PE20030653A1 - COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a - Google Patents

COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a

Info

Publication number
PE20030653A1
PE20030653A1 PE2002001149A PE2002001149A PE20030653A1 PE 20030653 A1 PE20030653 A1 PE 20030653A1 PE 2002001149 A PE2002001149 A PE 2002001149A PE 2002001149 A PE2002001149 A PE 2002001149A PE 20030653 A1 PE20030653 A1 PE 20030653A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxy
group
triazole
cr3r3a
Prior art date
Application number
PE2002001149A
Other languages
English (en)
Inventor
Bernard R Neustadt
Hong Liu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20030653A1 publication Critical patent/PE20030653A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS BICICLICO DE [1,2,4]-TRIAZOL DE FORMULA I DONDE A ES A ES CR1, N; R1 Y R1a SON H, ALQUILO, HALO, CN, CF3; Y ES O, S, SO, SO2, R5-HETEROARILDIILO, R5-ARILENO, GRUPO a; p Y q SON 2-3; Q Y Q1 SON N, CH, C-CN, COH, C-COCH3; UNO DE Q Y Q1 ES N; R ES R5-ARILO; R5-HETEROARILO; R6-ALQUENILO, R6-ALQUINILO; R2 ES R5-ARILO; R5-HETEROARILO, R5-ARIL-ALQUILO, R5-HETEROARIL-ALQUILO; R2-Y ES UN GRUPO b; U, V, W ES N, CR1; UNO DE U, V, W ES CR1; n ES 1-3; a)A ES CR1; X ES CR3R3a, CO, O, S, SO, SO2; R4-ARILENO, R4-HETEROARILDIILO, NR9; A ES CR1; Y ES UN ENLACE; X ES CR3R3a, CO, O, S, SO, SO2; b)A ES N, X ES NR9; Y ES R5-ARILENO; R2 ES UN GRUPO c; n ES 2-3; c)A ES N, X ES CR3R3a, CO, S, SO, SO2, NR9, ENTRE OTROS; d)A ES N, Y ES UN ENLACE; X ES NR9, R2 ES PIPERIDINA OPCIONALMENTE SUSTITUIDA CON R10; e)A ES N, X ES NR9; Y, R2 JUNTOS FORMAN UN GRUPO d; Z ES COCH2, CO-CH2-ALQUILO, CH2-CH2-ALQUILO, -CH2-ALQUILO-CH2-; R3 Y R3a SON H, OH, ALQUILO, HIDROXIALQUILO, ALCOXI-ALQUILO, ENTRE OTROS; R4 ES H, ALQUILO, OH, ALCOXI, HALO, CF3, ENTRE OTROS; R5 ES H, ALQUILO, OH, ALCOXI, ENTRE OTROS; R6 ES H, OH, ALCOXI, HALO; R7 Y R7a SON H, ALQUILO, ALCOXI-ALQUILO; R10 ES H, COO-ALQUILO, R5-ALQUILO, ENTRE OTROS. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL O ATAQUE APOPLETICO, DEPRESION ENFERMEDADES COGNITIVAS, NEURODEGENERATIVAS; PARKINSON, DEMENCIA SENIL, PSICOSIS DE ORIGEN ORGANICO
PE2002001149A 2001-11-30 2002-11-28 COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a PE20030653A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33438501P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
PE20030653A1 true PE20030653A1 (es) 2003-08-04

Family

ID=23306955

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001149A PE20030653A1 (es) 2001-11-30 2002-11-28 COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a

Country Status (19)

Country Link
US (2) US6875772B2 (es)
EP (1) EP1453836B1 (es)
JP (2) JP4429724B2 (es)
KR (1) KR20050044600A (es)
CN (1) CN1688581A (es)
AR (1) AR037681A1 (es)
AT (1) ATE358130T1 (es)
AU (1) AU2002352933A1 (es)
CA (1) CA2468658C (es)
DE (1) DE60219196T2 (es)
ES (1) ES2283625T3 (es)
HK (1) HK1064097A1 (es)
HU (1) HUP0402324A3 (es)
IL (1) IL161573A0 (es)
MX (1) MXPA04005158A (es)
PE (1) PE20030653A1 (es)
TW (1) TW200300689A (es)
WO (1) WO2003048163A1 (es)
ZA (1) ZA200404168B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2283625T3 (es) * 2001-11-30 2007-11-01 Schering Corporation Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos.
TW200300686A (en) 2001-11-30 2003-06-16 Schering Corp Adenosine A2a receptor antagonists
IL163828A0 (en) * 2002-03-12 2005-12-18 Wyeth Corp Process for making chiral 1,4-disubstituted piperazines
WO2004029056A1 (ja) * 2002-09-24 2004-04-08 Kyowa Hakko Kogyo Co., Ltd. [１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体
EP2295047A3 (en) * 2002-12-19 2011-05-18 Schering Corporation Use of adenosine A2a receptor antagonists for the treatment of restless leg syndrome and other movement disorders
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US7834014B2 (en) 2003-04-09 2010-11-16 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
WO2004092172A2 (en) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
TW200507850A (en) * 2003-07-25 2005-03-01 Kyowa Hakko Kogyo Kk Pharmaceutical composition
WO2006129626A1 (ja) * 2005-05-30 2006-12-07 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
ES2385702T3 (es) * 2005-06-07 2012-07-30 Kyowa Hakko Kirin Co., Ltd. Antagonistas de A2A para uso en el tratamiento de trastornos de la motricidad
WO2006131524A1 (en) * 2005-06-08 2006-12-14 Neurosearch A/S Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200803856A (en) 2005-09-02 2008-01-16 Mount Cook Biosciences Inc Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US7615556B2 (en) * 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
WO2009114533A2 (en) 2008-03-10 2009-09-17 Cornell University Modulation of blood brain barrier permeability
WO2010008775A1 (en) * 2008-06-23 2010-01-21 Ligand Pharmaceuticals Inc. Aminopyridopyrazinone derivatives for treating neurodegenerative diseases
GB201214106D0 (en) * 2012-08-07 2012-09-19 Univ Strathclyde Immunomodulatory compounds
WO2017173067A1 (en) 2016-03-31 2017-10-05 Versi Group, Llc Delta opioid agonist, mu opioid antagonist compositions and methods for treating parkinson's disease
CN106866582A (zh) * 2017-01-10 2017-06-20 广州隽沐生物科技有限公司 一种氟班色林中间体的制备方法
CA3103068A1 (en) * 2018-06-26 2020-01-02 Zhejiang Vimgreen Pharmaceuticals, Ltd Triazolotriazine derivatives as a2a receptor antagonists
US20220235056A1 (en) * 2019-05-03 2022-07-28 Nektar Therapeutics Adenosine 2 receptor antagonists
BR112023021918A2 (pt) * 2021-04-23 2023-12-19 Chong Kun Dang Pharmaceutical Corp Composto como antagonista do receptor de adenosina a2a e composição farmacêutica compreendendo o mesmo

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
EP0666079B1 (en) * 1993-07-27 2001-11-07 Kyowa Hakko Kogyo Co., Ltd. Remedy for parkinson's disease
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
CA2284737C (en) * 1997-03-24 2007-03-13 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]triazolo[1,5-c]pyrimidine derivatives
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
WO1999043678A1 (fr) 1998-02-24 1999-09-02 Kyowa Hakko Kogyo Co., Ltd. Medicaments et prophylaxie contre la maladie de parkinson
KR20010087361A (ko) * 1998-09-22 2001-09-15 히라타 다다시 [1,2,4]트리아졸로[1,5-ｃ]피리미딘 유도체
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
JP2002037787A (ja) * 2000-05-16 2002-02-06 Kyowa Hakko Kogyo Co Ltd ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法
MY132006A (en) 2000-05-26 2007-09-28 Schering Corp ADENOSINE A2a RECEPTOR ANTAGONISTS
MXPA04003474A (es) * 2001-10-15 2004-07-30 Schering Corp Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pirimidinas como antagonistas del receptor de adenosina a2a.
ES2283625T3 (es) * 2001-11-30 2007-11-01 Schering Corporation Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos.

Also Published As

Publication number Publication date
EP1453836B1 (en) 2007-03-28
JP2005511697A (ja) 2005-04-28
US7078408B2 (en) 2006-07-18
WO2003048163A1 (en) 2003-06-12
EP1453836A1 (en) 2004-09-08
ES2283625T3 (es) 2007-11-01
DE60219196D1 (de) 2007-05-10
AU2002352933A1 (en) 2003-06-17
TW200300689A (en) 2003-06-16
HK1064097A1 (en) 2005-01-21
ZA200404168B (en) 2005-09-02
JP4429724B2 (ja) 2010-03-10
US6875772B2 (en) 2005-04-05
HUP0402324A3 (en) 2008-09-29
ATE358130T1 (de) 2007-04-15
CA2468658C (en) 2009-04-14
HUP0402324A2 (hu) 2005-02-28
IL161573A0 (en) 2004-09-27
JP2010018634A (ja) 2010-01-28
US20030191130A1 (en) 2003-10-09
AR037681A1 (es) 2004-12-01
US20050113380A1 (en) 2005-05-26
CA2468658A1 (en) 2003-06-12
KR20050044600A (ko) 2005-05-12
CN1688581A (zh) 2005-10-26
DE60219196T2 (de) 2008-01-03
MXPA04005158A (es) 2004-08-11

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