PE20020514A1 - Aminas heterociclicas y fenilazacicloalcanos sustituidos para el tratamiento del sindrome de piernas inquietas - Google Patents
Aminas heterociclicas y fenilazacicloalcanos sustituidos para el tratamiento del sindrome de piernas inquietasInfo
- Publication number
- PE20020514A1 PE20020514A1 PE2001001052A PE2001001052A PE20020514A1 PE 20020514 A1 PE20020514 A1 PE 20020514A1 PE 2001001052 A PE2001001052 A PE 2001001052A PE 2001001052 A PE2001001052 A PE 2001001052A PE 20020514 A1 PE20020514 A1 PE 20020514A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- restless legs
- legs syndrome
- phenylazacicloalkanes
- substitute
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fats And Perfumes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A UNA COMBINACION QUE COMPRENDE: a) DE 0.1 mg A 50 mg/DIA DE UNA AMINA HETEROCICLICA DE FORMULA I DONDE R1, R2 Y R3 SON H, ALQUILO C1-C6, ALQUENILO C3-C5, ALQUINILO C3-C5, R1 Y R2 UNIDOS FORMAN UNA AMINA CICLICA C3-C7 QUE PUEDE CONTENER HETEROATOMOS; X ES H, ALQUILO C1-C6, HALOGENO, HIDROXILO, ALCOXILO, CIANO, ENTRE OTROS; A ES CH, CH2, CH-HALOGENO, CHCH3, C=O, C=S, C-SCH3, SO2, ENTRE OTROS; B ES CH2, CH, N, NH, O, ENTRE OTROS; n ES 0-1; D ES CH, CH2, CH-HALOGENO, O, N, ENTRE OTROS. SI A ES OXIGENO EL COMPUESTO ES (5R)-5-(METILAMINO)-5,6-DIHIDRO-4H-IMIDAZOL[4,5,1-ij]QUINOLIN-2(1H)-ONA; b) DE 10mg A 100mg/DIA UN FENILAZACICLOALCANO SUSTITUIDO DE FORMULA II DONDE n ES 0-3; R1 Y R2 SON H, OH (SIEMPRE Y CUANDO R4 NO SEA H), CH, CH2CN, ENTRE OTROS; R3 ES H, CF3, CH2CF3, ALQUILO C1-C8, ENTRE OTROS; R4 ES H, CF3, CH2CF3, ALQUILO C1-C8, ENTRE OTROS. LA COMPOSICION ES UTIL PARA TRATAR EL SINDROME DE PIERNAS INQUIETAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24466600P | 2000-10-31 | 2000-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020514A1 true PE20020514A1 (es) | 2002-06-12 |
Family
ID=22923642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001052A PE20020514A1 (es) | 2000-10-31 | 2001-10-24 | Aminas heterociclicas y fenilazacicloalcanos sustituidos para el tratamiento del sindrome de piernas inquietas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6602868B2 (es) |
| EP (1) | EP1330248A2 (es) |
| JP (1) | JP2004512367A (es) |
| KR (1) | KR20030042037A (es) |
| CN (1) | CN1606442A (es) |
| AR (1) | AR031152A1 (es) |
| AU (1) | AU2002211226A1 (es) |
| BR (1) | BR0115071A (es) |
| CA (1) | CA2421705A1 (es) |
| EA (1) | EA200300527A1 (es) |
| IL (1) | IL155591A0 (es) |
| MX (1) | MXPA03003912A (es) |
| NO (1) | NO20031923L (es) |
| NZ (1) | NZ525574A (es) |
| PE (1) | PE20020514A1 (es) |
| PL (1) | PL360904A1 (es) |
| WO (1) | WO2002036123A2 (es) |
| ZA (1) | ZA200301865B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU773642C (en) | 1997-12-22 | 2006-04-06 | Mundipharma Pty Limited | Opioid agonist/antagonist combinations |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| DE10053397A1 (de) | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
| DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| EP1387673B1 (en) | 2001-05-11 | 2010-12-29 | Endo Pharmaceuticals Inc. | Abuse-resistant controlled-release opioid dosage form |
| ES2733044T1 (es) * | 2002-04-05 | 2019-11-27 | Mundipharma Pharmaceuticals S L | Composición farmacéutica que contiene oxicodona y naloxona |
| AR040683A1 (es) * | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopamina |
| AU2003277296A1 (en) * | 2002-10-04 | 2004-05-04 | Pharmacia Corporation | Compositions and methods for treating sexual dysfunction |
| WO2004037971A2 (en) * | 2002-10-25 | 2004-05-06 | Pharmacia & Upjohn Company Llc | Use of heterocyclic amine-type compounds as neuroprotective agents |
| EP1677812A4 (en) | 2003-09-17 | 2010-03-24 | Xenoport Inc | TREATMENT OR PREVENTION OF NON-REST LEG SYNDROME USING GABA ANALOGUE-BASED PRODRUGS |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1604667A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
| EP3228308A1 (en) * | 2005-01-28 | 2017-10-11 | Euro-Celtique S.A. | Alcohol resistant dosage forms |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
| CN101263136A (zh) | 2005-07-13 | 2008-09-10 | 弗·哈夫曼-拉罗切有限公司 | 作为5-ht6、5-ht24的苯并咪唑衍生物 |
| US20100168119A1 (en) | 2008-11-05 | 2010-07-01 | Pharmorx, Inc. | Compositions and methods for minimizing or reducing agonist-induced desensitization |
| UY32487A (es) | 2009-03-10 | 2010-06-30 | Euro Celtique Sa | Composiciones farmacéuticas de liberación inmediata comprendiendo oxicodona y naloxona |
| US8690933B2 (en) * | 2009-08-31 | 2014-04-08 | Brigham Young University | System and method for treating symptoms of restless legs syndrome |
| EP2618826B1 (en) * | 2010-09-20 | 2016-04-13 | A.Carlsson Research AB | Phenylpiperidine compounds for the treatment of dementia |
| US20150342946A1 (en) | 2013-01-30 | 2015-12-03 | Pharmorx Therapeutics, Inc. | Treatments For Depression And Other Diseases With A Low Dose Agent |
| UA116567C2 (uk) | 2013-07-23 | 2018-04-10 | Євро-Селтік С.А. | Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації |
| US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
| EP3337497B1 (en) | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
| EP3337788A4 (en) | 2015-08-21 | 2019-03-27 | Portola Pharmaceuticals, Inc. | PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN / -KEXIN TYPE 9 P (CSK9) MODULATORS AND THEIR USE |
| US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| CN110603073B (zh) | 2017-01-05 | 2023-07-04 | 诺克特丽克丝健康公司 | 不宁腿综合征或过度活跃神经治疗 |
| WO2021067751A1 (en) | 2019-10-03 | 2021-04-08 | Noctrix Health, Inc. | Peripheral nerve stimulation for restless legs syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273975A (en) | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
| ES2157204T3 (es) | 1991-04-17 | 2001-08-16 | Upjohn Co | Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina. |
| AUPO274596A0 (en) * | 1996-10-04 | 1996-10-31 | Armstrong, Stuart Maxwell | Method for the treatment of neurological or neuropsychiatric disorders |
| US6001861A (en) | 1998-01-16 | 1999-12-14 | Pharmacia & Upjohn Company | Use of pramipexole in the treatment of restless legs syndrome |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| IL138522A0 (en) | 1998-03-27 | 2001-10-31 | Upjohn Co | Use of cabergoline in the treatment of restless legs syndrome |
| SE9802546D0 (sv) | 1998-07-15 | 1998-07-15 | Ross Nicholas Waters | Medicinal product and method for treatment and prevention of dyskinesia |
| US6455564B1 (en) | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
| DE19938823A1 (de) | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Medikamentöse Behandlung des Restless Leg Syndroms |
| ATE312608T1 (de) | 2000-04-21 | 2005-12-15 | Pharmacia & Upjohn Co Llc | Cabergolin zur behandlung von fibromyalgie und chronic-fatigue-syndrom |
| AR033520A1 (es) | 2000-04-27 | 2003-12-26 | Upjohn Co | (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona |
-
2001
- 2001-10-23 AR ARP010104960A patent/AR031152A1/es unknown
- 2001-10-24 PE PE2001001052A patent/PE20020514A1/es not_active Application Discontinuation
- 2001-10-29 CN CNA018156134A patent/CN1606442A/zh active Pending
- 2001-10-29 EP EP01979241A patent/EP1330248A2/en not_active Withdrawn
- 2001-10-29 BR BR0115071-5A patent/BR0115071A/pt not_active IP Right Cessation
- 2001-10-29 MX MXPA03003912A patent/MXPA03003912A/es not_active Application Discontinuation
- 2001-10-29 EA EA200300527A patent/EA200300527A1/ru unknown
- 2001-10-29 PL PL36090401A patent/PL360904A1/xx not_active Application Discontinuation
- 2001-10-29 NZ NZ52557401A patent/NZ525574A/xx unknown
- 2001-10-29 IL IL15559101A patent/IL155591A0/xx unknown
- 2001-10-29 KR KR10-2003-7005874A patent/KR20030042037A/ko not_active Application Discontinuation
- 2001-10-29 AU AU2002211226A patent/AU2002211226A1/en not_active Abandoned
- 2001-10-29 WO PCT/US2001/027785 patent/WO2002036123A2/en not_active Application Discontinuation
- 2001-10-29 CA CA002421705A patent/CA2421705A1/en not_active Abandoned
- 2001-10-29 US US10/039,446 patent/US6602868B2/en not_active Expired - Fee Related
- 2001-10-29 JP JP2002538934A patent/JP2004512367A/ja not_active Withdrawn
-
2003
- 2003-03-06 ZA ZA200301865A patent/ZA200301865B/en unknown
- 2003-04-25 US US10/423,078 patent/US6716854B2/en not_active Expired - Fee Related
- 2003-04-29 NO NO20031923A patent/NO20031923L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002036123A2 (en) | 2002-05-10 |
| NZ525574A (en) | 2004-12-24 |
| US20030212065A1 (en) | 2003-11-13 |
| AR031152A1 (es) | 2003-09-10 |
| US20020107257A1 (en) | 2002-08-08 |
| EA200300527A1 (ru) | 2003-08-28 |
| NO20031923L (no) | 2003-06-27 |
| MXPA03003912A (es) | 2004-09-10 |
| KR20030042037A (ko) | 2003-05-27 |
| CN1606442A (zh) | 2005-04-13 |
| NO20031923D0 (no) | 2003-04-29 |
| AU2002211226A1 (en) | 2002-05-15 |
| CA2421705A1 (en) | 2002-05-10 |
| ZA200301865B (en) | 2004-06-25 |
| BR0115071A (pt) | 2003-07-29 |
| JP2004512367A (ja) | 2004-04-22 |
| US6602868B2 (en) | 2003-08-05 |
| EP1330248A2 (en) | 2003-07-30 |
| US6716854B2 (en) | 2004-04-06 |
| IL155591A0 (en) | 2003-11-23 |
| WO2002036123A3 (en) | 2002-09-19 |
| PL360904A1 (en) | 2004-09-20 |
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |