LT2805945T - Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors - Google Patents

Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors

Info

Publication number
LT2805945T
LT2805945T LTEP14176452.2T LT14176452T LT2805945T LT 2805945 T LT2805945 T LT 2805945T LT 14176452 T LT14176452 T LT 14176452T LT 2805945 T LT2805945 T LT 2805945T
Authority
LT
Lithuania
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
LTEP14176452.2T
Other languages
Lithuanian (lt)
Inventor
Jesus Maria Ontoria Ontoria
Rita Scarpeli
Carsten Schultz-Fademrecht
Philip Jones
Original Assignee
Msd Italia S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2805945(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Italia S.R.L. filed Critical Msd Italia S.R.L.
Publication of LT2805945T publication Critical patent/LT2805945T/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory discuses, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo and/or radiosensitizers for cancer treatment.
LTEP14176452.2T 2007-01-10 2008-01-08 Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors LT2805945T (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02

Publications (1)

Publication Number Publication Date
LT2805945T true LT2805945T (en) 2019-06-25

Family

ID=37809722

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14176452.2T LT2805945T (en) 2007-01-10 2008-01-08 Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors

Country Status (21)

Country Link
CN (1) CN101578279B (en)
AT (1) ATE502933T1 (en)
CR (1) CR10910A (en)
DE (1) DE602008005711D1 (en)
DK (2) DK2109608T3 (en)
ES (3) ES2509115T3 (en)
GB (1) GB0700432D0 (en)
HN (1) HN2009001260A (en)
HU (1) HUE044513T2 (en)
LT (1) LT2805945T (en)
LU (1) LUC00072I2 (en)
ME (1) ME03481B (en)
MY (1) MY147789A (en)
NI (1) NI200900135A (en)
NZ (1) NZ578256A (en)
PE (1) PE20081558A1 (en)
PT (3) PT2805945T (en)
SI (2) SI2336120T1 (en)
TW (1) TWI528961B (en)
UA (1) UA97658C2 (en)
ZA (1) ZA200903898B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (en) * 2016-09-14 2017-03-15 陕西科技大学 A kind of synthetic method for preparing PARP inhibitor Niraparib
CN106432187A (en) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 Chiral resolution method of 2-[4-(-3-piperidyl)phenyl]-2H-indazole-7-formamide
CN106432188A (en) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 Preparation method of anti-cancer drug 2-[4-((3S)-3-Piperidinyl) phenyl]-2H-Indazole-7-Formamide
CN106632244A (en) * 2016-09-30 2017-05-10 陕西科技大学 A novel synthetic method for preparing an anticancer medicine Niraparib
CN106467513A (en) * 2016-09-30 2017-03-01 陕西科技大学 A kind of synthetic method preparing Niraparib
CN108201537A (en) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof
SG11201908977SA (en) * 2017-03-27 2019-10-30 Tesaro Inc Niraparib formulations
CN109081828B (en) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 Poly (ADP-ribose) polymerase inhibitor, preparation method and application
EA202090573A1 (en) 2017-09-26 2020-09-07 Тесаро, Инк. COMPOSITIONS OF NIRAPARIBA
CN108084157A (en) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 A kind of synthetic method of Ni Lapani
CN108203404A (en) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (R) synthetic method of -3- Phenylpiperidines or/and the chiral intermediate of (S) -3- Phenylpiperidines and Ni Lapani
JP2023514794A (en) 2020-02-24 2023-04-10 フーカン（シャンハイ） ヘルス テクノロジー カンパニー、 リミテッド Anticoronavirus application of poly ADP ribose polymerase inhibitors
CN115611860A (en) * 2021-07-13 2023-01-17 上海博璞诺科技发展有限公司 Method for synthesizing nilapanib

Also Published As

Publication number Publication date
PT2109608E (en) 2011-05-30
PT2805945T (en) 2019-06-06
SI2336120T1 (en) 2014-10-30
CN101578279B (en) 2013-07-17
CN101578279A (en) 2009-11-11
HUE044513T2 (en) 2019-10-28
CR10910A (en) 2010-01-19
NI200900135A (en) 2010-08-30
ES2728199T3 (en) 2019-10-22
MY147789A (en) 2013-01-31
LUC00072I2 (en) 2018-07-04
PE20081558A1 (en) 2008-10-30
TW200836731A (en) 2008-09-16
ATE502933T1 (en) 2011-04-15
GB0700432D0 (en) 2007-02-21
HN2009001260A (en) 2012-03-26
NZ578256A (en) 2011-12-22
DE602008005711D1 (en) 2011-05-05
SI2109608T1 (en) 2011-07-29
ZA200903898B (en) 2010-04-28
ES2509115T3 (en) 2014-10-17
TWI528961B (en) 2016-04-11
DK2109608T3 (en) 2011-07-11
DK2336120T3 (en) 2014-10-06
ME03481B (en) 2020-01-20
UA97658C2 (en) 2012-03-12
ES2362214T3 (en) 2011-06-29
PT2336120E (en) 2014-10-01

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