PE20081558A1 - INDAZOLES SUBSTITUTED WITH AMIDE AS POLY INHIBITORS (ADP-RIBOSE) POLYMERASE (PARP) - Google Patents

INDAZOLES SUBSTITUTED WITH AMIDE AS POLY INHIBITORS (ADP-RIBOSE) POLYMERASE (PARP)

Info

Publication number
PE20081558A1
PE20081558A1 PE2008000097A PE2008000097A PE20081558A1 PE 20081558 A1 PE20081558 A1 PE 20081558A1 PE 2008000097 A PE2008000097 A PE 2008000097A PE 2008000097 A PE2008000097 A PE 2008000097A PE 20081558 A1 PE20081558 A1 PE 20081558A1
Authority
PE
Peru
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
PE2008000097A
Other languages
Spanish (es)
Inventor
Philip Jones
Rita Scarpelli
Ontoria Jesus Maria Ontoria
Carsten Schultz-Fademrecht
Original Assignee
Ist P Angeletti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081558(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ist P Angeletti filed Critical Ist P Angeletti
Publication of PE20081558A1 publication Critical patent/PE20081558A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory discuses, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo and/or radiosensitizers for cancer treatment.
PE2008000097A 2007-01-10 2008-01-08 INDAZOLES SUBSTITUTED WITH AMIDE AS POLY INHIBITORS (ADP-RIBOSE) POLYMERASE (PARP) PE20081558A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02

Publications (1)

Publication Number Publication Date
PE20081558A1 true PE20081558A1 (en) 2008-10-30

Family

ID=37809722

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000097A PE20081558A1 (en) 2007-01-10 2008-01-08 INDAZOLES SUBSTITUTED WITH AMIDE AS POLY INHIBITORS (ADP-RIBOSE) POLYMERASE (PARP)

Country Status (21)

Country Link
CN (1) CN101578279B (en)
AT (1) ATE502933T1 (en)
CR (1) CR10910A (en)
DE (1) DE602008005711D1 (en)
DK (2) DK2336120T3 (en)
ES (3) ES2362214T3 (en)
GB (1) GB0700432D0 (en)
HN (1) HN2009001260A (en)
HU (1) HUE044513T2 (en)
LT (1) LT2805945T (en)
LU (1) LUC00072I2 (en)
ME (1) ME03481B (en)
MY (1) MY147789A (en)
NI (1) NI200900135A (en)
NZ (1) NZ578256A (en)
PE (1) PE20081558A1 (en)
PT (3) PT2805945T (en)
SI (2) SI2336120T1 (en)
TW (1) TWI528961B (en)
UA (1) UA97658C2 (en)
ZA (1) ZA200903898B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (en) * 2016-09-14 2017-03-15 陕西科技大学 A kind of synthetic method for preparing PARP inhibitor Niraparib
CN106432188A (en) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 Preparation method of anti-cancer drug 2-[4-((3S)-3-Piperidinyl) phenyl]-2H-Indazole-7-Formamide
CN106432187A (en) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 Chiral resolution method of 2-[4-(-3-piperidyl)phenyl]-2H-indazole-7-formamide
CN106632244A (en) * 2016-09-30 2017-05-10 陕西科技大学 A novel synthetic method for preparing an anticancer medicine Niraparib
CN106467513A (en) * 2016-09-30 2017-03-01 陕西科技大学 A kind of synthetic method preparing Niraparib
CN108201537A (en) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof
KR20190130625A (en) * 2017-03-27 2019-11-22 테사로, 인코포레이티드 Niraprip formulation
CN109081828B (en) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 Poly (ADP-ribose) polymerase inhibitor, preparation method and application
EP3687505A1 (en) 2017-09-26 2020-08-05 Tesaro Inc. Niraparib formulations
CN108084157A (en) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 A kind of synthetic method of Ni Lapani
CN108203404A (en) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (R) synthetic method of -3- Phenylpiperidines or/and the chiral intermediate of (S) -3- Phenylpiperidines and Ni Lapani
CA3169303A1 (en) 2020-02-24 2021-09-02 Xiaokun SHEN Application of poly adp-ribose polymerase inhibitors in corona virus resistance
CN115611860A (en) * 2021-07-13 2023-01-17 上海博璞诺科技发展有限公司 Method for synthesizing nilapanib

Also Published As

Publication number Publication date
DE602008005711D1 (en) 2011-05-05
CR10910A (en) 2010-01-19
GB0700432D0 (en) 2007-02-21
LUC00072I2 (en) 2018-07-04
ATE502933T1 (en) 2011-04-15
PT2109608E (en) 2011-05-30
CN101578279B (en) 2013-07-17
NI200900135A (en) 2010-08-30
TW200836731A (en) 2008-09-16
MY147789A (en) 2013-01-31
ES2362214T3 (en) 2011-06-29
DK2109608T3 (en) 2011-07-11
NZ578256A (en) 2011-12-22
ZA200903898B (en) 2010-04-28
HUE044513T2 (en) 2019-10-28
LT2805945T (en) 2019-06-25
TWI528961B (en) 2016-04-11
CN101578279A (en) 2009-11-11
ES2509115T3 (en) 2014-10-17
SI2109608T1 (en) 2011-07-29
ME03481B (en) 2020-01-20
UA97658C2 (en) 2012-03-12
ES2728199T3 (en) 2019-10-22
PT2805945T (en) 2019-06-06
SI2336120T1 (en) 2014-10-30
PT2336120E (en) 2014-10-01
HN2009001260A (en) 2012-03-26
DK2336120T3 (en) 2014-10-06

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