIL)-3-{(TRANS-4-METIL-CICLOHEXANOCARBONIL)-[TRANS-4-(PIRAZIN-2-ILOXI)-CICLOHEXIL]-AMINO}-TIOFENO-2-CARBOXILICO; ACIDO 5-(3,3-DIMETIL-BUT-1-INIL)-3-{(TRANS-4-METIL-CICLOHEXANOCARBONIL)-[TRANS-4-(6-METIL-PIRIDAZIN-3-ILOXI)-CICLOHEXIL]-AMINO}-TIOFENO-2-CARBOXILICO; ACIDO 5-(3,3-DIMETIL-BUT-1-INIL)-3-{(TRANS-4-METIL-CICLOHEXANOCARBONIL)-[TRANS-4-(PIRIDIN-3-ILOXI)-CICLOHEXIL]-AMINO}-TIOFENO-2-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LOS VIRUS FLAVIVIRIDAE SIENDO UTILES EN EL TRATAMIENTO DE LA INFECCION POR EL VIRUS DE LA HEPATITIS C (HCV)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22736709P | 2009-07-21 | 2009-07-21 | |
US24091109P | 2009-09-09 | 2009-09-09 | |
US35946610P | 2010-06-29 | 2010-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120666A1 true PE20120666A1 (es) | 2012-06-01 |
Family
ID=42711860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000069A PE20120666A1 (es) | 2009-07-21 | 2010-07-19 | Inhibidores de los virus flaviviridae |
Country Status (26)
Country | Link |
---|---|
US (2) | US8569302B2 (es) |
EP (1) | EP2475657B1 (es) |
JP (2) | JP5841531B2 (es) |
KR (1) | KR20120051022A (es) |
CN (1) | CN102471327A (es) |
AP (1) | AP3409A (es) |
AR (1) | AR077765A1 (es) |
AU (1) | AU2010276441B2 (es) |
CA (1) | CA2767088C (es) |
CL (1) | CL2012000147A1 (es) |
CO (1) | CO6491049A2 (es) |
CR (1) | CR20120081A (es) |
DK (1) | DK2475657T3 (es) |
EA (1) | EA020816B1 (es) |
EC (1) | ECSP12011684A (es) |
ES (1) | ES2427342T3 (es) |
HK (1) | HK1166788A1 (es) |
IL (1) | IL217243A (es) |
MX (1) | MX2012000959A (es) |
NZ (1) | NZ597528A (es) |
PE (1) | PE20120666A1 (es) |
SG (1) | SG177709A1 (es) |
TW (1) | TW201116525A (es) |
UY (1) | UY32793A (es) |
WO (1) | WO2011011303A1 (es) |
ZA (1) | ZA201200940B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102471327A (zh) * | 2009-07-21 | 2012-05-23 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
WO2011031669A1 (en) | 2009-09-09 | 2011-03-17 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
PT2480559E (pt) | 2009-09-21 | 2013-10-02 | Gilead Sciences Inc | Processos e intermediários para a preparação de análogos de 1'-ciano-carbanucleósido |
AP2012006413A0 (en) | 2010-01-15 | 2012-08-31 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
PT2523950T (pt) * | 2010-01-15 | 2017-06-01 | Gilead Sciences Inc | Inibidores dos vírus flaviridae |
CA2803248A1 (en) * | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2012010663A1 (en) | 2010-07-22 | 2012-01-26 | Novartis Ag | 2,3,5-trisubstituted thiophene compounds and uses thereof |
UA111163C2 (uk) | 2010-07-22 | 2016-04-11 | Гайлід Сайєнсіз, Інк. | Способи й сполуки для лікування вірусних інфекцій paramyxoviridae |
PT2734515E (pt) * | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
CA2877786C (en) | 2012-06-26 | 2020-08-25 | Bayer Pharma Aktiengesellschaft | N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products |
US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
US8759544B2 (en) * | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
CN102964295B (zh) * | 2012-12-17 | 2014-08-20 | 寿光富康制药有限公司 | 一种2-取代-4-(哌啶基甲基)吡啶的制备方法 |
EP2762124A1 (en) * | 2013-01-31 | 2014-08-06 | IP Gesellschaft für Management mbH | Packaging comprising administration units of polymorphs, amorphous forms or solvates |
US9492438B2 (en) * | 2014-07-25 | 2016-11-15 | Bette Pollard | Amphiphilic pyridinum compounds to treat epilepsy and other disorders of the nervous system |
TWI740546B (zh) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
KR20230130175A (ko) | 2014-12-26 | 2023-09-11 | 에모리 유니버시티 | N4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도 |
EP3785717B1 (en) | 2015-09-16 | 2022-01-05 | Gilead Sciences, Inc. | Methods for treating coronaviridae infections |
CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
PL3464336T3 (pl) | 2016-06-01 | 2022-05-16 | Athira Pharma, Inc. | Związki |
ES2961460T3 (es) | 2017-03-14 | 2024-03-12 | Gilead Sciences Inc | Métodos para tratar las infecciones por coronavirus felinas |
WO2018204198A1 (en) | 2017-05-01 | 2018-11-08 | Gilead Sciences, Inc. | Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
US10675296B2 (en) | 2017-07-11 | 2020-06-09 | Gilead Sciences, Inc. | Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections |
AU2018378832B9 (en) | 2017-12-07 | 2021-05-27 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
US11660307B2 (en) | 2020-01-27 | 2023-05-30 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
WO2021183750A2 (en) | 2020-03-12 | 2021-09-16 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
EP4157272A1 (en) | 2020-05-29 | 2023-04-05 | Gilead Sciences, Inc. | Remdesivir treatment methods |
MX2022016405A (es) | 2020-06-24 | 2023-01-30 | Gilead Sciences Inc | Análogos de nucleósido de 1¿-ciano y usos de estos. |
JP2023540225A (ja) | 2020-08-27 | 2023-09-22 | ギリアード サイエンシーズ, インコーポレイテッド | ウイルス感染症の治療のための化合物及び方法 |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
TW202400185A (zh) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5861421A (en) * | 1995-12-21 | 1999-01-19 | Smithkline Beecham Corporation | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds |
US20020002199A1 (en) * | 1998-03-12 | 2002-01-03 | Lone Jeppesen | Modulators of protein tyrosine phosphatases (ptpases) |
US20050119332A1 (en) * | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
KR100900304B1 (ko) * | 2001-06-11 | 2009-06-02 | 바이로켐 파마 인코포레이티드 | 플라비 바이러스 감염용 항바이러스제로서의 티오펜 유도체 |
CA2449999C (en) | 2001-06-11 | 2012-07-31 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
ES2345438T3 (es) * | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
NZ540799A (en) | 2002-12-10 | 2008-09-26 | Virochem Pharma Inc | Compounds and methods for the treatment or prevention of flavivirus infections |
DE10359791A1 (de) * | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
WO2005081954A2 (en) * | 2004-02-25 | 2005-09-09 | Wyeth | Inhibitors of protein tyrosine phosphatase 1b |
AU2005228899A1 (en) * | 2004-03-30 | 2005-10-13 | Novartis Vaccines And Diagnostics, Inc. | Substituted thiophene derivatives as anti-cancer agents |
DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
AU2007214710A1 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
JP5290186B2 (ja) * | 2006-11-15 | 2013-09-18 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染症の治療または予防用のチオフェン類似体 |
ATE524465T1 (de) * | 2006-11-17 | 2011-09-15 | Glaxosmithkline Llc | 2-carboxy-thiophen-derivate als viruzide |
CA2745119A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
CN102471327A (zh) * | 2009-07-21 | 2012-05-23 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
WO2011031669A1 (en) | 2009-09-09 | 2011-03-17 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
EP2504329A1 (en) | 2009-11-25 | 2012-10-03 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
AP2012006413A0 (en) * | 2010-01-15 | 2012-08-31 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
PT2523950T (pt) * | 2010-01-15 | 2017-06-01 | Gilead Sciences Inc | Inibidores dos vírus flaviridae |
CA2803248A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
-
2010
- 2010-07-19 CN CN2010800328463A patent/CN102471327A/zh active Pending
- 2010-07-19 AP AP2012006085A patent/AP3409A/xx active
- 2010-07-19 AR ARP100102629A patent/AR077765A1/es unknown
- 2010-07-19 NZ NZ597528A patent/NZ597528A/en not_active IP Right Cessation
- 2010-07-19 AU AU2010276441A patent/AU2010276441B2/en not_active Ceased
- 2010-07-19 EP EP10735402.9A patent/EP2475657B1/en active Active
- 2010-07-19 DK DK10735402.9T patent/DK2475657T3/da active
- 2010-07-19 CA CA2767088A patent/CA2767088C/en not_active Expired - Fee Related
- 2010-07-19 TW TW099123657A patent/TW201116525A/zh unknown
- 2010-07-19 US US12/838,684 patent/US8569302B2/en active Active
- 2010-07-19 PE PE2012000069A patent/PE20120666A1/es not_active Application Discontinuation
- 2010-07-19 UY UY0001032793A patent/UY32793A/es not_active Application Discontinuation
- 2010-07-19 WO PCT/US2010/042394 patent/WO2011011303A1/en active Application Filing
- 2010-07-19 MX MX2012000959A patent/MX2012000959A/es active IP Right Grant
- 2010-07-19 EA EA201290053A patent/EA020816B1/ru not_active IP Right Cessation
- 2010-07-19 ES ES10735402T patent/ES2427342T3/es active Active
- 2010-07-19 JP JP2012521700A patent/JP5841531B2/ja not_active Expired - Fee Related
- 2010-07-19 SG SG2012004115A patent/SG177709A1/en unknown
- 2010-07-19 KR KR1020127004379A patent/KR20120051022A/ko not_active Application Discontinuation
-
2011
- 2011-12-28 IL IL217243A patent/IL217243A/en not_active IP Right Cessation
-
2012
- 2012-01-17 CO CO12006267A patent/CO6491049A2/es active IP Right Grant
- 2012-01-19 CL CL2012000147A patent/CL2012000147A1/es unknown
- 2012-02-08 ZA ZA2012/00940A patent/ZA201200940B/en unknown
- 2012-02-16 EC ECSP12011684 patent/ECSP12011684A/es unknown
- 2012-02-16 CR CR20120081A patent/CR20120081A/es unknown
- 2012-07-27 HK HK12107401.4A patent/HK1166788A1/xx unknown
-
2013
- 2013-09-25 US US14/037,296 patent/US20140030223A1/en not_active Abandoned
-
2015
- 2015-08-18 JP JP2015160807A patent/JP2015205940A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20120666A1 (es) | Inhibidores de los virus flaviviridae | |
PE20121479A1 (es) | Inhibidores del virus de la hepatitis c | |
PE20140109A1 (es) | Inhibidores del virus de la hepatitis c | |
PE20130281A1 (es) | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae | |
PE20090630A1 (es) | Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion | |
PE20070124A1 (es) | Derivados de heteroaril para tratar virus | |
CY1113752T1 (el) | Μακροκυκλικες ενωσεις κινοξαλινης ως αναστολεις πρωτεασεις ns3 του hcv | |
NO341663B1 (no) | Cyklopropyl-kondenserte indolobenzaepin HCV NS5B inhibitorer | |
PE20080992A1 (es) | Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c | |
EA201000201A1 (ru) | Азотсодержащие бициклические химические вещества для лечения вирусных инфекций | |
NO20084645L (no) | Cyklopropyl kondenserte indolobenzazepin HCV NS5B inhibitorer | |
AR078976A1 (es) | Inhibidores heterociclicos de la proteina ns5a codificada por el virus de la hepatitis c(vhc), composiciones farmaceuticas que los comprenden y uso de los mismos para tratar infecciones por vhc | |
PE20071326A1 (es) | Inhibidores de la polimerasa viral | |
AR075510A1 (es) | Inhibidores del virus de la hepatitis c | |
PE20120257A1 (es) | Analogos carba-nucleosidicos para tratamiento antiviral | |
EA201100482A1 (ru) | Кристаллические формы 2-тиазолил-4-хинолинилоксипроизводного, активного ингибитора hcv | |
EA201491179A1 (ru) | 2',4'-дифтор-2'-метил замещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с | |
EA201171152A1 (ru) | Ингибиторы вируса гепатита c | |
EA201001273A1 (ru) | Ингибиторы вируса гепатита с | |
CY1111423T1 (el) | Αναστολεις ns5b hcv | |
PE20120995A1 (es) | Analogos de carba-nucleosidos sustituidos con 2'-fluoro para tratamiento antiviral | |
PE20091841A1 (es) | Inhibidores del virus de hepatitis c | |
PA8733401A1 (es) | Compuestos de pirro[1,2-b]piridazinona | |
PE20070814A1 (es) | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) | |
DK2209789T3 (da) | Cyclopropyl-kondenserede indolobenzazepin HCV NS5B-hæmmere |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |