ES2154167A1 - Aminoderivados ciclicos antagonistas del receptor ccr-3. - Google Patents

Aminoderivados ciclicos antagonistas del receptor ccr-3.

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Publication number
ES2154167A1
ES2154167A1 ES009801760A ES9801760A ES2154167A1 ES 2154167 A1 ES2154167 A1 ES 2154167A1 ES 009801760 A ES009801760 A ES 009801760A ES 9801760 A ES9801760 A ES 9801760A ES 2154167 A1 ES2154167 A1 ES 2154167A1
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Prior art keywords
ccr
receptor antagonists
methods
chem
preparing
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ES009801760A
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ES2154167B1 (es
Inventor
Leyi Gong
Denis John Kertesz
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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  • Pyrrole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Aminoderivados cíclicos antagonistas del receptor CCR-3, correspondientes a la fórmula (I), en la que T, U, R{sub,1}, R{sub,2}, m, n, R, R{sub,3}, R{sub,4} y Q tienen los significados expresados en la memoria y en las reivindicaciones. La invención se refiere también a composiciones farmacéuticas que contienen a esos compuestos, a métodos para su uso, y a métodos para la preparación de dichos compuestos. Estos compuestos se usan para el control o prevención de enfermedades inducidas por eosinófilos, particularmente el asma.
ES009801760A 1997-08-18 1998-08-14 Aminoderivados ciclicos antagonistas del receptor ccr-3. Expired - Lifetime ES2154167B1 (es)

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NO983749D0 (no) 1998-08-17
HU9801861D0 (en) 1998-10-28
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US6323223B1 (en) 2001-11-27
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