PE20071176A1 - Derivados diamina como inhibidores de leucotrieno a4 hidrolasa - Google Patents

Derivados diamina como inhibidores de leucotrieno a4 hidrolasa

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Publication number
PE20071176A1
PE20071176A1 PE2006001705A PE2006001705A PE20071176A1 PE 20071176 A1 PE20071176 A1 PE 20071176A1 PE 2006001705 A PE2006001705 A PE 2006001705A PE 2006001705 A PE2006001705 A PE 2006001705A PE 20071176 A1 PE20071176 A1 PE 20071176A1
Authority
PE
Peru
Prior art keywords
alkyl
haloalkyl
hydroxyalkyl
methyl
leucotriene
Prior art date
Application number
PE2006001705A
Other languages
English (en)
Inventor
Damian O Arnaiz
Greg Brown
Emmanuel Claret
Arwed Cleve
David D Davey
William Guilford
Seock-Kyu Khim
Thomas Kirkland
Monica J Kochanny
Amy Liang
David R Light
John Parkinson
David Vogel
Robert Guo Ping Wei
Bin Ye
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38080959&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071176(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20071176A1 publication Critical patent/PE20071176A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R ES DE PREFERENCIA FENILO, HETEROARILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R2 ES H, ALQUILO, HALOALQUILO, HALOALQUENILO, ENTRE OTROS; R3 ES ENLACE DIRECTO, -O-, ALQUILENO LINEAL, ENTRE OTROS; R4 ES UN ENLACE DIRECTO, -O-R-12a, ALQUILENO LINEAL, ENTRE OTROS; R5a, R5b, R5c, R6a, R6b Y R6c SON CADA UNO H, ALQUILO, HALOALQUILO, HIDROXIALQUILO, ENTRE OTROS; R7 ES H, ALQUILO, HALOALQUILO, CICLOLAQUILO SUSTITUIDO O NO, ENTRE OTROS; R8 ES H, ALQUILO, HIDROXIALQUILO, HALOALQUILO, ENTRE OTROS; R9 ES ALQUILO, HIDROXIALQUILO, HALO, ENTRE OTROS; R12a ES UNA CADENA ALQUILENO, LINEAL O RAMIFICADA, ENTRE OTROS; r ES 0-4; q ES 0-2. SON COMPUESTOS PREFERIDOS: ACIDO 4-[[(1S,4S)-5-[2-[4-(FENILMETIL)FENOXI]ETIL]-2,5-DIAZABICICLO[2.2.1]HEPT-2-IL]METIL]BENZOICO; 4-[[(1S,4S)-5-[[4-(4-FLUOROFENOXI]FENIL]METIL]-2,5-DIAZABICICLO[2.2.1]HEPT-2-IL]METIL]BENZOICO; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LTA4-h UTILES EN EL TRATAMIENTO DE INFLAMACION AGUDA O CRONICA, REACCIONES ALERGICAS, PSORIASIS, ENTRE OTROS
PE2006001705A 2005-12-29 2006-12-27 Derivados diamina como inhibidores de leucotrieno a4 hidrolasa PE20071176A1 (es)

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