PE20071313A1 - Derivados de cromano como agentes inhibidores de la bomba de acido - Google Patents
Derivados de cromano como agentes inhibidores de la bomba de acidoInfo
- Publication number
- PE20071313A1 PE20071313A1 PE2007000258A PE2007000258A PE20071313A1 PE 20071313 A1 PE20071313 A1 PE 20071313A1 PE 2007000258 A PE2007000258 A PE 2007000258A PE 2007000258 A PE2007000258 A PE 2007000258A PE 20071313 A1 PE20071313 A1 PE 20071313A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- hydroximethyl
- chromen
- carboxamide
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE CROMANO DE FORMULA (I), DONDE A-B ES -O-CH2- O -CH2-O-; R1 ES OH O UN RESTO QUE SE PUEDE CONVERTIR EN UN GRUPO HIDROXI; R2 ES ALQUILO C1-C6; R3 Y R4 SON ALQUILO C1-C6, CICLOALQUILO C3-C7 OPCIONALMENTE SUSTITUIDOS CON OH, HALOGENO, ALCOXI C1-C6, CICLOALQUILO C3-C7; O R3 Y R4 JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UN GRUPO HETEROCICLO DE 4 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON OH, ALQUILO C1-C6, ALCOXI C1-C6 O HIDROXIALQUILO C1-C6; R5, R6, R7 Y R8 SON H, HALOGENO O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: (S)-(-)-3-(HIDROXIMETIL)-N,N,2-TRIMETIL-8-[(5-METIL-3,4-DIHIDRO-2H-CROMEN-4-IL)AMINO]IMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, (+)-8-(3,4-DIHIDRO-2H-CROMEN-4-ILAMINO)-3-(HIDROXIMETIL)-N,N,2-TRIMETILIMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, (S)-(-)-8-[(5,7-DIFLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL)AMINO]-3-(HIDROXIMETIL)-N,N,2-TRIMETILIMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA BOMBA DE ACIDO Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES, REFLUJO GASTROESOFAGICO, GASTRITIS, ENTRE OTRAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78366306P | 2006-03-17 | 2006-03-17 | |
| US80487206P | 2006-06-15 | 2006-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071313A1 true PE20071313A1 (es) | 2008-01-25 |
Family
ID=38255490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000258A PE20071313A1 (es) | 2006-03-17 | 2007-03-09 | Derivados de cromano como agentes inhibidores de la bomba de acido |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070219237A1 (es) |
| EP (1) | EP1996589A1 (es) |
| JP (1) | JP2009530262A (es) |
| KR (1) | KR20080108129A (es) |
| AR (1) | AR059903A1 (es) |
| BR (1) | BRPI0708808A2 (es) |
| CA (1) | CA2645007A1 (es) |
| GT (1) | GT200700022A (es) |
| MX (1) | MX2008011044A (es) |
| NL (1) | NL2000532C2 (es) |
| PE (1) | PE20071313A1 (es) |
| RU (1) | RU2008137145A (es) |
| TW (1) | TW200804380A (es) |
| UY (1) | UY30205A1 (es) |
| WO (1) | WO2007107827A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32826A (es) | 2009-08-04 | 2011-02-28 | Takeda Pharmaceutical | Compuestos heterocíclicos |
| PL3071206T3 (pl) | 2013-11-22 | 2022-01-17 | CL BioSciences LLC | Antagoniści gastryny (eg yf476, netazepid) do leczenia i zapobiegania osteoporozie |
| KR101769204B1 (ko) * | 2015-08-04 | 2017-08-17 | 씨제이헬스케어 주식회사 | 크로마놀 유도체의 신규한 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191164B1 (en) * | 1996-05-15 | 2001-02-20 | Hoechst Aktiengesellschaft | Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them |
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| IL151018A0 (en) * | 2000-03-17 | 2003-02-12 | Bristol Myers Squibb Pharma Co | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| WO2001087293A1 (fr) * | 2000-05-19 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Inhibiteurs de la ?-secretase |
| US7169931B2 (en) * | 2001-01-26 | 2007-01-30 | Shionogi & Co., Ltd. | Cyclic compounds exhibiting thrombopoietin receptor agonism |
| SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
| CA2506027A1 (en) * | 2002-11-19 | 2004-06-03 | Altana Pharma Ag | 8-substituted imidazopyridines |
| US20090291977A1 (en) * | 2004-12-17 | 2009-11-26 | Madoka Jinno | Chromane Derivatives Useful As Acid Pump Antagonists |
-
2007
- 2007-03-06 JP JP2008558932A patent/JP2009530262A/ja active Pending
- 2007-03-06 BR BRPI0708808-6A patent/BRPI0708808A2/pt not_active IP Right Cessation
- 2007-03-06 EP EP07733953A patent/EP1996589A1/en not_active Withdrawn
- 2007-03-06 WO PCT/IB2007/000599 patent/WO2007107827A1/en active Application Filing
- 2007-03-06 RU RU2008137145/04A patent/RU2008137145A/ru not_active Application Discontinuation
- 2007-03-06 MX MX2008011044A patent/MX2008011044A/es not_active Application Discontinuation
- 2007-03-06 CA CA002645007A patent/CA2645007A1/en not_active Abandoned
- 2007-03-06 KR KR1020087025296A patent/KR20080108129A/ko not_active Application Discontinuation
- 2007-03-09 PE PE2007000258A patent/PE20071313A1/es not_active Application Discontinuation
- 2007-03-12 NL NL2000532A patent/NL2000532C2/nl not_active IP Right Cessation
- 2007-03-14 UY UY30205A patent/UY30205A1/es not_active Application Discontinuation
- 2007-03-14 GT GT200700022A patent/GT200700022A/es unknown
- 2007-03-15 AR ARP070101061A patent/AR059903A1/es unknown
- 2007-03-16 TW TW096109084A patent/TW200804380A/zh unknown
- 2007-03-19 US US11/687,781 patent/US20070219237A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NL2000532C2 (nl) | 2008-02-05 |
| NL2000532A1 (nl) | 2007-09-18 |
| WO2007107827A1 (en) | 2007-09-27 |
| US20070219237A1 (en) | 2007-09-20 |
| RU2008137145A (ru) | 2010-03-27 |
| TW200804380A (en) | 2008-01-16 |
| UY30205A1 (es) | 2007-10-31 |
| BRPI0708808A2 (pt) | 2011-06-14 |
| AR059903A1 (es) | 2008-05-07 |
| CA2645007A1 (en) | 2007-09-27 |
| EP1996589A1 (en) | 2008-12-03 |
| JP2009530262A (ja) | 2009-08-27 |
| KR20080108129A (ko) | 2008-12-11 |
| MX2008011044A (es) | 2008-10-09 |
| GT200700022A (es) | 2008-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |