PE20091093A1 - Compuesto heterociclico que contiene nitrogeno y su uso - Google Patents

Compuesto heterociclico que contiene nitrogeno y su uso

Info

Publication number
PE20091093A1
PE20091093A1 PE2008002010A PE2008002010A PE20091093A1 PE 20091093 A1 PE20091093 A1 PE 20091093A1 PE 2008002010 A PE2008002010 A PE 2008002010A PE 2008002010 A PE2008002010 A PE 2008002010A PE 20091093 A1 PE20091093 A1 PE 20091093A1
Authority
PE
Peru
Prior art keywords
piperidin
substituted
dichlorophenyl
carbonyl
methylbenzamide
Prior art date
Application number
PE2008002010A
Other languages
English (en)
Inventor
Yoshinori Ikeura
Junya Shirai
Hideyuki Sugiyama
Yuji Nishikimi
Taku Kamei
Nobuki Sakauchi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20091093A1 publication Critical patent/PE20091093A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES HETEROCICLOQUE CONTIENE N SUSTITUIDO O NO; B ES ANILLO AROMATICO SUSTITUIDO O NO; C ES UN GRUPO CICLICO SUSTITUIDO O NO; R1 ES H, ACILO, HETEROCICLO SUSTITUIDO O NO, ENTRE OTROS; R2 ES ALQUILO C1-C6 SUSTITUIDO O NO POR HALOGENO; m Y n SON CADA UNO 0-5 DONDE m+n ES UN NUMERO ENTERO DE 2-5; --- ES UN ENLACE SIMPLE O DOBLE. SON COMPUESTOS PREFERIDOS: N-[(3R,4R)-1-[(1-ACETILPIPERIDIN-4-IL)CARBONIL]-3-(3,4-DICLOROFENIL)PIPERIDIN-4-IL]-N-METIL-3,5-BIS(TRIFLUOROMETIL)BENZAMIDA; 4-CLORO-N-[(3R,4R)-3-(3,4-DICLOROFENIL)-1-{[1-(HIDROXIACETIL)PIPERIDIN-4-IL]CARBONIL}PIPERIDIN-4-IL]-N-METILBENZAMIDA; 4-BROMO-N-[(3R,4R)-3-(3,4-DICLOROFENIL)-1-{[1-(HIDROXIACETIL)PIPERIDIN-4-IL]CARBONIL}PIPERIDIN-4-IL]-N-METILBENZAMIDA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE TAQUININA UTILES EN EL TRATAMIENTO DE VESIVULA SUPER ACTIVA, SINDROME DEL INSTESTINO IRRITABLE, DISPEPSIA FUNCIONAL, ENFERMEDAD INFLAMATORIA INTESTINAL, ENTRE OTROS
PE2008002010A 2007-12-03 2008-12-02 Compuesto heterociclico que contiene nitrogeno y su uso PE20091093A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99673407P 2007-12-03 2007-12-03

Publications (1)

Publication Number Publication Date
PE20091093A1 true PE20091093A1 (es) 2009-08-25

Family

ID=40340719

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002010A PE20091093A1 (es) 2007-12-03 2008-12-02 Compuesto heterociclico que contiene nitrogeno y su uso

Country Status (6)

Country Link
US (1) US8470816B2 (es)
AR (1) AR069526A1 (es)
CL (1) CL2008003595A1 (es)
PE (1) PE20091093A1 (es)
TW (1) TW200930713A (es)
WO (1) WO2009072643A1 (es)

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EP2336105B9 (en) 2008-09-19 2014-09-17 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
US8022099B2 (en) * 2008-11-03 2011-09-20 Hoffmann-La Roche Inc. N-benzyl pyrrolidine derivatives
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
EP2361912A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
PL2552920T3 (pl) 2010-04-02 2017-08-31 Ogeda Sa Nowe wybiórcze związki antagonistów receptora NK-3, farmaceutyczne kompozycje i sposoby do zastosowania w zaburzeniach pośredniczonych przez receptory NK-3
US10065960B2 (en) 2010-04-02 2018-09-04 Ogeda Sa NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
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BR112014007652B1 (pt) * 2011-10-03 2022-05-17 Ogeda S.A N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9359330B2 (en) * 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
WO2016028971A1 (en) * 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Tied-back benzamide derivatives as potent rock inhibitors
EA201790327A1 (ru) * 2014-09-10 2017-10-31 Эпизим, Инк. Соединения замещенного пиперидина
JP6706250B2 (ja) * 2015-04-20 2020-06-03 武田薬品工業株式会社 複素環化合物
WO2018074461A1 (ja) 2016-10-18 2018-04-26 武田薬品工業株式会社 複素環化合物
EP3582779B1 (en) 2017-02-17 2024-04-17 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
WO2018152286A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
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DE60208178T2 (de) 2001-04-11 2006-08-24 Glaxosmithkline S.P.A. Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten
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Also Published As

Publication number Publication date
WO2009072643A1 (en) 2009-06-11
TW200930713A (en) 2009-07-16
US20090156572A1 (en) 2009-06-18
CL2008003595A1 (es) 2009-11-20
AR069526A1 (es) 2010-01-27
US8470816B2 (en) 2013-06-25

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