PE20090801A1 - Derivados de 2,3-benzodiazepina como agentes antipsicoticos - Google Patents
Derivados de 2,3-benzodiazepina como agentes antipsicoticosInfo
- Publication number
- PE20090801A1 PE20090801A1 PE2008000596A PE2008000596A PE20090801A1 PE 20090801 A1 PE20090801 A1 PE 20090801A1 PE 2008000596 A PE2008000596 A PE 2008000596A PE 2008000596 A PE2008000596 A PE 2008000596A PE 20090801 A1 PE20090801 A1 PE 20090801A1
- Authority
- PE
- Peru
- Prior art keywords
- benzodiazepine
- alkyl
- methyl
- dimetoxy
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
REFERIDA A UN DERIVADO DE 2,3-BENZODIAZEPINA DE FORMULA (I), DONDE R1 ES METILO; R2 ES H; R3 ES -C(=X)-N(R11)(R12), -C(=O)-O-R13, ENTRE OTROS; R11 ES H, ALQUILO C1-C4, FENILO, ENTRE OTROS; R12 ES ALQUILO C1-C4, FENILO, ALCOXI C1-C3, ENTRE OTROS; R13 ES ALQUILO C1-C4 O FENILO; R4, R5, R6, R7 Y R8 SON H, HALOGENO, ALQUILO C1-C3, ENTRE OTROS; R9 Y R10 SON ALCOXI C1-C3. SON COMPUESTOS PREFERIDOS: [R]-1-(4-AMINOFENIL)-7,8-DIMETOXI-4-METIL-3-(1,3-TIAZOL-2-IL)-4,5-DIHIDRO-3H-[2,3]BENZODIAZEPINA, [R]-1-(4-N-ACETIL-AMINOFENIL)-7,8-DIMETOXI-4-METIL-3-(1,3-TIAZOL-2-IL)-4,5-DIHIDRO-3H-[2,3]BENZODIAZEPINA, [R]-1-(4-AMINO-3-METILFENIL)-7,8-DIMETOXI-4-METIL-3-(1,2,4-OXADIAZOL-3-IL)-4,5-DIHIDRO-3H-[2,3]BENZODIAZEPINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTIPSICOTICA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92153207P | 2007-04-02 | 2007-04-02 | |
US93663107P | 2007-06-20 | 2007-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090801A1 true PE20090801A1 (es) | 2009-07-29 |
Family
ID=39598447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000596A PE20090801A1 (es) | 2007-04-02 | 2008-04-01 | Derivados de 2,3-benzodiazepina como agentes antipsicoticos |
Country Status (7)
Country | Link |
---|---|
US (1) | US20080269202A1 (es) |
AR (1) | AR065903A1 (es) |
CL (1) | CL2008000949A1 (es) |
IL (1) | IL201126A0 (es) |
PE (1) | PE20090801A1 (es) |
TW (1) | TW200902024A (es) |
WO (1) | WO2008124075A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015001880A (es) * | 2012-08-16 | 2015-05-11 | Bayer Pharma AG | 2,3-benzodiacepinas. |
EP2958909A1 (de) | 2013-02-19 | 2015-12-30 | Bayer Pharma Aktiengesellschaft | Bicyclo- und spirocyclisch substituierte 2,3-benzodiazepine |
CA2915419A1 (en) * | 2013-06-17 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Substituted phenyl-2,3-benzodiazepines |
WO2015121230A1 (de) * | 2014-02-14 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | 9-substituierte 2,3-benzodiazepine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
DK0771198T3 (da) * | 1994-08-31 | 2002-04-22 | Lilly Co Eli | Dihydro-2,3-benzodiazepinderivater |
DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
EP1296960A2 (en) * | 2000-06-16 | 2003-04-02 | Annovis, Inc. | 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors |
US6858605B2 (en) * | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
-
2008
- 2008-03-31 TW TW097111758A patent/TW200902024A/zh unknown
- 2008-04-01 PE PE2008000596A patent/PE20090801A1/es not_active Application Discontinuation
- 2008-04-01 AR ARP080101355A patent/AR065903A1/es unknown
- 2008-04-01 CL CL200800949A patent/CL2008000949A1/es unknown
- 2008-04-02 WO PCT/US2008/004420 patent/WO2008124075A1/en active Application Filing
- 2008-04-02 US US12/080,418 patent/US20080269202A1/en not_active Abandoned
-
2009
- 2009-09-23 IL IL201126A patent/IL201126A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200902024A (en) | 2009-01-16 |
CL2008000949A1 (es) | 2008-10-03 |
AR065903A1 (es) | 2009-07-08 |
US20080269202A1 (en) | 2008-10-30 |
IL201126A0 (en) | 2010-05-17 |
WO2008124075A1 (en) | 2008-10-16 |
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Legal Events
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FA | Abandonment or withdrawal |