PE20040165A1 - Uso de analogos del benzimidazol en el tratamiento de la proliferacion celular - Google Patents
Uso de analogos del benzimidazol en el tratamiento de la proliferacion celularInfo
- Publication number
- PE20040165A1 PE20040165A1 PE2003000304A PE2003000304A PE20040165A1 PE 20040165 A1 PE20040165 A1 PE 20040165A1 PE 2003000304 A PE2003000304 A PE 2003000304A PE 2003000304 A PE2003000304 A PE 2003000304A PE 20040165 A1 PE20040165 A1 PE 20040165A1
- Authority
- PE
- Peru
- Prior art keywords
- treatment
- cellular proliferation
- hydrogen
- benzimidazole analogs
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN METODO PARA EL TRATAMIENTO DEL CANCER QUE COMPRENDE LA ADMINISTRACION DE UN COMPUESTO DE FORMULA I, ENTRE OTROS DONDE X E Y PUEDEN SER DIFERENTES O IGUALES Y SON HIDROGENO, ALQUILO, ALCOXI, ARILO, HIDROXI, ENTRE OTROS; n ES 1 A 3; m ES 1 A 4; R ES HIDROGENO, METILO, ETILO, PROPILO, ENTRE OTROS; R1 Y R2 ES HIDROGENO, ALQUILO, ALQUILO SUSTITUIDO, ALQUENILO, CICLOALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES EL COMPUESTO DE FORMULA S-4, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36768602P | 2002-03-25 | 2002-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040165A1 true PE20040165A1 (es) | 2004-06-11 |
Family
ID=28675384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000304A PE20040165A1 (es) | 2002-03-25 | 2003-03-25 | Uso de analogos del benzimidazol en el tratamiento de la proliferacion celular |
Country Status (9)
Country | Link |
---|---|
US (1) | US20050197375A1 (es) |
EP (1) | EP1494668A4 (es) |
JP (1) | JP2005525389A (es) |
AU (1) | AU2003213768A1 (es) |
CA (1) | CA2479453A1 (es) |
PE (1) | PE20040165A1 (es) |
TW (1) | TW200304820A (es) |
UY (1) | UY27732A1 (es) |
WO (1) | WO2003082186A2 (es) |
Families Citing this family (64)
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US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
PT1368028E (pt) * | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
DE60322869D1 (de) * | 2002-04-22 | 2008-09-25 | Univ Johns Hopkins | Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen |
WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
JP2007501618A (ja) * | 2003-08-08 | 2007-02-01 | アバニール・ファーマシューティカルズ | タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法 |
WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
EP1807074B1 (en) | 2004-11-03 | 2013-10-23 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
WO2006094236A1 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
WO2006124780A2 (en) * | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
WO2007019345A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine derivatives as sirtuin modulating agents |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
ATE533485T1 (de) † | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
KR20150041174A (ko) | 2005-11-08 | 2015-04-15 | 버텍스 파마슈티칼스 인코포레이티드 | Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 |
CN101395147B (zh) * | 2005-12-28 | 2013-05-29 | 弗特克斯药品有限公司 | 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物 |
AU2012244242B2 (en) * | 2005-12-28 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis |
US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
PE20080888A1 (es) * | 2006-10-18 | 2008-08-26 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1) |
EP2121626A1 (en) * | 2006-12-15 | 2009-11-25 | Pfizer Products Inc. | Benzimidazole derivatives |
AU2008251504B2 (en) | 2007-05-09 | 2013-07-18 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
MY148636A (en) | 2007-06-29 | 2013-05-15 | Pfizer | Benzimidazole derivatives |
MX2010004965A (es) * | 2007-11-01 | 2010-05-20 | Sirtris Pharmaceuticals Inc | Derivados de amida como moduladores de la sirtuina. |
CA2705138A1 (en) * | 2007-11-08 | 2009-05-14 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
EP3170818B1 (en) | 2007-12-07 | 2020-02-19 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
DK2639224T3 (en) | 2007-12-07 | 2016-10-17 | Vertex Pharma | A process for the preparation of cycloalkylcarboxiamido-pyridinbenzoesyrer |
WO2009108657A2 (en) | 2008-02-28 | 2009-09-03 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as cftr modulators |
WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
PE20120057A1 (es) | 2008-12-19 | 2012-02-24 | Sirtris Pharmaceuticals Inc | Compuestos de tiazolopiridina moduladores de sirtuina |
JP2012513409A (ja) * | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
MX2011006333A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
EP2419404B1 (en) * | 2009-04-15 | 2015-11-04 | AbbVie Inc. | Anti-viral compounds |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
CN103819459B (zh) | 2009-06-11 | 2017-05-17 | 艾伯维巴哈马有限公司 | 抗病毒化合物 |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
HUE056525T2 (hu) | 2010-04-07 | 2022-02-28 | Vertex Pharma | 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)ciklopropánkarboxamido)-3-metilpiridin-2-il)benzoesav gyógyszerészeti készítményei és azok adagolása |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
CN103702984B (zh) * | 2011-08-08 | 2016-05-11 | 默克专利股份公司 | 作为溶血磷脂酸拮抗剂的n-(苯并咪唑-2-基)-环丙烷甲酰胺类 |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
WO2014082085A1 (en) * | 2012-11-26 | 2014-05-30 | The University Of North Carolina At Chapel Hill | Use of itk inhibitors for the treatment of cancer |
GB201302927D0 (en) * | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US10231932B2 (en) | 2013-11-12 | 2019-03-19 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
US10494376B2 (en) | 2014-09-03 | 2019-12-03 | Ctxt Pty. Ltd. | Tetrahydroisoquinoline derived PRMT5-inhibitors |
EP3189048B1 (en) | 2014-09-03 | 2021-03-17 | Ctxt Pty Ltd | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors |
DK3221692T3 (da) | 2014-11-18 | 2021-08-23 | Vertex Pharma | Fremgangsmåde til udførsel af tests med høj kapacitet ved hjælp af højtryksvæskekromatografi |
WO2017039318A1 (en) * | 2015-09-01 | 2017-03-09 | Kainos Medicine, Inc. | Benzimidazole derivatives for dna methylation inhibitors |
GB201604029D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604027D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604030D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604022D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604020D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604031D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
WO2020018848A1 (en) * | 2018-07-19 | 2020-01-23 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using amido compounds |
CA3110576A1 (en) * | 2018-09-18 | 2020-03-26 | Terns, Inc. | Compounds for treating certain leukemias |
EP4265247A1 (en) * | 2022-04-22 | 2023-10-25 | Université Paris Cité | Compounds inducing production of proteins by immune cells |
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DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
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US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
ATE292465T1 (de) * | 1998-05-22 | 2005-04-15 | Avanir Pharmaceuticals | Benzimidazol-derivate als ige-modulatoren |
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ID28787A (id) * | 1998-11-03 | 2001-07-05 | Basf Ag | 2-fenilbenzimidazol tersubstitusi, pembuatannya dan penggunaannya |
RU2001116581A (ru) * | 1998-11-17 | 2004-02-20 | БАСФ Акциенгезельшафт (DE) | Замещенные 2-фенилбензимидазолы и 2-фенилиндолы, их получение и применение |
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PT1368028E (pt) * | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
CN1638765A (zh) * | 2001-07-27 | 2005-07-13 | 柯里斯公司 | Hedgehog信号转导途径介质、其相关组合物以及应用 |
TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
WO2004024655A2 (en) * | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
BRPI0409097A (pt) * | 2003-04-10 | 2006-04-11 | Avanir Pharmaceuticals | derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos |
JP2007501618A (ja) * | 2003-08-08 | 2007-02-01 | アバニール・ファーマシューティカルズ | タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法 |
-
2003
- 2003-02-26 TW TW092104005A patent/TW200304820A/zh unknown
- 2003-03-06 EP EP03711459A patent/EP1494668A4/en not_active Withdrawn
- 2003-03-06 US US10/508,968 patent/US20050197375A1/en not_active Abandoned
- 2003-03-06 WO PCT/US2003/006981 patent/WO2003082186A2/en active Application Filing
- 2003-03-06 CA CA002479453A patent/CA2479453A1/en not_active Abandoned
- 2003-03-06 AU AU2003213768A patent/AU2003213768A1/en not_active Abandoned
- 2003-03-06 JP JP2003579729A patent/JP2005525389A/ja active Pending
- 2003-03-25 PE PE2003000304A patent/PE20040165A1/es not_active Application Discontinuation
- 2003-03-25 UY UY27732A patent/UY27732A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005525389A (ja) | 2005-08-25 |
EP1494668A4 (en) | 2007-03-21 |
WO2003082186A2 (en) | 2003-10-09 |
UY27732A1 (es) | 2003-10-31 |
CA2479453A1 (en) | 2003-10-09 |
TW200304820A (en) | 2003-10-16 |
EP1494668A2 (en) | 2005-01-12 |
AU2003213768A8 (en) | 2003-10-13 |
WO2003082186A3 (en) | 2004-03-25 |
AU2003213768A1 (en) | 2003-10-13 |
US20050197375A1 (en) | 2005-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |