PE20030012A1 - Composicion y actividad antiviral de derivados de indoloxoacetico piperazina sustituidos - Google Patents

Composicion y actividad antiviral de derivados de indoloxoacetico piperazina sustituidos

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Publication number
PE20030012A1
PE20030012A1 PE2001001132A PE2001001132A PE20030012A1 PE 20030012 A1 PE20030012 A1 PE 20030012A1 PE 2001001132 A PE2001001132 A PE 2001001132A PE 2001001132 A PE2001001132 A PE 2001001132A PE 20030012 A1 PE20030012 A1 PE 20030012A1
Authority
PE
Peru
Prior art keywords
alkyl
composition
antiviral activity
piperazine derivatives
substituted
Prior art date
Application number
PE2001001132A
Other languages
English (en)
Inventor
Owen B Wallace
Tao Wang
Kap-Sun Yeung
Bradley C Pearce
Nicholas A Meanwell
Zhilei Qiu
Haiquan Fang
Quifen May Xue
Zhiwei Yin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20030012A1 publication Critical patent/PE20030012A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/12—Radicals substituted by oxygen atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

SE REFIERE A DERIVADOS DE INDOLOXIACETICO PIPERAZINA SUSTITUIDOS DE FORMULA I DONDE A ES ALCOXI C1-C6, ARIL, HETEROARIL SELECCIONADO DE FENILO, NAFTILO, PIRIDINIL, PIRIMIDINIL, PERAZINIL, TRIAZINIL, FURANIL, TIENIL, ENTRE OTROS; W ES EL GRUPO a DONDE R ES H; R2-R5 SON H, HALO, CIANO, NITRO, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6; R8 ES ALQUILO C1-C6, FENILO, HETEROARILO, ENTRE OTROS; R9 Y R10 SON H, ALQUILO C1-C6, ALCOXI C1-C6, HETEROARIL, ENTRE OTROS; R11 ES H, ALCOXI C1-C6, ENTRE OTROS; R12 ES H, OH, ALQUILO C1-C6, ENTRE OTROS; R13-R20 SON H, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-[4-BENZOIL-PIPERAZIN-1-IL)-2-(4-FLUORO-7-FENILO-1H-INDOL-3-IL)-ETENO-1,2-DIONO, 1-[4-FLUORO-7-(2H-TETRAZOL-5-IL)-1H-INDOL-3-IL]-2-[4-PIRIDINA-2-CARBONIL)-PIPERACIN-1-IL]-ETANO-1,2-DIONO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION. LOS COMPUESTOS MENCIONADOS TIENEN ACTIVIDAD ANTIVIRAL Y SON UTILES PARA EL TRATAMIENTO DE VIH
PE2001001132A 2000-07-10 2001-11-14 Composicion y actividad antiviral de derivados de indoloxoacetico piperazina sustituidos PE20030012A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21744400P 2000-07-10 2000-07-10
US26597801P 2001-02-02 2001-02-02

Publications (1)

Publication Number Publication Date
PE20030012A1 true PE20030012A1 (es) 2003-01-30

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Country Status (12)

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EP (1) EP1299382B1 (es)
JP (1) JP2004502768A (es)
AT (1) ATE304853T1 (es)
AU (2) AU6872701A (es)
CA (1) CA2413044A1 (es)
DE (1) DE60113543T2 (es)
DK (1) DK1299382T3 (es)
ES (1) ES2250422T3 (es)
HU (1) HU230123B1 (es)
PE (1) PE20030012A1 (es)
UY (1) UY26825A1 (es)
WO (1) WO2002004440A1 (es)

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EP2696937B1 (en) 2011-04-12 2017-05-17 VIIV Healthcare UK (No.5) Limited Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
ES2616268T3 (es) 2011-08-29 2017-06-12 VIIV Healthcare UK (No.5) Limited Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH
ES2609579T3 (es) 2011-08-29 2017-04-21 VIIV Healthcare UK (No.5) Limited Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH
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US6469006B1 (en) * 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives

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WO2002004440A1 (en) 2002-01-17
AU6872701A (en) 2002-01-21
DE60113543T2 (de) 2006-07-13
DE60113543D1 (de) 2006-02-02
ATE304853T1 (de) 2005-10-15
DK1299382T3 (da) 2006-01-16
WO2002004440A9 (en) 2005-11-03
HUP0303082A3 (en) 2007-08-28
EP1299382A1 (en) 2003-04-09
JP2004502768A (ja) 2004-01-29
CA2413044A1 (en) 2002-01-17
UY26825A1 (es) 2002-01-31
EP1299382B1 (en) 2005-09-21
EP1299382A4 (en) 2004-02-11
HU230123B1 (hu) 2015-08-28
ES2250422T3 (es) 2006-04-16
AU2001268727B2 (en) 2005-03-24

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