PE20060842A1 - Amino-imidazolonas para la inhibicion de b-secretasa - Google Patents
Amino-imidazolonas para la inhibicion de b-secretasaInfo
- Publication number
- PE20060842A1 PE20060842A1 PE2006000052A PE2006000052A PE20060842A1 PE 20060842 A1 PE20060842 A1 PE 20060842A1 PE 2006000052 A PE2006000052 A PE 2006000052A PE 2006000052 A PE2006000052 A PE 2006000052A PE 20060842 A1 PE20060842 A1 PE 20060842A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- secretase
- amino
- pyrimidin
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
REFERIDA A UN COMPUESTO AMINO-IMIDAZOLONA DE FORMULA (I), DONDE R1 Y R2 SON H, ALQUILO C1-C4, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C4, ENTRE OTROS; R5, R6 Y R7 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R8, R9 Y R10 SON H, HALOGENO, NO2, CN, ALQUILO C1-C6, ENTRE OTROS; n ES UN ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: 8-(4-TER-BUTILFENIL)-8-FENIL-2,3,4,8-TETRAHIDROIMIDAZOL[1,5-a]PIRIMIDIN-6-AMINA, 8-(3-BENCILFENIL)-8-FENIL-2,3,4,8-TETRAHIDROIMIDAZOL[1,5-a]PIRIMIDIN-6-AMINA, 8-[3-(4-FLUORFENOXI)FENIL]-8-FENIL-2,3,4,8-TETRAHIDROIMIDAZOL[1,5-a]PIRIMIDIN-6-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA BETA-SECRETASA Y SON UTILES EN EL TRATAMIENTO DE DEPOSITOS BETA-AMILOIDES Y ENREDOS NEUROFIBRILARES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64380505P | 2005-01-14 | 2005-01-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060842A1 true PE20060842A1 (es) | 2006-10-12 |
Family
ID=36581776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000052A PE20060842A1 (es) | 2005-01-14 | 2006-01-10 | Amino-imidazolonas para la inhibicion de b-secretasa |
Country Status (20)
Country | Link |
---|---|
US (2) | US7563796B2 (es) |
EP (2) | EP2264036A1 (es) |
JP (1) | JP2008526966A (es) |
KR (1) | KR20070095948A (es) |
CN (1) | CN101103034A (es) |
AR (1) | AR052458A1 (es) |
AU (1) | AU2006205127A1 (es) |
BR (1) | BRPI0606690A2 (es) |
CA (1) | CA2593515A1 (es) |
CR (1) | CR9244A (es) |
GT (1) | GT200600009A (es) |
IL (1) | IL183938A0 (es) |
MX (1) | MX2007008555A (es) |
NO (1) | NO20073099L (es) |
PA (1) | PA8660001A1 (es) |
PE (1) | PE20060842A1 (es) |
RU (1) | RU2007126570A (es) |
TW (1) | TW200637866A (es) |
WO (1) | WO2006076284A2 (es) |
ZA (1) | ZA200705783B (es) |
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KR20070026811A (ko) | 2004-06-16 | 2007-03-08 | 와이어쓰 | 베타-세크리타제 억제제로서의 디페닐이미다조피리미딘 및디페닐이미다졸 아민 |
EP1756087B1 (en) * | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
KR20070107062A (ko) * | 2005-02-01 | 2007-11-06 | 와이어쓰 | β-세크리타제의 억제제로서의 아미노-피리딘 |
CN101146769A (zh) | 2005-02-14 | 2008-03-19 | 惠氏公司 | 作为β-分泌酶抑制剂的唑基酰基胍 |
ES2436795T3 (es) | 2005-06-14 | 2014-01-07 | Merck Sharp & Dohme Corp. | Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos |
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JP2009509957A (ja) * | 2005-09-26 | 2009-03-12 | ワイス | β−セクレターゼ阻害剤としてのアミノ−5−[4−(ジフルオロメトキシ)フェニル]−5−フェニルイミダゾロン化合物 |
CN103936690B (zh) | 2005-10-25 | 2016-06-08 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
JP2009520027A (ja) * | 2005-12-19 | 2009-05-21 | ワイス | 2−アミノ−5−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
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TW200808796A (en) * | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
TW200815443A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
TW200815449A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
TW200817406A (en) * | 2006-08-17 | 2008-04-16 | Wyeth Corp | Imidazole amines as inhibitors of β-secretase |
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WO2008036196A2 (en) * | 2006-09-21 | 2008-03-27 | Wyeth | Indolylalkylpyridin-2-amines for the inhibition of beta-secretase |
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US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
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2006
- 2006-01-09 WO PCT/US2006/000656 patent/WO2006076284A2/en active Application Filing
- 2006-01-09 MX MX2007008555A patent/MX2007008555A/es unknown
- 2006-01-09 EP EP10173563A patent/EP2264036A1/en not_active Withdrawn
- 2006-01-09 CA CA002593515A patent/CA2593515A1/en not_active Abandoned
- 2006-01-09 AU AU2006205127A patent/AU2006205127A1/en not_active Abandoned
- 2006-01-09 BR BRPI0606690-9A patent/BRPI0606690A2/pt not_active IP Right Cessation
- 2006-01-09 CN CNA2006800021783A patent/CN101103034A/zh active Pending
- 2006-01-09 KR KR1020077016053A patent/KR20070095948A/ko not_active Application Discontinuation
- 2006-01-09 JP JP2007551307A patent/JP2008526966A/ja not_active Withdrawn
- 2006-01-09 RU RU2007126570/04A patent/RU2007126570A/ru unknown
- 2006-01-09 EP EP06717815A patent/EP1836208A2/en not_active Withdrawn
- 2006-01-10 PE PE2006000052A patent/PE20060842A1/es not_active Application Discontinuation
- 2006-01-11 GT GT200600009A patent/GT200600009A/es unknown
- 2006-01-13 AR ARP060100150A patent/AR052458A1/es not_active Application Discontinuation
- 2006-01-13 PA PA20068660001A patent/PA8660001A1/es unknown
- 2006-01-13 US US11/332,732 patent/US7563796B2/en not_active Expired - Fee Related
- 2006-01-13 TW TW095101509A patent/TW200637866A/zh unknown
-
2007
- 2007-06-14 IL IL183938A patent/IL183938A0/en unknown
- 2007-06-18 NO NO20073099A patent/NO20073099L/no not_active Application Discontinuation
- 2007-07-12 CR CR9244A patent/CR9244A/es not_active Application Discontinuation
- 2007-07-13 ZA ZA200705783A patent/ZA200705783B/xx unknown
-
2009
- 2009-06-18 US US12/487,395 patent/US20090253716A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200637866A (en) | 2006-11-01 |
CR9244A (es) | 2007-09-07 |
KR20070095948A (ko) | 2007-10-01 |
JP2008526966A (ja) | 2008-07-24 |
EP2264036A1 (en) | 2010-12-22 |
AU2006205127A1 (en) | 2006-07-20 |
AR052458A1 (es) | 2007-03-21 |
RU2007126570A (ru) | 2009-02-20 |
WO2006076284A3 (en) | 2007-04-19 |
US20060160828A1 (en) | 2006-07-20 |
CN101103034A (zh) | 2008-01-09 |
CA2593515A1 (en) | 2006-07-20 |
WO2006076284A2 (en) | 2006-07-20 |
IL183938A0 (en) | 2007-10-31 |
NO20073099L (no) | 2007-07-31 |
MX2007008555A (es) | 2007-11-21 |
PA8660001A1 (es) | 2006-09-08 |
BRPI0606690A2 (pt) | 2009-07-14 |
ZA200705783B (en) | 2008-09-25 |
US7563796B2 (en) | 2009-07-21 |
US20090253716A1 (en) | 2009-10-08 |
GT200600009A (es) | 2006-08-17 |
EP1836208A2 (en) | 2007-09-26 |
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