PE20070614A1 - Derivados biciclicos como antagonistas de nk1/nk3 en el tratamiento de la esquizofrenia - Google Patents

Derivados biciclicos como antagonistas de nk1/nk3 en el tratamiento de la esquizofrenia

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Publication number
PE20070614A1
PE20070614A1 PE2006001077A PE2006001077A PE20070614A1 PE 20070614 A1 PE20070614 A1 PE 20070614A1 PE 2006001077 A PE2006001077 A PE 2006001077A PE 2006001077 A PE2006001077 A PE 2006001077A PE 20070614 A1 PE20070614 A1 PE 20070614A1
Authority
PE
Peru
Prior art keywords
treatment
alcoxy
halogen
schizophrenia
antagonists
Prior art date
Application number
PE2006001077A
Other languages
English (en)
Inventor
Giuseppe Alvaro
Sandro Belvedere
Alessandro Falchi
Daniele Andreotti
Riccardo Giovannini
Fabio Romano Di
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0518472A external-priority patent/GB0518472D0/en
Priority claimed from GB0611153A external-priority patent/GB0611153D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20070614A1 publication Critical patent/PE20070614A1/es

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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE X ES N; Y ES -(CH2)-, (-C(H)2-)2, -S(O2)-, -C(=O); Z ES -C(H2)-, -S(O2)-, O, S, ENTRE OTROS; A ES H, -CH2OH; R1 ES HALOGENO, ALCOXI C1-C6, =O, HIDROXILO, ENTRE OTROS; m ES 0-3; R2 ES HALOGENO, =O, ALCOXI C1-C6, HALOALCOXI C1-C6; n ES 0-3; p Y q SON CADA UNO 0-2; R3 ES -ARILO, -HETEROARILO, HETEROCICLIARILO, ENTRE OTROS; R4 Y R5 SON CADA UNO ALQUILO C1-C6, CICLOALQUILO C3-C8; R6 ES HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; s ES 0-4. SON COMPUESTOS PREFERIDOS: 2-[3,5-BIS(TRIFLUOROMETIL)FENIL]-N-{4-(4-FLUORO-2-METILFENIL)-6-[(7S,9aS)-7-(HIDROXIMETIL)HEXAHIDROPIRAZINO[2,1-c][1,4]OXAZIN-8(1H)-IL]-3-PIRIDINIL}-N,2-DIMETILPROPANAMIDA; 2-[3,5-BIS(TRIFLUOROMETIL)FENIL]-N-{4-(4-FLUORO-2-METILFENIL)-6-[(7S,9aS)-7-(HIDROXIMETIL)HEXAHIDROPIRAZINO[2,1-c][1,4]OXAZIN-8(1H)-IL]-3-PIRIDINIL}-N,2-DIMETILPROPANAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS PSICOTICOS, EN PARTICULAR ESQUIZOFRENIA
PE2006001077A 2005-09-09 2006-09-07 Derivados biciclicos como antagonistas de nk1/nk3 en el tratamiento de la esquizofrenia PE20070614A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0518472A GB0518472D0 (en) 2005-09-09 2005-09-09 Novel compounds
GB0611153A GB0611153D0 (en) 2006-06-06 2006-06-06 Novel compounds

Publications (1)

Publication Number Publication Date
PE20070614A1 true PE20070614A1 (es) 2007-08-02

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US (3) US7683056B2 (es)
EP (2) EP2336136A1 (es)
JP (1) JP5121716B2 (es)
KR (1) KR101292348B1 (es)
AR (1) AR058805A1 (es)
AT (1) ATE505472T1 (es)
AU (1) AU2006289281B2 (es)
BR (1) BRPI0615787B8 (es)
CA (1) CA2621564C (es)
CR (1) CR9847A (es)
CY (1) CY1111907T1 (es)
DE (1) DE602006021323D1 (es)
DK (1) DK1928886T3 (es)
EA (1) EA013909B1 (es)
HR (1) HRP20110457T1 (es)
IL (1) IL189578A (es)
JO (1) JO2722B1 (es)
MA (1) MA29780B1 (es)
MY (1) MY145713A (es)
NO (1) NO340921B1 (es)
NZ (1) NZ565983A (es)
PE (1) PE20070614A1 (es)
PL (1) PL1928886T3 (es)
PT (1) PT1928886E (es)
SI (1) SI1928886T1 (es)
TW (1) TWI378101B (es)
WO (1) WO2007028654A1 (es)

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AU2006289281A1 (en) 2007-03-15
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