PE20030712A1 - Indazolilpirrolotriazinas c-5 modificadas - Google Patents
Indazolilpirrolotriazinas c-5 modificadasInfo
- Publication number
- PE20030712A1 PE20030712A1 PE2002001102A PE2002001102A PE20030712A1 PE 20030712 A1 PE20030712 A1 PE 20030712A1 PE 2002001102 A PE2002001102 A PE 2002001102A PE 2002001102 A PE2002001102 A PE 2002001102A PE 20030712 A1 PE20030712 A1 PE 20030712A1
- Authority
- PE
- Peru
- Prior art keywords
- indazol
- triazin
- heterocycle
- benzyl
- ilmetil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
- C04B41/4584—Coating or impregnating of particulate or fibrous ceramic material
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00793—Uses not provided for elsewhere in C04B2111/00 as filters or diaphragms
Abstract
SE REFIERE A DERIVADOS DE INDAZOLILPIRROLOTRIAZINAS C-5 MODIFICADAS, DE FORMULA I SUS ENANTIOMEROS, DIASTEREOMEROS, SALES DONDE R ES SR2, SOR2, OR2, NR3R4; R1 ES ARILO, HETEROCICLO, ENTRE OTROS; R2 ES H, ALQUILO, ARILO, ARALQUILO, HETEROCICLO; R3 Y R4 SON H, ALQUILO, ARILO, HETEROCICLO; R2 Y R3 JUNTOS FORMAN UN ANILLO CARBOCICLO, HETEROCICLO. SON COMPUESTOS PREFERIDOS (5-[1,4]DIAZEPAN-1-ILMETIL-PIRROLO[2,1-f][1,2,4]TRIAZIN-4-IL)-[1-(3-FLUOR-BENCIL)-1H-INDAZOL-5-IL]-AMINA, [1-(3-FLUOR-BENCIL)-1H-INDAZOL-5-IL]-(5-IMIDAZOL-1-ILMETIL-PIRROLO[2,1-f][1,2,4]TRIAZIN-5-ILMETIL}-PIPERIDIN-3-CARBOXILICO, AMIDA DEL ACIDO 1-{4-[1-(3-FLUORO-BENCIL)-1H-INDAZOL-5-ILAMINO]-PIRROLO[2,1-f][1,2,4]TRIAZIN-5-ILMETIL}-PIPERIDIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS INHIBEN LA ACTIVIDAD DE LA TIROSINA CINASA DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO TALES COMO HER1, HER2, HER4 Y SON UTILES COMO AGENTES ANTIPROLIFERATIVOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33301401P | 2001-11-14 | 2001-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030712A1 true PE20030712A1 (es) | 2003-08-21 |
Family
ID=23300880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001102A PE20030712A1 (es) | 2001-11-14 | 2002-11-14 | Indazolilpirrolotriazinas c-5 modificadas |
Country Status (24)
Country | Link |
---|---|
US (2) | US6908916B2 (es) |
EP (1) | EP1446401B1 (es) |
JP (1) | JP4301440B2 (es) |
KR (1) | KR20050044441A (es) |
CN (1) | CN1615306A (es) |
AR (1) | AR037368A1 (es) |
AT (1) | ATE524462T1 (es) |
BR (1) | BR0214112A (es) |
CA (1) | CA2467068A1 (es) |
ES (1) | ES2370709T3 (es) |
HR (1) | HRP20040422A2 (es) |
HU (1) | HUP0402566A3 (es) |
IL (1) | IL161616A0 (es) |
IS (1) | IS7243A (es) |
MX (1) | MXPA04004492A (es) |
NO (1) | NO20041983L (es) |
NZ (1) | NZ533034A (es) |
PE (1) | PE20030712A1 (es) |
PL (1) | PL368909A1 (es) |
RU (1) | RU2004117549A (es) |
TW (1) | TW200300350A (es) |
UY (1) | UY27540A1 (es) |
WO (1) | WO2003042172A2 (es) |
ZA (1) | ZA200403694B (es) |
Families Citing this family (44)
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US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
EP2289894A3 (en) * | 2002-04-23 | 2011-07-20 | Bristol-Myers Squibb Company | Pyrrolo-triazine compounds useful as kinase inhibitors |
WO2003091229A1 (en) | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
US7388009B2 (en) | 2002-04-23 | 2008-06-17 | Bristol-Myers Squibb Company | Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
JP4791183B2 (ja) | 2002-08-23 | 2011-10-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体、類似体の合成およびその使用 |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
MXPA05008183A (es) | 2003-02-05 | 2005-10-05 | Bristol Myers Squibb Co | Proceso para preparar pirrolotriazina como inhibidores de cinasa. |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7432373B2 (en) | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
TW200600513A (en) | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
US7253167B2 (en) | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
US7102003B2 (en) * | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US7504521B2 (en) | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
US7148348B2 (en) | 2004-08-12 | 2006-12-12 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
TW200635927A (en) * | 2004-12-22 | 2006-10-16 | Bristol Myers Squibb Co | Synthetic process |
ES2319462T3 (es) | 2005-03-28 | 2009-05-07 | Bristol-Myers Squibb Company | Inhibidores competitivos de atp cinasas. |
US7534882B2 (en) | 2005-04-06 | 2009-05-19 | Bristol-Myers Squibb Company | Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles |
US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
CN101466710B (zh) | 2005-12-02 | 2013-05-29 | 拜尔健康护理有限责任公司 | 用于治疗与血管生成有关的过度增殖性病症和疾病的取代的4-氨基-吡咯并三嗪衍生物 |
PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
US8063208B2 (en) | 2006-02-16 | 2011-11-22 | Bristol-Myers Squibb Company | Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol |
DE102006030479A1 (de) * | 2006-07-01 | 2008-03-20 | Merck Patent Gmbh | Indazolderivate |
US8071779B2 (en) | 2006-12-18 | 2011-12-06 | Inspire Pharmaceuticals, Inc. | Cytoskeletal active rho kinase inhibitor compounds, composition and use |
WO2010071885A1 (en) | 2008-12-19 | 2010-06-24 | Cephalon, Inc. | Pyrrolotriazines as alk and jak2 inhibitors |
US20120149902A1 (en) * | 2009-07-28 | 2012-06-14 | Ube Industries, Ltd. | Pyrrolo[2,3-d]pyrimidine derivative |
CN102627647A (zh) * | 2012-03-20 | 2012-08-08 | 南京药石药物研发有限公司 | 4-氯-5-甲基-1H-吡咯并[2,1-f][1,2,4]三嗪的合成方法 |
EP2948454B1 (en) | 2013-01-24 | 2017-05-31 | Council of Scientific & Industrial Research An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) | Triazine compounds and a process for preparation thereof |
JP6473146B2 (ja) | 2013-10-11 | 2019-02-20 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ピロロトリアジンキナーゼ阻害剤 |
WO2015081783A1 (zh) * | 2013-12-06 | 2015-06-11 | 江苏奥赛康药业股份有限公司 | 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途 |
Family Cites Families (11)
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US4908056A (en) | 1986-04-25 | 1990-03-13 | E. I. Du Pont De Nemours And Company | Heterocyclic acyl sulfonamides |
DK0778277T3 (da) | 1995-12-08 | 2003-10-27 | Pfizer | Substituerede heterocycliske derivater som CRF antagonister |
CZ68199A3 (cs) | 1996-08-28 | 1999-11-17 | Pfizer Inc. | 6,5-Heterobicyklické deriváty, farmaceutická kompozice na jejich bázi a způsob léčení chorob |
ES2328269T3 (es) * | 1999-05-21 | 2009-11-11 | Bristol-Myers Squibb Company | Pirrolotriazinas como inhibires de quinasas. |
JP4623483B2 (ja) | 1999-08-23 | 2011-02-02 | 塩野義製薬株式会社 | sPLA2阻害作用を有するピロロトリアジン誘導体 |
