PE20081378A1 - Derivados de 1,2,4-triazol como moduladores de mglur5 - Google Patents

Derivados de 1,2,4-triazol como moduladores de mglur5

Info

Publication number
PE20081378A1
PE20081378A1 PE2007001288A PE2007001288A PE20081378A1 PE 20081378 A1 PE20081378 A1 PE 20081378A1 PE 2007001288 A PE2007001288 A PE 2007001288A PE 2007001288 A PE2007001288 A PE 2007001288A PE 20081378 A1 PE20081378 A1 PE 20081378A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
triazole
modulators
etoxy
Prior art date
Application number
PE2007001288A
Other languages
English (en)
Inventor
Methvin Isaac
Abdelmalik Slassi
Louise Edwards
Peter Dove
Tao Xin
Tomislav Stefanac
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39032082&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081378(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081378A1 publication Critical patent/PE20081378A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE [1,2,4]TRIAZOL DE FORMULA (I), EN DONDE R1 ES METILO, HALOGENO Y CIANO; R2 ES H Y FLUORO; R3 ES H Y ALQUILO(C1-C3); R4 ES H Y ALQUILO(C1-C3); R5 ES ALQUILO(C1-C3) Y CICLOPROPILO; X ES UN GRUPO a), b) O c); Z ES e), f), ENTRE OTROS; R6 ES H, ALQUILO(C1-C3), (C1-C3)HALOALQUILO, ENTRE OTROS; R7 ES H, ALQUILO(C1-C3), ENTRE OTROS. SON SELECCIONADOS: 4-(5-{(1R)-1-[5-(3-CLOROFENIL)ISOXAZOL-3-IL]ETOXI}-4-METIL-4H-1,2,4-TRIAZOL-3-IL)-1-METILPIRIDIN-2(1H)-ONA, 4-(5-{(1R)-1-[5-(3-CLOROFENIL)-1,2,4-OXADIAZOL-3-IL]ETOXI}-4-METIL-4H-1,2,4-TRIAZOL-3-IL)-1-METILPIRIMIDIN-2(1H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE GLUTAMATO METABOTROPICOS (mGluRs), Y PRESENTAN UNA ACCION PREDOMINANTEMENTE PERIFERICA, SIENDO UTILES EN EL TRATAMIENTO DE REFLUJO ESOFAGICO, DOLOR, ANSIEDAD, SINDROME DE COLON IRRITABLE (IBS)
PE2007001288A 2006-10-05 2007-09-25 Derivados de 1,2,4-triazol como moduladores de mglur5 PE20081378A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82832506P 2006-10-05 2006-10-05

Publications (1)

Publication Number Publication Date
PE20081378A1 true PE20081378A1 (es) 2008-11-12

Family

ID=39032082

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001288A PE20081378A1 (es) 2006-10-05 2007-09-25 Derivados de 1,2,4-triazol como moduladores de mglur5

Country Status (21)

Country Link
US (1) US7772235B2 (es)
EP (1) EP2079730A1 (es)
JP (1) JP2010505809A (es)
KR (1) KR20090060328A (es)
CN (1) CN101547916A (es)
AR (1) AR062965A1 (es)
AU (1) AU2007303889B2 (es)
BR (1) BRPI0719155A2 (es)
CA (1) CA2665083A1 (es)
CL (1) CL2007002757A1 (es)
CO (1) CO6220935A2 (es)
IL (1) IL197722A0 (es)
MX (1) MX2009003227A (es)
NO (1) NO20091626L (es)
NZ (1) NZ575657A (es)
PE (1) PE20081378A1 (es)
RU (1) RU2439068C2 (es)
SA (1) SA07280518B1 (es)
TW (1) TW200821305A (es)
UY (1) UY30610A1 (es)
WO (1) WO2008041075A1 (es)

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Publication number Priority date Publication date Assignee Title
WO2009054786A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5
WO2009054785A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole ether derivatives as modulators of mglur5
WO2009054793A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Thiophene 1,2,4-triazole derivatives as modulators of mglur5
WO2009054790A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amide linked heteroaromatic derivatives as modulators of mglur5
WO2009054787A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole carboxylic acid derivatives as modulators of mglur5
KR20100089091A (ko) * 2007-10-26 2010-08-11 아스트라제네카 아베 Ｍｇｌｕｒ5의 조절제로서의 아미노 1,2,4-트리아졸 유도체
KR20110040910A (ko) * 2008-08-12 2011-04-20 아스트라제네카 아베 4-(5-((1ｒ)-1-[5-(3-클로로페닐)이속사졸-3-일]에톡시)-4-메틸-4ｈ-1,2,4-트리아졸-3-일)피리딘의 결정질 형태
KR20110044864A (ko) * 2008-08-12 2011-05-02 아스트라제네카 아베 4-(5-((1ｒ)-1-[5-(3-클로로페닐)이속사졸-3-일]에톡시)-4-메틸-4ｈ-1,2,4-트리아졸-3-일)피리딘의 신규 결정질 형태
CA2747507A1 (en) * 2008-12-18 2010-06-24 Astrazeneca Ab New process for the preparation of 1- [5-(3-chloro-phenyl)-isooxazol-3-yl]-ethanone and (r)-1-[5-(3-chloro-phenyl)-isooxazol-3-yl]-ethanol
US20100273805A1 (en) * 2009-04-23 2010-10-28 Astrazeneca Ab Sulphide bridged derivatives as modulators of mglur5 733
IN2012DN03322A (es) * 2009-09-21 2015-10-23 Univ Vanderbilt
WO2012058128A2 (en) * 2010-10-28 2012-05-03 Merck Sharp & Dohme Corp. Caprolactam mglur5 receptor modulators
JP2013544891A (ja) 2010-12-08 2013-12-19 ヴァンダービルト ユニバーシティー ｍＧＬＵＲ５受容体のアロステリック調節剤としての二環式ピラゾール化合物
AU2011343477A1 (en) * 2010-12-17 2013-07-04 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
US8471027B2 (en) 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
EP2857387A1 (en) 2013-10-07 2015-04-08 Boehringer Ingelheim International Gmbh Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid
WO2018010163A1 (zh) * 2016-07-15 2018-01-18 泸州东方农化有限公司 一种1,2,4-***-3-硫酮化合物的合成方法及其中间体

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UA87653C2 (en) * 2002-08-09 2009-08-10 Астразенека Аб 1,2,4-oxadiazols as modulators of receptor-5 for metabotropic glutamate
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0514296D0 (en) 2005-07-12 2005-08-17 Novartis Ag Organic compounds
AR058807A1 (es) * 2005-09-29 2008-02-27 Astrazeneca Ab 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V

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UY30610A1 (es) 2008-05-02
MX2009003227A (es) 2009-04-06
CL2007002757A1 (es) 2008-06-20
JP2010505809A (ja) 2010-02-25
NO20091626L (no) 2009-05-04
SA07280518B1 (ar) 2011-01-15
CA2665083A1 (en) 2008-04-10
BRPI0719155A2 (pt) 2014-02-04
CO6220935A2 (es) 2010-11-19
AU2007303889A1 (en) 2008-04-10
TW200821305A (en) 2008-05-16
RU2009111113A (ru) 2010-11-10
AU2007303889A2 (en) 2010-07-15
EP2079730A1 (en) 2009-07-22
IL197722A0 (en) 2009-12-24
US7772235B2 (en) 2010-08-10
US20080125436A1 (en) 2008-05-29
KR20090060328A (ko) 2009-06-11
RU2439068C2 (ru) 2012-01-10
CN101547916A (zh) 2009-09-30
AR062965A1 (es) 2008-12-17
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AU2007303889B2 (en) 2011-02-24
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