PE20091157A1 - Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - 155 - Google Patents
Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - 155Info
- Publication number
- PE20091157A1 PE20091157A1 PE2008002119A PE2008002119A PE20091157A1 PE 20091157 A1 PE20091157 A1 PE 20091157A1 PE 2008002119 A PE2008002119 A PE 2008002119A PE 2008002119 A PE2008002119 A PE 2008002119A PE 20091157 A1 PE20091157 A1 PE 20091157A1
- Authority
- PE
- Peru
- Prior art keywords
- treatment
- androgen receptor
- triazolo
- conditions associated
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS BICICLICOS DE FORMULA (Ic) DONDE X3 ES CH O N; R4 ES C2F2, CF3 O CClF2; Y ES CH, COH O N; R14 ES H O CH3; n Y p SON CADA UNO 1 O 2; L1 ES UN ENLACE DIRECTO, -S-, -S(O)-, -S(O)2-, ENTRE OTROS; J ES ARILO, UN ANILLO CARBOCICLICO DE 3 A 6 MIEMBROS MONOCICLICO, HETEROCICLICO DE 4 A 7 MIEMBROS, ENTRE OTROS; L3 ES -C(O)-(CH2)q, -O-(CH2)q, (CH2)q, ENTRE OTROS, DONDE q ES DE 0 A 3; R12 ES OH, HALO, AMINO, CN, OXO, ENTRE OTROS; r ES DE 0 A 3. SON COMPUESTOS PREFERIDOS: 4-[[4-[3-(TRIFLUOROMETIL)-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-6-IL]PIPERAZIN-1-IL]METIL]BENZONITRILO, 3-(TRIFLUOROMETIL)-6-[4-[[3-(TRIFLUOROMETIL)FENIL]METIL]PIPERAZIN-1-IL]-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZINA, 4-PIRIDIN-3-IL-1-[3-(TRIFLUOROMETIL)-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-6-IL]PIPERIDIN-4-OL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR DE ANDROGENO (AR) SIENDO UTILES EN EL TRATAMIENTO DEL CANCER DE PROSTATA
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1575507P | 2007-12-21 | 2007-12-21 | |
US9609008P | 2008-09-11 | 2008-09-11 | |
US10780408P | 2008-10-23 | 2008-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091157A1 true PE20091157A1 (es) | 2009-09-03 |
Family
ID=40428336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008002119A PE20091157A1 (es) | 2007-12-21 | 2008-12-18 | Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - 155 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8003649B2 (es) |
EP (1) | EP2235010A1 (es) |
JP (1) | JP2011507824A (es) |
KR (1) | KR20100099742A (es) |
CN (1) | CN101952286A (es) |
AR (1) | AR069911A1 (es) |
AU (1) | AU2008339572B2 (es) |
BR (1) | BRPI0821676A2 (es) |
CA (1) | CA2709514A1 (es) |
CL (1) | CL2008003846A1 (es) |
CO (1) | CO6331441A2 (es) |
CR (1) | CR11524A (es) |
DO (1) | DOP2010000195A (es) |
EA (1) | EA017144B1 (es) |
EC (1) | ECSP10010291A (es) |
IL (1) | IL206284A0 (es) |
NI (1) | NI201000110A (es) |
NZ (1) | NZ586913A (es) |
PE (1) | PE20091157A1 (es) |
TW (1) | TW200927121A (es) |
UY (1) | UY31559A1 (es) |
WO (1) | WO2009081197A1 (es) |
ZA (1) | ZA201004227B (es) |
Families Citing this family (47)
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US7550505B2 (en) * | 2006-07-24 | 2009-06-23 | University Of Delaware | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
US8188083B2 (en) * | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
US8067448B2 (en) | 2008-02-22 | 2011-11-29 | Radius Health, Inc. | Selective androgen receptor modulators |
DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DK2361250T3 (da) | 2008-12-22 | 2013-11-04 | Merck Patent Gmbh | Nye polymorfe former af 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-on-dihydrogenphosphat og fremgangsmåder til fremstilling deraf |
WO2010092371A1 (en) | 2009-02-10 | 2010-08-19 | Astrazeneca Ab | Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer |
CA2759884A1 (en) * | 2009-05-11 | 2010-11-18 | Astrazeneca Ab | [1,2,4] triazolo [4,3-b] pyridazines as ligands of the androgen receptor |
US8450374B2 (en) * | 2009-06-29 | 2013-05-28 | University Of Delaware | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal |
LT3093291T (lt) | 2009-10-23 | 2019-07-10 | Janssen Pharmaceutica Nv | Dipakeistieji oktahidropirolo [3,4-c]pirolai, kaip oreksino receptoriaus moduliatoriai |
JP5847087B2 (ja) | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
JP5848251B2 (ja) | 2009-10-23 | 2016-01-27 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
WO2011082271A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted triazolo-pyrimidine compounds |
JP5964756B2 (ja) | 2010-02-04 | 2016-08-03 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
EP2568806B1 (en) | 2010-05-12 | 2016-05-11 | Radius Health, Inc. | Therapeutic regimens |
AU2011253057B2 (en) | 2010-05-13 | 2014-11-20 | Amgen Inc. | Nitrogen heterocyclic compounds useful as PDE10 inhibitors |
US9006450B2 (en) | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
US9422290B2 (en) * | 2012-11-13 | 2016-08-23 | Boehringer Ingelheim International Gmbh | Triazolopyridazine |
US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
HUP1300139A2 (en) * | 2013-03-06 | 2014-09-29 | Richter Gedeon Nyrt | Phenoxypiperidine h3 antagonists |
US9765075B2 (en) | 2013-05-13 | 2017-09-19 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
PT3009424T (pt) * | 2013-06-10 | 2018-01-16 | Astellas Pharma Inc | Composto amida heterocíclico aromático bicíclico contendo azoto |
NO2719005T3 (es) | 2014-07-28 | 2018-01-20 | ||
EP3034499A1 (en) * | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
EP3034501A1 (en) * | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
WO2016161125A1 (en) * | 2015-03-31 | 2016-10-06 | University Of Vermont And State Agricultural College | Methods for treating cryptosporidiosis using triazolopyridazines |
MA43468B1 (fr) | 2016-03-10 | 2020-08-31 | Janssen Pharmaceutica Nv | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
SG11201810600WA (en) | 2016-06-13 | 2018-12-28 | Gilead Sciences Inc | Fxr (nr1h4) modulating compounds |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
US20170368036A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
CN110461328A (zh) | 2017-03-28 | 2019-11-15 | 吉利德科学公司 | 治疗肝疾病的治疗组合 |
KR20200036913A (ko) * | 2017-08-04 | 2020-04-07 | 브리스톨-마이어스 스큅 컴퍼니 | [1,2,4]트리아졸로[4,3-a]피리디닐 치환된 인돌 화합물 |
GB201716871D0 (en) * | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
GB201806663D0 (en) * | 2018-04-24 | 2018-06-06 | Avexxin As | 2-Oxothiazole compositions for treatment of fibrotic disease |
WO2020123670A1 (en) * | 2018-12-11 | 2020-06-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of the androgen receptor activity and/or expression and uses thereof |
CN109942574B (zh) * | 2019-01-11 | 2022-04-01 | 成都阿奇生物医药科技有限公司 | 天奇替尼及其制备方法和用途 |
CA3124702A1 (en) | 2019-01-15 | 2020-07-23 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
CA3129949C (en) | 2019-02-19 | 2024-04-30 | Gilead Sciences, Inc. | Solid forms of fxr agonists |
JP7434265B2 (ja) * | 2020-12-30 | 2024-02-20 | 財團法人工業技術研究院 | アンドロゲン受容体結合分子およびその使用 |
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CA2345146C (en) | 1998-09-22 | 2010-02-23 | Yamanouchi Pharmaceutical Co., Ltd. | Cyanophenyl derivative |
US6184249B1 (en) | 1998-12-18 | 2001-02-06 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
US6472415B1 (en) | 1998-12-18 | 2002-10-29 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
ATE481969T1 (de) | 2004-10-01 | 2010-10-15 | Merck Sharp & Dohme | Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes |
WO2008109104A1 (en) * | 2007-03-07 | 2008-09-12 | The Regents Of The University Of California | Bivalent inhibitors of akt protein kinase |
-
2008
- 2008-12-18 EA EA201000946A patent/EA017144B1/ru not_active IP Right Cessation
- 2008-12-18 WO PCT/GB2008/051206 patent/WO2009081197A1/en active Application Filing
- 2008-12-18 US US12/338,405 patent/US8003649B2/en not_active Expired - Fee Related
- 2008-12-18 JP JP2010538919A patent/JP2011507824A/ja active Pending
- 2008-12-18 CA CA2709514A patent/CA2709514A1/en not_active Abandoned
- 2008-12-18 AU AU2008339572A patent/AU2008339572B2/en not_active Ceased
- 2008-12-18 EP EP08863828A patent/EP2235010A1/en not_active Withdrawn
- 2008-12-18 KR KR1020107016410A patent/KR20100099742A/ko not_active Application Discontinuation
- 2008-12-18 CN CN200880127073XA patent/CN101952286A/zh active Pending
- 2008-12-18 PE PE2008002119A patent/PE20091157A1/es not_active Application Discontinuation
- 2008-12-18 BR BRPI0821676-2A patent/BRPI0821676A2/pt not_active IP Right Cessation
- 2008-12-18 NZ NZ586913A patent/NZ586913A/en not_active IP Right Cessation
- 2008-12-19 UY UY31559A patent/UY31559A1/es not_active Application Discontinuation
- 2008-12-19 TW TW097149898A patent/TW200927121A/zh unknown
- 2008-12-19 AR ARP080105584A patent/AR069911A1/es not_active Application Discontinuation
- 2008-12-19 CL CL2008003846A patent/CL2008003846A1/es unknown
-
2010
- 2010-06-10 IL IL206284A patent/IL206284A0/en unknown
- 2010-06-14 ZA ZA2010/04227A patent/ZA201004227B/en unknown
- 2010-06-21 DO DO2010000195A patent/DOP2010000195A/es unknown
- 2010-06-21 CO CO10074454A patent/CO6331441A2/es not_active Application Discontinuation
- 2010-06-21 EC EC2010010291A patent/ECSP10010291A/es unknown
- 2010-06-21 NI NI201000110A patent/NI201000110A/es unknown
- 2010-06-21 CR CR11524A patent/CR11524A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200927121A (en) | 2009-07-01 |
ECSP10010291A (es) | 2010-07-30 |
US20100016279A1 (en) | 2010-01-21 |
US8003649B2 (en) | 2011-08-23 |
KR20100099742A (ko) | 2010-09-13 |
NZ586913A (en) | 2012-06-29 |
AU2008339572B2 (en) | 2012-05-10 |
BRPI0821676A2 (pt) | 2015-06-16 |
CN101952286A (zh) | 2011-01-19 |
CO6331441A2 (es) | 2011-10-20 |
CR11524A (es) | 2010-08-05 |
NI201000110A (es) | 2012-05-14 |
CA2709514A1 (en) | 2009-07-02 |
AU2008339572A1 (en) | 2009-07-02 |
DOP2010000195A (es) | 2010-08-31 |
EP2235010A1 (en) | 2010-10-06 |
JP2011507824A (ja) | 2011-03-10 |
WO2009081197A1 (en) | 2009-07-02 |
EA201000946A1 (ru) | 2010-12-30 |
IL206284A0 (en) | 2010-12-30 |
UY31559A1 (es) | 2009-08-03 |
EA017144B1 (ru) | 2012-10-30 |
CL2008003846A1 (es) | 2010-02-05 |
AR069911A1 (es) | 2010-03-03 |
ZA201004227B (en) | 2011-10-26 |
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