AR065903A1 - Derivados nuevos de 2,3- benzodiazepina y su uso como agentes antipsicoticos - Google Patents

Derivados nuevos de 2,3- benzodiazepina y su uso como agentes antipsicoticos

Info

Publication number
AR065903A1
AR065903A1 ARP080101355A ARP080101355A AR065903A1 AR 065903 A1 AR065903 A1 AR 065903A1 AR P080101355 A ARP080101355 A AR P080101355A AR P080101355 A ARP080101355 A AR P080101355A AR 065903 A1 AR065903 A1 AR 065903A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
phenyl
independently
compound
Prior art date
Application number
ARP080101355A
Other languages
English (en)
Inventor
Emese Csuzdi
Katalin Horvath
Sandor Solyom
Pal Berzsenyi
Istvan Sziraki
Zoltan Nagy
Ferenc Andrasi
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of AR065903A1 publication Critical patent/AR065903A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Reivindicacion 1: Un compuesto de la formula (1) caracterizado porque R1 es metilo y R2 es hidrogeno; R3 es a) un anillo heterocíclico de 5 o 6 miembros que es aromático, saturado o parcialmente saturado, dicho anillo heterocíclico contiene 1, 2, o3 heteroátomos seleccionados del grupo formado por O, S, o N, dicho anillo heterocíclico opcionalmente sustituido por un grupo alquilo C1-3, alquenilo C2-3 o un grupo oxo; o b) un compuesto de formula (2) caracterizado porque X es O o S; R11 eshidrogeno, alquilo C1-4 o cicloalquilo o fenilo, y R12 es alquilo C1-4, cicloalquilo, fenilo, o alcoxi C1-3, o R11 y R12 juntos con el átomo de nitrogeno al cual están unidos forman un grupo imidazolio o morfolinilo, o c) un compuesto de formula (3)caracterizado porque R13 es alquilo C1-4 o fenilo; R4, R5, R6, R7 y R8 son cada una independientemente H, halogeno, alquilo C1-3, nitro, NR15R16 caracterizado porque R15 y R16 pueden independientemente ser H, alquilo C1-3, acil C2-5, alcoxicarboniloC2-5, aminocarbonilo, o alquiloaminocarbonilo C1-5; y R9 y R10 son cada uno independientemente alcoxi C1-3; o un estereoisomero o una sal farmacéuticamente aceptable del mismo.
ARP080101355A 2007-04-02 2008-04-01 Derivados nuevos de 2,3- benzodiazepina y su uso como agentes antipsicoticos AR065903A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92153207P 2007-04-02 2007-04-02
US93663107P 2007-06-20 2007-06-20

Publications (1)

Publication Number Publication Date
AR065903A1 true AR065903A1 (es) 2009-07-08

Family

ID=39598447

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101355A AR065903A1 (es) 2007-04-02 2008-04-01 Derivados nuevos de 2,3- benzodiazepina y su uso como agentes antipsicoticos

Country Status (7)

Country Link
US (1) US20080269202A1 (es)
AR (1) AR065903A1 (es)
CL (1) CL2008000949A1 (es)
IL (1) IL201126A0 (es)
PE (1) PE20090801A1 (es)
TW (1) TW200902024A (es)
WO (1) WO2008124075A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015001880A (es) * 2012-08-16 2015-05-11 Bayer Pharma AG 2,3-benzodiacepinas.
EP2958909A1 (de) 2013-02-19 2015-12-30 Bayer Pharma Aktiengesellschaft Bicyclo- und spirocyclisch substituierte 2,3-benzodiazepine
CA2915419A1 (en) * 2013-06-17 2014-12-24 Bayer Pharma Aktiengesellschaft Substituted phenyl-2,3-benzodiazepines
WO2015121230A1 (de) * 2014-02-14 2015-08-20 Bayer Pharma Aktiengesellschaft 9-substituierte 2,3-benzodiazepine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
DK0771198T3 (da) * 1994-08-31 2002-04-22 Lilly Co Eli Dihydro-2,3-benzodiazepinderivater
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
EP1296960A2 (en) * 2000-06-16 2003-04-02 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
TW200902024A (en) 2009-01-16
PE20090801A1 (es) 2009-07-29
CL2008000949A1 (es) 2008-10-03
US20080269202A1 (en) 2008-10-30
IL201126A0 (en) 2010-05-17
WO2008124075A1 (en) 2008-10-16

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