PE20091676A1 - Preparacion selectiva de pirimidinas sustituidas - Google Patents
Preparacion selectiva de pirimidinas sustituidasInfo
- Publication number
- PE20091676A1 PE20091676A1 PE2009000401A PE2009000401A PE20091676A1 PE 20091676 A1 PE20091676 A1 PE 20091676A1 PE 2009000401 A PE2009000401 A PE 2009000401A PE 2009000401 A PE2009000401 A PE 2009000401A PE 20091676 A1 PE20091676 A1 PE 20091676A1
- Authority
- PE
- Peru
- Prior art keywords
- precipitate
- preparation
- group
- sec
- pyrimidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN PROCEDIMIENO DE PREPARACION DEL COMPUESTO III, DONDE X2 ES UN GRUPO SALIENTE; R1 Y R2 SON CADA UNO H, GRUPO AROMATICO, GRUPO ALIFATICO QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA I, DONDE X1 ES UN GRUPO SALIENTE, CON UNA AMINA [HN(R1)R2] EN PRESENCIA DE UNA BASE AUXILIAR NO NUCLEOFILICA TAL COMO N-N-DIISOPROPIL-ETILAMINA EN UN DISOLVENTE O MEZCLA DE DISOLVENTES SELECCIONADOS DE ALCOHOLES NO NUCLEOFILICOS TALES COMO TERC-BUTANOL, NEOPENTANOL, SEC-PENTANOL Y ALCOHOL SEC-ISOAMILICO; B) PRECIPITAR EL COMPUESTO III DE LA MEZCLA DE RECCION; C) SUSPENDER OPCIONALEMTNE EL PRECIPITADO EN AGUA; C) RECOGER EL PRECIPITADO, LAVAR EL PRECIPITADO Y SECAR. DICHA REACCION SE LLEVA A CABO A UNA TEMPERATURA DE RECCION DE APROXIMADAMENTE 40-80 ºC. MEDIANTE DICHO PROCESO SE OBTIENE DERIVADOS DE 2-AMINO-5-TRIFLUOROMETILPIRIMIDINA QUE PUEDE UTILIZARSE PARA LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08153122 | 2008-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091676A1 true PE20091676A1 (es) | 2009-11-12 |
Family
ID=40933625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000401A PE20091676A1 (es) | 2008-03-20 | 2009-03-18 | Preparacion selectiva de pirimidinas sustituidas |
Country Status (9)
Country | Link |
---|---|
US (2) | US8334383B2 (es) |
EP (1) | EP2268622A1 (es) |
JP (2) | JP5330497B2 (es) |
AR (1) | AR071005A1 (es) |
CA (1) | CA2718892A1 (es) |
PE (1) | PE20091676A1 (es) |
TW (1) | TW200944509A (es) |
UY (1) | UY31714A (es) |
WO (1) | WO2009115587A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
JP2011515372A (ja) | 2008-03-20 | 2011-05-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ピリミジン類の位置選択的製造法 |
JP5539518B2 (ja) * | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−アミノ−5−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
US8933227B2 (en) * | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | 5−(トリフルオロメチル)ピリミジン誘導体の製造方法及び新規5−(トリフルオロメチル)ピリミジン誘導体 |
CN108440499A (zh) * | 2018-03-22 | 2018-08-24 | 盐城师范学院 | 一种色瑞替尼及其关键中间体的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6262A (ja) | 1986-03-05 | 1987-01-06 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物の製造方法 |
ES2276344T3 (es) * | 2003-09-05 | 2007-06-16 | Pfizer Products Inc. | Sintesis selectiva de pirimidinas sustituidas con cf3. |
EP1888561A1 (en) * | 2005-05-05 | 2008-02-20 | AstraZeneca AB | Pyrazolyl-amino- substituted pyrimidines and their use in the treatment of cancer |
BRPI0620324A2 (pt) * | 2005-12-21 | 2011-11-08 | Pfizer Prod Inc | derivados de pirimidina, composição farmaceutica e uso dos mesmos |
JP2009533378A (ja) * | 2006-04-10 | 2009-09-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2,4−ジアミノピリミジン誘導体及び癌の治療のためのそれらの使用 |
PE20080068A1 (es) * | 2006-05-15 | 2008-03-17 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
AU2007332654B2 (en) | 2006-12-13 | 2013-06-20 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
NZ580372A (en) * | 2007-04-18 | 2012-01-12 | Pfizer Prod Inc | Pyrimidine and triazine derivatives including a sulfonamide group for the treatment of abnormal cell growth such as cancer |
UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
JP2011515372A (ja) | 2008-03-20 | 2011-05-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ピリミジン類の位置選択的製造法 |
JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−アミノ−5−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
-
2009
- 2009-03-16 UY UY0001031714A patent/UY31714A/es not_active Application Discontinuation
- 2009-03-18 PE PE2009000401A patent/PE20091676A1/es not_active Application Discontinuation
- 2009-03-19 US US12/933,174 patent/US8334383B2/en not_active Expired - Fee Related
- 2009-03-19 EP EP09723550A patent/EP2268622A1/en not_active Withdrawn
- 2009-03-19 TW TW098108958A patent/TW200944509A/zh unknown
- 2009-03-19 CA CA2718892A patent/CA2718892A1/en not_active Abandoned
- 2009-03-19 AR ARP090100998A patent/AR071005A1/es unknown
- 2009-03-19 WO PCT/EP2009/053271 patent/WO2009115587A1/en active Application Filing
- 2009-03-19 JP JP2011500230A patent/JP5330497B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-16 US US13/678,660 patent/US20130079519A1/en not_active Abandoned
-
2013
- 2013-07-25 JP JP2013154342A patent/JP2013237687A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20130079519A1 (en) | 2013-03-28 |
EP2268622A1 (en) | 2011-01-05 |
CA2718892A1 (en) | 2009-09-24 |
JP2013237687A (ja) | 2013-11-28 |
WO2009115587A1 (en) | 2009-09-24 |
TW200944509A (en) | 2009-11-01 |
US8334383B2 (en) | 2012-12-18 |
US20110077403A1 (en) | 2011-03-31 |
UY31714A (es) | 2009-11-10 |
AR071005A1 (es) | 2010-05-19 |
JP5330497B2 (ja) | 2013-10-30 |
JP2011515375A (ja) | 2011-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |