PE20020208A1 - Derivados de n-heterociclos condensados como ligandos para receptores de melanocortina - Google Patents
Derivados de n-heterociclos condensados como ligandos para receptores de melanocortinaInfo
- Publication number
- PE20020208A1 PE20020208A1 PE2001000626A PE2001000626A PE20020208A1 PE 20020208 A1 PE20020208 A1 PE 20020208A1 PE 2001000626 A PE2001000626 A PE 2001000626A PE 2001000626 A PE2001000626 A PE 2001000626A PE 20020208 A1 PE20020208 A1 PE 20020208A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitor
- glustes
- ligands
- melanosetment
- cr9r10
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I O UNA MEZCLA DE SUS ESTEREOISOMEROS, DONDE m ES 0-2; HET ES UN RESTO HETEROCICLO TAL COMO EL GRUPO a, GRUPO b, ENTRE OTROS DONDE d ES 0-2; e ES 1-2; Y2 ES O, S; A ES UN RADICAL EN EL LADO IZQUIERDO DEL RADICAL CONECTADO A C SELECCIONADO DE NR2-CO-NR2, NR2SO2-NR2, O-C(O)-NR2, NR2-C(O)-O, D(O)-NR2-C(O), ENTRE OTROS; Q ES UN ENLACE COVALENTE, CH2; W ES CH, N; X ES CR9R10, C=CH2, C=O; Y ES CR9R10, O, NR2; Z ES C=O, C=S, S(O)2; R1 ES H, (CH2)qN(X6)C(O)X6, (CH2)qN(X6)S(O)2(CH2)t-A1, ENTRE OTROS; q ES 0-4; t ES 0-3 SON COMPUESTOS PREFERIDOS {(R)-1-(4-CLOROBENCIL)-2-[1,3-DIOXO-(S)-8a-PIRIDIN-2-ILMETIL-2-(2,2,2,TRIFLUOROETIL)-HEXAHIDROIMIDAZOL[1,5-a]PIRAZIN-7-il]-2-OXOETIL} AMIDA DE ACIDO 1,2,3,4-TETRAHIDRO-ISOQUINOLIN-(S)-3-CARBOXILICO, {(R)-1-(4-CLOROBENCIL)-2-[(R)-8a-(4-FLUOROBENCIL)-2-METILl-1,3-DIOXOHEXAHIDRO-IMIDAZOLO[1,5-a]PIRAZIN-7-il]-2-OXOETIL} AMIDA DE ACIDO 1,2,3,4-TETRAHIDRO-ISOQUINOLIN-(R)-3-CARBOXILICO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DERIVADOS DE N-HETEROCICLOS CONDENSADOS COMO LIGANDOS PARA RECEPTORES DE MELANOCORTINA JUNTO A INGREDIENTES ACTIVOS COMO SENSIBILIZADOR DE INSULINA, SULFONILUREA, INHIBIDOR DE O-GLUCOSIDASA, ENTRE OTROS UTILES PARA EL TRATAMIENTO DE LA OBESIDAD, DIABETES MELLITUS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21461600P | 2000-06-28 | 2000-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020208A1 true PE20020208A1 (es) | 2002-03-13 |
Family
ID=22799775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000626A PE20020208A1 (es) | 2000-06-28 | 2001-06-26 | Derivados de n-heterociclos condensados como ligandos para receptores de melanocortina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20020072604A1 (es) |
| EP (1) | EP1294719A1 (es) |
| JP (1) | JP2004501917A (es) |
| KR (1) | KR20030017571A (es) |
| CN (1) | CN1440406A (es) |
| AP (1) | AP2001002196A0 (es) |
| AR (1) | AR030301A1 (es) |
| AU (1) | AU2001260548A1 (es) |
| BG (1) | BG107268A (es) |
| BR (1) | BR0111567A (es) |
| CA (1) | CA2412563A1 (es) |
| EA (1) | EA200201119A1 (es) |
| EC (1) | ECSP024404A (es) |
| IL (1) | IL152781A0 (es) |
| IS (1) | IS6617A (es) |
| MA (1) | MA26920A1 (es) |
| MX (1) | MXPA03000063A (es) |
| NO (1) | NO20026280D0 (es) |
| OA (1) | OA12296A (es) |
| PA (1) | PA8521501A1 (es) |
| PE (1) | PE20020208A1 (es) |
| PL (1) | PL360855A1 (es) |
| TN (1) | TNSN01097A1 (es) |
| UY (1) | UY26804A1 (es) |
| WO (1) | WO2002000654A1 (es) |
| ZA (1) | ZA200210277B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001264977B2 (en) * | 2000-05-30 | 2005-04-14 | Merck & Co., Inc. | Melanocortin receptor agonists |
| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| CA2462200A1 (en) * | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| JP2005519876A (ja) | 2001-11-27 | 2005-07-07 | メルク エンド カムパニー インコーポレーテッド | ２−アミノキノリン化合物 |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| CA2515717A1 (en) | 2003-02-10 | 2004-08-19 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| JP2005306839A (ja) * | 2003-08-29 | 2005-11-04 | Takeda Chem Ind Ltd | 二環性ピペラジン化合物およびその用途 |
| US7795267B2 (en) | 2003-08-29 | 2010-09-14 | Takeda Pharmaceutical Company Limited | Bicyclic piperazine compound having TGR23 antagonistic activity |
| BRPI0508787A (pt) * | 2004-04-08 | 2007-09-04 | Astellas Pharma Inc | composto ws727713, cepa de actinomiceto, composto com atividade moduladora de receptor de melanocortina, processo para produzir o composto ws727713, modulador de receptor de melanocortina, uso do composto e composição farmacêutica |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| DK3354273T3 (da) * | 2005-07-08 | 2021-06-28 | Ipsen Pharma | Melanocortinreceptorligander |
| US8227476B2 (en) | 2005-08-03 | 2012-07-24 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
| JP2009513604A (ja) | 2005-10-29 | 2009-04-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 月経前障害及び他の女性の性的障害治療用のベンゾイミダゾロン誘導体 |
| PE20080145A1 (es) * | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
| WO2008007664A1 (fr) | 2006-07-11 | 2008-01-17 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique bicycique et son utilisation |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| KR20090042967A (ko) | 2006-08-14 | 2009-05-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 플리반세린 제형 및 이의 제조방법 |
| EA200900270A1 (ru) | 2006-08-25 | 2009-08-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Системы регулируемого высвобождения и способ их приготовления |
| JP5250026B2 (ja) | 2007-05-25 | 2013-07-31 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | ヒダントインで修飾したメラノコルチン受容体リガンド |
| UY31335A1 (es) | 2007-09-12 | 2009-04-30 | Tratamiento de sintomas vasomotores | |
| JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999055679A1 (en) * | 1998-04-28 | 1999-11-04 | Trega Biosciences, Inc. | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| CA2334551A1 (en) * | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| AU766191B2 (en) * | 1999-06-04 | 2003-10-09 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
-
2001
- 2001-05-31 PL PL36085501A patent/PL360855A1/xx not_active Application Discontinuation
- 2001-05-31 AP APAP/P/2001/002196A patent/AP2001002196A0/en unknown
- 2001-05-31 AU AU2001260548A patent/AU2001260548A1/en not_active Abandoned
- 2001-05-31 KR KR1020027017822A patent/KR20030017571A/ko not_active Application Discontinuation
- 2001-05-31 IL IL15278101A patent/IL152781A0/xx unknown
- 2001-05-31 OA OA1200200389A patent/OA12296A/en unknown
- 2001-05-31 EP EP01934254A patent/EP1294719A1/en not_active Withdrawn
- 2001-05-31 EA EA200201119A patent/EA200201119A1/ru unknown
- 2001-05-31 MX MXPA03000063A patent/MXPA03000063A/es unknown
- 2001-05-31 BR BR0111567-7A patent/BR0111567A/pt not_active IP Right Cessation
- 2001-05-31 JP JP2002505778A patent/JP2004501917A/ja not_active Withdrawn
- 2001-05-31 CA CA002412563A patent/CA2412563A1/en not_active Abandoned
- 2001-05-31 CN CN01812163A patent/CN1440406A/zh active Pending
- 2001-05-31 WO PCT/IB2001/000995 patent/WO2002000654A1/en not_active Application Discontinuation
- 2001-06-25 US US09/891,026 patent/US20020072604A1/en not_active Abandoned
- 2001-06-26 AR ARP010103037A patent/AR030301A1/es unknown
- 2001-06-26 PE PE2001000626A patent/PE20020208A1/es not_active Application Discontinuation
- 2001-06-27 UY UY26804A patent/UY26804A1/es not_active Application Discontinuation
- 2001-06-27 TN TNTNSN01097A patent/TNSN01097A1/fr unknown
- 2001-06-28 PA PA20018521501A patent/PA8521501A1/es unknown
-
2002
- 2002-11-12 BG BG107268A patent/BG107268A/xx unknown
- 2002-11-14 IS IS6617A patent/IS6617A/is unknown
- 2002-12-19 ZA ZA200210277A patent/ZA200210277B/en unknown
- 2002-12-24 MA MA26976A patent/MA26920A1/fr unknown
- 2002-12-26 EC EC2002004404A patent/ECSP024404A/es unknown
- 2002-12-30 NO NO20026280A patent/NO20026280D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2412563A1 (en) | 2002-01-03 |
| EP1294719A1 (en) | 2003-03-26 |
| MXPA03000063A (es) | 2003-09-25 |
| US20020072604A1 (en) | 2002-06-13 |
| TNSN01097A1 (fr) | 2005-11-10 |
| BR0111567A (pt) | 2003-05-06 |
| PA8521501A1 (es) | 2002-10-24 |
| UY26804A1 (es) | 2002-01-31 |
| NO20026280L (no) | 2002-12-30 |
| KR20030017571A (ko) | 2003-03-03 |
| JP2004501917A (ja) | 2004-01-22 |
| IL152781A0 (en) | 2003-06-24 |
| ECSP024404A (es) | 2003-02-06 |
| OA12296A (en) | 2006-05-12 |
| AR030301A1 (es) | 2003-08-20 |
| ZA200210277B (en) | 2003-12-19 |
| NO20026280D0 (no) | 2002-12-30 |
| MA26920A1 (fr) | 2004-12-20 |
| BG107268A (en) | 2003-06-30 |
| IS6617A (is) | 2002-11-14 |
| CN1440406A (zh) | 2003-09-03 |
| WO2002000654A1 (en) | 2002-01-03 |
| PL360855A1 (en) | 2004-09-20 |
| EA200201119A1 (ru) | 2003-06-26 |
| AU2001260548A1 (en) | 2002-01-08 |
| AP2001002196A0 (en) | 2002-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |