PE20061078A1 - Derivados de piridotienopirimidina como inhibidores de la fosfodiesterasa 4 (pde4) - Google Patents
Derivados de piridotienopirimidina como inhibidores de la fosfodiesterasa 4 (pde4)Info
- Publication number
- PE20061078A1 PE20061078A1 PE2005001379A PE2005001379A PE20061078A1 PE 20061078 A1 PE20061078 A1 PE 20061078A1 PE 2005001379 A PE2005001379 A PE 2005001379A PE 2005001379 A PE2005001379 A PE 2005001379A PE 20061078 A1 PE20061078 A1 PE 20061078A1
- Authority
- PE
- Peru
- Prior art keywords
- morpholin
- pde4
- phosphodiesterase
- inhibitors
- isoquinolin
- Prior art date
Links
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title abstract 4
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title abstract 4
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- GUSYANXQYUJOBH-UHFFFAOYSA-N isoquinolin-8-amine Chemical compound C1=NC=C2C(N)=CC=CC2=C1 GUSYANXQYUJOBH-UHFFFAOYSA-N 0.000 abstract 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE G1 ES CR6R7 O NR6 DONDE R6 Y R7 SON H O ALQUILO(C1-C4); m Y n SON 0 o 1; R1 Y R2 SON H O ALQUILO(C1-C4); R3 ES ARILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS; R4 Y R5 SON H, ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(2-MORFOLIN-4-ILETIL)-1,2,3,4-TETRAHIDROPIRIMIDO[4',5':4,5]TIENO[2,3-c]ISOQUINOLIN-8-AMINA, 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(PIRIDIN-4-ILMETIL)-1,2,3,4-TETRAHIDROPIRIMIDO[4',5':4,5]TIENO[2,3-c]ISOQUINOLIN-8-AMINA, 2,2-DIMETIL-5-MORFOLIN-4-IL-N-(PIRIDIN-3-ILMETIL)-1,2,3,4-TETRAHIDROPIRIMIDO[4',5':4,5]TIENO[2,3-c]ISOQUINOLIN-8-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 4 (PDE4) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ARTRITIS REUMATOIDE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200402876A ES2259891B1 (es) | 2004-11-30 | 2004-11-30 | Nuevos derivados de piridotienopirimidina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061078A1 true PE20061078A1 (es) | 2006-11-10 |
Family
ID=35064879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001379A PE20061078A1 (es) | 2004-11-30 | 2005-11-28 | Derivados de piridotienopirimidina como inhibidores de la fosfodiesterasa 4 (pde4) |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20090029955A1 (es) |
| EP (1) | EP1819710B1 (es) |
| JP (1) | JP2008521855A (es) |
| KR (1) | KR20070086869A (es) |
| CN (1) | CN101068816A (es) |
| AR (1) | AR051686A1 (es) |
| AT (1) | ATE425167T1 (es) |
| AU (1) | AU2005311423A1 (es) |
| BR (1) | BRPI0518094A (es) |
| CA (1) | CA2588741A1 (es) |
| DE (1) | DE602005013278D1 (es) |
| ES (2) | ES2259891B1 (es) |
| HK (1) | HK1101638A1 (es) |
| IL (1) | IL183142A0 (es) |
| MX (1) | MX2007006173A (es) |
| NO (1) | NO20073283L (es) |
| PE (1) | PE20061078A1 (es) |
| RU (1) | RU2007124326A (es) |
| TW (1) | TW200635932A (es) |
| UY (1) | UY29239A1 (es) |
| WO (1) | WO2006058724A1 (es) |
| ZA (1) | ZA200703827B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| ES2281251B1 (es) * | 2005-07-27 | 2008-08-16 | Laboratorios Almirall S.A. | Nuevos derivados de pirido (3',2':4,5) furo (3,2-d) pirimidina. |
| MX2008004024A (es) * | 2005-09-23 | 2009-02-27 | Schering Corp | Antagonistas de receptor de glutamato metabotropico-1 tetraciclicos fusionados como agentes terapeuticos. |
| DK2558473T3 (da) * | 2010-04-14 | 2016-12-19 | Bayer Ip Gmbh | Fremgangsmåde til fremstilling af dithiin-tetracarboximider |
| BR112018003417B1 (pt) | 2016-06-22 | 2023-10-24 | Vanderbilt University | Composto modulador alostérico positivo do receptor muscarínico de acetilcolina m4 e composição farmacêutica que o compreende |
| MA46899A (fr) | 2016-11-07 | 2021-04-14 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 |
| MA46722A (fr) | 2016-11-07 | 2019-09-11 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4 |
| JP7099725B2 (ja) | 2016-11-07 | 2022-07-12 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| US11376254B2 (en) | 2017-12-05 | 2022-07-05 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| EP4058027A4 (en) * | 2019-11-13 | 2023-11-01 | Metabomed Ltd | GLUCOSE UPtake INHIBITORS AND THEIR USES |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| KR20010105399A (ko) * | 1999-03-30 | 2001-11-28 | 쓰끼하시 다미까따 | 티에노피리미딘 화합물 및 그의 염, 및 그들의 제조 방법 |
-
2004
- 2004-11-30 ES ES200402876A patent/ES2259891B1/es not_active Expired - Fee Related
-
2005
- 2005-11-28 AR ARP050104956A patent/AR051686A1/es unknown
- 2005-11-28 PE PE2005001379A patent/PE20061078A1/es not_active Application Discontinuation
- 2005-11-29 UY UY29239A patent/UY29239A1/es unknown
- 2005-11-30 BR BRPI0518094-5A patent/BRPI0518094A/pt not_active IP Right Cessation
- 2005-11-30 KR KR1020077015102A patent/KR20070086869A/ko not_active Application Discontinuation
- 2005-11-30 JP JP2007543767A patent/JP2008521855A/ja active Pending
- 2005-11-30 AT AT05814833T patent/ATE425167T1/de not_active IP Right Cessation
- 2005-11-30 EP EP05814833A patent/EP1819710B1/en active Active
- 2005-11-30 CN CNA200580040992XA patent/CN101068816A/zh active Pending
- 2005-11-30 WO PCT/EP2005/012774 patent/WO2006058724A1/en active Application Filing
- 2005-11-30 US US11/791,450 patent/US20090029955A1/en not_active Abandoned
- 2005-11-30 DE DE602005013278T patent/DE602005013278D1/de not_active Expired - Fee Related
- 2005-11-30 TW TW094142175A patent/TW200635932A/zh unknown
- 2005-11-30 RU RU2007124326/04A patent/RU2007124326A/ru not_active Application Discontinuation
- 2005-11-30 AU AU2005311423A patent/AU2005311423A1/en not_active Abandoned
- 2005-11-30 MX MX2007006173A patent/MX2007006173A/es not_active Application Discontinuation
- 2005-11-30 ES ES05814833T patent/ES2321966T3/es active Active
- 2005-11-30 CA CA002588741A patent/CA2588741A1/en not_active Abandoned
-
2007
- 2007-05-10 IL IL183142A patent/IL183142A0/en unknown
- 2007-05-11 ZA ZA200703827A patent/ZA200703827B/xx unknown
- 2007-06-27 NO NO20073283A patent/NO20073283L/no not_active Application Discontinuation
- 2007-08-28 HK HK07109343.8A patent/HK1101638A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1819710B1 (en) | 2009-03-11 |
| IL183142A0 (en) | 2007-09-20 |
| AU2005311423A1 (en) | 2006-06-08 |
| MX2007006173A (es) | 2007-07-09 |
| UY29239A1 (es) | 2006-02-24 |
| RU2007124326A (ru) | 2009-01-10 |
| ZA200703827B (en) | 2008-08-27 |
| ATE425167T1 (de) | 2009-03-15 |
| EP1819710A1 (en) | 2007-08-22 |
| ES2321966T3 (es) | 2009-06-15 |
| AR051686A1 (es) | 2007-01-31 |
| ES2259891A1 (es) | 2006-10-16 |
| CA2588741A1 (en) | 2006-06-08 |
| HK1101638A1 (en) | 2007-10-18 |
| TW200635932A (en) | 2006-10-16 |
| JP2008521855A (ja) | 2008-06-26 |
| BRPI0518094A (pt) | 2008-10-28 |
| DE602005013278D1 (de) | 2009-04-23 |
| WO2006058724A1 (en) | 2006-06-08 |
| NO20073283L (no) | 2007-06-27 |
| CN101068816A (zh) | 2007-11-07 |
| US20090029955A1 (en) | 2009-01-29 |
| KR20070086869A (ko) | 2007-08-27 |
| ES2259891B1 (es) | 2007-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |