PE20071143A1 - Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 - Google Patents

Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6

Info

Publication number
PE20071143A1
PE20071143A1 PE2006001716A PE2006001716A PE20071143A1 PE 20071143 A1 PE20071143 A1 PE 20071143A1 PE 2006001716 A PE2006001716 A PE 2006001716A PE 2006001716 A PE2006001716 A PE 2006001716A PE 20071143 A1 PE20071143 A1 PE 20071143A1
Authority
PE
Peru
Prior art keywords
hydroxitriptamine
antagonist
pharmaceutical composition
composition including
acetylcholinesterase inhibitor
Prior art date
Application number
PE2006001716A
Other languages
English (en)
Inventor
Thomas Anthony Comery
Lee Erwin Schechter
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071143A1 publication Critical patent/PE20071143A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A)UN INHIBIDOR DE ACETILCOLINESTERASA SELECCIONADO DE DONEPEZIL, GALANTAMINA Y RIVASTIGMINA; Y B) UN ANTAGONISTA 5-HIDROXITRIPTAMINA-6 DE FORMULA (I), EN DONDE R1 ES -W(CR5R6)nNR7R8, a), ENTRE OTROS, DONDE W ES O, S, NR, ENTRE OTROS; R2 ES H, HALOGENO, CN, OR12, CO2R17, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R4 ES ARILO, HETEROARILO O UN ANILLO BI O TRICICLICO DE 8 A 13 MIEMBROS, SIENDO SELECCIONADOS: 3-(1-NAFTILSULFONIL)-5-PIPERAZIN-1-IL-1H-INDAZOL, 1,1-DIMETIL-3-{[3-(1-NAFTILSULFONIL)-1H-INDAZOL-5-IL]OXI}PROPAN-1-AMINA, ENTRE OTROS. DICHA COMPOSICION PUEDE ADMINISTRARSE EN FORMA SIMULTANEA, SEPARADA O SECUENCIAL, SIENDO UTIL EN EL TRATAMIENTO DE TRASTORNO COGNOCITIVO, TAL COMO LA ENFERMEDAD DE ALZHEIMER
PE2006001716A 2006-01-13 2006-12-28 Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 PE20071143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75884106P 2006-01-13 2006-01-13

Publications (1)

Publication Number Publication Date
PE20071143A1 true PE20071143A1 (es) 2008-01-20

Family

ID=38109582

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001716A PE20071143A1 (es) 2006-01-13 2006-12-28 Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6

Country Status (20)

Country Link
US (1) US20070167431A1 (es)
EP (1) EP1971334A2 (es)
JP (1) JP2009523728A (es)
KR (1) KR20080096657A (es)
CN (1) CN101370499A (es)
AR (1) AR060019A1 (es)
AU (1) AU2007208516A1 (es)
BR (1) BRPI0706515A2 (es)
CA (1) CA2635920A1 (es)
CR (1) CR10139A (es)
EC (1) ECSP088619A (es)
GT (1) GT200800138A (es)
IL (1) IL192694A0 (es)
MX (1) MX2008009021A (es)
NO (1) NO20082894L (es)
PE (1) PE20071143A1 (es)
RU (1) RU2008126245A (es)
TW (1) TW200733976A (es)
WO (1) WO2007087151A2 (es)
ZA (1) ZA200806070B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200523253A (en) 2003-07-22 2005-07-16 Arena Pharm Inc Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
US20100120747A1 (en) * 2006-06-23 2010-05-13 Laboratorios Del Dr. Esteve, S.A. Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity
AR061637A1 (es) * 2006-06-26 2008-09-10 Epix Delaware Inc Composiciones y metodos de tratamiento de trastornos del snc
WO2009074607A1 (en) * 2007-12-12 2009-06-18 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
RU2467749C1 (ru) * 2011-04-21 2012-11-27 Государственное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции уровня сахара крови и лечения пациентов с сахарным диабетом второго типа с когнитивными нарушениями
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
CA2965741C (en) 2014-11-03 2022-05-17 Iomet Pharma Ltd Pharmaceutical compound
CN107847499A (zh) * 2015-05-07 2018-03-27 阿速万科学有限责任公司 治疗神经退行性疾病的方法
MX2017016413A (es) 2015-06-12 2018-08-01 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem.
CA2992518A1 (en) 2015-07-15 2017-01-19 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
WO2017147601A1 (en) * 2016-02-25 2017-08-31 Axovant Sciences Gmbh Methods of improving balance, gait or both in patients with neurological disease
BR112017026928B1 (pt) * 2016-04-26 2023-04-11 H. Lundbeck A/S Uso de idalopirdina em combinação com um inibidor de acetilcolinesterase
US10864191B2 (en) * 2016-05-11 2020-12-15 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity
PT3484467T (pt) * 2016-05-18 2020-06-16 Suven Life Sciences Ltd Combinação de antagonistas puros do recetor 5-ht6 com inibidores de acetilcolinesterase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2426031C (en) * 2000-11-02 2011-10-04 Wyeth 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
JP2006510662A (ja) * 2002-12-11 2006-03-30 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー α７ニコチン性アセチルコリン受容体アゴニストとその他の化合物との組合せによる疾患の治療
WO2004074243A2 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
NZ565872A (en) * 2005-08-15 2011-06-30 Wyeth Corp Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
CN101370499A (zh) 2009-02-18
AR060019A1 (es) 2008-05-21
CR10139A (es) 2008-09-30
WO2007087151A2 (en) 2007-08-02
US20070167431A1 (en) 2007-07-19
MX2008009021A (es) 2008-09-24
AU2007208516A1 (en) 2007-08-02
ZA200806070B (en) 2009-04-29
KR20080096657A (ko) 2008-10-31
IL192694A0 (en) 2009-02-11
ECSP088619A (es) 2008-08-29
JP2009523728A (ja) 2009-06-25
EP1971334A2 (en) 2008-09-24
CA2635920A1 (en) 2007-08-02
TW200733976A (en) 2007-09-16
RU2008126245A (ru) 2010-02-20
NO20082894L (no) 2008-09-30
AU2007208516A8 (en) 2008-08-07
GT200800138A (es) 2008-10-06
WO2007087151A3 (en) 2007-11-15
BRPI0706515A2 (pt) 2011-03-29

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