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US20040082585A1 (en) * | 2001-10-03 | 2004-04-29 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
WO2003091229A1 (en) * | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
TW200400034A (en) * | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
-
2002
- 2002-11-08 TW TW091132942A patent/TW200300350A/zh unknown
- 2002-11-12 EP EP02793930A patent/EP1446401B1/en not_active Expired - Lifetime
- 2002-11-12 KR KR1020047007261A patent/KR20050044441A/ko not_active Application Discontinuation
- 2002-11-12 AT AT02793930T patent/ATE524462T1/de not_active IP Right Cessation
- 2002-11-12 NZ NZ533034A patent/NZ533034A/en unknown
- 2002-11-12 BR BR0214112-4A patent/BR0214112A/pt not_active Application Discontinuation
- 2002-11-12 HU HU0402566A patent/HUP0402566A3/hu unknown
- 2002-11-12 CA CA002467068A patent/CA2467068A1/en not_active Abandoned
- 2002-11-12 IL IL16161602A patent/IL161616A0/xx unknown
- 2002-11-12 RU RU2004117549/04A patent/RU2004117549A/ru not_active Application Discontinuation
- 2002-11-12 JP JP2003544009A patent/JP4301440B2/ja not_active Expired - Fee Related
- 2002-11-12 ES ES02793930T patent/ES2370709T3/es not_active Expired - Lifetime
- 2002-11-12 WO PCT/US2002/036528 patent/WO2003042172A2/en active IP Right Grant
- 2002-11-12 CN CNA028270657A patent/CN1615306A/zh active Pending
- 2002-11-12 PL PL02368909A patent/PL368909A1/xx not_active Application Discontinuation
- 2002-11-13 AR ARP020104360A patent/AR037368A1/es not_active Application Discontinuation
- 2002-11-14 PE PE2002001102A patent/PE20030712A1/es not_active Application Discontinuation
- 2002-11-14 UY UY27540A patent/UY27540A1/es not_active Application Discontinuation
- 2002-11-14 US US10/294,281 patent/US6908916B2/en not_active Expired - Lifetime
-
2004
- 2004-04-30 IS IS7243A patent/IS7243A/is unknown
- 2004-05-11 HR HR20040422A patent/HRP20040422A2/hr not_active Application Discontinuation
- 2004-05-12 MX MXPA04004492A patent/MXPA04004492A/es unknown
- 2004-05-13 NO NO20041983A patent/NO20041983L/no not_active Application Discontinuation
- 2004-05-13 ZA ZA200403694A patent/ZA200403694B/en unknown
-
2005
- 2005-05-09 US US11/125,021 patent/US20050209235A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003042172A3 (en) | 2004-01-29 |
WO2003042172A2 (en) | 2003-05-22 |
EP1446401A4 (en) | 2006-04-12 |
JP4301440B2 (ja) | 2009-07-22 |
NO20041983L (no) | 2004-06-24 |
CA2467068A1 (en) | 2003-05-22 |
AR037368A1 (es) | 2004-11-03 |
HUP0402566A2 (hu) | 2005-03-29 |
IL161616A0 (en) | 2004-09-27 |
IS7243A (is) | 2004-04-30 |
ATE524462T1 (de) | 2011-09-15 |
US20050209235A1 (en) | 2005-09-22 |
HUP0402566A3 (en) | 2009-01-28 |
JP2005509030A (ja) | 2005-04-07 |
ES2370709T3 (es) | 2011-12-22 |
PL368909A1 (en) | 2005-04-04 |
TW200300350A (en) | 2003-06-01 |
EP1446401A2 (en) | 2004-08-18 |
US6908916B2 (en) | 2005-06-21 |
KR20050044441A (ko) | 2005-05-12 |
RU2004117549A (ru) | 2006-01-10 |
CN1615306A (zh) | 2005-05-11 |
UY27540A1 (es) | 2003-07-31 |
BR0214112A (pt) | 2004-09-14 |
NZ533034A (en) | 2004-11-26 |
EP1446401B1 (en) | 2011-09-14 |
MXPA04004492A (es) | 2004-08-11 |
US20030186983A1 (en) | 2003-10-02 |
ZA200403694B (en) | 2006-06-28 |
HRP20040422A2 (en) | 2005-04-30 |
NO20041983D0 (no) | 2004-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |