PE20001234A1 - Compuestos azabiciclicos sustituidos de heteroaril-aminoetil/benzisoxazol como antagonistas serotonergicos 5-ht1 - Google Patents
Compuestos azabiciclicos sustituidos de heteroaril-aminoetil/benzisoxazol como antagonistas serotonergicos 5-ht1Info
- Publication number
- PE20001234A1 PE20001234A1 PE1999001116A PE00111699A PE20001234A1 PE 20001234 A1 PE20001234 A1 PE 20001234A1 PE 1999001116 A PE1999001116 A PE 1999001116A PE 00111699 A PE00111699 A PE 00111699A PE 20001234 A1 PE20001234 A1 PE 20001234A1
- Authority
- PE
- Peru
- Prior art keywords
- fluoro
- compounds
- aminoethyl
- heteroaryl
- pyrid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
SE REFIERE A COMPUESTOS AZABICICLICOS HETEROARIL-AMINOETIL/BENZOISOXAZOL SUSTITUIDOS DE FORMULA I; DONDE R1, R2, R3, R4 SON H, ALQUILO C1-C4, ALCOXI C1-C4, (ALQUILO C1-C4)(ALCOXI C1-C4) OPCIONALMENTE SUSTITUIDOS CON F; X ES CH, N. SON COMPUESTOS PREFERIDOS (7R,9aS)-TRANS-[2-(5-FLUORO-BENZO[d]ISOXAZOL-3-IL)-OCTAHIDRO-PIRIDO[1,2-a]PIRAZIN-7-ILMETIL]-(5-FLUORO-PIRIMIDIN-2-IL)AMINA, (7R, 9aS)-CIS-[2-(5-FLUORO-BENZO[d]ISOXAZOL-3-IL)-OCTAHIDRO-PIRIDO[1,2-a]PIRAZIN-7-ILMETIL]PIRIMIDIN-2-IL)-AMINA, (7S,9aS)-CIS-[2-(5-FLUORO-BENZO[d]ISOXAZOL-3-IL)-OCTAHIDRO-PIRIDO[1,2-a]PIRAZIN-7-ILMETIL]-(5-FLUORO-PIRIDIN-2-IL)AMINA), ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN INHIBIDOR DE LA RECAPTACION DE 5-HT TAL COMO SERTRALINA. LOS COMPUESTOS I MODULAN LA NEUROTRASMISION SEROTONERGICA 5-HT1 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE HIPERTENSION, DEPRESION, TRASTORNO DE LA ANSIEDAD GENERALIZADA, FOBIAS, SINDROME DE ESTRES POST TRAUMATICO, EYACULACION PRECOZ, OBESIDAD, CEFALEA, MIGRANA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11395798P | 1998-12-28 | 1998-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001234A1 true PE20001234A1 (es) | 2000-11-07 |
Family
ID=22352526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999001116A PE20001234A1 (es) | 1998-12-28 | 1999-11-04 | Compuestos azabiciclicos sustituidos de heteroaril-aminoetil/benzisoxazol como antagonistas serotonergicos 5-ht1 |
Country Status (43)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855729B2 (en) * | 2001-02-20 | 2005-02-15 | Timothy G. Dinan | Treatment of fibromyalgia and related fatigue syndromes using antagonists or partial agonists of 5HT1a receptors |
GB0203778D0 (en) * | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
EA009527B1 (ru) * | 2003-03-12 | 2008-02-28 | Пфайзер Продактс Инк. | Пиридилоксиметильные и бензизоксазольные азабициклические производные |
GB0316915D0 (en) * | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
BRPI0507250A (pt) * | 2004-01-29 | 2007-06-26 | Pfizer Prod Inc | combinações para tratar desordens do snc |
AR049478A1 (es) | 2004-03-25 | 2006-08-09 | Solvay Pharm Bv | Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas. |
AR048112A1 (es) * | 2004-03-25 | 2006-03-29 | Solvay Pharm Bv | Derivados de 1-(2h-1-benzopiran-2-on-8-il)-piperazina para el tratamiento de dolor |
MX2007002460A (es) * | 2004-09-10 | 2007-05-04 | Pfizer Prod Inc | Metodos para tratar trastornos del humor utilizando derivados azabiciclicos de piridiloximetilo y benzisoxazol. |
MX2007002842A (es) * | 2004-09-10 | 2007-04-30 | Pfizer Prod Inc | Metodos de tratamiento de trastornos cognitivos que usan derivados azabiciclicos de piridiloximetilo y benzoisoxazol. |
DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
US20230057844A1 (en) * | 2019-12-20 | 2023-02-23 | The Jackson Laboratory | Molecular targets for addiction |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5157034A (en) * | 1991-02-27 | 1992-10-20 | Pfizer Inc. | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines |
GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
EP0763034A1 (en) * | 1994-05-28 | 1997-03-19 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
HUP0001123A3 (en) * | 1997-04-18 | 2002-04-29 | Smithkline Beecham Plc | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
PA8469101A1 (es) * | 1998-04-09 | 2000-09-29 | Pfizer Prod Inc | Ligandos azabiciclicos de receptores 5ht1 |
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1999
- 1999-03-11 UA UA2001064492A patent/UA62015C2/uk unknown
- 1999-04-11 AR ARP990105589A patent/AR024840A1/es unknown
- 1999-11-03 ID IDW00200101401A patent/ID30117A/id unknown
- 1999-11-03 CZ CZ20012386A patent/CZ291163B6/cs not_active IP Right Cessation
- 1999-11-03 BR BR9916807-3A patent/BR9916807A/pt not_active Application Discontinuation
- 1999-11-03 NZ NZ511964A patent/NZ511964A/en unknown
- 1999-11-03 IL IL14338599A patent/IL143385A0/xx unknown
- 1999-11-03 KR KR10-2001-7008261A patent/KR100417506B1/ko not_active IP Right Cessation
- 1999-11-03 DE DE69915113T patent/DE69915113T2/de not_active Expired - Fee Related
- 1999-11-03 ES ES99951040T patent/ES2214892T3/es not_active Expired - Lifetime
- 1999-11-03 YU YU44301A patent/YU44301A/sh unknown
- 1999-11-03 EP EP99951040A patent/EP1140931B1/en not_active Expired - Lifetime
- 1999-11-03 GE GEAP19995963A patent/GEP20043227B/en unknown
- 1999-11-03 WO PCT/IB1999/001772 patent/WO2000039128A1/en active IP Right Grant
- 1999-11-03 SK SK900-2001A patent/SK9002001A3/sk unknown
- 1999-11-03 DK DK99951040T patent/DK1140931T3/da active
- 1999-11-03 AU AU63614/99A patent/AU761711B2/en not_active Ceased
- 1999-11-03 HU HU0104852A patent/HUP0104852A3/hu unknown
- 1999-11-03 AP APAP/P/2001/002188A patent/AP2001002188A0/en unknown
- 1999-11-03 JP JP2000591039A patent/JP2002533463A/ja active Pending
- 1999-11-03 PT PT99951040T patent/PT1140931E/pt unknown
- 1999-11-03 CN CN99815202A patent/CN1332740A/zh active Pending
- 1999-11-03 CA CA002356985A patent/CA2356985C/en not_active Expired - Fee Related
- 1999-11-03 TR TR2001/01979T patent/TR200101979T2/xx unknown
- 1999-11-03 OA OA1200100172A patent/OA11742A/en unknown
- 1999-11-03 AT AT99951040T patent/ATE260278T1/de not_active IP Right Cessation
- 1999-11-03 EA EA200100517A patent/EA003099B1/ru not_active IP Right Cessation
- 1999-11-03 EE EEP200100346A patent/EE04439B1/xx not_active IP Right Cessation
- 1999-11-04 PE PE1999001116A patent/PE20001234A1/es not_active Application Discontinuation
- 1999-11-05 TW TW088119374A patent/TW523514B/zh not_active IP Right Cessation
- 1999-11-10 MA MA25844A patent/MA26706A1/fr unknown
- 1999-11-10 DZ DZ990233A patent/DZ2933A1/xx active
- 1999-11-17 TN TNTNSN99218A patent/TNSN99218A1/fr unknown
- 1999-11-18 CO CO99072703A patent/CO5150179A1/es unknown
- 1999-12-06 US US09/454,509 patent/US6525196B1/en not_active Expired - Fee Related
- 1999-12-07 PA PA19998486701A patent/PA8486701A1/es unknown
- 1999-12-23 GT GT199900224A patent/GT199900224A/es unknown
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2001
- 2001-05-22 IS IS5951A patent/IS5951A/is unknown
- 2001-06-19 CR CR6398A patent/CR6398A/es not_active Application Discontinuation
- 2001-06-20 ZA ZA200105041A patent/ZA200105041B/en unknown
- 2001-06-27 NO NO20013215A patent/NO20013215L/no not_active Application Discontinuation
- 2001-06-28 HR HR20010488A patent/HRP20010488A2/hr not_active Application Discontinuation
- 2001-07-16 BG BG105710A patent/BG105710A/xx unknown
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FD | Application declared void or lapsed |